Systematic review and Meta-analysis of brain plasticity associated with electroacupuncture in experimental ischemic stroke

doi:10.19852/j.cnki.jtcm.20240828.008

Abstract

Abstract:

OBJECTIVE: To systematically evaluate the role of electroacupuncture in maintaining brain plasticity in ischemic stroke mediated brain damage.

METHODS: We searched for all relevant trials published through Oct 7, 2022 from seven databases. Metho-dological quality was assessed using the CAMARADES Risk of Bias Tool. A Meta-analysis of comparative effects was performed using Review Manager v.5.3 software.

RESULTS: A total of 101 studies involving 2148 animals were included. For most studies, primary outcomes results of the Meta-analysis indicate that EA significantly improved ischemic stroke rat’s postsynaptic density thickness [Standardized Mean Difference (SMD) = 1.41, 95% confidence interval (CI) (0.59, 2.23), P = 0.0008], numerical density of synapses [SMD = 1.55, 95% CI (0.48, 2.63), P = 0.005] compared with non-EA-treated. Similarly, EA could improve parts of biomarkers of synapses, neurogenesis, angiogenesis and neurotrophin activity than the control group (P < 0.05).

CONCLUSION: The existing evidence suggests EA regulating ischemic stroke may be through brain plasticity. More rigorous and high quality studies should be conducted in the future.

Key words: electroacupuncture, brain plasticity, experimental ischemic stroke, animal, systematic review, Meta-analysis

XU Yingshan, WU Chunxiao, YU Wei, GUO Hongji, LU Liming, XU Nenggui, TANG Chunzhi. Systematic review and Meta-analysis of brain plasticity associated with electroacupuncture in experimental ischemic stroke[J]. Journal of Traditional Chinese Medicine, 2024, 44(5): 859-870.

