Journal of Traditional Chinese Medicine ›› 2025, Vol. 45 ›› Issue (1): 107-114.DOI: 10.19852/j.cnki.jtcm.2025.01.009
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Effectiveness of combining Qingyanyin formulated granules (轻燕饮配方颗粒) with press needles in treating abdominal obesity: a multicenter randomized controlled trial
YE Wujie1, YANG Yawei2, ZHANG Da3, TANG Ling5, CUI Minying6, FU Bin4, ZHANG Meng7, HU Xingang8, ZHAO Yan1(
)
- 1 School of Chinese Medicine, Beijing University of Traditional Chinese Medicine, Beijing 100029, China
2 Department of Dermatology, the Afiliated Traditional Chinese Medicine Hospital of Guangzhou Medical University, Guangzhou 510100, China
3 School of Life Sciences, Beijing University of Traditional Chinese Medicine, Beijing 100029, China
4 Physical Examination Center, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100078, China
5 Gynecology Department, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China
6 Preventive Treatment Center, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China
7 Physical Examination Center, Beijing University of Chinese Medicine East Hospital, Zaozhuang 277101, China
8 Internal Encephalopathy of Traditional Chinese Medicine, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100078, China
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Received:2023-12-22Accepted:2024-04-25Online:2025-02-15Published:2025-01-10 -
Contact:Dr. ZHAO Yan, School of Chinese Medicine, Beijing University of Traditional Chinese Medicine, Beijing 100029, China.yanzh3232@126.com Telephone: + 86-10-64826498 -
Supported by:National Key Research and Development Project: Clinical Evaluation of the Interventional Techniques for Abdominal Obesity(2019YFC1710102)
Cite this article
YE Wujie, YANG Yawei, ZHANG Da, TANG Ling, CUI Minying, FU Bin, ZHANG Meng, HU Xingang, ZHAO Yan. Effectiveness of combining Qingyanyin formulated granules (轻燕饮配方颗粒) with press needles in treating abdominal obesity: a multicenter randomized controlled trial[J]. Journal of Traditional Chinese Medicine, 2025, 45(1): 107-114.
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Figure 1 Study flow diagram
Figure 1 Study flow diagram
Table 1 Baseline characteristics of patients ($\bar{x}±s$)
| Item | Placebo + SPN (n = 102) | QYY + SPN (n = 110) | Placebo＋PN (n = 106) | QYY + PN (n = 111) | Total (n = 429) |
|---|---|---|---|---|---|
| Gender (women) [n (%)] | 83 (81) | 81 (74) | 87 (82) | 95 (86) | 346 (81) |
| Age (years) | 34±10 | 35±11 | 35±11 | 36±10 | 35±11 |
| Waist circumference (cm) | 93±9 | 93±9 | 95±10 | 91±9 | 93±9 |
| BMI (kg/m2) | 28±3 | 28±3 | 28±3 | 27±3 | 28±3 |
| Weight (kg) | 76±13 | 76±12 | 77±12 | 73±11 | 76±12 |
| Height (cm) | 164±8 | 165±8 | 164±8 | 164±7 | 164±8 |
| BDI (scores) | 8±7 | 7±7 | 8±7 | 7±6 | 7±7 |
| BAI (scores) | 8±11 | 6±7 | 6±8 | 5±7 | 6±8 |
| PSQI (scores) | 6±4 | 6±3 | 6±3 | 6±3 | 6±3 |
Table 1 Baseline characteristics of patients ($\bar{x}±s$)
