Natural products for treatment of premature ovarian failure: a narrative review

doi:10.19852/j.cnki.jtcm.20230227.002

Abstract

Abstract:

Premature ovarian failure (POF) is a female reproductive system disease caused by many factors and systems, which has seriously affected the quality of life of women of childbearing age. Clinically, the disease is difficult to treat while its incidence rate shows an increasing trend. In recent years, natural products used as multi-pathway, multi-target and efficient drugs, have become the focus of many research and clinical studies in China and abroad, and the effect of phytochemicals derived from edible plants and Chinese medicine herbs on POF were investigated in several papers. Using "premature ovarian failure" or "ovary" and related natural products as keywords, we retrieved and reviewed research articles from China National Knowledge Infrastructure Database, Wanfang, PubMed, Web of Science and other literature databases. Up to October, 2021, natural compounds with prophylactic or interference inhibition effects on POF mainly included flavonoids, polysaccharides, saponins, and polyphenols. Their effect on POF and ovarian function was closely related to their antioxidant, antiapoptotic, antiaging, immunoregulatory and estrogen-like activities.

Key words: biological products, primary ovarian insufficiency, flavonoids, review

LIU Xueling, MA Kun, TAO Wenhua, XU Zhongkun, LIU Gang, HU Chunyan, MAO Weiwei, GU Chang, GUO Qi. Natural products for treatment of premature ovarian failure: a narrative review[J]. Journal of Traditional Chinese Medicine, 2023, 43(3): 606-617.

Figures/Tables 1

Figure 1 Mechanism of natural products in the treatment of premature ovarian failure AP: Angelica polysaccharide; LBP: Lycium barbarum polysaccharide; SIP: Squid ink polysaccharide; TFSC: total flavonoids from semen cuscutae; DOP: dendrobium officinale polysaccharides; EPS: epimedium polysaccharide; CRY: cryptotanshinoneh; SI: soybean isoflavone; SOD: superoxide dismutase; CAT: catalase; MDA/LPO: malondialdehyde/lipid peroxidation; Nrf2/ARE: nuclear transcription factor/antioxidant response element; NF-κB: nuclear factor-κB; SIRT: Sirtuin; FSHR: follicle-stimulating hormone receptor; LHR: luteinizing hormone receptor; PRA: progesterone receptor A; ER: estrogen receptor; AOAb: anti-ovarian antibody; ANA: antinuclear antibody; AZPA: anti-zona pellucida antibody; IL: interleukin; IFN-γ: interferon-γ; TNF-α: tumor necrosis factor alpha; TGF-β: transforming growth factor-beta:; FOXO: forkhead box O.

References 143

[1]	Chon SJ, Umair Z, Yoon MS. Premature ovarian insufficiency: past, present, and future. Front Cell Dev Biol 2021; 9: 672890.
[2]	Lin J, Wu D, Jia L, et al. The Treatment of complementary and alternative medicine on premature ovarian failure. Evid Based Complement Alternat Med 2021; 2021: 6677767.
[3]	Song XY, Jiang YT. Study on the pharmacological effect of Cuscuta flavonoids and its treatment of dysmenorrhea. Yi Xue Xin Xi 2020; 33: 29-31.
[4]	Liu Q, Tian YC, Bin B, et al. Research progress of flavonoid of Semen Cuscutae on the protection effects of reproductive system. Zhong Yi Yao Zao Bao 2020; 26: 148-56.
[5]	Wang YX, Ma N, Zhong XM, et al. Study of TFSC on ovarian function in rat rodel with premature ovarian failure. Yi Xue Zong Shu 2019; 25: 2695-99.
[6]	Zhang SL, Ma S, Shi WY, et al. Effects of Bisphenol A on uterine and ovarian related factors and the alleviation of flavonoids from semen cuscutae in pregnant rats. Zhong Guo Shou Yi Xue Bao 2019; 39: 337-48.
[7]	Wei J, Zhang X, Li Y, et al. Novel application of bergapten and quercetin with anti-bacterial, osteogenesis-potentiating, and anti-inflammation tri-effects. Acta Biochim Biophys Sin (Shanghai) 2021; 53: 683-69. DOI URL
[8]	Grewal AK, Singh TG, Sharma D, et al. Mechanistic insights and perspectives involved in neuroprotective action of quercetin. Biomed Pharmacother 2021; 140: 111729.
