Journal of Traditional Chinese Medicine ›› 2024, Vol. 44 ›› Issue (2): 403-407.DOI: 10.19852/j.cnki.jtcm.2024.02.001
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Priyanka Sharma1, Aakash Deep1(), Harish Kumar1, Nitin Bansal1, Sanjiv Kumar1, Arun 1, Davinder Kumar2
Received:
2022-10-22
Accepted:
2023-02-17
Online:
2024-04-15
Published:
2024-03-05
Contact:
Aakash Deep, Department of Pharmaceutical Sciences, Chaudhary Bansi Lal University, Bhiwani 127021, India. Priyanka Sharma, Aakash Deep, Harish Kumar, Nitin Bansal, Sanjiv Kumar, Arun , Davinder Kumar. Pharmacological potential of Manilkara zapota (L.) P. Royen (Sapodilla): a narrative review[J]. Journal of Traditional Chinese Medicine, 2024, 44(2): 403-407.
Sr. No. | Part of plant | Active constituents |
---|---|---|
1. | Root | Arginine, Lysine |
2. | Seed | Methyl chlorogenate, 4-O-galloychlorogenic acid, Lupeol acetate, oleanolic acid, Apigenin-7-O-a-L-rhamnoside, Methyl 4-O-galloylchlorogenate, Caffeic acid, n-triacontane, n-octacosane, stigmasterol and 2 sterols-β-sitosterol |
3. | Leaves | Rhamnose, Glucose, Sucrose, Succinic acid, Malic acid, Adipic acid, 3-Oxoadipic acid, Salicylic acid, 3,4-dihydrobenzoic acid, Vanillic acid, Gallic acid, Caffeic acid, Ferulic acid, Syringic acid, Chlorogenic acid, Afzeleehic, Epicatechin, Epigallocatechin Myricetin-3-O-Rhamnoside, Laricitrin-3-O-rhamnoside, Prodelphinidin B, 2-Hydroxybenzaldehyde, Guaiacol, Pyroglutamic acid, Thronic acid, Vanillin, 3-Hydrxy coumarin, Shikimic acid, Aesculetin, Quinic acid, Norathyriol, Hydroquinone glucuronide, Leucodelphinidin, Apigenin-7-O-α-L-rhamnoside 3-glucogallic acid, 3-p-Coumaroyl-Quinic acid, Oleanolic acid, 3-O- Galloyl quinic acid, Lupeol acetate, Erythrodiol |
4. | Fruit | Catechin, Quercetin, Kaempferol, Chlorogenic acid, p-hydrobenzoic, Ellagic Acid, ferulic Acid, Trans cinnamic acid, Lucopine, |
Table 1 Various active constituents of M. Zapota (Sapodilla)
Sr. No. | Part of plant | Active constituents |
---|---|---|
1. | Root | Arginine, Lysine |
2. | Seed | Methyl chlorogenate, 4-O-galloychlorogenic acid, Lupeol acetate, oleanolic acid, Apigenin-7-O-a-L-rhamnoside, Methyl 4-O-galloylchlorogenate, Caffeic acid, n-triacontane, n-octacosane, stigmasterol and 2 sterols-β-sitosterol |
3. | Leaves | Rhamnose, Glucose, Sucrose, Succinic acid, Malic acid, Adipic acid, 3-Oxoadipic acid, Salicylic acid, 3,4-dihydrobenzoic acid, Vanillic acid, Gallic acid, Caffeic acid, Ferulic acid, Syringic acid, Chlorogenic acid, Afzeleehic, Epicatechin, Epigallocatechin Myricetin-3-O-Rhamnoside, Laricitrin-3-O-rhamnoside, Prodelphinidin B, 2-Hydroxybenzaldehyde, Guaiacol, Pyroglutamic acid, Thronic acid, Vanillin, 3-Hydrxy coumarin, Shikimic acid, Aesculetin, Quinic acid, Norathyriol, Hydroquinone glucuronide, Leucodelphinidin, Apigenin-7-O-α-L-rhamnoside 3-glucogallic acid, 3-p-Coumaroyl-Quinic acid, Oleanolic acid, 3-O- Galloyl quinic acid, Lupeol acetate, Erythrodiol |
4. | Fruit | Catechin, Quercetin, Kaempferol, Chlorogenic acid, p-hydrobenzoic, Ellagic Acid, ferulic Acid, Trans cinnamic acid, Lucopine, |
1. | Silva OD. Phytochemical screening and in vitro antimicrobial activity of Calycobolus heudelotii stem planta medica. Drug Invent Today 2010; 4: 667-70. |
2. | Kumar H, Sharma S, Vasudeva N. Pharmacological profile of Calotropis gigantea in various diseases: a profound look. IJCRT 2021; 9: 2987-96. |
3. | Lopes EA, Santos MMM, Mori M. Pharmacological treatment of Malaria. Antiprotozoal drug development and delivery. Topics in Medicinal Chemistry 2021; 39: 219-40. |
4. | Shirley T, Shivangi P, Nilkamal S, Balkrishna A. Research on Traditional Medicine: What has been done, the difficulties, and possible solutions. J Evid Based Complementary Altern Med 2014; 2014: 495635. |
5. | Adam A. The Editors of Encyclopaedia Britannica. Traditional Chinese medicine (TCM) online, 2023-10-27, cited 2023-12-01; Available from URL: https://www.britannica.com/science/traditional-Chinese-medicine/Hua-Tuo. |
6. | Rogers K. The Editors of Encyclopaedia Britannica. Unani medicine online, 2023-11-04, cited 2023-12-01; Available from URL: https://www.britannica.com/science/Unani-medicine/Modes-of-treatment. |
7. | Patwardhan B, Vaidya A. Ayurveda: scientific research and publications. Curr Sci 2009; 97: 117-21. |
8. |
Sen SS, Chakraborty R. Revival, modernization and integration of Indian Traditional Herbal medicine in clinical practice: Importance, challenges and future. J Tradit Complement Med 2016; 7: 234-44.
