Journal of Traditional Chinese Medicine ›› 2023, Vol. 43 ›› Issue (1): 146-153.DOI: 10.19852/j.cnki.jtcm.2023.01.013
• Original articles • Previous Articles Next Articles
Long-term efficacy of point application therapy on different acupoints and durations in the treatment of asthma: a randomized controlled trial
JIN Yutong1, WU Lingtao2, GUO Yanglu1, XIA Chong3, YU Binyan1, XUAN Lihua1(
)
- 1 Department of Acupuncture and Moxibustion, the First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, China
2 Department of Massage, Hangzhou Fuyang Hospital of Traditional Chinese Medicine, Hangzhou 311400, China
3 Department of Acupuncture and Moxibustion, Hangzhou Fuyang Hospital of TCM Orthopedics and Traumatology, Hangzhou 311400, China
-
Received:2022-06-26Accepted:2022-10-18Online:2023-02-15Published:2023-01-10 -
Contact:XUAN Lihua -
About author:Prof. XUAN Lihua, Department of Acupuncture and Moxibustion, the First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, China. xlh1083@163.com. Telephone:+86-13588420630
-
Supported by:Research and Application of Key Techniques of Point Application Therapy for Treating Winter Diseases and Summer Diseases to Prevent and Treat Respiratory Allergic Diseases(2014C03046-2);Study on the Mechanism of Point Application Therapy Regulating Autophagy of Airway Epithelial Cells in the Treatment of Asthma Based on AMPK/mTOR Signal Pathway(82004454);based on the Theory of "Lung Intestine Axis", a Comparative Study on the Therapeutic Effect of Different Point Application Therapy on Patients with AnaphyLactic Asthma in Remission Stage(2021ZQ035)
Cite this article
JIN Yutong, WU Lingtao, GUO Yanglu, XIA Chong, YU Binyan, XUAN Lihua. Long-term efficacy of point application therapy on different acupoints and durations in the treatment of asthma: a randomized controlled trial[J]. Journal of Traditional Chinese Medicine, 2023, 43(1): 146-153.
share this article
Table 1 Baseline characteristics
| Item | 12 acupoints × 2 h | 12 acupoints × 4 h | 6 acupoints × 2 h | Total | F/χ2 value | P value | ||
|---|---|---|---|---|---|---|---|---|
| Age (years) | Mean | 43.28 | 43.59 | 43.27 | 43.38 | 0.046 | 0.956 | |
| SD | 10.41 | 10.09 | 10.23 | 10.22 | ||||
| Median | 43.0 | 43.5 | 43.0 | 43.0 | ||||
| Min | 18 | 18 | 22 | 18 | ||||
| Max | 65 | 65 | 65 | 65 | ||||
| Sex [n (%)] | male | 58 (39.5) | 59 (39.3) | 50 (34.2) | 167 (37.7) | 1.105 | 0.576 | |
| female | 89 (60.5) | 91 (60.7) | 96 (65.8) | 276 (62.3) | ||||
| Height (m) | Mean | 1.64 | 1.65 | 1.64 | 1.65 | 1.021 | 0.361 | |
| SD | 0.07 | 0.07 | 0.08 | 0.08 | ||||
| Median | 1.63 | 1.63 | 1.63 | 1.63 | ||||
| Min | 1.5 | 1.5 | 1.5 | 1.5 | ||||
| Max | 1.9 | 1.9 | 1.9 | 1.9 | ||||
| Weight (kg) | Mean | 60.24 | 61.50 | 60.11 | 60.62 | 0.301 | 0.740 | |
| SD | 8.95 | 9.44 | 9.33 | 9.25 | ||||
| Median | 60.00 | 60.00 | 60.00 | 60.00 | ||||
| Min | 40.0 | 40.0 | 40.0 | 40.0 | ||||