[9]	Bostancıeri N, Taşlidere A, Elbe H, et al. Protective effects of quercetin against testis damage caused by cisplatin. Biotechnic Histochemistry 2022; 97: 180-4. DOI URL
[10]	Dutta A, Dahiya A, Verma S. Quercetin-3-rutinoside protects against gamma radiation inflicted hematopoietic dysfunction by regulating oxidative, inflammatory, and apoptotic mediators in mouse spleen and bone marrow. Free Radic Res 2021; 55: 230-45. DOI URL
[11]	Karimi A, Naeini F, Asghari Azar V, et al. A comprehensive systematic review of the therapeutic effects and mechanisms of action of quercetin in sepsis. Phytomedicine 2021; 86: 153567. DOI URL
[12]	Huang CS, He SD, Guan YC, et al. Effects of flavonoids and quercetin from Semen Cuscutae on ovarian function of rats with POF induced by Tripterygium Glycosides. Zhong Guo Lin Chuang Yao Li Xue Za Zhi 2020; 36: 667-70.
[13]	Li N. Effect of quercetin on rat reproduction develpopment and genistein and quercetin on mice ovary and serum hormones and blood rat. Nanchang: Nanchang University, 2013: 26-68.
[14]	Li JH. Quercetin inhibits the loss of primordial follicles induced by cyclophosphamide by regulating PI3K/AKT/FOXO3a pathway. Shanghai: Shanghai Jiaotong University, 2020: 36-73.
[15]	Wang WX, Cai SF, Zhang WC. Effects of continuous soy isoflavones exposure on ovarian development in mice. Zhong Guo Gong Gong Wei Sheng 2015; 31: 597-99.
[16]	Chen JX, Chen RY, Lian Y, et al. Progress in microbial conversion and functional activity of Soy Isoflavones. Shi Pin Yan Jiu Yu Kai Fa 2021; 42: 176-82.
[17]	Dong HS, Xue L, Cui LH, et al. Effects of soy isoflavones on antibody of anti-zonapellucida in peripheral blood of mice with immune premature ovarian failure. Xian Dai Yu Fang Yi Xue 2014; 41: 429-30.
[18]	Chen YQ, Guan FY, Shen Q. Effects of soybean isoflavones on ovarian follicle development in adult rats. Huan Jing Yu Zhi Ye Yi Xue 2019; 36: 812-17.
[19]	Shen XH, Zhang WC, Luo LF, et al. Effects of soybean isoflavones on ovarian development in juvenile mice. Hai Xia Yu Fang Yi Xue Za Zhi 2011; 17: 43-5.
[20]	Guan LH, Ma XP, Lui HB, et al. Effects of soybean isoflavones on ovarian function, reproductive hormones and muscle quality of Bashang long-tailed chickens. Zhong Guo Shou Yi Xue Bao 2021; 41: 338-44.
[21]	Fernandez-Garcia JM, Carrillo B, Tezanos P, et al. Genistein during development alters differentially the expression of POMC in male and female rats. Metabolites 2021; 11: 3-11. DOI URL
[22]	Duan X, Li Y, Xu F, et al. Study on the neuroprotective effects of Genistein on Alzheimer's disease. Brain Behav 2021; 11: e02100.
[23]	Rumman M, Pandey S, Singh B, et al. Genistein prevents hypoxia-induced cognitive dysfunctions by ameliorating oxidative stress and inflammation in the hippocampus. Neurotox Res 2021: 39: 1123-33. DOI
[24]	Seidemann L, Kruger A, Kegel-Hubner V, et al. Influence of genistein on hepatic lipid metabolism in an in vitro model of hepatic steatosis. Molecules 2021; 26: 3-18. DOI URL
[25]	Zhang YH, Pang HY, Xiao XH, et al. Effects of soybean isoflavones and genistein on the expression of estrogen receptor α in rat ovary. Zhong Hua Yi Xue Za Zhi 2011; 91: 1987-91.
[26]	Wen HX, Zhang YN. Effect of Genistein on FSHR gene expression in ovarian granulosa cells of female rats. Zhong Guo Yi Yao Zao Bao 2019; 16: 16-18.
[27]	Wen HX, Zhang XH, Meng Y, et al. Effects of Genistein on CREB gene expression in rat ovarian granulosa cells. Zhong Guo Yi Yao Zao Bao 2019; 16: 19-21.