DOI URL |
9. | Tilburt JC, Kaptchuk TJ. Herbal medicine research and global health: an ethical analysis. Bull. World Health Organ 2008; 86: 594-99. |
10. | Bano M, Ahmed B. Manilkara Zapota (L.) P. Royen (Sapodilla): a review. IJARIIT 2014; 3: 1364-71. |
11. | Rao GV, Sahoo MR, Madhavi MSL, Mukhopadhyay T. Phytoconstituents from the leaves and seeds of Manilkara zapota Linn. Scholar Res Lib 2014; 6: 69-73. |
12. |
Milind P, Preeti. Chickoo: a wonderful gift from nature. Int J Res Ayurveda Pharm 2015; 6: 544-50.
DOI URL |
13. | Gilly CL. Studies in the Sapotaceae. Ⅱ. The Sapodilla-nispero complex. Trop Woods 1943; 73: 1-22. |
14. | Orwa C, Mutua A, Kindt R, Jamnadass R, Anthony S. Agroforestree database: a tree reference and selection guide, version 4.0. World Agroforest Centre UCRAF 2009; 1-5. |
15. |
Karle PP, Dhawale SC. Manilkara zapota (L.) Royen Fruit Peel: a phytochemical and pharmacological review. Syst Rev Pharm 2019; 10: 11-4.
DOI URL |
16. |
Fayek NM, Monem AR, Mossa MY, Meselhy MR, Shazly AH. Chemical and biological study of Manilkara zapota (L.) Van Royen leaves (Sapotaceae) cultivated in Egypt. Pharmacog Res 2012; 4: 85-91.
DOI URL |
17. |
Yan G, Guo JM, Liu YY, et al. Prenylated coumarins from the fruits of Manilkara zapota with potential anti-inflammatory effects and anti-HIV activities. J Agri Food Chem 2019; 67: 11942-7.
DOI URL |
18. | Mickelbart MV. Sapodilla:A potential crop for subtropical climates. J. Janick (ed.), Progress in new crops. Alexandria: ASHS Press, 1996; 439-46. |
19. | Mohanapriya C, Uma S, Modilal RD, Nithyalakshmi V. Phytochemical screening and in vitro antioxidant studies on acetone extract of Manilkara zapota L. seeds. Int J Pharm Sci Res 2014; 5: 2354. |
20. |
Mosquera OM, Correa YM, Buitrago DC, Nio J. Antioxidant activity of twenty-five plants from Colombian biodiversity. Memorias do Instituto Oswaldo Cruz 2007; 102: 631-4.
PMID |
21. |
Adrian T, Andrea G, Dennis B, Sonal G. Manilkara zapota (Naseberry): medicinal properties and food application. Int J Fruit Sci 2020; 20: S1-7.
DOI URL |
22. | Anjali, Garg V, Dhiman A, Dutt R, Ranga S. The genus manilkara: an update. The Pharma Innovat J 2018; 7: 316-18. |
23. |
Islam S, Alam MB, Ann HJ, Park JH, Lee SH, Kim S. Metabolite profiling of Manilkara zapota L. leaves by high resolution mass spectrometry coupled with ESI and APCI and in vitro antioxidant activity, α-glucosidase, AD elastase inhibition assays. Int J Mol Sci 2021; 22: 1-18.
DOI URL |
24. |
Fayek NM, Monem AR, Mossa MY, Meselhy MR, Shazly AH. Chemical and biological study of Manilkara zapota (L.) Van Royen leaves (Sapotaceae) cultivated in Egypt. Pharmacog Res 2012; 4: 85-91.