Figures/Tables 3

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Author		Year	1		2		3			6		9		10		Score
Bai MH⁸⁷		2005	√		√		√			√						4
Bao DP⁴⁹		2007			√		√			√						3
Cao XL et al ¹⁶		2018	√		√		√			√						4
Chen B et al ⁴¹		2014	√		√		√			√						4
Chen C et al ⁷⁰		2015	√		√		√			√						4
Chen JJ²⁴		2004					√			√						2
Chen LR¹¹		2008			√		√			√						3
Chen WS⁷¹		2011			√		√			√						3
Chen YH，Huang XF⁷²		2000	√				√			√		√		√		5
Cheng CY et al ⁹⁴		2014	√		√		√			√						4
Ding J et al ⁷³		2017	√		√		√			√						4
Ding J et al ⁷⁴		2018	√				√			√						3
Ding L et al ⁹⁰		2012	√		√		√			√						4
Du YX¹²		2008			√		√			√						3
Duan XD et al ⁷⁵		2018	√		√		√			√						4
Fan YS, Luo Y⁷⁶		2008	√				√			√						3
Fan YS⁹¹		2006			√		√			√						3
Han XH et al ⁹²		2006	√				√			√						3
Han YS¹⁷		2013	√		√		√			√						4
Huang GX¹³		2009			√		√			√						3
Huang LJ et al ⁵⁵		2013	√				√									2
Huang XF，Chen YH¹⁸		2002	√				√			√						3
Ji Z⁷⁷		2005	√				√			√						3
Jiang C⁵⁰		2006			√		√			√						3
Jiang HZ et al ⁶³		2006	√				√			√						3
Kim Won-Seok et al ⁹⁷		2009	√		√		√			√						4
Li HL³¹		2015			√		√			√						3
Li J et al ⁶⁴		2014	√		√		√									3
Li M et al ¹⁰⁹		2009	√				√			√						3
Li QL et al ⁵⁶		2018			√		√			√						3
Li QP et al ²⁵		2015	√		√		√			√						4
Li T³²		2016			√		√			√						3
Li XJ et al ⁹⁹		2017	√				√			√						3
Li XJ et al ⁹⁸		2015	√		√		√			√						4
Lin R et al ³³		2017	√		√		√			√		√				5
Lin T⁵⁷		2009			√		√			√						3
Lin XM et al ²⁶		2017	√		√		√			√						4
Liu B²⁷		2004			√		√			√						3
Liu D et al ¹⁰⁰		2014	√				√			√						3
Liu L, Zhang XQ⁷⁸		2018	√		√		√			√						4
Liu Y et al ¹⁰¹		2014	√				√			√						3
Liu YN et al ¹⁰²		2010	√				√			√						3
Liu D et al ⁸⁸		2011	√				√			√						3
Luo D et al ⁴²		2014	√				√			√				√		4
Luo Y¹⁴		2009			√		√			√						3
Luo ZD et al ¹⁰³		2002	√				√			√						3
Luo ZD et al ⁷⁹		2004	√				√			√						3
Lyu H⁴³		2016			√		√			√						3
Ma JX et al ⁵¹		2013	√				√			√						3
Ma JX⁶⁵		2008	√				√			√						3
Ma RR(1) et al ^[19		2011	√				√			√						3
Ma XM⁸⁰		2009			√		√			√						3
Ma Y et al ⁸¹		2018	√				√			√						3
Mao QJ, Chen BG⁶⁶		2012	√		√		√			√						4
Mi XJ²⁰		2010					√			√						2
Pan J⁵⁸		2011	√				√			√						3
Pan J et al ⁸²		2017	√		√		√									3
Qin B et al ²¹		2014	√		√		√			√						4
Shen F⁸³		2006			√		√			√						3
Shen F et al ⁸⁹		2012	√		√		√			√						4
Shen GY⁵²	2009					√		√			√						3
Song CM²⁸	2018					√		√			√						3
Song YS, Zhou MF³⁴	2008			√		√		√			√						4
Tan F et al ³⁵	2017			√		√		√			√						4
Tan F et al ⁴⁴	2018			√		√		√	√		√		√		√		7
Tao J et al ³⁶	2016			√		√		√	√		√				√		6
Tao J⁹⁶	2014			√		√		√	√		√		√		√		7
Wang GB et al ^[15	2005			√		√		√			√						4
Wang J et al ⁵⁹	2015			√				√			√						3
Wang L⁶⁰	2015							√			√						2
Wang MP et al ⁶⁷	2018			√		√		√			√						4
Wang Q et al ⁸⁴	2010			√				√			√						3
Wang S et al ¹⁰⁴	2018			√		√		√									3
Wang YC et al ¹⁰⁵	2012			√				√			√						3
Wei XY⁹³	2013					√		√			√						3
Xiang F⁶¹	2015					√		√									2
Xiao YC et al ³⁷	2013			√		√		√			√		√				5
Xie CC⁶⁸	2014					√		√			√						3
Xu L et al ²²	2013			√		√		√			√						4
Xu NG et al ¹⁰⁶	2004			√		√		√			√						4
Yang MG et al ²⁹	2018			√				√			√						3
Yao G et al ²³	2007			√				√									2
Ye F et al ⁴⁵	2012			√		√		√			√						4
Ye XQ et al ¹⁰⁷	2014			√		√		√			√						4
Yi W et al ⁸⁵	2006			√		√		√			√						4
Yin TR⁸⁶	2005					√		√			√						3
You HL⁴⁶	2012					√		√			√						3
Yu JH et al ¹¹⁰	2015			√				√			√						3
Zhang HX et al ⁴⁷	2011			√				√			√						3
Zhang SL⁵³	2016					√		√			√						3
Zhang XM⁵⁴	2012							√			√						2
Zhang YG et al ³⁸	2014			√				√			√						3
Zhang YK, Tao LF⁴⁸	2013			√				√			√						3
Zhao HJ et al ³⁹	2018			√		√		√	√		√		√				6
Zhao JH et al ⁴⁰	2015			√		√		√	√		√						5
Zhao JP et al ³⁰	2017			√		√		√			√						4
Zhao JX et al ¹¹¹	2013			√		√		√									3
Zheng CX¹⁰⁸	2017			√		√		√			√						4
Zhou CL et al ⁶²	2007							√			√						2
Zhu YH et al ⁶⁹	2015			√				√			√						3

