Journal of Traditional Chinese Medicine ›› 2023, Vol. 43 ›› Issue (4): 780-786.DOI: 10.19852/j.cnki.jtcm.20230608.002
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Effect of catgut embedding at acupoints versus non-acupoints in abdominal obesity: a randomized clinical trial
ZHANG Xinghe1, LI Qifu1, YI Rong2, XING Chonghui3, JIN Yuhao1, MENG Jiangqiong1, FENG Jialei4, ZHAO Siwen1, LIANG Fanrong5(
), GUO Taipin1()
- 1 School of Second Clinical Medicine/The Second Affiliated Hospital, Yunnan University of Chinese Medicine, Kunming 650500, China
2 Department of Acupuncture and Moxibustion, Kunming Hospital of Traditional Chinese Medicine, Kunming 650200, China
3 Department of Acupuncture and Moxibustion, the Sports Trauma Specialist Hospital of Yunnan Province, Kunming 650051, China
4 Institute for History of Medicine and Medical Literature, China Academy of Chinese Medical Sciences, Beijing 100027, China
5 School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China
-
Received:2022-03-08Accepted:2022-08-18Online:2023-08-15Published:2023-06-08 -
Contact:LIANG Fanrong, School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. acuresearch@126.com. Telephone: +86-18487272658
GUO Taipin, School of Second Clinical Medicine/the Second Affiliated Hospital, Yunnan University of Chinese Medicine, Kunming 650500, China. gtphncs@126.com -
Supported by:Yunnan Expert Workstation - Liang Fanrong Station: Study and Transformation of Classical Syndrome Differentiation System on Acupuncture and Moxibustion(202305AF150072);Yunnan Province Ten-thousand Plan: Youth Special - Guo Taipin(YNWR-QNBJ-2019-257);Yunnan Provincial Science Project: Study on the Bidirectional Regulation Mechanism of Central Network of Shu-Mu Catgut Embedding in Abdominal Obesity of Stomach Heat-Spleen Deficiency Type Which based on Multimodal Technique(2017FF117-011);Study on the Central Mechanism of Synergistic Potentiation of Shu-Mu Catgut Embedding in Abdominal Obesity(2019FF002-021);Study on the Brain Network Mechanism of Shu-Mu Catgut Embedding in Abdominal Obesity which based on Multi-Modal Technique(202101AZ070001-096)
Cite this article
ZHANG Xinghe, LI Qifu, YI Rong, XING Chonghui, JIN Yuhao, MENG Jiangqiong, FENG Jialei, ZHAO Siwen, LIANG Fanrong, GUO Taipin. Effect of catgut embedding at acupoints versus non-acupoints in abdominal obesity: a randomized clinical trial[J]. Journal of Traditional Chinese Medicine, 2023, 43(4): 780-786.
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Figure 1 Flowchart of the screening, enrollment, randomization, and follow-up ACE: acupoint catgut embedding; ITT: intention-to-treat.
Figure 1 Flowchart of the screening, enrollment, randomization, and follow-up ACE: acupoint catgut embedding; ITT: intention-to-treat.
