Journal of Traditional Chinese Medicine ›› 2024, Vol. 44 ›› Issue (2): 388-395.DOI: 10.19852/j.cnki.jtcm.20240203.004
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WANG Shaosong, SUN Jingqing(), FENG Qingyin, LI Bin, WANG Xin, YUAN Fan, CUI Yingxue()
Received:
2023-08-05
Accepted:
2023-12-12
Online:
2024-04-15
Published:
2024-02-03
Contact:
SUN Jingqing, Department of acupuncture, Beijing Hospital of Traditional Chinese Medicine, Beijing 100010, China. Supported by:
WANG Shaosong, SUN Jingqing, FENG Qingyin, LI Bin, WANG Xin, YUAN Fan, CUI Yingxue. Effectivenss of electroacupuncture for skeletal muscle pain in Parkinson's disease: a Clinical randomized controlled trial[J]. Journal of Traditional Chinese Medicine, 2024, 44(2): 388-395.
Variable | Control group (n = 29) | Intervention group (n = 30) | P value |
---|---|---|---|
Sex (M/F) (n) | M: 14, F: 15 | M: 17, F: 13 | 0.242 |
Age (years) | 64.30±7.99 | 64.30±9.76 | 0.516 |
History of PD (years) | 5.33±2.77 | 5.07±2.99 | 0.539 |
Young's modulus of the biceps (Kpa) | 48.81±2.95 | 58.12±5.42 | 0.143 |
Young's modulus of the quadriceps muscle (Kpa) | 9.71±1.01 | 11.9±1.28 | 0.190 |
SWE velocity of the biceps (m/s) | 3.92±0.15 | 5.16±0.95 | 0.254 |
SWE velocity of the quadriceps muscle (m/s) | 2.23±0.32 | 2.35±0.23 | 0.406 |
KPPS score (points) | 18.67±1.61 | 25.47±4.47 | 0.603 |
VAS score (points) | 4.93±0.32 | 5.87±0.39 | 0.073 |
MAS (points) | 2.20±0.20 | 2.60±0.19 | 0.177 |
UPDRSⅡ (points) | 15.27±2.29 | 18.00±2.22 | 0.982 |
UPDRS Ⅲ (points) | 25.00±2.22 | 38.67±4.01 | 0.056 |
HAMD score (points) | 9.33±5.96 | 10.26±5.18 | 0.551 |
Table 1 Baseline data of Parkinson's disease patients in the two groups
Variable | Control group (n = 29) | Intervention group (n = 30) | P value |
---|---|---|---|
Sex (M/F) (n) | M: 14, F: 15 | M: 17, F: 13 | 0.242 |
Age (years) | 64.30±7.99 | 64.30±9.76 | 0.516 |
History of PD (years) | 5.33±2.77 | 5.07±2.99 | 0.539 |
Young's modulus of the biceps (Kpa) | 48.81±2.95 | 58.12±5.42 | 0.143 |
Young's modulus of the quadriceps muscle (Kpa) | 9.71±1.01 | 11.9±1.28 | 0.190 |
SWE velocity of the biceps (m/s) | 3.92±0.15 | 5.16±0.95 | 0.254 |
SWE velocity of the quadriceps muscle (m/s) | 2.23±0.32 | 2.35±0.23 | 0.406 |
KPPS score (points) | 18.67±1.61 | 25.47±4.47 | 0.603 |
VAS score (points) | 4.93±0.32 | 5.87±0.39 | 0.073 |
MAS (points) | 2.20±0.20 | 2.60±0.19 | 0.177 |
UPDRSⅡ (points) | 15.27±2.29 | 18.00±2.22 | 0.982 |
UPDRS Ⅲ (points) | 25.00±2.22 | 38.67±4.01 | 0.056 |
HAMD score (points) | 9.33±5.96 | 10.26±5.18 | 0.551 |
Group | Treatment timing | Sample | KPPS score (points) | VAS score (points) |
---|---|---|---|---|
Intervention group | 0 week | 30 | 25.47±4.47 | 5.87±0.39 |
4 weeks | 30 | 13.67±2.94ab | 3.73±0.23ab | |
Control group | 0 week | 29 | 18.67±1.61 | 4.93±0.32 |
4 weeks | 29 | 19.00±1.64 | 4.87±0.29 |
Table 2 Comparison of Skeletal muscle pain in the two groups of Parkinson's disease patients ($\bar{x}±s$)
Group | Treatment timing | Sample | KPPS score (points) | VAS score (points) |