| Item | Placebo + SPN (n = 102) | QYY + SPN (n = 110) | Placebo＋PN (n = 106) | QYY + PN (n = 111) | Total (n = 429) |
|---|---|---|---|---|---|
| Gender (women) [n (%)] | 83 (81) | 81 (74) | 87 (82) | 95 (86) | 346 (81) |
| Age (years) | 34±10 | 35±11 | 35±11 | 36±10 | 35±11 |
| Waist circumference (cm) | 93±9 | 93±9 | 95±10 | 91±9 | 93±9 |
| BMI (kg/m2) | 28±3 | 28±3 | 28±3 | 27±3 | 28±3 |
| Weight (kg) | 76±13 | 76±12 | 77±12 | 73±11 | 76±12 |
| Height (cm) | 164±8 | 165±8 | 164±8 | 164±7 | 164±8 |
| BDI (scores) | 8±7 | 7±7 | 8±7 | 7±6 | 7±7 |
| BAI (scores) | 8±11 | 6±7 | 6±8 | 5±7 | 6±8 |
| PSQI (scores) | 6±4 | 6±3 | 6±3 | 6±3 | 6±3 |
Table 2 Outcomes with regard to weight, waist circumference, BMI, PSQI, BAI, BDI [change from baseline, mean (95% CI)]
| Group | Weight (kg) | Waist circumference (cm) | BMI | PSQI | BAI | BDI |
|---|---|---|---|---|---|---|
| Placebo SPN | －2.32 (－2.91,－1.73) | －3.65 (－4.68,－2.61) | －0.93 (－1.16,－0.71) | －1.47 (－2.04,－0.90) | －2.58 (－3.82,－1.33) | 0.26 (－0.90,1.42) |
| QYY + SPN | －2.97 (－3.53,－2.40) | －4.46 (－5.46,－3.46) | －1.16 (－1.38,－0.95) | －1.06 (－1.60,－0.51) | －0.86 (－2.06,0.33) | －0.67 (－1.79,0.45) |
| Placebo + PN | －2.97 (－3.55,－2.39) | －4.07 (－5.09,－3.05) | －1.12 (－1.34,－0.90) | －1.34 (－1.89,－0.78) | －2.64 (－3.85,－1.42) | 0.42 (－0.72,－1.55) |
| QYY + PN | －2.91 (－3.48,－2.34) | －5.66 (－6.66,－4.66) | －1.10 (－1.31,－0.88) | －1.65 (－2.19,－1.11) | －1.15 (－2.34,0.04) | 0.16 (－0.95,1.27) |
Table 2 Outcomes with regard to weight, waist circumference, BMI, PSQI, BAI, BDI [change from baseline, mean (95% CI)]
| Group | Weight (kg) | Waist circumference (cm) | BMI | PSQI | BAI | BDI |
|---|---|---|---|---|---|---|
| Placebo SPN | －2.32 (－2.91,－1.73) | －3.65 (－4.68,－2.61) | －0.93 (－1.16,－0.71) | －1.47 (－2.04,－0.90) | －2.58 (－3.82,－1.33) | 0.26 (－0.90,1.42) |
| QYY + SPN | －2.97 (－3.53,－2.40) | －4.46 (－5.46,－3.46) | －1.16 (－1.38,－0.95) | －1.06 (－1.60,－0.51) | －0.86 (－2.06,0.33) | －0.67 (－1.79,0.45) |
| Placebo + PN | －2.97 (－3.55,－2.39) | －4.07 (－5.09,－3.05) | －1.12 (－1.34,－0.90) | －1.34 (－1.89,－0.78) | －2.64 (－3.85,－1.42) | 0.42 (－0.72,－1.55) |
| QYY + PN | －2.91 (－3.48,－2.34) | －5.66 (－6.66,－4.66) | －1.10 (－1.31,－0.88) | －1.65 (－2.19,－1.11) | －1.15 (－2.34,0.04) | 0.16 (－0.95,1.27) |
Table 3 Outcomes with regard to weight, waist circumference, BMI, PSQI, BAI, BDI (two-way comparison results)
| Group | Item | Weight (kg) | Waist circumference (cm) | BMI | PSQI | BAI | BDI |
|---|---|---|---|---|---|---|---|
| QYY + SPN vs | Difference (95% CI) | －0.64 (－1.46, 0.18) | －0.81 (－2.25, 0.63) | －0.23 (－0.54, 0.08) | 0.41 (－0.37, 1.20) | 1.72 (－0.01, 3.44) | －0.93 (－2.55, 0.69) |
| placebo＋SPN | |||||||
| P value | 0.124 | 0.268 | 0.148 | 0.3 | 0.051 | 0.26 | |
| Placebo + PN vs | Difference (95% CI) | －0.65 (－1.48, 0.18) | －0.42 (－1.88, 1.03) | －0.18 (－0.50, 0.13) | 0.13 (－0.66, 0.92) | －0.06 (－1.80, 1.68) | 0.16 (－1.47, 1.78) |
| placebo+ SPN | |||||||
