Journal of Traditional Chinese Medicine ›› 2024, Vol. 44 ›› Issue (2): 408-416.DOI: 10.19852/j.cnki.jtcm.20240203.002
• Reviews • Previous Articles
LI Zhenxuan1,2,3,4, WANG Xuerui1,2,3,4, Luis Ulloa5, Ayman Youssef5, BAI Yunjing1,2,3,4, XU Xiaolong1,2,3,4(), LIU Qingquan1,2,3,4()
Received:
2023-01-22
Accepted:
2023-04-27
Online:
2024-04-15
Published:
2024-02-03
Contact:
XU Xiaolong, Department of Infectious Diseases, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China; Beijing Key Laboratory of Basic Research with Traditional Chinese Medicine on Infectious Diseases, Beijing 100010, China; Infection immunity laboratory, Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China; Clinical College of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China. Supported by:
LI Zhenxuan, WANG Xuerui, Luis Ulloa, Ayman Youssef, BAI Yunjing, XU Xiaolong, LIU Qingquan. Complementary and alternative medicine on cognitive defects and neuroinflammation after sepsis[J]. Journal of Traditional Chinese Medicine, 2024, 44(2): 408-416.
1. |
Rudd KE, Johnson SC, Agesa KM, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet 2020; 395: 200-11.
DOI PMID |
2. |
Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 2016; 315: 801-10.
DOI PMID |
3. |
Polito A, Eischwald F, Maho AL, et al. Pattern of brain injury in the acute setting of human septic shock. Crit Care 2013; 17: R204.
DOI URL |
4. |
Hughes CG, Patel MB, Pandharipande PP. Pathophysiology of acute brain dysfunction: what's the cause of all this confusion? Curr Opin Crit Care 2012; 18: 518-26.
DOI URL |
5. |
Akrout N, Sharshar T, Annane D. Mechanisms of brain signaling during sepsis. Curr Neuropharmacol 2009; 7: 296-301.
DOI PMID |
6. |
Barbosa-Silva MC, Lima MN, Battaglini D, et al. Infectious disease-associated encephalopathies. Crit Care 2021; 25: 236.
DOI |
7. |
Stollings JL, Kotfis K, Chanques G, et al. Delirium in critical illness: clinical manifestations, outcomes, and management. Intensive Care Med 2021; 47: 1089-103.
DOI PMID |
8. |
Kadoi Y, Saito S, Kunimoto F, et al. Impairment of the brain beta-adrenergic system during experimental endotoxemia. J Surg Res 1996; 61: 496-502.
PMID |
9. |
Catarina AV, Branchini G, Bettoni L, et al. Sepsis-associated encephalopathy: from pathophysiology to progress in experimental studies. Mol Neurobiol 2021; 58: 2770-9.
DOI PMID |
10. |
Barichello T, Sayana P, Giridharan VV, et al. Long-term cognitive outcomes after sepsis: a translational systematic review. Mol Neurobiol 2019; 56: 186-251.
DOI PMID |
11. | Nwafor DC, Brichacek AL, Mohammad AS, et al. Targeting the blood-brain barrier to prevent sepsis-associated cognitive impairment. J Cent Nerv Syst Dis 2019; 11: 1179573519840652. |
12. | Pandharipande PP, Girard TD, Ely EW. Long-term cognitive impairment after critical illness. N Engl J Med 2014; 370: 185-6. |
13. | Huang M, Liu C, Hu Y, et al. Γ-secretase inhibitor DAPT prevents neuronal death and memory impairment in sepsis associated encephalopathy in septic rats. Chin Med J (Engl) 2014; 127: 924-8. |
14. |
Gao R, Ji MH, Gao DP, et al. Neuroinflammation-induced downregulation of hippocampacal neuregulin 1-ErbB4 signaling in the parvalbumin interneurons might contribute to cognitive impairment in a mouse model of sepsis-associated encephalopathy. Inflammation 2017; 40: 387-400.
DOI PMID |
15. |
Cassol OJ Jr., Comim CM, Constantino LS, et al. Acute low dose of MK-801 prevents memory deficits without altering hippocampal DARPP-32 expression and BDNF levels in sepsis survivor rats. J Neuroimmunol 2011; 230: 48-51.
DOI PMID |
16. |
Comim CM, Cassol OJ, Jr., Constantino LC, et al. Depressive-like parameters in sepsis survivor rats. Neurotox Res 2010; 17: 279-86.