[28]	Win HX, Meng Y, Yang YB, et al. Effects of Genistein on the CYP19 expression in rat ovarian granulosa cells. Zhong Guo Yi Yao Zao Bao 2016; 13: 20-3.
[29]	He LJ, Jiang JJ, Chen H, et al. Research progress on pharmacological action and clinical application of Herba Epimedii. Zhong Yi Lin Chuang Yan Jiu 2020; 12: 17-20.
[30]	Caroline WM. Impact and mechanism of Epimedium and its ingreients on murine female reproductive development. Nanjing: Nanjing Agricultural University 2016: 71-107.
[31]	Xu YP. Effect of Icariin and epimedium polysaccharide on follicular development and antioxdation. Nanjing: Nanjing Agricultural University, 2016: 17-54.
[32]	Dong RX. Mechanism research of Icariin improves Chemotherapy-induced premature ovarian failure in rats by inhibiting oxidative stress. Shanghai: Shanghai Zhong Yi Yao Da Xue, 2019: 1-39.
[33]	Diopan V, Babula P, Shestivska V, et al. Electrochemical and spectrometric study of antioxidant activity of pomiferin, isopomiferin, osajin and catalposide. J Pharm Biomed Anal 2008; 48: 127-33. DOI PMID
[34]	Bartosikova L, Necas J, Bartosik T, et al. Effect of pomiferin administration on kidney ischaemia-reperfusion injury in rats. Interdiscip Toxicol 2010; 3: 76-81. DOI PMID
[35]	Matthews J, Gustafsson JA. Estrogen signaling: a subtle balance between ER alpha and ER beta. Mol Interv 2003; 3: 281-92. DOI PMID
[36]	Song Y, Intervention effect of Pomifern on premature ovarian failure in mice and its mocular mechanism. Zhengzhou: Zhengzhou University, 2011: 1-33.
[37]	Quan MC, Su ZH, Fang DW, et al. Research progress on extraction and function of Ginkgo flavonoids. Jin Ri Yao Xue 2020; 30: 789-92.
[38]	Song LL, Li Q. The research progress of Ginkgo biloba flavone and its application prospect in feed. Zhong Guo Si Liao 2020; 667: 15-9.
[39]	Du H, Zhang YB, Wang HL. The study of the protective effect of GBE on ovary granulosa cell that damaged by cDDP. Xian Dai Fu Chan Ke Jin Zhan 2015; 24: 504-7.
[40]	Chang Z. Preventive application of Ginkgo flavone, amifostine and leuprorelin on ovarian function protection. Shijiazhuang: Hebei Medical University, 2013: 24-78.
[41]	Chen Y, Wen JY, Xie XF, et al. Research progress on the chemical composition and pharmacological action of Radix Puerariae. Zhong Yao Yu Lin Chuang 2021; 12: 53-60.
[42]	Zhang JH, Wang HL, Chen BB, et al. Clinical study of sequential puerarin-medroxyprogesterone acetate therapy for premature ovarian failure. Zhong Guo Chu Ji Wei Sheng Bao Jian 2012; 26: 52-4.
[43]	Zhang JH, Du HL, Zhou QQ. The immunomodulatory effect of puerarin in patients with premature ovarian failure. Zhong Guo Lin Chuang Yi Xue 2016; 23: 816-9.
[44]	Wang Y, Liu XJ, Chen JB, et al. Citrus flavonoids and their antioxidant evaluation. Crit Rev Food Sci Nutr 2022; 62: 3833-54. DOI URL
[45]	Pontifex MG, Malik M, Connell E, et al. Citrus polyphenols in brain health and disease: current perspectives. Front Neurosci 2021; 15: 640648. DOI URL
[46]	Wang M, Zhao H, Wen X, et al. Citrus flavonoids and the intestinal barrier: Interactions and effects. Compr Rev Food Sci Food Saf 2021; 20: 225-51. DOI URL
[47]	Yin C, Wang R. Experimental study on protective effect of citrus flavonoids on ovary of rats. Zhong Yi Yao Dao Bao 2019; 25: 41-3.
[48]	Chen YL, Tan ZC, Peng Y. Traditional uses and modern research of leaves of Malus hupehensis (Pamp.) Rehd. Zhong Guo Xian Dai Zhong Yao 2017; 19: 1505-10.