---|---|---|---|---|
Intervention group | 0 week | 30 | 25.47±4.47 | 5.87±0.39 |
4 weeks | 30 | 13.67±2.94ab | 3.73±0.23ab | |
Control group | 0 week | 29 | 18.67±1.61 | 4.93±0.32 |
4 weeks | 29 | 19.00±1.64 | 4.87±0.29 |
Group | Treatment Timing | Sample | Biceps | Quadriceps muscle | MAS (points) | |||
---|---|---|---|---|---|---|---|---|
Young's modulus (Kpa) | SWE velocity (m/s) | Young's modulus (Kpa) | SWE velocity (m/s) | |||||
Intervention | 0 week | 30 | 58.12±5.42 | 5.16±0.95 | 11.90±1.28 | 2.35±0.23 | 2.60±0.19 | |
4 weeks | 30 | 39.14±3.72ab | 3.48±0.15ab | 9.19±1.09 | 1.64±0.07a | 1.87±0.17ab | ||
Control | 0 week | 29 | 48.81±2.95 | 3.92±0.15 | 9.71±1.01 | 2.23±0.32 | 2.20±0.20 | |
4 weeks | 29 | 49.87±3.06 | 4.02±0.14 | 11.09±1.19 | 1.64±0.07 | 2.00±0.22 |
Table 3 Comparison of Muscle tention in the two groups of Parkinson's disease patients ($\bar{x}±s$)
Group | Treatment Timing | Sample | Biceps | Quadriceps muscle | MAS (points) | |||
---|---|---|---|---|---|---|---|---|
Young's modulus (Kpa) | SWE velocity (m/s) | Young's modulus (Kpa) | SWE velocity (m/s) | |||||
Intervention | 0 week | 30 | 58.12±5.42 | 5.16±0.95 | 11.90±1.28 | 2.35±0.23 | 2.60±0.19 | |
4 weeks | 30 | 39.14±3.72ab | 3.48±0.15ab | 9.19±1.09 | 1.64±0.07a | 1.87±0.17ab | ||
Control | 0 week | 29 | 48.81±2.95 | 3.92±0.15 | 9.71±1.01 | 2.23±0.32 | 2.20±0.20 | |
4 weeks | 29 | 49.87±3.06 | 4.02±0.14 | 11.09±1.19 | 1.64±0.07 | 2.00±0.22 |
Group | Treatment timing | Sample | UPDRSⅡ (point) | UPDRSⅢ (points) | HAMD score (points) |
---|---|---|---|---|---|
Intervention | 0 week | 30 | 18.00±2.22 | 38.67±4.01 | 10.26±5.18 |
4 weeks | 30 | 9.47±1.18ab | 22.27±2.60ab | 7.26±4.62ab | |
Control | 0 week | 29 | 15.27±2.29 | 25.00±2.22 | 9.33±5.96 |
4 weeks | 29 | 15.73±2.10 | 25.13±2.28 | 9.33±5.90 |
Table 4 Comparison of UPDRSⅡ, UPDRSⅢ, HAMD score in the two groups of Parkinson's disease patients ($\bar{x}±s$)
Group | Treatment timing | Sample | UPDRSⅡ (point) | UPDRSⅢ (points) | HAMD score (points) |
---|---|---|---|---|---|
Intervention | 0 week | 30 | 18.00±2.22 | 38.67±4.01 | 10.26±5.18 |
4 weeks | 30 | 9.47±1.18ab | 22.27±2.60ab | 7.26±4.62ab | |
Control | 0 week | 29 | 15.27±2.29 | 25.00±2.22 | 9.33±5.96 |
4 weeks | 29 | 15.73±2.10 | 25.13±2.28 | 9.33±5.90 |
Figure 2 Correlation between KPPS score and SWE velocity of the biceps, Young's modulus of the biceps, MAS A: correlation between KPPS score and SWE velocity of the biceps; B: correlation between KPPS score and Young's modulus of the biceps; C: correlation between KPPS score and MAS. KPPS: King's Parkinson's Pain Scale; SWE: Shear wave ultrasonic elastography; MAS: modified Ashworth score.
Figure 3 Correlation between KPPS score and UPDRS Ⅲ, HAMD score A: correlation between KPPS score and UPDRS Ⅲ score; B: correlation between KPPS score and HAMD score. KPPS: King's Parkinson's Pain Scale; UPDRS Ⅲ: Unified-Parkinson Disease Rating for motor function examination; HAMD: Hamilton depression scale.
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