| P value | 0.123 | 0.567 | 0.251 | 0.745 | 0.947 | 0.851 | |
| QYY + PN vs | Difference (95% CI) | －0.59 (－1.41, 0.24) | －2.01 (－3.46, －0.57) | －0.16 (－0.48, 0.15) | －0.18 (－0.96, 0.60) | 1.43 (－0.30, 3.16) | －0.10 (－1.70, 1.51) |
| Placebo + SPN | |||||||
| P value | 0.162 | 0.006 | 0.305 | 0.654 | 0.104 | 0.906 | |
| QYY + PN vs | Difference (95% CI) | 0.06 (－0.75, 0.86) | －1.20 (－2.62, 0.21) | 0.07 (－0.24, 0.37) | －0.59 (－1.36, 0.18) | －0.28 (－1.97, 1.40) | 0.83 (－0.75, 2.42) |
| QYY + SPN | |||||||
| P value | 0.888 | 0.095 | 0.669 | 0.13 | 0.741 | 0.301 | |
| QYY + PN vs | Difference (95% CI) | 0.07 (－0.75, 0.88) | －1.59 (－3.03, －0.16) | 0.02 (－0.29, 0.33) | －0.31 (－1.09, 0.47) | 1.49 (－0.21, 3.19) | －0.25 (－1.84, 1.34) |
| placebo + PN | |||||||
| P value | 0.875 | 0.03 | 0.897 | 0.432 | 0.086 | 0.756 | |
| QYY + SPN vs | Difference (95% CI) | 0.01 (－0.80, 0.82) | －0.39 (－1.81, 1.04) | －0.05 (－0.36, 0.26) | 0.28 (－0.49, 1.09) | 1.77 (0.07,3.48) | －1.09 (－2.68, 0.51) |
| placebo + PN | |||||||
| P value | 0.985 | 0.593 | 0.77 | 0.474 | 0.041 | 0.182 |
Table 3 Outcomes with regard to weight, waist circumference, BMI, PSQI, BAI, BDI (two-way comparison results)
| Group | Item | Weight (kg) | Waist circumference (cm) | BMI | PSQI | BAI | BDI |
|---|---|---|---|---|---|---|---|
| QYY + SPN vs | Difference (95% CI) | －0.64 (－1.46, 0.18) | －0.81 (－2.25, 0.63) | －0.23 (－0.54, 0.08) | 0.41 (－0.37, 1.20) | 1.72 (－0.01, 3.44) | －0.93 (－2.55, 0.69) |
| placebo＋SPN | |||||||
| P value | 0.124 | 0.268 | 0.148 | 0.3 | 0.051 | 0.26 | |
| Placebo + PN vs | Difference (95% CI) | －0.65 (－1.48, 0.18) | －0.42 (－1.88, 1.03) | －0.18 (－0.50, 0.13) | 0.13 (－0.66, 0.92) | －0.06 (－1.80, 1.68) | 0.16 (－1.47, 1.78) |
| placebo+ SPN | |||||||
| P value | 0.123 | 0.567 | 0.251 | 0.745 | 0.947 | 0.851 | |
| QYY + PN vs | Difference (95% CI) | －0.59 (－1.41, 0.24) | －2.01 (－3.46, －0.57) | －0.16 (－0.48, 0.15) | －0.18 (－0.96, 0.60) | 1.43 (－0.30, 3.16) | －0.10 (－1.70, 1.51) |
| Placebo + SPN | |||||||
| P value | 0.162 | 0.006 | 0.305 | 0.654 | 0.104 | 0.906 | |
| QYY + PN vs | Difference (95% CI) | 0.06 (－0.75, 0.86) | －1.20 (－2.62, 0.21) | 0.07 (－0.24, 0.37) | －0.59 (－1.36, 0.18) | －0.28 (－1.97, 1.40) | 0.83 (－0.75, 2.42) |
| QYY + SPN | |||||||
| P value | 0.888 | 0.095 | 0.669 | 0.13 | 0.741 | 0.301 | |
| QYY + PN vs | Difference (95% CI) | 0.07 (－0.75, 0.88) | －1.59 (－3.03, －0.16) | 0.02 (－0.29, 0.33) | －0.31 (－1.09, 0.47) | 1.49 (－0.21, 3.19) | －0.25 (－1.84, 1.34) |
| placebo + PN | |||||||
| P value | 0.875 | 0.03 | 0.897 | 0.432 | 0.086 | 0.756 | |
| QYY + SPN vs | Difference (95% CI) | 0.01 (－0.80, 0.82) | －0.39 (－1.81, 1.04) | －0.05 (－0.36, 0.26) | 0.28 (－0.49, 1.09) | 1.77 (0.07,3.48) | －1.09 (－2.68, 0.51) |
| placebo + PN | |||||||
| P value | 0.985 | 0.593 | 0.77 | 0.474 | 0.041 | 0.182 |
| 1. |
Smith U. Abdominal obesity: a marker of ectopic fat accumulation. J Clin Invest 2015; 125: 1790-2.