[49]	Guo DY, Fan Y, Cheng JX, et al. Effect of total flavonoids of Malus hupehensis on ovarian function and bone metabolism in rats with premature ovarian failure. Zhong Guo Gu Zhi Shu Song Za Zhi 2020; 26: 214-20.
[50]	Jing W, Wang Y, Yang J, Zhang L. Progress in structure modifications and biological activities of Chrysin derivatives. Hua Xue Shi Ji 2018; 40: 225-30.
[51]	Melekoglu R, Ciftci O, Eraslan S, et al. The protective effects of Glycyrrhetinic acid and Chrysin against ischemia-reperfusion injury in rat ovaries. Biomed Res Int 2018; 2018: 5421308.
[52]	Yang Q, Ren HY, Zhu HY, et al. The protective effect of Chrysin on perimenopausal depression model rats by inhibiting NLRP3 inflammasome signaling pathway. Zhong Guo Yao Li Xue Tong Bao 2020; 36 : 1006-11.
[53]	Mantawy EM, Said RS, Abdel-Aziz AK. Mechanistic approach of the inhibitory effect of chrysin on inflammatory and apoptotic events implicated in radiation-induced premature ovarian failure: Emphasis on TGF-beta/MAPKs signaling pathway. Biomed Pharmacother 2019; 109: 293-303. DOI PMID
[54]	Shi ZP, Jiang CH, Liang Q, et al. Research progress on the structure and pharmacological action of LBP. Gansu Zhong Yi Yao Da Xue Xue Bao 2021; 38: 90-5.
[55]	Gao LL, Ma JM, Fan YN, et al. Lycium barbarum polysaccharide combined with aerobic exercise ameliorated nonalcoholic fatty liver disease through restoring gut microbiota, intestinal barrier and inhibiting hepatic inflammation. Int J Biol Macromol 2021; 183: 1379-92. DOI URL
[56]	Huang T, Zheng XX, Qiu XH, et al. Protective effect of LBP on autoimmune premature ovarian failure model mice. Yao Xue Yan Jiu 2014; 33: 437-40.
[57]	Sun HX, Guo Z, Xu J. Protective effect of LBP on rat model of POF induced by cisplatin chemotherapy. Lin Chuang Yu Bing Li Za Zhi 2020; 40: 578-84.
[58]	Liu B, Wang JL, Wang XM, et al. Reparative effects of lycium barbarum polysaccharide on mouse ovarian injuries induced by repeated superovulation. Theriogenology 2020; 145: 115-25. DOI PMID
[59]	Wei W, Lei F, Bao WR, et al. Structure characterization and immunomodulating effects of polysaccharides isolated from Dendrobium officinale. J Agric Food Chem 2016; 64: 881-9. DOI URL
[60]	Liang J, Chen S, Chen J, et al. Therapeutic roles of polysaccharides from Dendrobium Officinaleon colitis and its underlying mechanisms. Carbohydr Polym 2018; 185: 159-68. DOI URL
[61]	Yang K, Zhan L, Lu T, et al. Dendrobium officinale polysaccharides protected against ethanol-induced acute liver injury in vivo and in vitro via the TLR4/NF-κb signaling pathway. Cytokine 2020; 130: 155058.
[62]	Shen HT, Liu X, Wu TT, et al. Study on the inhibitory effect of dendrobium candidum polysaccharide on neuronal apoptosis. Anhui Yi Ke Da Xue Xue Bao 2020; 55: 1214-20.
[63]	Sun L, Chen XM, Wu CM, et al. Advances and prospects of pharmacological activities of Dendrobium officinale Kimura et Migo polysaccharides. Yao Xue Xue Bao 2020; 5: 2322-9.
[64]	Fang JY, Xie HL, Feng SM, et al. Research progress on the influencing factors and mechanism of dendrobium polysaccharide in ameliorating diabetic symptoms. Shi Pin Yu Fa Jiao Gong Ye 2021; 47: 237-44.
[65]	Wu YY, Liang CY, Liu TT, et al. Protective roles and mechanisms of polysaccharides from Dendrobium officinal on natural aging-induced premature ovarian failure. Biomed Pharmacother 2018; 101: 953-60. DOI URL
[66]	Li C, Chen FF, Yang YJ, et al. Analysis of composition and immunomodulatory effect of neutral and acidic Epimedium polysaccharides. Zhong Guo Zhong Yao Za Zhi online, 2021-07-28, cited 2021-11-08: 1-9. Available from URL: https//doi.org/10.19540/j.cnki.cjcmm.20210525.306.
