Revealing the scientific connotation of compatibility of Chinese medicine medica based on self-assembly technology

doi:10.19852/j.cnki.jtcm.2024.06.013

Abstract

Abstract:

Chinese materia medica (CMM) compatibility is one core content in the theory of Traditional Chinese Medicine (TCM), and elaborating the scientific connotation of CMM compatibility is of great significance to promote the modernization of TCM. Self-assembly is the combination of active ingredients into aggregates through non-covalent bonds, such as hydrogen bonding, electrostatic interactions, ionic interactions, and hydrophobic interactions. The complex properties and special structures of CMM components create the basis for self-assembly. The self-assembled materials formed after CMM compatibility is an important part of the material basis for the efficacy of TCM, which can help explain the scientific connotations of CMM compatibility. This review summarizes the self-assembly phenomenon from the perspective of drug pair combinations in recent decades and explains the scientific connotation of CMM compatibility about the material basis, pharmacodynamic changes, and mechanism of action, providing new ideas and methods for the study of TCM.

Key words: Chinese materia medica compatibility, medicine, Chinese Traditional, self-assembly phenomenon, reduce adverse reactions and increase desired effects, component interactions, review

DONG Yingying, GUO Qin, GAO Yuan, WANG Huanhuan, BAI Dong. Revealing the scientific connotation of compatibility of Chinese medicine medica based on self-assembly technology[J]. Journal of Traditional Chinese Medicine, 2024, 44(6): 1288-1295.

References 61.