DOI PMID |
| 2. | Jin WS, Pan CY. International diabetes federation global consensus on the definition of metabolic syndrome. Zhong Hua Nei Fen Mi Dai Xie Za Zhi 2005; 21: 412-3. |
| 3. | Zhang L, Wang Z, Wang X, et al. China hypertension survey investigators. prevalence of abdominal obesity in China: results from a cross-sectional study of nearly half a million participants. Obesity (Silver Spring) 2019; 27: 1898-905. |
| 4. | Ma ZS, Feng XL, Zhu P. Clinical research progress of metabolic syndrome and related diseases. Zhong Hua Nei Ke Za Zhi 2015; 18: 1991-5. |
| 5. | Heymsfield SB, Wadden TA. Mechanisms, pathophysiology, and management of obesity. N Engl J Med 2017; 376: 254-66. |
| 6. | Hong HC, Hwang SY, Park S, et al. Implications of pericardial, visceral and subcutaneous adipose tissue on vascular inflammation measured Using 18FDG-PET/CT. PLoS One 2015; 10: e0135294. |
| 7. | Zhang L, Yang YJ, Wen R, et al. Research on the association of overweight, obesity, abdominal obesity and cardiometabolic diseases. Xian Dai Yu Fang Yi Xue 2016; 43: 3887-91. |
| 8. |
Yuan S, Bruzelius M, Xiong Y, et al. Overall and abdominal obesity in relation to venous thromboembolism. J Thromb Haemost 2021; 19: 460-9.
DOI PMID |
| 9. | Hou X, Lu J, Weng J, et al. China National Diabetes and Metabolic Disorders Study Group. Impact of waist circumference and body mass index on risk of cardiometabolic disorders and cardiovascular disease in Chinese adults: a national diabetes and metabolic disorderss urvey. PLoS One 2013; 8: e57319. |
| 10. | Li J, Wang YX. Research status of obesity mechanism and weight loss methods. Zhong Guo Ti Yu Ke Ji 2006; 46: 64-7. |
| 11. | Butryn ML, Webb V, Wadden TA. Behavioral treatment of obesity. Psychiatr Clin North Am 2011; 34: 841-59. |
| 12. | Gadde KM, Martin CK, Berthoud HR, Heymsfield SB. Obesity: pathophysiology and management. J Am Coll Cardiol 2018; 71: 69-84. |
| 13. | Garg R, Hussey C, Ibrahim S. Pancreatitis associated with the use of sitagliptin and orlistat combination: a case report. Diabet Med 2010; 27: 485-6. |
| 14. | Ahmad FA, Mahmud S. Acute pancreatitis following orlistat therapy: report of two cases. JOP 2010; 11: 61-3. |
| 15. | Thurairajah PH, Syn WK, Neil DA, Stell D, Haydon G. Orlistat (Xenical)-induced subacute liver failure. Eur J Gastroenterol Hepatol 2005; 17: 1437-8. |
| 16. | Courtney AE, O'Rourke DM, Maxwell AP. Rapidly progressive renal failure associated with successful pharmacotherapy for obesity. Nephrol Dial Transplant 2007; 22: 621-3. |
| 17. | Casimiro I, Sam S, Brady MJ. Endocrine implications of bariatric surgery: a review on the intersection between incretins, bone, and sex hormones. Physiol Rep 2019; 7: e14111. |
| 18. |
Decker GA, Swain JM, Crowell MD, Scolapio JS. Gastrointestinal and nutritional complications after bariatric surgery. Am J Gastroenterol 2007; 102: 2571-81.