[67]	Ma LL, Li CR, Li H, et al. Experimental study on the effect of Epimedium polysaccharide on improving learning and memory disorders in mice. Zhong Yao Cai 2019; 42: 212-5.
[68]	He J, Han R, Yu G, et al. Epimedium polysaccharide ameliorates benzene-induced aplastic anemia in mice. Evid Based Complement Alternat Med 2020; 2020: 5637507.
[69]	Zhou Y, Yan B, Tian J, et al. Effect of Epimedium polysaccharide on cryopreservation of sperm asthenospermia. Tian Ran Chan Wu Yan Jiu Yu Kai Fa 2021; 33: 1013-9.
[70]	Afedo SY, Xu Y, Muneri CW, et al. Effects of epimedium polysaccharide on female mouse (Mus musculus) ovarian and uterine development. Turk J Vet Anim Sci 2015; 39: 714-8. DOI URL
[71]	Yang X, Cao KJ, Han T, et al. Effect of Epimedium polysaccharide on mouse follicular development. Xu Mu Yu Shou Yi 2014; 46: 21-4.
[72]	Zhao KJ, Qian WX, Li YL, et al. Study on the effect and mechanism of epimedium polysaccharide on follicular cell apoptosis. Anhui Ke Ji Da Xue Xue Bao 2017; 31: 6-10.
[73]	Zhen WY, Zheng YL, Zhang YM, et al. Research progress of pharmacological action of angelica polysaccharide. Shi Zhen Guo Yi Guo Yao 2020; 31: 2484-7.
[74]	Li L, Lu P, Gao X. Angelica polysaccharide regulates endocrine function in mice with immune premature ovarian failure via AKT/FOXO3 pathway. Jin Yin Zu Xue Yu Ying Yong Sheng Wu Xue 2019; 38: 3268-72.
[75]	Chen Y. The reseacher of squid ink polysaccharides on improving the oxidative damage of fibroblasts by regulating Connexin 43 and NADPH oxidase. Guangdong: Southern Medical University, 2016: 46-57.
[76]	Xiao W. Study on the mechanism of DDP combined with SIP on apoptosis and autophagy in MDA-MB-231. Zhanjiang: Guangdong Ocean University, 2016: 27-47.
[77]	Tian WL, Liu F, Wang FS. Research progress on antioxidant activity of cuttlefish ink. Zhong Guo Hai Yang Yao Wu Za Zhi 2019; 38: 83-8.
[78]	Liu H, Zhang YB, Li M, et al. Beneficial effect of Sepia esculenta ink polysaccharide on cyclophosphamide-induced immunosuppression and ovarian failure in mice. Int J Biol Macromol 2019; 140: 1098-105. DOI PMID
[79]	Shen N, Li X, Zhou T, et al. Shensong Yangxin capsule prevents diabetic myocardial fibrosis by inhibiting TGF-beta1/Smad signaling. J Ethnopharmacol 2014; 157: 161-170. DOI URL
[80]	Lai Y, Tan Q, Xv S, et al. Ginsenoside Rb1 alleviates alcohol-induced liver injury by inhibiting steatosis, oxidative stress, and inflammation. Front Pharmacol 2021; 12: 616409.
[81]	Jia LQ, Ju X, Ma YX, et al. Comprehensive multiomics analysis of the effect of ginsenoside Rb1 on hyperlipidemia. Aging (Albany NY) 2021; 13 : 9732-47.
[82]	Fan Q, Xi P, Tian D, et al. Ginsenoside Rb1 facilitates browning by repressing Wnt/beta-catenin signaling in 3T3-L1 adipocytes. Med Sci Monit 2021; 27: e928619.
[83]	Dai XM, Zeng GR, Hong LY, et al. Ginsenoside Rg1 and astaxanthin act on the hypothalamus to protect female mice against reproductive aging. Chin Med J (Engl) 2021; 135: 107-9
[84]	He L, Ling L, Wei T, et al. Ginsenoside Rg1 improves fertility and reduces ovarian pathological damages in premature ovarian failure model of mice. Exp Biol Med (Maywood) 2017; 242: 683-91. DOI PMID
[85]	He LL. Study on Rg1 delaying the pathological damage of reproductive system and improving reproductive function and its mechanism in D-gal POF mouse model. Chongqing: Chongqing Medical University, 2017: 24-62.