1.	Li Z, Yan M, Cao L, et al. Glycyrrhetinic acid accelerates the clearance of triptolide through P-gp in vitro. Phytother Res 2017; 31: 1090-6.
2.	Liu L, Duan J, Tang Y, et al. Study on the correlation of chemical constituents and activities of Radix Angelicae Sinensis and Semen Persicae. Zhong Hua Zhong Yi Yao Za Zhi 2011; 26: 2415-20.
3.	Tu P, Shi S, Jiang Y. Strategies and approaches on exploring material basis of Chinese materia medica. Zhong Cao Yao 2012; 43: 209-15.
4.	Guo Y, Gao T, Li C, et al. Detoxification mechanisms of a combination of Semen Strychni and Radix Glycyrrhizae: a comparative analyses of differences in toxicokinetics and tissue distribution after oral administration of Semen Strychni-Radix Glycyrrhizae decoction. Biomed Chromatogr 2022; 36: e5321.
5.	Ma BL, Yin C, Zhang BK, et al. Naturally occurring proteinaceous nanoparticles in Coptidis Rhizoma extract act as concentration-dependent carriers that facilitate berberine absorption. Sci Rep 2016; 6: 20110.
6.	Wang L, Cao X, Li H, Wang M, Ren X. Application of molecular recognition and self-assembly of chemical components in study of Chinese materia medica. Zhong Cao Yao 2020; 51: 516-21.
7.	Gao Y, Hu J, Ju Y. Supramolecular self-assembly based on natural small molecules. Hua Xue Xue Bao 2016;74: 312-29.
8.	He F, Zhou Y, Deng K, et al. Special impact of supramolecular chemistry on Chinese medicine theories. Zhong Guo Zhong Yao Za Zhi 2014; 39: 1534-43.
9.	Whitesides GM, Mathias JP, Seto CT. Molecular self-assembly and nanochemistry: a chemical strategy for the synthesis of nanostructures. Science 1991; 254: 1312-9. PMID
10.	Liu K, Zha XQ, Li QM, Pan LH, Luo JP. Hydrophobic interaction and hydrogen bonding driving the self-assembling of quinoa protein and flavonoids. Food Hydrocolloids 2021; 118: 106807.
11.	Lai LF, Guo HX. Preparation of new 5-fluorouracil-loaded zein nanoparticles for liver targeting. Int J Pharm 2011; 404: 317-23.
12.	Xiang H, Sun-Waterhouse D, Cui C, Wang W, Dong K. Modification of soy protein isolate by glutaminase for nanocomplexation with curcumin. Food Chem 2018; 268: 504-12. DOI PMID
13.	Yan B, Davachi SM, Ravanfar R, Dadmohammadi Y, Abbaspourrad A. Improvement of vitamin C stability in vitamin gummies by encapsulation in casein gel. Food Hydrocolloids 2020: 113: 106414.
14.	Ping Y, Li Y, Lu S, et al. A study of nanometre aggregates formation mechanism and antipyretic effect in Bai-Hu-Tang, an ancient Chinese herbal decoction. Biomed Pharmacother 2020; 124: 109826. DOI PMID
15.	Zhou J, Zhang J, Gao G, et al. Boiling licorice produces self-assembled protein nanoparticles: a novel source of bioactive nanomaterials. J Agric Food Chem 2019; 67: 9354-61.
16.	Weng Q, Cai X, Zhang F, Wang S. Fabrication of self-assembled Radix Pseudostellariae protein nanoparticles and the entrapment of curcumin. Food Chem 2019; 274: 796-802. DOI PMID
17.	Yang W, Yu S, Chen S, Liu Y, Shao Z, Chen X. Doxorubicin-loaded silk fibroin nanospheres. Hua Xue Xue Bao 2014; 74: 1164-8.
18.	He Y, Xu Y, Huang Y, et al. Redox sensitive nano-capsules self-assembled from hyaluronic acid-hydroxychloroquine conjugates for CD44-targeted delivery of hydroxychloroquine to combat breast cancer metastasis in vitro and in vivo. Colloids Surf B Biointerfaces 2022; 210: 112249.
19.	Pang X, Lu Z, Du H, Yang X, Zhai G. Hyaluronic acid-quercetin conjugate micelles: synthesis, characterization, in vitro and in vivo evaluation. Colloids Surf B Biointerfaces 2014; 123: 778-86.
20.	Zhou J, Gao G, Chu Q, Wang H, Rao P, Ke L. Chromatographic isolation of nanoparticles from Ma-Xing-Shi-Gan-Tang decoction and their characterization. J Ethnopharmacol 2014; 151: 1116-23. DOI PMID
21.	Zheng J, Fan R, Wu H, et al. Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation. Nat Commun 2019; 10: 1604. DOI PMID
22.	Li W, Wang Z, Liu X, et al. Based on weak bond chemistry, the interaction mechanism between glycyrrhiza protein and berberine in water decocting process of Rhizoma Coptidis and Liquorice was investigated. Yao Xue Xue Bao 2021; 56: 2119-26.