| Max | 86.0 | 86.0 | 82.0 | 86.0 | ||||
Table 1 Baseline characteristics
| Item | 12 acupoints × 2 h | 12 acupoints × 4 h | 6 acupoints × 2 h | Total | F/χ2 value | P value | ||
|---|---|---|---|---|---|---|---|---|
| Age (years) | Mean | 43.28 | 43.59 | 43.27 | 43.38 | 0.046 | 0.956 | |
| SD | 10.41 | 10.09 | 10.23 | 10.22 | ||||
| Median | 43.0 | 43.5 | 43.0 | 43.0 | ||||
| Min | 18 | 18 | 22 | 18 | ||||
| Max | 65 | 65 | 65 | 65 | ||||
| Sex [n (%)] | male | 58 (39.5) | 59 (39.3) | 50 (34.2) | 167 (37.7) | 1.105 | 0.576 | |
| female | 89 (60.5) | 91 (60.7) | 96 (65.8) | 276 (62.3) | ||||
| Height (m) | Mean | 1.64 | 1.65 | 1.64 | 1.65 | 1.021 | 0.361 | |
| SD | 0.07 | 0.07 | 0.08 | 0.08 | ||||
| Median | 1.63 | 1.63 | 1.63 | 1.63 | ||||
| Min | 1.5 | 1.5 | 1.5 | 1.5 | ||||
| Max | 1.9 | 1.9 | 1.9 | 1.9 | ||||
| Weight (kg) | Mean | 60.24 | 61.50 | 60.11 | 60.62 | 0.301 | 0.740 | |
| SD | 8.95 | 9.44 | 9.33 | 9.25 | ||||
| Median | 60.00 | 60.00 | 60.00 | 60.00 | ||||
| Min | 40.0 | 40.0 | 40.0 | 40.0 | ||||
| Max | 86.0 | 86.0 | 82.0 | 86.0 | ||||
Table 2 Course of bronchial asthma baseline
| Item | 12 acupoints × 2 h | 12 acupoints × 4 h | 6 acupoints × 2 h | Total | Z value | P value | |
|---|---|---|---|---|---|---|---|
| Mean | 155.81 | 144.93 | 115.60 | 138.88 | 3.659 | 0.161 | |
| SD | 137.84 | 125.34 | 92.69 | 121.15 | |||
| Median | 108.0 | 120.0 | 96.0 | 108.0 | |||
| Min | 12 | 3 | 12 | 3 | |||
| Max | 600 | 600 | 492 | 600 | |||
Table 2 Course of bronchial asthma baseline
| Item | 12 acupoints × 2 h | 12 acupoints × 4 h | 6 acupoints × 2 h | Total | Z value | P value | |
|---|---|---|---|---|---|---|---|
| Mean | 155.81 | 144.93 | 115.60 | 138.88 | 3.659 | 0.161 | |
| SD | 137.84 | 125.34 | 92.69 | 121.15 | |||
| Median | 108.0 | 120.0 | 96.0 | 108.0 | |||
| Min | 12 | 3 | 12 | 3 | |||
| Max | 600 | 600 | 492 | 600 | |||
Table 3 Baseline comparison of asthma attacks
| Item | 12 acupoints × 2 h | 12 acupoints × 4 h | 6 acupoints × 2 h | Total | Z value | P value | |
|---|---|---|---|---|---|---|---|
| Mean | 4.31 | 4.40 | 4.75 | 4.48 | 0.628 | 0.731 | |
| SD | 2.91 | 3.07 | 3.36 | 3.11 | |||
| Median | 4.0 | 4.0 | 4.0 | 4.0 | |||
| Min | 0 | 0 | 0 | 0 | |||
| Max | 12 | 15 | 14 | 15 | |||
Table 3 Baseline comparison of asthma attacks
| Item | 12 acupoints × 2 h | 12 acupoints × 4 h | 6 acupoints × 2 h | Total | Z value | P value | |
|---|---|---|---|---|---|---|---|
| Mean | 4.31 | 4.40 | 4.75 | 4.48 | 0.628 | 0.731 | |
| SD | 2.91 | 3.07 | 3.36 | 3.11 | |||
| Median | 4.0 | 4.0 | 4.0 | 4.0 | |||
| Min | 0 | 0 | 0 | 0 | |||
| Max | 12 | 15 | 14 | 15 | |||
Figure 1 Herbal acupoint sticking method A: paster; B: treatment group 3 acupoint selection, Feishu (BL13), Xinshu (BL15), and Geshu (BL17); C, D: Treatment group 1 and 2 acupoint selection, Dazhui (GV14), Feishu (BL13), Xinshu (BL15), Geshu (BL17), Pishu (BL20), Shenshu (BL23), and Guanyuan (CV4).