[86]	Liu XH, Zhao ZH, Zhou Y, et al. Effect of ginsenoside Rg1 in delaying premature ovarian failure induced by D-gal in mice through PI3K/Akt /mTOR autophagy pathway. Zhong Guo Zhong Yao Za Zhi 2020; 45: 6036-42.
[87]	Liu XH, Zhao ZH, Zhou Y, et al. Effect of SIRT1 on delay of D-gal-induced premature ovarian failure in mice with ginsenoside Rg1. Zhong Guo Zhong Yao Za Zhi 2020; 45: 4699-704.
[88]	Tang ZY. Effects of ginsenoside Rb1 on sex hormones in rats with POF induced by chemotherapy. Dang Dai Yi Xue 2013; 19: 30+115.
[89]	Huang WW, Hong LF, Zhu CC, et al. Effects of total saponins of Momordica charantia on the expression of Caspase-3 and MMP-2 in rats with chronic heart failure. Liaoning Zhong Yi Yao Da Xue Xue Bao 2018; 20: 38-42.
[90]	Wang BJ, Wang R, Zhang PP, et al. Preparation of saponins from bittermelon and its antioxidant activity in vitro. Zhong Guo Shi Pin Tian Jia Ji 2011; 106: 153-7.
[91]	Ma CY, Yu HY, Wang HJ, et al. Hypoglycemic mechanism of total Saponins of Momordica Charantia in type 2 Diabetes mellitus rats. Tianjin Yi Yao 2014; 42: 321-4.
[92]	Xiao Y, Ma CY. Effect of total saponins of fructus Momordicae charantiae on inflammatory factors of insulin-resistant 3T3-L1 adiopoctyes. Zhong Yao Xin Yao Yu Lin Chuang Yao Li 2016; 27: 672-6.
[93]	Yin HZ, Wan SQ. Effect of total Momordicoside on Nrf2 expression in rats’ovarian tissue Injured by cyclophosphamide. Zhong Guo Yi Yao Ke Ji 2017; 24: 724-8.
[94]	Yin HZ, Wan SQ. PPARγ expression effect of total Momordicoside on ovarian tissue injuries of rats caused by cisplatin. Jilin Zhong Yi Yao 2017; 37: 1029-32.
[95]	Yin HZ, Zhang QD. Effect of total saponins from bitter gourd on Caspase-3 protein expression of rat model with anovulation. Liaoning Zhong Yi Yao Da Xue Xue Bao 2017; 19: 41-4.
[96]	Chen X, Li FL, Xing XY, et al. Research progress on pharmacological activity of resveratrol. Yao Xue Yan Jiu 2020; 39: 284-8.
[97]	Mongioi LM, Perelli S, Condorelli RA, et al. The role of resveratrol in human male fertility. Molecules 2021; 26: 2495. DOI URL
[98]	Pasquariello R, Verdile N, Brevini TAL, et al. The role of resveratrol in mammalian reproduction. Molecules 2020; 25: 4554. DOI URL
[99]	Jiang Y, Zhang Z, Cha L, et al. Resveratrol plays a protective role against premature ovarian failure and prompts female Germline stem cell survival. Int J Mol Sci 2019; 20: 2-16. DOI URL
[100]	Zhou J, Xue Z, He H, et al. Resveratrol delays postovulatory aging of mouse oocytes through activating mitophagy. Aging (Albany NY) 2019; 11: 11504-19.
[101]	Ibrahim MA, Albahlol IA, Wani FA, et al. Resveratrol protects against cisplatin-induced ovarian and uterine toxicity in female rats by attenuating oxidative stress, inflammation and apoptosis. Chem Biol Interact 2021; 338: 109402.
[102]	Wu M, Ma L, Xue L, et al. Resveratrol alleviates chemotherapy-induced oogonial stem cell apoptosis and ovarian aging in mice. Aging (Albany NY) 2019; 11: 1030-44.
[103]	Song LP, Wang Y. Research progress of curcumin pharmacological effect and mechanism. Zhong Yi Yao Dao Bao 2020; 17: 29-33.