23.	Zhao Y, Wan P, Wang J, Li P, Hu Q, Zhao R. Polysaccharide from vinegar baked Radix Bupleuri as efficient solubilizer for water-insoluble drugs of Chinese medicine. Carbohydr Polym 2020; 229: 115473.
24.	Zhang C, Zhao R, Yan W, et al. Compositions, formation mechanism, and neuroprotective effect of compound precipitation from the traditional chinese prescription Huang-Lian-Jie-Du-Tang. Molecules 2016; 21: 1094.
25.	Li T, Wang P, Guo W, et al. Natural berberine-based Chinese herb medicine assembled nanostructures with modified antibacterial application. ACS Nano 2019; 13: 6770-81. DOI PMID
26.	Lei Y, Sun L, Sui H, Wang W. Formation rules of baicalin-berberine complex. Zhong Cheng Yao 2018; 40: 577-82.
27.	Chen M, Wang P, Li T, et al. Comprehensive analysis of Huanglian Jiedu decoction: revealing the presence of a self-assembled phytochemical complex in its naturally-occurring precipitate. J Pharm Biomed Anal 2021; 195: 113820.
28.	Zhang CH, Yu RY, Liu YH, et al. Interaction of baicalin with berberine for glucose uptake in 3T3-L1 adipocytes and HepG2 hepatocytes. J Ethnopharmacol 2014; 151: 864-72.
29.	Bi X, Gong M, Di L. Review on prescription compatibility of shaoyao gancao decoction and reflection on pharmacokinetic compatibility mechanism of Traditional Chinese Medicine prescription based on in vivo drug interaction of main efficacious components. Evid Based Complement Alternat Med 2014; 2014: 208129.
30.	Shen CY, Zhu JJ, Dai B, Li XF, Shen BD, Yuan HL. Effect of self-assembled nanoparticles from Shaoyao Gancao decoction on release and absorption of main components of Baishao. Zhong Guo Zhong Yao Za Zhi 2021; 46: 2190-6.
31.	Shen C, Shen B, Zhu J, Wang J, Yuan H, Li X. Glycyrrhizic acid-based self-assembled micelles for improving oral bioavailability of paeoniflorin. Drug Dev Ind Pharm 2021; 47: 207-14. DOI PMID
32.	Hu J, Wu Z, Yan J, Pang W, Liang D, Xu X. A promising approach for understanding the mechanism of Traditional Chinese Medicine by the aggregation morphology. J Ethnopharmacol 2009; 123: 267-74. DOI PMID
33.	Lin D, Du Q, Wang H, et al. Antidiabetic micro-/nanoaggregates from Ge-Gen-Qin-Lian-Tang decoction increase absorption of baicalin and cellular antioxidant activity in vitro. Biomed Res Int 2017; 2017: 9217912.
34.	Chen R, Chen ZC. A new strategy to explore the antiviral mechanism of Maxin Shigan decotion by supramolecular assembly theory. Nanjing Zhong Yi Yao Da Xue Xue Bao 2021; 37: 136-9.
35.	Zhu Y, Chen W, Wang Z, Qiao H-z, Di L. Spatial heterogeneity and physical structure basis of antibacterial activity of Ma-Xing-Shi-Gan decoction. Yao Xue Xue Bao 2021; 56: 2112-8.
36.	Du X, Huang Y, Wang H, et al. Influence of Maxing Shigan Decoction and its aggregates on the anti-influenza virus A activity in vitro. Zhong Hua Zhong Yi Yao Za Zhi 2014; 29: 2746-3750.
37.	Gu T, Wang L, Zhu L, Song Z. Study on the change law of main components in compatibility of Coptis chinensis and rhubarb. Lin Chuang He Li Yong Yao 2020; 30: 43-4.
38.	Tian X, Wang P, Li T, et al. Self-assembled natural phytochemicals for synergistically antibacterial application from the enlightenment of traditional Chinese medicine combination. Acta Pharm Sin B 2020; 10: 1784-95. DOI PMID
39.	Xu Y, Wei L, Wang Y. Determination of cinnamic acid before and after the compatibility of Coptis chinensis with cinnamon by HPLC. Zhong Guo Zhong Yao Za Zhi 2001; 26: 48-50.
40.	Yan QN, Zhang S, Zhang ZQ. Study on the tissue distribution of berberine from Rhizoma Coptidis and compatibility with Rhizoma Coptidis and Cortex Cinnamomi in rats. Zhong Yao Cai 2009; 32: 575-8.
41.	Huang X, Wang P, Li T, et al. Self-assemblies based on traditional medicine berberine and cinnamic acid for adhesion-induced inhibition multidrug-resistant staphylococcus aureus. ACS Appl Mater Interfaces 2020; 12: 227-37.
42.	Han N, Huang X, Tian X, et al. Self-assembled nanoparticles of natural phytochemicals (berberine and 3,4,5-methoxycinnamic acid) originated from Traditional Chinese Medicine for inhibiting multidrug-resistant staphylococcus aureus. Curr Drug Deliv 2021; 18: 914-21. DOI PMID