PMID |
| 19. |
O'Brien PE, Hindle A, Brennan L, et al. Long-term outcomes after bariatric surgery: a systematic review and Meta-analysis of weight loss at 10 or more years for all bariatric procedures and a single-centre review of 20-year outcomes after adjustable gastric banding. Obes Surg 2019; 29: 3-14.
DOI PMID |
| 20. | Chen X, Huang W, Deng J, Cheng XL, Chen L, Zhou ZY. Current status of clinical research on simple obesity treated with Traditional Chinese Medicine. Zhong Yi Za Zhi 2017; 35: 1454 -58. |
| 21. | Lin T, Liu M. Research on the treatment of simple obesity with Traditional Chinese Medicine. Zhong Guo Zhong Yi Ji Chu Yi Xue Za Zhi 2021; 27: 1036- 40. |
| 22. |
Zhang WL, Zhu L, Jiang JG. Active ingredients from natural botanicals in the treatment of obesity. Obes Rev 2014; 15: 957-67.
DOI PMID |
| 23. | Ye WJ, Xing JY, Yu ZK, et al. Systematic review and Meta-analysis of acupuncture and acupoint catgut embedding for the treatment of abdominal obesity. Zhong Yi Za Zhi 2022; 42 : 848-57. |
| 24. | Moher D, Hopewell S, Schulz KF, et al. CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomized trials. Int J Surg 2012; 10: 28-55. |
| 25. | MacPherson H, Altman DG, Hammerschlag R, et al. Revised standards for reporting interventions in clinical trials of acupuncture (STRICTA): extending the CONSORT statement. PLoS Med 2010; 7: e1000261. |
| 26. | Tan CE, Ma S, Wai D, Chew SK, Tai ES. Can we apply the national cholesterol education program adult treatment panel definition of the metabolic syndrome to Asians? Diabetes Care 2004; 27: 1182-6. |
| 27. | Wang Z, Yuan CM, Huang J, et al. Reliability and validity of the Chinese version of the second edition of the beck depression inventory in patients with depression. Zhong Guo Xin Li Wei Sheng Za Zhi 2011; 25: 476-80. |
| 28. |
Beck AT, Steer RA, Ball R, et al. Comparison of beck depression inventories-IA and-Ⅱ in psychiatric outpatients. J Pers Assess 1996; 67: 588-97.
DOI PMID |
| 29. | Wang L. Research on reliability and validity of baker anxiety inventory (BAI) in graduate students. Shenyang: Northeastern University, 2017: 11. |
| 30. | Vural M, Satiroglu O, Akbas B, et al. Coronary artery disease in association with depression or anxiety among patients.undergoing angiography to investigate chest pain. Tex Heart Inst J 2009; 36: 17-23. |
| 31. | Zhao ZX, Zhang P, Huang LQ. Guidelines for the diagnosis and treatment of insomnia in Chinese adults. Zhong Hua Shen Jing Ke Za Zhi 2012; 56: 534-40. |
| 32. | Yu ZK, Ye WJ, Xing JY, et al. Clinical efficacy of Huatan Qushi prescription combined with pressing acupuncture on abdominal obesity. Shandong Zhong Yi Za Zhi 2023; 42: 809-13 + 68. |
| 33. |
Luppino FS, de Wit LM, Bouvy PF, et al. Overweight, obesity, and depression: a systematic review and Meta-analysis of longitudinal studies. Arch Gen Psychiatry 2010; 67: 220-9.
DOI PMID |
| 34. |
Epel E, Lapidus R, McEwen B, Brownell K. Stress may add bite to appetite in women: a laboratory study of stress-induced cortisol and eating behavior. Psychoneuroendocrinology 2001; 26: 37-49.
DOI PMID |
| 35. |
Torres SJ, Nowson CA. Relationship between stress, eating behavior, and obesity. Nutrition 2007; 23: 887-94.