[104]	Wei YF, Yu HC, Liu XL, et al. Research progress on the main chemical components and pharmacological effects of turmeric. Xinxiang Yi Xue Yuan Xue Bao 2020; 37: 990-5.
[105]	Zhang M, Li T, Lin T, et al. Recent progress on anti-aging and molecular mechanisms of curcumin. Zhong Yi Yao Dao Bao 2020; 17: 10-43.
[106]	Murphy CJ, Tang H, Van Kirk EA, et al. Reproductive effects of a pegylated curcumin. Reprod Toxicol 2012; 34: 120-4. DOI PMID
[107]	Jie YY. Effects of HMGB1/TLR2 on ovulation-related genes in bovine ovarian granulosa cells and the intervention effect of curcumin. Beijing: Chinese Academy of Agricultural Sciences, 2020: 38-65.
[108]	Wang XN, Zhang CJ, Zhang Y, et al. Inhibit effect of curcumin on lipid peroxidation product in the reproductive organs of mice. Zhongguo Xing Ke Xue 2015; 24: 77-80.
[109]	Yan ZJ, Dai YJ, Hou DR. Effects of curcumin on ovarian function of aging mice. Zhong Guo Lao Nian Xue Za Zhi 2018; 38: 4030-3.
[110]	Li Q, Zhang RC, Zhang JS, et al. Protective effect of curcumin against ovarian oxidative damage induced by Bisphenol A in mice. Dong Wu Xue Za Zhi 2019; 54: 875-82.
[111]	Qin XY, Hu Z, Zhang HM, et al. Progress in research on pharmacological action and related mechanism of osthole. Tianjin Zhong Yi Yao 2018; 35: 877-80.
[112]	Du MF, Xiang R, Fan Y, et al. Research progress on pharmacological action and anti-inflammatory activity mechanism of osthole. Yunnan Zhong Yi Yao Da Xue Xue Bao 2020; 43: 92-8.
[113]	Zhang XW, Zhang DS, Xue GQ, et al. Experimental study of the estrogen-like effect of osthole in rats. Zhong Guo Yao Li Xue Tong Bao 2013; 27: 1031-2.
[114]	Lu XS, Wu H, Xi HT, et al. Effects of Osthole on oxidative stress in ovarian tissue. Zhong Guo Xian Dai Yi Sheng 2020; 58: 35-9.
[115]	H Li H, Gao C, Liu C, et al. A review of the biological activity and pharmacology of cryptotanshinone, an important active constituent in Danshen. Biomed Pharmacother 2021; 137: 111332.
[116]	Wu YH, Wu YR, Li B, et al. Cryptotanshinone: a review of its pharmacology activities and molecular mechanisms. Fitoterapia 2020; 145: 104633.
[117]	Yang Y, Yang L, Qi C, et al. Cryptotanshinone alleviates polycystic ovary syndrome in rats by regulating the HMGB1/TLR4/NF-κB signaling pathway. Mol Med Rep 2020; 22: 3851-61.
[118]	Ye D, Li M, Zhang Y, et al. Cryptotanshinone regulates androgen synthesis through the ERK/c-Fos/CYP 17 pathway in porcine granulosa cells. Evid Based Complement Alternat Med 2017; 2017: 5985703.
[119]	Wang Y, Hu M, Hang YH, et al. Effects and mechanism of cryptotanshione on reproductive function in the female mice lacking of Akt2. Zhong Guo Zhong Xi Yi Jie He Za Zhi 2019; 39: 577-82.
[120]	Huang J, Zeng F, Xu Q, et al. Cryptotanshinone decreases granulosa cell apoptosis and restores ovarian function in mice with premature ovarian failure. Gen Physiol Biophys 2020; 39: 277-83. DOI PMID
[121]	Hu M, L MQ. Research progress on pharmacological effects and medicinal preparations of allicin. Xian Dai Yi Yao Wei Za Zhi 2017; 33: 2799-802.
[122]	Gao T, Chai H, Wo XD. Pharmacological effects of allicin and its development and application. Yi Xue Yan Jiu Za Zhi 2011; 40: 12-5.