43.	Rai M, Ingle AP, Pandit R, Paralikar P, Anasane N, Santos CAD. Curcumin and curcumin-loaded nanoparticles: antipathogenic and antiparasitic activities. Expert Rev Anti Infect Ther 2020; 18: 367-79. DOI PMID
44.	Hu X. Studies on bioactivity of turmeric compatibility and curcumin composite nanoliposome. Quanzhou: Huaqiao University, 2020: 1-69.
45.	Song J, Kim JY, You G, Kang YY, Yang J, Mok H. Formulation of glycyrrhizic acid-based nanocomplexes for enhanced anti-cancer and anti-inflammatory effects of curcumin. Biotechnol Bioprocess Eng 2022; 27: 163-70.
46.	Chen L, Hu C, Hood M, et al. A novel combination of vitamin C, curcumin and glycyrrhizic acid potentially regulates immune and inflammatory response associated with coronavirus infections: a perspective from system biology analysis. Nutrients 2020; 12: 1193.
47.	Wang Y, Sun R, Xu X, Du M, Zhu B, Wu C. Structural interplay between curcumin and soy protein to improve the water-solubility and stability of curcumin. Int J Biol Macromol 2021; 193: 1471-80. DOI PMID
48.	Teng Z, Luo Y, Wang Q. Nanoparticles synthesized from soy protein: preparation, characterization, and application for nutraceutical encapsulation. J Agric Food Chem 2012; 60: 2712-20.
49.	Wang S, Lu Y, Ouyang XK, Ling J. Fabrication of soy protein isolate/cellulose nanocrystal composite nanoparticles for curcumin delivery. Int J Biol Macromol 2020; 165: 1468-74. DOI PMID
50.	Xu G, Li L, Bao X, Yao P. Curcumin, casein and soy polysaccharide ternary complex nanoparticles for enhanced dispersibility, stability and oral bioavailability of curcumin. Food Bioscience 2020; 35: 100569.
51.	Zhang JM, Fu CM, He YX, et al. Comparison on chemical components in sediments of Aconiti Lateralis Radix Preparata-Glycyrrhizae Radix before and after their compatibility. Zhong Cao Yao 2013; 44: 165-9.
52.	Peng W, Jiang Y, Fu C, et al. Changing rules study of effective components of Glycyrrhizae Radix et Rhizoma before and after compatibilities in Sini decoction. Zhong Guo Zhong Yao Za Zhi 2015; 40: 84-8.
53.	Chen Q, Zhang J, Ji N, Fu C, Lin Y. Comparative studies between physicochemical properties in Aconiti Laterdis Radix Praeparata and Glycyrrhizae Radix et Rhizoma Decocyion before and after combination. Zhong Guo Shi Yan Fang Ji Xue Za Zhi 2014; 20: 92-5.
54.	LI B, Shen Y, Liao R, et al. Investigating mechanism of toxicity reduction by combination of Glycyrrhizae Radix et Rhizoma and Aconiti Lateralis Radix Preparata on terms of proteins self-assembly. Zhong Guo Zhong Yao Za Zhi 2015; 40: 661-6.
55.	Ke LJ, Gao GZ, Shen Y, Zhou JW, Rao PF. Encapsulation of aconitine in self-assembled licorice protein nanoparticles reduces the toxicity in vivo. Nanoscale Res Lett 2015; 10: 449.
56.	Lu S, Ma W, Shao H, Li G, Sun S, Guo Y. Research progress on the poisoning mechanism of Strychnia serrata and the attenuation effect of compatibility with licorice. Hebei Zhong Yi Yao Xue Bao 2018; 33: 59-64.
57.	Guo Y, Ma W, Xiao H, et al. Changes of toxic substance in different phase of compatibility decoction Strychni Semen and Glycyrrhizae Radix et Rhizoma based on UPLC-MS technique. Zhong Cao Yao 2017; 48: 4880-84.
58.	Qiao HZ, Di LQ, Ping QN, Hu LH. Structural Chinese medicine: new research field on pharmacodynamic substance basis of Traditional Chinese Medicine. Zhong Guo Zhong Yao Za Zhi 2021; 46: 2443-8.
59.	Jiang M, Zhao S, Yang S, et al. An "essential herbal medicine"-licorice: a review of phytochemicals and its effects in combination preparations. J Ethnopharmacol 2020; 249: 112439.
60.	You G, Feng T, Zhang G, et al. Preparation, optimization, characterization and in vitro release of baicalein-solubilizing glycyrrhizic acid nano-micelles. Int J Pharm 2021; 601: 120546.
61.	Huang X, Liu X, Lin X, et al. Thermodynamics driving phytochemical self-assembly morphological change and efficacy enhancement originated from single and co-decoction of Traditional Chinese Medicine. J Nanobiotechnology 2022; 20: 527.