DOI PMID |
17. |
Barichello T, Machado RA, Constantino L, et al. Antioxidant treatment prevented late memory impairment in an animal model of sepsis. Crit Care Med 2007; 35: 2186-90.
PMID |
18. |
Barichello T, Martins MR, Reinke A, et al. Behavioral deficits in sepsis-surviving rats induced by cecal ligation and perforation. Braz J Med Biol Res 2007; 40: 831-7.
PMID |
19. |
Anderson ST, Commins S, Moynagh P, et al. Chronic fluoxetine treatment attenuates post-septic affective changes in the mouse. Behav Brain Res 2016; 297: 112-5.
DOI PMID |
20. |
Ge L, Liu L, Liu H, et al. Resveratrol abrogates lipopolysaccharide-induced depressive-like behavior, neuroinflammatory response, and CREB/BDNF signaling in mice. Eur J Pharmacol 2015; 768: 49-57.
DOI PMID |
21. |
Wang Z, Zhang Q, Yuan L, et al. The effects of curcumin on depressive-like behavior in mice after lipopolysaccharide administration. Behav Brain Res 2014; 274: 282-90.
DOI PMID |
22. |
Zheng M, Li K, Chen T, et al. Geniposide protects depression through BTK/JAK2/STAT1 signaling pathway in lipopolysaccharide-induced depressive mice. Brain Res Bull 2021; 170: 65-73.
DOI PMID |
23. | Adetuyi BO, Farombi EO. 6-Gingerol, an active constituent of ginger, attenuates lipopolysaccharide-induced oxidation, inflammation, cognitive deficits, neuroplasticity, and amyloidogenesis in rat. J Food Biochem 2021; 45: e13660. |
24. | Jing W, Song S, Sun H, et al. Mahuang-Fuzi-Xixin decoction reverses depression-like behavior in LPS-induced mice by regulating NLRP 3 inflammasome and neurogenesis. Neural Plast 2019; 2019: 1571392. |
25. |
Zhe Q, Sulei W, Weiwei T, et al. Effects of Jiaotaiwan on depressive-like behavior in mice after lipopolysaccharide administration. Metab Brain Dis 2017; 32: 415-26.
DOI PMID |
26. |
Wang X, Xu X, Guo Y, et al. Qiang Xin 1 formula suppresses excessive pro-inflammatory cytokine responses and microglia activation to prevent cognitive impairment and emotional dysfunctions in experimental sepsis. Front Pharmacol 2020; 11: 579.
DOI PMID |
27. |
Jun G, Yong Y, Lu L, et al. Electroacupuncture treatment ameliorated the long-term cognitive impairment via activating eNOS/NO pathway and related Aβ downregulation in sepsis-survivor mice. Physiol Behav 2022; 243: 113646.
DOI URL |
28. |
Li C, Yu TY, Zhang Y, et al. Electroacupuncture improves cognition in rats with sepsis-associated encephalopathy. J Surg Res 2020; 256: 258-66.
DOI PMID |
29. |
Han YG, Qin X, Zhang T, et al. Electroacupuncture prevents cognitive impairment induced by lipopolysaccharide via inhibition of oxidative stress and neuroinflammation. Neurosci Lett 2018; 683: 190-5.
DOI URL |
30. |
Raymond SL, Holden DC, Mira JC, et al. Microbial recognition and danger signals in sepsis and trauma. Biochim Biophys Acta Mol Basis Dis 2017; 1863: 2564-73.
DOI URL |
31. |
Tang D, Kang R, Coyne CB, et al. PAMPs and DAMPs: signal 0s that spur autophagy and immunity. Immunol Rev 2012; 249: 158-75.
DOI PMID |
32. |
Pahl HL. Activators and target genes of Rel/NF-kappa B transcription factors. Oncogene 1999; 18: 6853-66.
DOI PMID |
33. |
Lyu C, Huang L. Xenobiotic receptors in mediating the effect of sepsis on drug metabolism. Acta Pharm Sin B 2020; 10: 33-41.
DOI PMID |
34. |
Nedeva C, Menassa J, Puthalakath H. Sepsis: inflammation is a necessary evil. Front Cell Dev Biol 2019; 7: 108.
DOI PMID |
35. |
Hotchkiss RS, Moldawer LL, Opal SM, et al. Sepsis and septic shock. Nat Rev Dis Primers 2016; 2: 16045.