DOI URL |
25. | Anjaria J, Parabia M, Dwivedi S. Ethnovete heritage: Indian ethnoveterinary medicine, an overview. Ahmedabad: Pathik Enterprise, 2002: 1-612. |
26. |
Mohiddin YBH, Chin W, Holdsworth D. Traditional medicinal plants of Brunei, Darussalam part II; Sengkurong. Int J Pharmacog 1991; 30: 105-8.
DOI URL |
27. | Salunkhe A, Ghumre S, Shirke S, Nikam S, Kadam V. Anti-microbial activity of Psidium guajava and Manilkara zapota against human pathogenic bacteria. Int J Pharm Sci Res 2018; 9: 3944-48. |
28. | Jain PK, Soni P, Upmanyu N, Shivhare YK. Evaluation of analgesic activity of Manilkara zapota (leaves). European J Exp Bio 2011; 1: 14-7. |
29. |
Ankli A, Heinrich M, Bork P, et al. Yucatec Mayan Medicinal plant: evaluation based on indigenous use. J Ethnopharmacol 2002; 79: 43-52.
DOI URL |
30. | Hossain H, Jahan F, Howlader SI, et al. Evaluation of anti-inflammatory activity and total flavonoids content of Manilkara zapota (L.) bark. Int J Pharm Phytopharmacol Res 2012; 2: 35-9. |
31. | Singh M, Soni P, Upmanyu N, Shivhare Y. In-vitro anti-arthritic activity of Manilkara zapota Linn. Asian J Pharm Tech 2011; 1: 123-4. |
32. | Wersja P. Herbs from distant lands. Manilkara zapota - Sapodilla, Chico, Chicle. Herbs from Distant Lands online, 2015-01-26, cited 2023-12-01; Available from URL: https://herbsfromdistantlands.blogspot.com/2015/01/manilkara-zapota-sapodilla-chico-chicle.html. |
33. | Salunkhe A, Ghumre S, Shirke S, Nikam S, Kadam V. Anti-microbial activity of Psidium guajava and Manilkara zapota against human pathogenic bacteria. Int J Pharm Sci Res 2018; 9: 3944-48. |
34. |
Kiriyanthan RM, Sharmili SA, Balaji R, et al. Photocatalytic, antiproliferative and antimicrobial properties of copper nanoparticles synthesized using Manilkara zapota leaf extract: a photodynamic approach. Photodiagn Photodyn 2020; 32: 102058.
DOI URL |
35. | Paul S, Hakim M. In vivo Hypoglycemic study of Manilkara zapota leaf and seed extracts. Bangladesh J Pharmacol 2015; 10: 246-50. |
36. | Leelarungrayub J, Sriboonreung T, Pothasak Y, Kaju J, Puntumetakul R. Anti-oxidant and anti-inflammatory activities of Manilkara zapota (Sapodilla) in vitro and efficiency in healthy elderly person. Biomed J Sci tech Res 2019; 15: 11294-304. |
37. | Shaniba VS, Aziz AA, Jayasree PR, Kumar P. Manilkara zapota (L.) P. Royen leaf extract derived silver nanoparticles induce apoptosis in human colorectal carcinoma cells without affecting human lymphocytes or erythrocytes. Bio Trace Element Res 2019; 192: 160-74. |
38. | Sara TA, Abdulrahman K, Abdullah K, et al. Protective effect of lyophilized sapodilla (Manilkara zapota) fruit extract against CCl4-induced liver damage in rat. Saudi J Biol Scie 2020; 1-7. |
39. | Ansari SF, Khan AU, Qazi NG, Shah FA, Naeem K. In vivo, proteomic and in silico investigation of sapodilla for therapeutic potential in gastro-intestinal disorders. Hindwai-Bio Med Research International 2019; 2019: 4921086. |
40. | Manirujjaman, Sultana F, Chowdhury M, et al. In vivo assay of anti-diarrheal activity of methanolic and petroleum ether extracts of Manilkara zapota leaves. Int J Pharm Pharm Sci 2013; 5: 164-71. |
41. |
Konuku K, Karri KC, Gopalakrishnan VK, et al. Anti-inflammatory activity of Manilkara Zapota leaf extract. Int J Curr Pharm Res 2017; 9: 130.
DOI URL |
42. |
Manirujjaman, Fahamida S, Chowdhury M, et al. In vivo assay of analgesic activity of methanolic and petroleum ether extracts of Manilkara zapota leaves. Br J Pharm Res 2014; 4: 186-91.
DOI URL |
43. | Singh M, Soni P, Upmanyu N, et al. In-vitro anti-arthritic activity of Manilkara zapota Linn. Asian J Pharm Tech 2011; 4: 123-4. |
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