Figure 1 Herbal acupoint sticking method A: paster; B: treatment group 3 acupoint selection, Feishu (BL13), Xinshu (BL15), and Geshu (BL17); C, D: Treatment group 1 and 2 acupoint selection, Dazhui (GV14), Feishu (BL13), Xinshu (BL15), Geshu (BL17), Pishu (BL20), Shenshu (BL23), and Guanyuan (CV4).
Figure 2 Technology roadmap
Figure 2 Technology roadmap
Table 4 Comparisons of the number of attacks before and after treatment in each group of patients with asthma (n, $\bar{x}\pm s$)
| Group | n | Before treatment | 1 year after treatment |
|---|---|---|---|
| Treatment group 1 | 147 | 4.3±2.9 | 2.1±2.1abc |
| Treatment group 2 | 150 | 4.4±3.1 | 2.6±2.3a |
| Treatment group 3 | 146 | 4.7±3.4 | 3.4±2.7a |
Table 4 Comparisons of the number of attacks before and after treatment in each group of patients with asthma (n, $\bar{x}\pm s$)
| Group | n | Before treatment | 1 year after treatment |
|---|---|---|---|
| Treatment group 1 | 147 | 4.3±2.9 | 2.1±2.1abc |
| Treatment group 2 | 150 | 4.4±3.1 | 2.6±2.3a |
| Treatment group 3 | 146 | 4.7±3.4 | 3.4±2.7a |
Table 5 Comparisons of the total clinical efficacy rate after treatment amon g groups of patients with asthma ($\bar{x}\pm s$)
| Group | n | Ineffectiveness | Effectiveness | Significant effectiveness | Clinical remission | Total effective rate (%) |
|---|---|---|---|---|---|---|
| Treatment group 1 | 147 | 31 | 47 | 49 | 20 | 78.9a |
| Treatment group 2 | 150 | 30 | 50 | 56 | 14 | 80.0 |
| Treatment group 3 | 146 | 63 | 42 | 39 | 2 | 56.8 |
Table 5 Comparisons of the total clinical efficacy rate after treatment amon g groups of patients with asthma ($\bar{x}\pm s$)
| Group | n | Ineffectiveness | Effectiveness | Significant effectiveness | Clinical remission | Total effective rate (%) |
|---|---|---|---|---|---|---|
| Treatment group 1 | 147 | 31 | 47 | 49 | 20 | 78.9a |
| Treatment group 2 | 150 | 30 | 50 | 56 | 14 | 80.0 |
| Treatment group 3 | 146 | 63 | 42 | 39 | 2 | 56.8 |
Figure 3 Comparisons of the quality of life scores before and after treatment in each group of patients with asthma After treatment, compared with treatment group 3, aP < 0.05.
Figure 3 Comparisons of the quality of life scores before and after treatment in each group of patients with asthma After treatment, compared with treatment group 3, aP < 0.05.
Figure 4 Comparisons of serum immunoglobulin E levels before and after treatment in each group of patients with asthma Compared to before treatment within each group, aP < 0.05; after treatment, compared with the treatment group 3, bP < 0.05.
Figure 4 Comparisons of serum immunoglobulin E levels before and after treatment in each group of patients with asthma Compared to before treatment within each group, aP < 0.05; after treatment, compared with the treatment group 3, bP < 0.05.