DOI PMID |
36. |
Gu M, Mei XL, Zhao YN. Sepsis and cerebral dysfunction: BBB damage, neuroinflammation, oxidative stress, apoptosis and autophagy as key mediators and the potential therapeutic approaches. Neurotox Res 2021; 39: 489-503.
DOI |
37. |
Thayer JF, Sternberg EM. Neural aspects of immunomodulation: focus on the vagus nerve. Brain Behav Immun 2010; 24: 1223-8.
DOI PMID |
38. | Maciel M, Benedet SR, Lunardelli EB, et al. Predicting long-term cognitive dysfunction in survivors of critical illness with plasma inflammatory markers: a retrospective cohort study. Mol Neurobiol 2019; 56: 763-7. |
39. |
Dantzer R, Konsman JP, Bluthé RM, et al. Neural and humoral pathways of communication from the immune system to the brain: parallel or convergent? Auton Neurosci 2000; 85: 60-5.
DOI URL |
40. |
Kang A, Xie T, Zhu D, et al. Suppressive effect of ginsenoside Rg3 against lipopolysaccharide-induced depression-like behavior and neuroinflammation in mice. J Agric Food Chem 2017; 65: 6861-9.
DOI URL |
41. |
Liu L, Zhang Q, Cai Y, et al. Resveratrol counteracts lipopolysaccharide-induced depressive-like behaviors via enhanced hippocampal neurogenesis. Oncotarget 2016; 7: 56045-59.
DOI URL |
42. |
Rubab S, Naeem K, Rana I, et al. Enhanced neuroprotective and antidepressant activity of curcumin-loaded nanostructured lipid carriers in lipopolysaccharide-induced depression and anxiety rat model. Int J Pharm 2021; 603: 120670.
DOI URL |
43. |
Zhang F, Zhang JG, Yang W, et al. 6-Gingerol attenuates LPS-induced neuroinflammation and cognitive impairment partially via suppressing astrocyte overactivation. Biomed Pharmacother 2018; 107: 1523-9.
DOI PMID |
44. |
Li P, Zhang F, Li Y, et al. Isoginkgetin treatment attenuated lipopolysaccharide-induced monoamine neurotransmitter deficiency and depression-like behaviors through downregulating p38/NF-κB signaling pathway and suppressing microglia-induced apoptosis. J Psychopharmacol 2021; 35: 1285-99.
DOI URL |
45. |
Wang L, Liang Q, Lin A, et al. Borneol alleviates brain injury in sepsis mice by blocking neuronal effect of endotoxin. Life Sci 2019; 232: 116647.
DOI URL |
46. |
Sun Y, Zhang H, Wu Z, et al. Quercitrin rapidly alleviated depression-like behaviors in lipopolysaccharide-treated mice: the involvement of PI3K/AKT/NF-κB signaling suppression and CREB/BDNF signaling restoration in the hippocampus. ACS Chem Neurosci 2021; 12: 3387-96.
DOI PMID |
47. |
Sun X, Zhang T, Zhao Y, et al. The protective effect of 5-O-methylvisammioside on LPS-induced depression in mice by inhibiting the over activation of BV-2 microglia through NF-κB/IκB-α pathway. Phytomedicine 2020; 79: 153348.
DOI URL |
48. |
Araki R, Hiraki Y, Nishida S, et al. Gomisin N ameliorates lipopolysaccharide-induced depressive-like behaviors by attenuating inflammation in the hypothalamic paraventricular nucleus and central nucleus of the amygdala in mice. J Pharmacol Sci 2016; 132: 138-44.
DOI PMID |
49. |
Xu M, Zhang X, Ren F, et al. Essential oil of Schisandra chinensis ameliorates cognitive decline in mice by alleviating inflammation. Food Funct 2019; 10: 5827-42.
DOI PMID |
50. |
Andy SN, Pandy V, Alias Z, et al. Deoxyelephantopin ameliorates lipopolysaccharides (LPS)-induced memory impairments in rats: evidence for its anti-neuroinflammatory properties. Life Sci 2018; 206: 45-60.
DOI PMID |
51. |
Liu S, Li G, Tang H, et al. Madecassoside ameliorates lipopolysaccharide-induced neurotoxicity in rats by activating the Nrf2-HO-1 pathway. Neurosci Lett 2019; 709: 134386.