Table 1 Location of the points and the details operation of catgut embedding
| Acupoints | Location | Operation |
|---|---|---|
| Pishu (BL20) | In the upper back region, at the same level of inferior border of the 11th thoracic spine (T11), 1.5 cun lateral to the posterior median line | Slightly oblique needling in the medial direction of the spine to the depth of 0.5-1 cun |
| Weishu (BL21) | In the upper back region, at the same level of inferior border of the 12th thoracic spine (T12), 1.5 cun lateral to the posterior median line | |
| Dachangshu (BL25) | In the lumbar region, at the same level thoracic spine 4th lumbar spine (L4), 1.5 cun lateral to the posterior median line | |
| Zhongwan (CV12) | On the upper abdomen, 4 cun superior to the navel, on the anterior median line | Pinch and lift the skin slightly with the thumb and index finger. Needling at 90 degrees to the depth of 1-1.5 cun |
| Tianshu (ST25) | On the left and right abdomen, 2 cun lateral to the navel | |
| Zhangmen (LR13) | On the lateral abdomen, inferior to the free extremity of the 11th rib | Pinch and lift the skin slightly with the thumb and index finger. Needling at 15 degrees to the depth of 1 cun |
| NA1 | 2 cun outward from the Pishu (BL20) | Pinch and lift the skin slightly with the thumb and index finger. Needling at 45 degrees downward to a depth of 0.5-1 cun |
| NA2 | 2 cun outward from the Weishu (BL21) | |
| NA3 | 2 cun outward from the Dachangshu (BL25) | |
| NA4 | 1.5 cun to the left of the Zhongwan (CV12) | Pinch and lift the skin slightly with the thumb and index finger. Needling at 90 degrees to a depth of 1-1.5 cun |
| NA5 | 1 cun outward from the Tianshu (ST25) | |
| NA6 | 2 cun forward from the Zhangmen (LR13) | Pinch and lift the skin slightly with the thumb and index finger. Needling at 15 degrees to the depth of 1 cun |
Table 1 Location of the points and the details operation of catgut embedding
| Acupoints | Location | Operation |
|---|---|---|
| Pishu (BL20) | In the upper back region, at the same level of inferior border of the 11th thoracic spine (T11), 1.5 cun lateral to the posterior median line | Slightly oblique needling in the medial direction of the spine to the depth of 0.5-1 cun |
| Weishu (BL21) | In the upper back region, at the same level of inferior border of the 12th thoracic spine (T12), 1.5 cun lateral to the posterior median line | |
| Dachangshu (BL25) | In the lumbar region, at the same level thoracic spine 4th lumbar spine (L4), 1.5 cun lateral to the posterior median line | |
| Zhongwan (CV12) | On the upper abdomen, 4 cun superior to the navel, on the anterior median line | Pinch and lift the skin slightly with the thumb and index finger. Needling at 90 degrees to the depth of 1-1.5 cun |
| Tianshu (ST25) | On the left and right abdomen, 2 cun lateral to the navel | |
| Zhangmen (LR13) | On the lateral abdomen, inferior to the free extremity of the 11th rib | Pinch and lift the skin slightly with the thumb and index finger. Needling at 15 degrees to the depth of 1 cun |
| NA1 | 2 cun outward from the Pishu (BL20) | Pinch and lift the skin slightly with the thumb and index finger. Needling at 45 degrees downward to a depth of 0.5-1 cun |
| NA2 | 2 cun outward from the Weishu (BL21) | |
| NA3 | 2 cun outward from the Dachangshu (BL25) | |
| NA4 | 1.5 cun to the left of the Zhongwan (CV12) | Pinch and lift the skin slightly with the thumb and index finger. Needling at 90 degrees to a depth of 1-1.5 cun |
| NA5 | 1 cun outward from the Tianshu (ST25) | |
| NA6 | 2 cun forward from the Zhangmen (LR13) | Pinch and lift the skin slightly with the thumb and index finger. Needling at 15 degrees to the depth of 1 cun |
Table 2 Baseline characteristics of 123 participants included in the ITT analysis
| Baseline characteristic | All participants (n = 123) | ACE group (n = 60) | Control group (n = 63) |
|---|---|---|---|
| Women [n (%)] | 101 (82) | 47 (78) | 54 (86) |
| Age [years] | 36.28 (9.60) | 36.43 (10.30) | 36.13 (8.96) |
| WC [cm] | 94.00 (9.70) | 94.00 (9.82) | 94.00 (9.70) |
| Body weight [kg] | 73.47 (11.60) | 74.81 (13.08) | 70.78 (12.60) |
| BMI [kg/m2] | 27.94 (3.45) | 27.93 (3.31) | 28.01 (3.75) |
| HC [cm] | 103.10 (8.50) | 103.05 (5.88) | 103.50 (10.00) |
| Appetite (VAS) | 6.90 (1.41) | 6.78 (1.26) | 7.02 (1.54) |
Table 2 Baseline characteristics of 123 participants included in the ITT analysis
| Baseline characteristic | All participants (n = 123) | ACE group (n = 60) | Control group (n = 63) |
|---|---|---|---|
| Women [n (%)] | 101 (82) | 47 (78) | 54 (86) |
| Age [years] | 36.28 (9.60) | 36.43 (10.30) | 36.13 (8.96) |
| WC [cm] | 94.00 (9.70) | 94.00 (9.82) | 94.00 (9.70) |
| Body weight [kg] | 73.47 (11.60) | 74.81 (13.08) | 70.78 (12.60) |
| BMI [kg/m2] | 27.94 (3.45) | 27.93 (3.31) | 28.01 (3.75) |
| HC [cm] | 103.10 (8.50) | 103.05 (5.88) | 103.50 (10.00) |
| Appetite (VAS) | 6.90 (1.41) | 6.78 (1.26) | 7.02 (1.54) |
Figure 2 Waist circumference during the treatment and follow-up Data were presented as median (IQR). ACE group received acupoint catgut embedding, control group received non-acupoints catgut embedding. ACE: acupoint catgut embedding; IQR: interquartile range. During the treatment from 0 to 12 week, the differences within ACE group (n = 60) and control group (n = 63) were significant (aP < 0.001). At 12 weeks, the difference between ACE group and control group was significant (bP < 0.05). During the follow-up from 12 to 16 week, the differences within ACE group and control group were significant (cP < 0.001). At 16 weeks, the difference between ACE group (n = 58) and control group (n = 61) was significant (dP < 0.05). Friedman test (treatment) and Wilcoxon test (follow-up) within group, Mann-Whitney test between two groups.