DOI PMID |
| 36. | Elder CR, Gullion CM, Funk KL, et al. Impact of sleep, screen time, depression and stress on weight change in the intensive weight loss phase of the LIFE study. Int J Obes (Lond) 2012; 36: 86-92. |
| 37. |
Napoli N, Shah K, Waters DL, et al. Effect of weight loss, exercise, or both on cognition and quality of life in obese older adults. Am J Clin Nutr 2014; 100: 189-98.
DOI PMID |
| 38. |
Payne ME, Porter Starr KN, Orenduff M, et al. Quality of life and mental health in older adults with obesity and frailty: associations with a weight loss intervention. J Nutr Health Aging 2018; 22: 1259-65.
DOI PMID |
| 39. | Dong Y, Huang Q, Tang J, et al. Clinical observation of modified Jianpi Quzhuo recipe in the treatment of abdominal obesity with impaired glucose tolerance of phlegm-damp type. Zhejiang Zhong Xi Yi Jie He Za Zhi 2023; 33: 418-21. |
| 40. | Zhang Z, Wan XY, Zhou FZ, et al. Treating abdominal obesity with spleen deficiency and phlegm dampness with Yiqi Huaju prescription. Zhong Hua Yi Xue Za Zhi 2023; 38: 397-402. |
| 41. | Xia MH, Yu Z, Liu DH, et al. Electroacupuncture combined with pressing acupuncture in the treatment of simple obesity and its effect on serum intestinal lymphatic function-related factors. Zhong Guo Zhen Jiu 2022; 42: 966-70 + 76. |
| 42. | Cui YH, Chang LC, Li PN, et al. The effect of pressing acupuncture therapy on simple obesity of spleen deficiency and dampness type and its influence on serum adipokines LEP, ADP, Ins levels. Zhong Yi Za Zhi 2023; 41: 230-3. |
| 43. | Li D, Tang W, Wang Y, et al. An overview of Traditional Chinese Medicine affecting gut microbiota in obesity. Front Endocrinol (Lausanne) 2023; 14: 1149751. |
| 44. | Zhang Q, Bai Y, Wang W, et al. Role of herbal medicine and gut microbiota in the prevention and treatment of obesity. J Ethnopharmacol 2023; 305: 116127. |
| 45. | Park S, Lee JB, Daily J W. Anti-obesity effects of Chang-Chul-Eui-Ee-In-Tang in female rats with diet-induced obesity. Zhong Guo Jie He Yi Xue Za Zhi 2011; 17: 925-32. |
| 46. | Ansari A, Bose S, Yadav MK, et al. CST, an herbal formula, exerts antiobesity effects through brain-gut-adipose tissue axis modulation in highfat diet fed mice. Molecules 2016; 21: 1522. |
| 47. | Sung YY, Kim DS, Choi G, et al. Dohaekseunggi-Tang extract inhibits obesity, hyperlipidemia, and hypertension in high-fat diet induced obese mice. BMC Complement Altern Med 2014; 14: 372. |
| 48. | Lee YH, Jin B, Lee SH, et al. Herbal formula HT 048 attenuates dietinduced obesity by improving hepatic lipid metabolism and insulin resistance in obese rats. Molecules 2016; 21: 1424. |
| 49. |
Yao QY, Li SY, Cheng XL, et al. Yin Zhi Huang, a traditional Chinese herbal formula, ameliorates diet-induced obesity and hepatic steatosis by activating the AMPK/SREBP-1 and the AMPK/ACC/CPT1A pathways. Ann Transl Med 2020; 8: 231.
DOI PMID |
| 50. | Hao MJ, Guan ZJ, Gao Y, et al. Huang-Qi San ameliorates hyperlipidemia with obesity rats via activating brown adipocytes and converting white adipocytes into brown-like adipocytes. Phytomedicine 2020; 78: 153292. |
| 51. | Si YC, Miao WN, He JY, et al. Based on the "brain-intestine-bacterium" axis to explore the regulation mechanism of invigorating spleen and replenishing Qi acupuncture on intestinal flora and TLR4 in obese mice. Zhong Yi Za Zhi 2017; 32: 4457-60. |
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