DOI URL |
52. |
Tian Q, Fan X, Ma J, et al. Resveratrol ameliorates lipopolysaccharide-induced anxiety-like behavior by attenuating YAP-mediated neuro-inflammation and promoting hippocampal autophagy in mice. Toxicol Appl Pharmacol 2020; 408: 115261.
DOI URL |
53. |
An L, Li J, Yu ST, et al. Effects of the total flavonoid extract of Xiaobuxin-Tang on depression-like behavior induced by lipopolysaccharide and proinflammatory cytokine levels in mice. J Ethnopharmacol 2015; 163: 83-7.
DOI PMID |
54. |
Brognara F, Castania JA, Dias DPM, et al. Baroreflex stimulation attenuates central but not peripheral inflammation in conscious endotoxemic rats. Brain Res 2018; 1682: 54-60.
DOI PMID |
55. |
Michels M, Ávila P, Pescador B, et al. Microglial cells depletion increases inflammation and modifies microglial phenotypes in an animal model of severe sepsis. Mol Neurobiol 2019; 56: 7296-304.
DOI PMID |
56. | Pan S, Lyu Z, Wang R, et al. Sepsis-induced brain dysfunction: pathogenesis, diagnosis, and treatment. Oxid Med Cell Longev 2022; 2022: 1328729. |
57. |
Li M, Hu J, Peng Y, et al. CircPTK2-miR-181c-5p-HMGB1: a new regulatory pathway for microglia activation and hippocampal neuronal apoptosis induced by sepsis. Mol Med 2021; 27: 45.
DOI PMID |
58. |
Zhou W, Hu M, Hu J, et al. Luteolin suppresses microglia neuroinflammatory responses and relieves inflammation-induced cognitive impairments. Neurotox Res 2021; 39: 1800-11.
DOI PMID |
59. | Li Y, Liu T, Li Y, et al. Baicalin ameliorates cognitive impairment and protects microglia from LPS-induced neuroinflammation via the SIRT1/HMGB1 pathway. Oxid Med Cell Longev 2020; 2020: 4751349. |
60. |
He MC, Shi Z, Qin M, et al. Muscone ameliorates LPS-induced depressive-like behaviors and inhibits neuroinflammation in prefrontal cortex of mice. Am J Chin Med 2020; 48: 559-77.
DOI URL |
61. |
Su J, Pan YW, Wang SQ, et al. Saikosaponin-d attenuated lipopolysaccharide-induced depressive-like behaviors via inhibiting microglia activation and neuroinflammation. Int Immunopharmacol 2020; 80: 106181.
DOI URL |
62. |
Li Y, Wang F, Luo Y. Ginsenoside Rg1 protects against sepsis-associated encephalopathy through beclin 1-independent autophagy in mice. J Surg Res 2017; 207: 181-9.
DOI PMID |
63. |
Lin SP, Wei JX, Hu JS, et al. Artemisinin improves neurocognitive deficits associated with sepsis by activating the AMPK axis in microglia. Acta Pharmacol Sin 2021; 42: 1069-79.
DOI |
64. |
Tauber SC, Djukic M, Gossner J, et al. Sepsis-associated encephalopathy and septic encephalitis: an update. Expert Rev Anti Infect Ther 2021; 19: 215-31.
DOI URL |
65. |
Zhuang X, Yu Y, Jiang Y, et al. Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway. Int Immunopharmacol 2020; 81: 106287.
DOI URL |
66. |
Jiang T, Yu JT, Zhu XC, et al. Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice. Neurobiol Aging 2014; 35: 1243-51.
DOI PMID |
67. |
Shi K, Chen L, Chen L, et al. Epimedii Folium and Curculiginis Rhizoma ameliorate lipopolysaccharides-induced cognitive impairment by regulating the TREM2 signaling pathway. J Ethnopharmacol 2022; 284: 114766.
DOI URL |
68. |
Baradaran Rahimi V, Rajabian A, Rajabi H, et al. The effects of hydro-ethanolic extract of Capparis spinosa (C. spinosa) on lipopolysaccharide (LPS)-induced inflammation and cognitive impairment: Evidence from in vivo and in vitro studies. J Ethnopharmacol 2020; 256: 112706.
DOI URL |
69. |
Jha MK, Jo M, Kim JH, et al. Microglia-astrocyte crosstalk: An intimate molecular conversation. Neuroscientist 2019; 25: 227-40.