[1]	XI Hanqing, LI Xia, ZHANG Ziyi, CUI Xiang, JING Xianghong, ZHU Bing, GAO Xinyan. Neuro- and immuno-modulation mediated by the cardiac sympathetic nerve: a novel insight into the anti-ischemic efficacy of acupuncture [J]. Journal of Traditional Chinese Medicine, 2024, 44(5): 1058-1066.
[2]	XU Yingshan, WU Chunxiao, YU Wei, GUO Hongji, LU Liming, XU Nenggui, TANG Chunzhi. Systematic review and Meta-analysis of brain plasticity associated with electroacupuncture in experimental ischemic stroke [J]. Journal of Traditional Chinese Medicine, 2024, 44(5): 859-870.
[3]	DENG Yasheng, HAN Siyin, XI Lanhua, HUANG Hui, LIANG Tianwei, ZHENG Yiqing, FAN Yanping, LIN Jiang. Traditional Chinese Medicine in the treatment of recurrent respiratory tract infections in children: an overview of systematic reviews and Meta-analyses [J]. Journal of Traditional Chinese Medicine, 2024, 44(5): 871-884.
[4]	CHEN Dandan, JIN Qianhong, SHEN Yuanjuan, WANG Qing, DAI Zhengxiang. Scraping therapy for knee osteoarthritis: a systematic review and Meta-analysis [J]. Journal of Traditional Chinese Medicine, 2024, 44(4): 633-641.
[5]	Shikha Agrawal, Adarsh Kumar, Ankit Kumar Singh, Harshwardhan Singh, Suresh Thareja, Pradeep Kumar. A comprehensive review on pharmacognosy, phytochemistry and pharmacological activities of 8 potent Prunus species of southeast Asia [J]. Journal of Traditional Chinese Medicine, 2024, 44(3): 620-628.
[6]	WANG Yuhuang, ZHANG Le, ZHANG Zhengshan, YAO Zhi, LI Xiyao, SUN Luying, LIAO Xing. Characteristics and quality of clinical practice guidelines for diabetic kidney disease: a systematic review [J]. Journal of Traditional Chinese Medicine, 2024, 44(3): 609-619.
[7]	Priyanka Sharma, Aakash Deep, Harish Kumar, Nitin Bansal, Sanjiv Kumar, Arun , Davinder Kumar. Pharmacological potential of Manilkara zapota (L.) P. Royen (Sapodilla): a narrative review [J]. Journal of Traditional Chinese Medicine, 2024, 44(2): 403-407.
[8]	LI Zhenxuan, WANG Xuerui, Luis Ulloa, Ayman Youssef, BAI Yunjing, XU Xiaolong, LIU Qingquan. Complementary and alternative medicine on cognitive defects and neuroinflammation after sepsis [J]. Journal of Traditional Chinese Medicine, 2024, 44(2): 408-416.
[9]	LIU Tingting, LIU Tongou, LIU Mingfu. Effectiveness and safety of acupuncture in treatment of pregnancy-related symptoms: a systematic review and Meta-analysis [J]. Journal of Traditional Chinese Medicine, 2024, 44(1): 16-26.
[10]	REN Ping, WANG Quanwu, BAI Wei, SUN Miao, LIU Zheling, GAO Ming, WANG Liang, PENG Bo, XU Liguang. Identifying the effective combination of acupuncture and traditional Chinese medicinal herbs for postmenopausal osteoporosis therapy through studies of their molecular regulation of bone homeostasis [J]. Journal of Traditional Chinese Medicine, 2024, 44(1): 212-219.
[11]	WANG Jiabao, ZHANG Lishuang, NIU Baihan, YU Yajun, YANG Fengwen, MIAO Lin, CHAI Lijuan, DING Xinya, SUN Yingjie, WANG Yujing, WANG Lin, ZHANG Han, WANG Yi, LI Lin. Efficacy and safety of Weichang’ an pill (胃肠安丸) combined with Western Medicine on gastrointestinal diseases: a systematic review and Meta-analysis [J]. Journal of Traditional Chinese Medicine, 2023, 43(6): 1057-1067.
[12]	FAN Rong, HE Haoyu, TANG Tao, CUI Hanjin. Long-term effects of Qingfei Paidu decoction (清肺排毒汤) in patients with coronavirus disease 2019 acute pneumonia after treatment: a protocol for systematic review and Meta-analysis [J]. Journal of Traditional Chinese Medicine, 2023, 43(6): 1068-1071.
[13]	WANG Lili, FENG Ju, ZHAN Daqian, WANG Junshuai, ZHOU Daixing. Protective effects of tanshinone ⅡA on sepsis-induced multiple organ dysfunction: a literature review [J]. Journal of Traditional Chinese Medicine, 2023, 43(5): 1040-1046.
[14]	MEI Pingping, FENG Wenzhe, SHI Peng, ZHANG Wenxiu, ZHUANG Yu. Clinical research progress in Traditional Chinese Medicine in treating wound healing after anal fistula surgery [J]. Journal of Traditional Chinese Medicine, 2023, 43(5): 1047-1054.
[15]	ZHAO HuiYan, JUN Purumea, LEE Chaewon, HAN Chang-Hyun. Acupoint catgut embedding for simple obesity in animal studies: a systematic review and Meta-analysis [J]. Journal of Traditional Chinese Medicine, 2023, 43(5): 860-867.

Home

Online First

Author Center

Reviewer Center

Issues

Announcement

About Us