Table 6 Adverse event rate ($\bar{x}\pm s$)
| Group | n | Adverse event | Adverse event rate (%) |
|---|---|---|---|
| Treatment group 1 | 147 | 4 | 2.72 |
| Treatment group 2 | 150 | 7 | 4.67 |
| Treatment group 3 | 146 | 2 | 1.37 |
Table 6 Adverse event rate ($\bar{x}\pm s$)
| Group | n | Adverse event | Adverse event rate (%) |
|---|---|---|---|
| Treatment group 1 | 147 | 4 | 2.72 |
| Treatment group 2 | 150 | 7 | 4.67 |
| Treatment group 3 | 146 | 2 | 1.37 |
| 1 | Global Initiative for Asthma. Difficult-to-treat and severe asthma in adolescent and adult patients: diagnosis and management. A GINA pocket guide for health professionals. Version 3 Fontana, WI: Global Initiative for Asthma; 2021. Available from URL: https://www.ginasthma.org/reports |
| 2 |
To T, Stanojevic S, Moores G, et al. Global asthma prevalence in adults: findings from the cross-sectional world health survey. BMC Public Health 2012; 12: 204.
DOI PMID |
| 3 |
Nathan RA, Meltzer EO, Derebery J, et al. The prevalence of nasal symptoms attributed to allergies in the United States: findings from the burden of rhinitis in an America survey. Allergy Asthma Proc 2008; 29: 600-8.
DOI PMID |
| 4 | Song SJ, Luo M. Advances in research on autophagy and respiratory diseases. World Latest Inf (Electron Version) 2019; 19: 38-9. |
| 5 |
Sobieraj DM, Weeda ER, Nguyen E, et al. Association of inhaled corticosteroids and long-acting β-agonists as controller and quick relief therapy with exacerbations and symptom control in persistent asthma: a systematic review and Meta-analysis. JAMA 2018; 319: 1485-96.
DOI PMID |
| 6 | Demenais F, Margaritte-Jeannin P, Barnes KC, et al. Multi-ancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nat Genet 2018; 50: 42-53. |
| 7 | Allen CS, Yeung JH, Vandermeer B, Homik J. Bisphosphonates for steroid-induced osteoporosis. Cochrane Database Syst Rev 2016; 10: CD001347. |
| 8 | Spang C, Chen J, Backman LJ. The tenocyte phenotype of human primary tendon cells in vitro is reduced by glucocorticoids. BMC Musculoskelet Disord 2016; 17: 467. |
| 9 |
Hu J, Zhang C, Zhao SM, et al. A systematic review and meta-analysis of acupoint application combined with Western Medicine therapy in the treatment of bronchial asthma. Ann Palliat Med 2021; 10: 11473-81.
DOI PMID |
| 10 | Wei CL, Zhang X, Li PF, Li W. Acupoint herbal patching during Sanfu Days on reducing frequency of acute asthma attack in children: a systematic review and Meta-analysis. Medicine 2020; 99: e18962. |
| 11 | Shi K, Wu W, Liu L, et al. Optimization of acupoint application scheme in the treatment of bronchial asthma based on the orthogonal design method. Zhong Guo Zhen Jiu 2017; 37: 571-5. |
| 12 | Zhang KY, Xu SW, Yang Y, Shou Y, Jiang H, Zhang B. Clinical study of optimizing acupoint combining in treatment of bronchial asthma with acupoint application. J Acupunct Tuina Sci 2019; 17: 344-9. |
| 13 |
Wu X, Peng J, Li G, Zhang W, Liu G, Liu B. Efficacy evaluation of summer acupoint application treatment on asthma patients: a two-year follow-up clinical study. J Tradit Chin Med 2015; 35: 21-7.