DOI PMID |
70. |
Hasegawa-Ishii S, Inaba M, Umegaki H, et al. Endotoxemia-induced cytokine-mediated responses of hippocampal astrocytes transmitted by cells of the brain-immune interface. Sci Rep 2016; 6: 25457.
DOI PMID |
71. |
Oh YC, Jeong YH, Pak ME, et al. Banhasasim-tang attenuates lipopolysaccharide-induced cognitive impairment by suppressing neuroinflammation in mice. Nutrients 2020; 12: 2019.
DOI URL |
72. |
Wu Y, Qiu A, Yang Z, et al. Malva sylvestris extract alleviates the astrogliosis and inflammatory stress in LPS-induced depression mice. J Neuroimmunol 2019; 336: 577029.
DOI URL |
73. |
Lu L, Yang LK, Yue J, et al. Scutellarin alleviates depression-like behaviors induced by LPS in mice partially through inhibition of astrocyte-mediated neuroinflammation. Neurosci Lett 2021; 765: 136284.
DOI URL |
74. |
Santiago AP, Chaves EA, Oliveira MF, et al. Reactive oxygen species generation is modulated by mitochondrial kinases: correlation with mitochondrial antioxidant peroxidases in rat tissues. Biochimie 2008; 90: 1566-77.
DOI PMID |
75. |
Sebai H, Gadacha W, Sani M, et al. Protective effect of resveratrol against lipopolysaccharide-induced oxidative stress in rat brain. Brain Inj 2009; 23: 1089-94.
DOI PMID |
76. |
Ninković M, Malicević I, Jelenković A, et al. Oxidative stress in the rats brain capillaries in sepsis--the influence of 7-nitroindazole. Acta Physiol Hung 2006; 93: 315-23.
PMID |
77. |
Hamed SA, Hamed EA, Abdella MM. Septic encephalopathy: relationship to serum and cerebrospinal fluid levels of adhesion molecules, lipid peroxides and S-100B protein. Neuropediatrics 2009; 40: 66-72.
DOI PMID |
78. |
Sulakhiya K, Kumar P, Jangra A, et al. Honokiol abrogates lipopolysaccharide-induced depressive like behavior by impeding neuroinflammation and oxido-nitrosative stress in mice. Eur J Pharmacol 2014; 744: 124-31.
DOI PMID |
79. |
Zhuo R, Cheng X, Luo L, et al. Cinnamic acid improved lipopolysaccharide-induced depressive-like behaviors by inhibiting neuroinflammation and oxidative stress in mice. Pharmacology 2022; 107: 281-9.
DOI URL |
80. |
Baluchnejadmojarad T, Zeinali H, Roghani M. Scutellarin alleviates lipopolysaccharide-induced cognitive deficits in the rat: Insights into underlying mechanisms. Int Immunopharmacol 2018; 54: 311-9.
DOI PMID |
81. |
Shal B, Khan A, Naveed M, et al. Effect of 25-methoxy hispidol A isolated from Poncirus trifoliate against bacteria-induced anxiety and depression by targeting neuroinflammation, oxidative stress and apoptosis in mice. Biomed Pharmacother 2019; 111: 209-23.
DOI PMID |
82. |
Chowdhury AA, Gawali NB, Shinde P, et al. Imperatorin ameliorates lipopolysaccharide induced memory deficit by mitigating proinflammatory cytokines, oxidative stress and modulating brain-derived neurotropic factor. Cytokine 2018; 110: 78-86.
DOI PMID |
83. |
Chen Y, Lei Y, Mo LQ, et al. Electroacupuncture pretreatment with different waveforms prevents brain injury in rats subjected to cecal ligation and puncture via inhibiting microglial activation, and attenuating inflammation, oxidative stress and apoptosis. Brain Res Bull 2016; 127: 248-59.
DOI PMID |
84. |
Sewal RK, Modi M, Saikia UN, et al. Increase in seizure susceptibility in sepsis like condition explained by spiking cytokines and altered adhesion molecules level with impaired blood brain barrier integrity in experimental model of rats treated with lipopolysaccharides. Epilepsy Res 2017; 135: 176-86.
DOI PMID |
85. |
Ehler J, Barrett LK, Taylor V, et al. Translational evidence for two distinct patterns of neuroaxonal injury in sepsis: a longitudinal, prospective translational study. Crit Care 2017; 21: 262.
DOI URL |
86. |
Stubbs DJ, Yamamoto AK, Menon DK. Imaging in sepsis-associated encephalopathy--insights and opportunities. Nat Rev Neurol 2013; 9: 551-61.