[123]	Sun D, Sun C, Qiu G, et al. Allicin mitigates hepatic injury following cyclophosphamide administration via activation of Nrf2/ARE pathways and through inhibition of inflammatory and apoptotic machinery. Environ Sci Pollut Res Int 2021: 28: 39625-36. DOI
[124]	Ding W, Tang J, Zhou YF. Effects of allicin on the apoptosis of porcine ovarian granulosa cells. Jiangsu Nong Ye Xue Bao 2018; 46: 177-80.
[125]	Yu Y, Liu SB, Li SY, et al. Effects of Allicin on FSHR, LHR and active Caspase-3 expressions in the ovarian tissues of aged mice induced by D-galactose. Jilin Yi Ke Da Xue Xue Bao 2016; 37: 321-4.
[126]	Liu XL, Hu CY, Liu G, et al. The latest research progress of pathogenesis and related treatment mechanism of premature ovarian failure. Jiangsu Da Xue Xue Bao (Yi Xue Ban) 2021; 31: 541-8.
[127]	Ye N, Dong XY, Li DH. The progress in apoptotic mechanism of ovarian granulosa cells involved in premature ovarian failure. Shou Du Yi Ke Da Xue 2014; 35: 379-83.
[128]	Yang Y, Tao SY, Zhao PW, et al. Research progress on the regulation mechanism of granulosa cell apoptosis in premature ovarian failure. Yi Xue Yan Jiu Za Zhi 2018; 47: 16-9.
[129]	Wang XF, He YL. The relationship between apoptosis regulatory gene bcl-2/bax and premature ovarian failure. Sheng Zhi Yu Bi Yun 2008; 28: 487-90.
[130]	Flaws JA, Hirshfield AN, Hewitt JA, et al. Effect of Bcl-2 on the primordial follicle endowment in the mouse ovary. Biol Reprod 2001; 64: 1153-9. PMID
[131]	Ratts VS, Flaws JA, Kolp R, et al. Ablation of bcl-2 gene expression decreases the numbers of oocytes and primordial follicles established in the post-natal female mouse gonad. Endocrinology 1995; 136: 3665-68. PMID
[132]	Lin HL, Sun XH, Liu JX, et al. Study on the correlation between Bcl-2 and apoptosis of ovarian granulosa cells. Hebei Yi Yao 2015; 37: 1316-19.
[133]	Phaniendra A, Jestadi DB, Periyasamy L. Free radicals: properties, sources, targets, and their implication in various diseases. Indian J Clin Biochem 2015; 30: 11-26.
[134]	Valko M, Leibfritz D, Moncol J, et al. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007; 39: 44-84. DOI URL
[135]	Kumar M, Pathak D, Venkatesh S, et al. Chromosomal abnormalities & oxidative stress in women with premature ovarian failure (POF). Indian J Med Res 2012; 135: 92-7. DOI URL
[136]	Yang KF, Li L, Zhou H, et al. Research progress of oxidative stress and autophagy apoptosis on the regulation of premature ovarian failure. Hunan Zhong Yi Yao Da Xue Xue Bao 2021; 41: 809-14.
[137]	Wang CL. The mechanism of SIRT6/NF-κB signaling pathway in mouse model of premature ovarian failure. Dali: Dali University 2020: 23-36.
[138]	Sirotkin AV, Harrath AH. Phytoestrogens and their effects. Eur J Pharmacol 2014; 741: 230-6. DOI PMID
[139]	Zhao Y, Zheng HX, Xu Y, et al. Research progress of phytoestrogens of traditional Chinese medicine. Zhong Guo Zhong Yao Za Zhi 2017; 42: 3474-87.
[140]	Zhao QH, Xue WH, Guo Yu, et al. Research progress of total flavonoids of Cuscuta chinensis on reproductive endocrine regulation. Zhong Guo Xu Mu Shou Yi 2021; 48: 2002-10.
[141]	Zeng FL, Sun WF. Research progress on immune factors of premature ovarian failure. Guo Ji Sheng Yu Jian Kang/Ji Hua Sheng Yu Za Zhi 2018; 37: 316-19.
[142]	Zhang WJ, Song JY, Dou Z, et al. Effects of inflammatory factors on follicular development. Zhong Guo Sheng Zhi Yu Bi Yun Za Zhi 2021; 41: 377-81.
[143]	Huang Y, Hu C, Ye H, et al. Inflamm-aging: a new mechanism affecting premature ovarian insufficiency. J Immunol Res 2019; 2019: 8069898.

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