PMID |
| 14 | Wen BL, Zhou H, Liu BY, et al. Analysis on acupoint prescription for acupoint sticking therapy of treating winter diseases in summer for preventing and curing chronic cough and asthma. Zhong Guo Zhen Jiu 2010; 30: 647-52. |
| 15 | Asthma Group, Respiratory Branch of Chinese Medical Association. Guidelines for prevention and treatment of bronchial asthma (2016). Chin J Tuberc Respir Dis 2016; 39: 675-97. |
| 16 | Chinese Acupuncture and Moxibustion Association. Evidence-based clinical practice guidelines of acupuncture and moxibustion: bronchial asthma in adults. Beijing: China Press of Traditional Chinese Medicine, 2015: 14-5. |
| 17 | Li M, Yin K, Cai Y. Asthmology. 2nd ed. Beijing: People’s Medical Publishing House, 2005: 734-6. |
| 18 | Zhang B. Internal medicine of Traditional Chinese Medicine. Shang-hai: Shanghai Scientific and Technical Publishers, 1985; 59-60. |
| 19 |
Vieira Braga FA, Kar G, Berg M, et al. A cellular census of human lungs identifies novel cell states in health and in asthma. Nat Med 2019; 25: 1153-63.
DOI PMID |
| 20 | Saunders R, Kaul H, Berair R, et al. DP2 antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment. Sci Transl Med 2019; 11: 479. |
| 21 | Chen S, Jin YT, Zhu ZY, et al. In vivo study on site of action of sinapine thiocyanate following acupoint herbal patching. Evid Based Complement Alternat Med 2018; 2018: 1-6. |
| 22 | Xuan L, inven tor. A kind of plaster for preventing disease and its preparation. China ZL201010154886. 2012 Jun 13. |
| [1] | QIN Xiaoyu, WANG Chunai, XUE Jianjun, ZHANG Jie, LU Xiaoting, DING Shengshuang, GE Long, WANG Minzhen. Efficacy of electroacupuncture on myocardial protection and postoperative rehabilitation in patients undergoing cardiac surgery with cardiopulmonary bypass: a systematic review and Meta-analysis [J]. Journal of Traditional Chinese Medicine, 2024, 44(1): 1-15. |
| [2] | DAI Xiaoling, ZHANG Anming, LIN Hui, SHI Bei, REN Yi, WEN Hongzhu, FEI Xiaoyan, LIN Jiang. Qingchang suppositry (清肠栓) induced remission in patients with mild-to-moderate ulcerative proctitis: a multicenter, prospective, randomized, parallel-controlled clinical trial [J]. Journal of Traditional Chinese Medicine, 2024, 44(1): 156-162. |
| [3] | WANG Yichen, WU Shiyi, WANG Zhengyan, CHANG Wenling, XIE Zhihao, TANG Xing, ZHAO Songmei, ZHOU Jing, CHEN Zehong, WANG Chao, YANG Chunxia. Efficacy of Zhumian Tang formula granules (助眠汤配方颗粒) combined with eszopiclone for the treatment of poor sleep quality: a multi-center, randomized controlled, superiority trial [J]. Journal of Traditional Chinese Medicine, 2024, 44(1): 163-171. |
| [4] | YANG Yi, YE Huijun, ZHENG Huiling, JIN Lihua. Clinical observation on 90 cases of primary dysmenorrhea treated by buccal acupuncture therapy: a randomized controlled study [J]. Journal of Traditional Chinese Medicine, 2024, 44(1): 172-181. |
| [5] | DAI Zeqi, LIAO Xing, GUAN Yueyue, ZENG Zixiu, TANG Jun, HU Jing. Bloodletting puncture in the treatment of acute ischemic stroke: protocol for a mixed-method study of a multi-center randomized controlled trial and focus group [J]. Journal of Traditional Chinese Medicine, 2023, 43(6): 1259-1267. |