DOI PMID |
87. | Zhou HC, Guo CA, Yu WW, et al. Zizyphus jujuba cv. Muzao polysaccharides enhance intestinal barrier function and improve the survival of septic mice. J Food Biochem 2021; 45: e13722. |
88. |
Zhao Z, Hu J, Gao X, et al. Activation of AMPK attenuates lipopolysaccharide-impaired integrity and function of blood-brain barrier in human brain microvascular endothelial cells. Exp Mol Pathol 2014; 97: 386-92.
DOI PMID |
89. |
Sekino N, Selim M, Shehadah A. Sepsis-associated brain injury: underlying mechanisms and potential therapeutic strategies for acute and long-term cognitive impairments. J Neuroinflammation 2022; 19: 101.
DOI |
90. |
Goldblum SE, Ding X, Campbell-Washington J. TNF-alpha induces endothelial cell F-actin depolymerization, new actin synthesis, and barrier dysfunction. Am J Physiol 1993; 264: C894-905.
DOI URL |
91. |
Haines RJ, Beard RS, Jr., Wu MH. Protein tyrosine kinase 6 mediates TNFα-induced endothelial barrier dysfunction. Biochem Biophys Res Commun 2015; 456: 190-6.
DOI URL |
92. |
Zou P, Ji HM, Zhao JW, et al. Protective effect of isoliquiritigenin against cerebral injury in septic mice via attenuation of NF-κB. Inflammopharmacology 2019; 27: 809-16.
DOI |
93. |
Cheng X, Yang YL, Yang H, et al. Kaempferol alleviates LPS-induced neuroinflammation and BBB dysfunction in mice via inhibiting HMGB1 release and down-regulating TLR4/MyD88 pathway. Int Immunopharmacol 2018; 56: 29-35.
DOI PMID |
94. |
Liu K, Wan G, Jiang R, et al. Astragalus injection ameliorates lipopolysaccharide-induced cognitive decline via relieving acute neuroinflammation and BBB damage and upregulating the BDNF-CREB pathway in mice. Pharm Biol 2022; 60: 825-39.
DOI PMID |
95. |
Moradi Vastegani S, Hajipour S, Sarkaki A, et al. Curcumin mitigates lipopolysaccharide-induced anxiety/depression-like behaviors, blood-brain barrier dysfunction and brain edema by decreasing cerebral oxidative stress in male rats. Neurosci Lett 2022; 782: 136697.
DOI URL |
96. |
Mei B, Li J, Zuo Z. Dexmedetomidine attenuates sepsis-associated inflammation and encephalopathy via central α2A adrenoceptor. Brain Behav Immun 2021; 91: 296-314.
DOI URL |
97. | Hoover DB, Poston MD, Brown S, et al. Cholinergic leukocytes in sepsis and at the neuroimmune junction in the spleen. Int Immunopharmacol 2020; 81: 106359. |
98. |
Ji MH, Zhang L, Mao MJ, et al. Overinhibition mediated by parvalbumin interneurons might contribute to depression-like behavior and working memory impairment induced by lipopolysaccharide challenge. Behav Brain Res 2020; 383: 112509.
DOI URL |
99. |
Li F, Zhang B, Duan S, et al. Small dose of L-dopa/Benserazide hydrochloride improved sepsis-induced neuroinflammation and long-term cognitive dysfunction in sepsis mice. Brain Res 2020; 1737: 146780.
DOI URL |
100. |
Barbosa-Silva MC, Lima MN, Battaglini D, et al. Infectious disease-associated encephalopathies. Crit Care 2021; 25: 236.
DOI |
101. |
Stollings JL, Kotfis K, Chanques G, et al. Delirium in critical illness: clinical manifestations, outcomes, and management. Intensive Care Med 2021; 47: 1089-103.
DOI PMID |
102. | Gao J, Wang L, Liu J, et al. Abnormalities of mitochondrial dynamics in neurodegenerative diseases. Antioxidants (Basel) 2017; 6: 25. |
103. |
van Gool WA, van de Beek D, Eikelenboom P. Systemic infection and delirium: when cytokines and acetylcholine collide. Lancet 2010; 375: 773-5.
DOI PMID |
104. |
O'Connor JC, Lawson MA, André C, et al. Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice. Mol Psychiatry 2009; 14: 511-22.
