Journal of Traditional Chinese Medicine ›› 2023, Vol. 43 ›› Issue (4): 801-808.DOI: 10.19852/j.cnki.jtcm.20230526.001
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Moxibustion modulates working memory in patients with amnestic mild cognitive impairment: a functional magnetic resonance imaging study
LI Xingjie1,2, LIU Qiqi1, XIA Rui2, LIU Jun1, WANG Dan2, SHI Jiao2, KUANG Yuxing2, DAI Yalan2, HUANG Haoyu2, TANG Wei1(
), CHEN Shangjie2()
- 1 College of Acupuncture and Massage, Anhui University of Chinese Medicine, Hefei 230031, China
2 Department of Rehabilitation, The People's Hospital of Baoan Shenzhen, Southern Medical University, and the Second Affiliated Hospital of Shenzhen University, Shenzhen 518101, China
-
Received:2022-12-06Accepted:2023-04-19Online:2023-08-15Published:2023-05-26 -
Contact:Prof. TANG Wei, College of Acupuncture and Massage, Anhui University of Chinese Medicine, Hefei 230000, China. Tangwei2633@163.com. Telephone: +86-18988785288, +86-13605690300
Prof. CHEN Shangjie, Department of Rehabilitation, the People's Hospital of Baoan Shenzhen, Southern Medical University, and the Second Affiliated Hospital of Shenzhen University, Shenzhen 518101, China. csjmesz@sina.com -
Supported by:National Natural Science Foundation of China: to Study the Mechanism of Acupuncture Intervention for Amnestic Mild Cognitive Impairment Based on Episodic Memory Related Large-Scale Network(81973922);Shenzhen Science and Technology Plan: to Explore the Effect of Tiaoshen Yizhi Acupuncture on Episodic Memory Effect Network in Patients with Amnestic Mild Cognitive Impairment Based on fMRI and EEG(JCYJ20190809151013581);Mechanism of Acupuncture Intervention for Amnestic Mild Cognitive Impairment Combined with Insomnia Based on Large-Scale Network(JCYJ20210324110809025);Explore the Effect Mechanism of Baduanjin Training on Cognitive Impairment after Stroke Based on Attention Lateralization(JCYJ20220530142806014);Guangdong Basic and Applied Basic Research Foundation: to Explore the Mechanism of Baduanjin in Reducing the Risk of Falls in the Elderly with MCI Based on Vestibular Network Functional Connectivity(2021A1515110764);Shenzhen Baoan District Science and Technology Program: Effects of Repetitive Magnetic Stimulation on Brain Electrical Activity and Functional Network in Patients with Type 2 Diabetes Mellitus and Mild Cognitive Impairment(20210507221914001)
Cite this article
LI Xingjie, LIU Qiqi, XIA Rui, LIU Jun, WANG Dan, SHI Jiao, KUANG Yuxing, DAI Yalan, HUANG Haoyu, TANG Wei, CHEN Shangjie. Moxibustion modulates working memory in patients with amnestic mild cognitive impairment: a functional magnetic resonance imaging study[J]. Journal of Traditional Chinese Medicine, 2023, 43(4): 801-808.
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Figure 1 Schematic illustration of the task design
Figure 1 Schematic illustration of the task design
Table 2 Difference in blood oxygen signal between the MT group and PM group
| Cluster | Peak MNI coordinate region | Peak intensity | Number of voxels | Peak MNI coordinate | ||
|---|---|---|---|---|---|---|
| X | Y | Z | ||||
| 1 | Precentral Gyrus, Postcentral_R (aal) | 3.6130 | 44 | 54 | —9 | 36 |
| 2 | Temporal_Sup_R (aal), Superior Temporal Gyrus | 3.2825 | 39 | 51 | —42 | 12 |
| 3 | Thalamus_R (aal) | 6.1411 | 35 | 6 | —9 | 0 |
| 4 | Insula, Insula_R (aal) | 3.8462 | 34 | 36 | —12 | 18 |
| 5 | Lingual_R (aal), Lingual Gyrus | 3.1463 | 30 | 21 | —81 | —6 |
| 6 | Posterior Cingulate | 4.9833 | 24 | 18 | —69 | 6 |
| 7 | Middle Frontal Gyrus, Frontal_Sup_R (aal) | 3.5283 | 23 | 27 | —3 | 51 |
| 8 | Middle Frontal Gyrus, Precentral_L (aal) | 3.3632 | 23 | —30 | 6 | 54 |
Table 2 Difference in blood oxygen signal between the MT group and PM group
| Cluster | Peak MNI coordinate region | Peak intensity | Number of voxels | Peak MNI coordinate | ||
|---|---|---|---|---|---|---|
| X | Y | Z | ||||
| 1 | Precentral Gyrus, Postcentral_R (aal) | 3.6130 | 44 | 54 | —9 | 36 |
| 2 | Temporal_Sup_R (aal), Superior Temporal Gyrus | 3.2825 | 39 | 51 | —42 | 12 |
| 3 | Thalamus_R (aal) | 6.1411 | 35 | 6 | —9 | 0 |
| 4 | Insula, Insula_R (aal) | 3.8462 | 34 | 36 | —12 | 18 |
| 5 | Lingual_R (aal), Lingual Gyrus | 3.1463 | 30 | 21 | —81 | —6 |
| 6 | Posterior Cingulate | 4.9833 | 24 | 18 | —69 | 6 |
| 7 | Middle Frontal Gyrus, Frontal_Sup_R (aal) | 3.5283 | 23 | 27 | —3 | 51 |
| 8 | Middle Frontal Gyrus, Precentral_L (aal) | 3.3632 | 23 | —30 | 6 | 54 |
Figure 2 Schematics of the moxibustion activation maps show the difference in the blood oxygenation signal between the MT and PM groups A: seed point show in sagittal plane, 1: right thalamus, 2: right middle frontal gyrus, 3: right lingual gyrus, 4: right insula. B: seed point show in coronal plane, 5: posterior cingulate, 6: right postcentral, 7: left precentral gyrus. C: seed point show in transverse plane, 8: right superior temporal gyrus. The smallest number indicates the corresponding layer in the brain. D: the red-yellow hue signifies the regions that have been activated, with a darker shade indicating a more pronounced outcome. The light gray bars denote the gray matter. MT Group used Tiaoshen Yizhi moxibustion as prescribed, and PM Group used placebo moxibustion. Both groups received 20-min treatment once a day, five times a week, for eight weeks. Statistical analysis was performed using the two-sample independent t-test.