Figure 2 Waist circumference during the treatment and follow-up Data were presented as median (IQR). ACE group received acupoint catgut embedding, control group received non-acupoints catgut embedding. ACE: acupoint catgut embedding; IQR: interquartile range. During the treatment from 0 to 12 week, the differences within ACE group (n = 60) and control group (n = 63) were significant (aP < 0.001). At 12 weeks, the difference between ACE group and control group was significant (bP < 0.05). During the follow-up from 12 to 16 week, the differences within ACE group and control group were significant (cP < 0.001). At 16 weeks, the difference between ACE group (n = 58) and control group (n = 61) was significant (dP < 0.05). Friedman test (treatment) and Wilcoxon test (follow-up) within group, Mann-Whitney test between two groups.
Figure 3 Secondary outcomes during the treatment and follow-up A: body weight; B: BMI; C: hip circumference; D: VAS of appetite. Data were presented as median (IQR) in A-C, presented as mean (SD) in D. ACE group received acupoint catgut embedding, control group received non-acupoints catgut embedding. BMI: body mass index; HC: hip circumference; IQR: interquartile range; VAS: visual analogue scale. During the treatment from 0 to 12 week, body weight, BMI, HC and appetite decreased significantly within ACE group (n = 60) and control group (n = 63), aP < 0.001. During the follow-up from 12 to 16 week, the differences within the groups were also significant (bP < 0.001, cP < 0.01). For appetite, at 12 weeks, the differences between ACE group and control group were significant (dP < 0.01). At 16 weeks, the differences between ACE group (n = 58) and control group (n = 61) were significant (eP < 0.001). For body weight, BMI and HC, Friedman test (treatment) and Wilcoxon test (follow-up) within group, Mann-Whitney test between two groups. For appetite, One-way analysis of variance (treatment) and Paired t-test (follow-up) within the group. Independent-Sample t-test between two groups.
Figure 3 Secondary outcomes during the treatment and follow-up A: body weight; B: BMI; C: hip circumference; D: VAS of appetite. Data were presented as median (IQR) in A-C, presented as mean (SD) in D. ACE group received acupoint catgut embedding, control group received non-acupoints catgut embedding. BMI: body mass index; HC: hip circumference; IQR: interquartile range; VAS: visual analogue scale. During the treatment from 0 to 12 week, body weight, BMI, HC and appetite decreased significantly within ACE group (n = 60) and control group (n = 63), aP < 0.001. During the follow-up from 12 to 16 week, the differences within the groups were also significant (bP < 0.001, cP < 0.01). For appetite, at 12 weeks, the differences between ACE group and control group were significant (dP < 0.01). At 16 weeks, the differences between ACE group (n = 58) and control group (n = 61) were significant (eP < 0.001). For body weight, BMI and HC, Friedman test (treatment) and Wilcoxon test (follow-up) within group, Mann-Whitney test between two groups. For appetite, One-way analysis of variance (treatment) and Paired t-test (follow-up) within the group. Independent-Sample t-test between two groups.
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