DOI |
105. |
Pandharipande PP, Morandi A, Adams JR, et al. Plasma tryptophan and tyrosine levels are independent risk factors for delirium in critically ill patients. Intensive Care Med 2009; 35: 1886-92.
DOI PMID |
106. |
Li Y, Hadden C, Cooper A, et al. Sepsis-induced elevation in plasma serotonin facilitates endothelial hyperpermeability. Sci Rep 2016; 6: 22747.
DOI PMID |
107. |
Liang W, Liu Y, Zhou K, et al. Ginsenoside Rb1 prevents lipopolysaccharide-induced depressive-like behavior by inhibiting inflammation and neural dysfunction and F2 elicits a novel antidepressant-like effect: a metabolite-based network pharmacology study. J Ethnopharmacol 2022; 282: 114655.
DOI URL |
108. |
Tao W, Wang H, Su Q, et al. Paeonol attenuates lipopolysaccharide-induced depressive-like behavior in mice. Psychiatry Res 2016; 238: 116-21.
DOI URL |
109. |
Yang R, Chen W, Lu Y, et al. Dioscin relieves endotoxemia induced acute neuro-inflammation and protect neurogenesis via improving 5-HT metabolism. Sci Rep 2017; 7: 40035.
DOI PMID |
110. | Kozisek ME, Middlemas D, Bylund DB. Brain-derived neurotrophic factor and its receptor tropomyosin-related kinase B in the mechanism of action of antidepressant therapies. Pharmacol Ther 2008; 117: 30-51. |
111. |
Heldt SA, Stanek L, Chhatwal JP, et al. Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories. Mol Psychiatry 2007; 12: 656-70.
DOI |
112. |
Li Z, Zhao L, Chen J, et al. Ginsenoside Rk1 alleviates LPS-induced depression-like behavior in mice by promoting BDNF and suppressing the neuroinflammatory response. Biochem Biophys Res Commun 2020; 530: 658-64.
DOI URL |
113. |
Chen LX, Qi Z, Shao ZJ, et al. Study on antidepressant activity of pseudo-ginsenoside HQ on depression-like behavior in mice. Molecules 2019; 24: 870.
DOI URL |
114. |
Wang W, Liu X, Liu J, et al. Sesquiterpenoids from the root of panax ginseng attenuates lipopolysaccharide-induced depressive-like behavior through the brain-derived neurotrophic factor/tropomyosin-related kinase B and sirtuin type 1/Nuclear factor-κB signaling pathways. J Agric Food Chem 2018; 66: 265-71.
DOI URL |
115. |
Su Q, Tao W, Huang H, et al. Protective effect of liquiritigenin on depressive-like behavior in mice after lipopolysaccharide administration. Psychiatry Res 2016; 240: 131-6.
DOI URL |
116. |
Chen S, Guo W, Qi X, et al. Natural alkaloids from lotus plumule ameliorate lipopolysaccharide-induced depression-like behavior: integrating network pharmacology and molecular mechanism evaluation. Food Funct 2019; 10: 6062-73.
DOI PMID |
117. |
Wu L, Zhang T, Chen K, et al. Rapid antidepressant-like effect of Fructus Aurantii depends on cAMP-response element binding protein/Brain-derived neurotrophic factor by mediating synaptic transmission. Phytother Res 2021; 35: 404-14.
DOI URL |
118. |
Ruan SS, Xiao YC, He PC, et al. Identification of potential gene signatures related to sleep deprivation. J Comput Biol 2020; 27: 904-13.
DOI URL |
119. | Xie J, Zhao ZZ, Li P, et al. Senkyunolide I protects against sepsis-associated encephalopathy by attenuating sleep deprivation in a murine model of cecal ligation and puncture. Oxid Med Cell Longev 2021; 2021: 6647258. |
120. |
Berg RM, Plovsing RR, Bailey DM, et al. Dynamic cerebral autoregulation to induced blood pressure changes in human experimental and clinical sepsis. Clin Physiol Funct Imaging 2016; 36: 490-6.
DOI URL |
121. |
Michels M, Vieira AS, Vuolo F, et al. The role of microglia activation in the development of sepsis-induced long-term cognitive impairment. Brain Behav Immun 2015; 43: 54-9.
DOI PMID |
122. |
Banks WA, Gray AM, Erickson MA, et al. Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit. J Neuroinflammation 2015; 12: 223.