Figure 2 Schematics of the moxibustion activation maps show the difference in the blood oxygenation signal between the MT and PM groups A: seed point show in sagittal plane, 1: right thalamus, 2: right middle frontal gyrus, 3: right lingual gyrus, 4: right insula. B: seed point show in coronal plane, 5: posterior cingulate, 6: right postcentral, 7: left precentral gyrus. C: seed point show in transverse plane, 8: right superior temporal gyrus. The smallest number indicates the corresponding layer in the brain. D: the red-yellow hue signifies the regions that have been activated, with a darker shade indicating a more pronounced outcome. The light gray bars denote the gray matter. MT Group used Tiaoshen Yizhi moxibustion as prescribed, and PM Group used placebo moxibustion. Both groups received 20-min treatment once a day, five times a week, for eight weeks. Statistical analysis was performed using the two-sample independent t-test.
Table 1 Comparison of cognitive scores between the MT group and the PM group ( x - ± s)
| Item | TM group (n = 16) | PM group (n = 16) | |||||
|---|---|---|---|---|---|---|---|
| Pre-treatment | Post-treatment | Difference | Pre-treatment | Post-treatment | Difference | ||
| RBMT | 9.9±3.2 | 12.2±3.4 a | 2.4±1.3 | 9.6±3.2 | 23.9±2.6 | 0.9±1.0b | |
| MMSE | 24.6±0.9 | 27.4±1.8a | 2.7± 2.3 | 24.5±0.8 | 10.4±3.1b | 0.9±1.3b | |
| MoCA | 22.8±2.7 | 26.1±2.6a | 3.3±2.2 | 23.3±3.0 | 25.4±1.4b | 0.6±0.7b | |
| N-back | 67.6±14.6 | 85.9±8.9a | 18.3±15.6 | 64.6±19.4 | 72.9±13.8b | 8.4±19.0 | |
Table 1 Comparison of cognitive scores between the MT group and the PM group ( x - ± s)
| Item | TM group (n = 16) | PM group (n = 16) | |||||
|---|---|---|---|---|---|---|---|
| Pre-treatment | Post-treatment | Difference | Pre-treatment | Post-treatment | Difference | ||
| RBMT | 9.9±3.2 | 12.2±3.4 a | 2.4±1.3 | 9.6±3.2 | 23.9±2.6 | 0.9±1.0b | |
| MMSE | 24.6±0.9 | 27.4±1.8a | 2.7± 2.3 | 24.5±0.8 | 10.4±3.1b | 0.9±1.3b | |
| MoCA | 22.8±2.7 | 26.1±2.6a | 3.3±2.2 | 23.3±3.0 | 25.4±1.4b | 0.6±0.7b | |
| N-back | 67.6±14.6 | 85.9±8.9a | 18.3±15.6 | 64.6±19.4 | 72.9±13.8b | 8.4±19.0 | |
Figure 3 Correlations between changes in gray matter activation and cognitive scale scores A: positive correlation between activity in posterior cingulate and RBMT; B: positive correlation between activity in lingual gyrus and RBMT; C: positive correlation between activity in thalamus and RBMT; D: positive correlation between activity in superior temporal gyrus and RBMT; E: positive correlation between activity in postcentral gyrus and RBMT; F: positive correlation between activity in posterior cingulate and 0-back accuracy; G: positive correlation between activity in lingual gyrus and 0-back accuracy; H: positive correlation between activity in insula and 0-back accuracy. These formulae indicate the data from the 32 patients. RBMT: Rivermead Behavioral Memory Test. Statistics were carried out using simple linear regression.
Figure 3 Correlations between changes in gray matter activation and cognitive scale scores A: positive correlation between activity in posterior cingulate and RBMT; B: positive correlation between activity in lingual gyrus and RBMT; C: positive correlation between activity in thalamus and RBMT; D: positive correlation between activity in superior temporal gyrus and RBMT; E: positive correlation between activity in postcentral gyrus and RBMT; F: positive correlation between activity in posterior cingulate and 0-back accuracy; G: positive correlation between activity in lingual gyrus and 0-back accuracy; H: positive correlation between activity in insula and 0-back accuracy. These formulae indicate the data from the 32 patients. RBMT: Rivermead Behavioral Memory Test. Statistics were carried out using simple linear regression.
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