Author		Year	1		2		3			6		9		10		Score
Bai MH⁸⁷		2005	√		√		√			√						4
Bao DP⁴⁹		2007			√		√			√						3
Cao XL et al ¹⁶		2018	√		√		√			√						4
Chen B et al ⁴¹		2014	√		√		√			√						4
Chen C et al ⁷⁰		2015	√		√		√			√						4
Chen JJ²⁴		2004					√			√						2
Chen LR¹¹		2008			√		√			√						3
Chen WS⁷¹		2011			√		√			√						3
Chen YH，Huang XF⁷²		2000	√				√			√		√		√		5
Cheng CY et al ⁹⁴		2014	√		√		√			√						4
Ding J et al ⁷³		2017	√		√		√			√						4
Ding J et al ⁷⁴		2018	√				√			√						3
Ding L et al ⁹⁰		2012	√		√		√			√						4
Du YX¹²		2008			√		√			√						3
Duan XD et al ⁷⁵		2018	√		√		√			√						4
Fan YS, Luo Y⁷⁶		2008	√				√			√						3
Fan YS⁹¹		2006			√		√			√						3
Han XH et al ⁹²		2006	√				√			√						3
Han YS¹⁷		2013	√		√		√			√						4
Huang GX¹³		2009			√		√			√						3
Huang LJ et al ⁵⁵		2013	√				√									2
Huang XF，Chen YH¹⁸		2002	√				√			√						3
Ji Z⁷⁷		2005	√				√			√						3
Jiang C⁵⁰		2006			√		√			√						3
Jiang HZ et al ⁶³		2006	√				√			√						3
Kim Won-Seok et al ⁹⁷		2009	√		√		√			√						4
Li HL³¹		2015			√		√			√						3
Li J et al ⁶⁴		2014	√		√		√									3
Li M et al ¹⁰⁹		2009	√				√			√						3
Li QL et al ⁵⁶		2018			√		√			√						3
Li QP et al ²⁵		2015	√		√		√			√						4
Li T³²		2016			√		√			√						3
Li XJ et al ⁹⁹		2017	√				√			√						3
Li XJ et al ⁹⁸		2015	√		√		√			√						4
Lin R et al ³³		2017	√		√		√			√		√				5
Lin T⁵⁷		2009			√		√			√						3
Lin XM et al ²⁶		2017	√		√		√			√						4
Liu B²⁷		2004			√		√			√						3
Liu D et al ¹⁰⁰		2014	√				√			√						3
Liu L, Zhang XQ⁷⁸		2018	√		√		√			√						4
Liu Y et al ¹⁰¹		2014	√				√			√						3
Liu YN et al ¹⁰²		2010	√				√			√						3
Liu D et al ⁸⁸		2011	√				√			√						3
Luo D et al ⁴²		2014	√				√			√				√		4
Luo Y¹⁴		2009			√		√			√						3
Luo ZD et al ¹⁰³		2002	√				√			√						3
Luo ZD et al ⁷⁹		2004	√				√			√						3
Lyu H⁴³		2016			√		√			√						3
Ma JX et al ⁵¹		2013	√				√			√						3
Ma JX⁶⁵		2008	√				√			√						3
Ma RR(1) et al ^[19		2011	√				√			√						3
Ma XM⁸⁰		2009			√		√			√						3
Ma Y et al ⁸¹		2018	√				√			√						3
Mao QJ, Chen BG⁶⁶		2012	√		√		√			√						4
Mi XJ²⁰		2010					√			√						2
Pan J⁵⁸		2011	√				√			√						3
Pan J et al ⁸²		2017	√		√		√									3
Qin B et al ²¹		2014	√		√		√			√						4
Shen F⁸³		2006			√		√			√						3
Shen F et al ⁸⁹		2012	√		√		√			√						4
Shen GY⁵²	2009					√		√			√						3
Song CM²⁸	2018					√		√			√						3
Song YS, Zhou MF³⁴	2008			√		√		√			√						4
Tan F et al ³⁵	2017			√		√		√			√						4
Tan F et al ⁴⁴	2018			√		√		√	√		√		√		√		7
Tao J et al ³⁶	2016			√		√		√	√		√				√		6
Tao J⁹⁶	2014			√		√		√	√		√		√		√		7
Wang GB et al ^[15	2005			√		√		√			√						4
Wang J et al ⁵⁹	2015			√				√			√						3
Wang L⁶⁰	2015							√			√						2
Wang MP et al ⁶⁷	2018			√		√		√			√						4
Wang Q et al ⁸⁴	2010			√				√			√						3
Wang S et al ¹⁰⁴	2018			√		√		√									3
Wang YC et al ¹⁰⁵	2012			√				√			√						3
Wei XY⁹³	2013					√		√			√						3
Xiang F⁶¹	2015					√		√									2
Xiao YC et al ³⁷	2013			√		√		√			√		√				5
Xie CC⁶⁸	2014					√		√			√						3
Xu L et al ²²	2013			√		√		√			√						4
Xu NG et al ¹⁰⁶	2004			√		√		√			√						4
Yang MG et al ²⁹	2018			√				√			√						3
Yao G et al ²³	2007			√				√									2
Ye F et al ⁴⁵	2012			√		√		√			√						4
Ye XQ et al ¹⁰⁷	2014			√		√		√			√						4
Yi W et al ⁸⁵	2006			√		√		√			√						4
Yin TR⁸⁶	2005					√		√			√						3
You HL⁴⁶	2012					√		√			√						3
Yu JH et al ¹¹⁰	2015			√				√			√						3
Zhang HX et al ⁴⁷	2011			√				√			√						3
Zhang SL⁵³	2016					√		√			√						3
Zhang XM⁵⁴	2012							√			√						2
Zhang YG et al ³⁸	2014			√				√			√						3
Zhang YK, Tao LF⁴⁸	2013			√				√			√						3
Zhao HJ et al ³⁹	2018			√		√		√	√		√		√				6
Zhao JH et al ⁴⁰	2015			√		√		√	√		√						5
Zhao JP et al ³⁰	2017			√		√		√			√						4
Zhao JX et al ¹¹¹	2013			√		√		√									3
Zheng CX¹⁰⁸	2017			√		√		√			√						4
Zhou CL et al ⁶²	2007							√			√						2
Zhu YH et al ⁶⁹	2015			√				√			√						3

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