| [6] | XU Yani, ZHANG Yutong, HE Weile, DAI Linglin, TANG Ding, WANG Jialing, ZHANG Xufen, CHEN Qin, CHEN Lifang, WANG Zhanglian, ZHAN Mingjie. Efficiency and safety of acupuncture for women with premature ovarian insufficiency: study protocol for a randomized controlled trial [J]. Journal of Traditional Chinese Medicine, 2023, 43(6): 1268-1274. |
| [7] | XU Xiangru, ZHOU Yi, CHEN Gang, LEI Ming, ZHANG Wen, WU Xinxin, PU Yuting, CHEN Caiyu, SUN Yuting, ZHOU Shuang, FANG Bangjiang. Clinical efficacy of Buzhong Yiqi decoction (补中益气汤) in the treatment of hospital-acquired pneumonia with multi-drug resistant bacteria: a prospective, randomized, multicenter controlled trial [J]. Journal of Traditional Chinese Medicine, 2023, 43(5): 1010-1018. |
| [8] | ZHAO Ming, LUO Yimiao, WANG Huichan, CAO Yu, MA Lina, PEI Hui, LI Hao. Guilingji capsule (龟龄集胶囊) for Alzheimer's disease: secondary analysis of a randomized non-inferiority controlled trial [J]. Journal of Traditional Chinese Medicine, 2023, 43(5): 1019-1025. |
| [9] | ZHANG Meizhen, HAO Xiaohui, TANG Yiting, CHEN Yupeng, HE Puyu, ZHAO Liming, PANG Bing, NI Qing. Efficacy and safety of Buyang Huanwu decoction (补阳还五汤) for diabetic peripheral neuropathy: a systematic review and Meta-analysis [J]. Journal of Traditional Chinese Medicine, 2023, 43(5): 841-850. |
| [10] | YANG Yuqing, CHEN Yuhuan, LI Chunxiao, LING Xiao, WANG Panpan, GUO Jing, ZHANG Yingying. Effectiveness and safety of Pingxiao capsule (平消胶囊) as adjuvant therapy in treatment of breast cancer: a systematic review and Meta-analysis [J]. Journal of Traditional Chinese Medicine, 2023, 43(5): 851-859. |
| [11] | WANG Chao, WU Qiong, LI Ping, WANG Zhigang, LOU Xusheng, LI Yuanyuan, ZHANG Lin. Effect of Traditional Chinese Medicine combined with Western Medicine on blood lipid levels and inflammatory factors in patients with angina pectoris in coronary heart disease identified as intermingled phlegm and blood stasis syndrome: a network Meta-analysis [J]. Journal of Traditional Chinese Medicine, 2023, 43(4): 640-649. |
| [12] | ZHANG Xinghe, LI Qifu, YI Rong, XING Chonghui, JIN Yuhao, MENG Jiangqiong, FENG Jialei, ZHAO Siwen, LIANG Fanrong, GUO Taipin. Effect of catgut embedding at acupoints versus non-acupoints in abdominal obesity: a randomized clinical trial [J]. Journal of Traditional Chinese Medicine, 2023, 43(4): 780-786. |
| [13] | ZHANG Yuehong, DONG Dandan, YAN Youqin, ZHANG Hao, WANG Guangli, ZHOU Wei, LI Wei, QIU Li, LI Tingming, LIU Quan, XIA Ping, MAO Lina, YANG Danlin, YANG Lu, LIAN Fengmei, TONG Xiaolin, BA Yuanming. Effectiveness and safety of Jinshuibao capsules (金水宝胶囊) in treatment of residual cardiopulmonary symptoms in convalescent patients of coronavirus disease 2019: a pilot randomized, double-blind, placebo-controlled clinical trial [J]. Journal of Traditional Chinese Medicine, 2023, 43(1): 134-139. |
| [14] | YAO Yao, ZHAO Zhenni, CHEN Fengqin, LENG Yufei, PANG Xiangtian, XU Xiao, SUN Zhiling. Effectiveness of moxibustion alone on lumbar disc herniation: a Meta-analysis of randomized controlled trials [J]. Journal of Traditional Chinese Medicine, 2023, 43(1): 14-26. |
| [15] | SHEN Mengxia, SHANG Wenfang, WU Jiangxia, YU Zelin, XUAN Lihua. Efficacy and safety of acupoint application for allergic rhinitis: a systematic review and Meta-analysis of randomized controlled trials [J]. Journal of Traditional Chinese Medicine, 2022, 42(6): 858-868. |
| Viewed | ||||||
|
Full text |
|
|||||
|
Abstract |
|
|||||