DOI URL |
123. |
Liang M, Li G, Guan X, et al. Intravoxel incoherent motion imaging study of madecassoside in improving lipopolysaccharide-induced cognitive impairment in rats. J Magn Reson Imaging 2020; 51: 1836-43.
DOI PMID |
124. |
Iima M, Le Bihan D. Clinical intravoxel incoherent motion and diffusion MR imaging: past, present, and future. Radiology 2016; 278: 13-32.
DOI PMID |
125. |
Le Bihan D, Breton E, Lallemand D, et al. MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology 1986; 161: 401-7.
DOI PMID |
126. |
Gasparotto J, Girardi CS, Somensi N, et al. Receptor for advanced glycation end products mediates sepsis-triggered amyloid-β accumulation, Tau phosphorylation, and cognitive impairment. J Biol Chem 2018; 293: 226-44.
DOI PMID |
127. |
Kirk RA, Kesner RP, Wang LM, et al. Lipopolysaccharide exposure in a rat sepsis model results in hippocampal amyloid-β plaque and phosphorylated tau deposition and corresponding behavioral deficits. Geroscience 2019; 41: 467-81.
DOI PMID |
128. |
Yuan Q, Wu Y, Wang G, et al. Preventive effects of arctigenin from Arctium lappa L against LPS-induced neuroinflammation and cognitive impairments in mice. Metab Brain Dis 2022; 37: 2039-52.
DOI PMID |
129. |
Austin SA, Santhanam AV, Katusic ZS. Endothelial nitric oxide modulates expression and processing of amyloid precursor protein. Circ Res 2010; 107: 1498-502.
DOI PMID |
130. |
Austin SA, d'Uscio LV, Katusic ZS. Supplementation of nitric oxide attenuates AβPP and BACE1 protein in cerebral microcirculation of eNOS-deficient mice. J Alzheimers Dis 2013; 33: 29-33.
DOI PMID |
131. |
Pan Y, Chen XY, Zhang QY, et al. Corrigendum to "Microglial NLRP3 inflammasome activation mediates IL-1beta-related inflammation in prefrontal cortex of depressive rats" [Brain Behav. Immun. 41 (2014) 90-100]. Brain Behav Immun 2021; 97: 455.
DOI URL |
132. |
Jang J, Park S, Jin Hur H, et al. 25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome. Nat Commun 2016; 7: 13129.
DOI PMID |
133. |
Heneka MT, Kummer MP, Stutz A, et al. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature 2013; 493: 674-8.
DOI |
134. |
Ding H, Li Y, Chen S, et al. Fisetin ameliorates cognitive impairment by activating mitophagy and suppressing neuro-inflammation in rats with sepsis-associated encephalopathy. CNS Neurosci Ther 2022; 28: 247-58.
DOI URL |
135. |
Bian HT, Wang GH, Huang JJ, et al. Scutellarin protects against lipopolysaccharide-induced behavioral deficits by inhibiting neuroinflammation and microglia activation in rats. Int Immunopharmacol 2020; 88: 106943.
DOI URL |
136. |
Zhang L, Previn R, Lu L, et al. Crocin, a natural product attenuates lipopolysaccharide-induced anxiety and depressive-like behaviors through suppressing NF-kB and NLRP3 signaling pathway. Brain Res Bull 2018; 142: 352-9.
DOI PMID |
137. |
Chen M, Zhang QP, Zhu JX, et al. Involvement of FGF-2 modulation in the antidepressant-like effects of liquiritin in mice. Eur J Pharmacol 2020; 881: 173297.
DOI URL |
138. | Tang MM, Lin WJ, Pan YQ, et al. Fibroblast growth factor 2 modulates hippocampal microglia activation in a neuroinflammation induced model of depression. Front Cell Neurosci 2018; 12: 255. |
139. |
Cheng J, Chen M, Wan HQ, et al. Paeoniflorin exerts anti-depressant-like effects through enhancing neuronal FGF-2 by microglial inactivation. J Ethnopharmacol 2021; 274: 114046.
DOI URL |
140. |
Chen M, Zhang QP, Zhu JX, et al. Involvement of FGF-2 modulation in the antidepressant-like effects of liquiritin in mice. Eur J Pharmacol 2020; 881: 173297.
DOI URL |
141. |
Sekino N, Selim M, Shehadah A. Sepsis-associated brain injury: underlying mechanisms and potential therapeutic strategies for acute and long-term cognitive impairments. J Neuroinflammation 2022; 19: 101.
DOI |
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