Journal of Traditional Chinese Medicine ›› 2022, Vol. 42 ›› Issue (6): 839-847.DOI: 10.19852/j.cnki.jtcm.2022.06.001
• Systematic Reviews • Next Articles
WEI Jiali1, LAI Lily2, LIN Zhechao1, LIU Jianping3(), HAN Mei2,3()
Received:
2021-09-12
Accepted:
2021-12-22
Online:
2022-12-15
Published:
2022-11-01
Contact:
LIU Jianping,HAN Mei
About author:
Dr. HAN Mei, School of Traditional medicine, Beijing University of Chinese Medicine, Beijing 100029, China. hanmeizoujin@163.com, Telephone: +86-13401131731; +86-13552379149Supported by:
WEI Jiali, LAI Lily, LIN Zhechao, LIU Jianping, HAN Mei. Acupoint catgut embedding versus acupuncture for simple obesity: a systematic review and Meta-analysis of randomized controlled trials[J]. Journal of Traditional Chinese Medicine, 2022, 42(6): 839-847.
Figure 1 Flowchart of study searches and screening CNKI: China National Knowledge Infrastructure Database; VIP: China Science and Technology Journal Database.
ID | Sample size(T/C) | Age (years) | Interventions | Treatment frequency | Treatment duration | Diet and Exercise | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
T | C | T | C | T | C | ||||||||||
Chen RZ 2016 | 47/47 | 42.8±2.9 | ACE | MA | 1/1 w | 6/1 w | 8 w | 8 w | NO | ||||||
Chen YY et al 2015 | 40/40 | 29 | ACE | MA | 1/3 w | 4/1 w | 12 w | 10 w | NO | ||||||
Di YL 2016 | 41/41 | 31.5±6.8 | ACE | MA | 1/1 w | 4/1 w | 8 w | 8 w | NO | ||||||
Duan YQ et al 2018 | 25/25 | 18-45 | ACE | MA | 1/15 d | 7/1 w | 8 w | 8 w | YES | ||||||
He LY et al 2017 | 30/28 | 38.2±2.8 | ACE | EA | 1/2 w | 5/1 w | 12 w | 12 w | NO | ||||||
Huang Q 2020 | 39/39 | 38.3±2.5 | ACE | MA | 1/1 w | 4/1 w | 12 w | 12 w | NO | ||||||
Huang W et al 2017 | 40/40 | 20-45 | ACE | EA | 1/10 d | 4/1 w | 8 w | 8 w | YES | ||||||
Jin WW, Chen ZL 2016 | 80/80 | 39.2±4.8 | ACE | EA | 1/2 w | 5/1 w | 6 w | 6 w | YES | ||||||
Li MM et al 2017 | 30/30 | 37.43 | ACE | EA | 1/2 w | 2/1 w | 8 w | 8 w | NO | ||||||
Li MM et al 2018 | 33/33 | 31.61 | ACE | EA | 1/2 w | 2/1 w | 8 w | 8 w | NO | ||||||
Li QL 2016 | 40/40 | 33.4±2.4 | ACE | EA | 1/15 d | 2/1 w | 12 w | 12 w | NO | ||||||
Liu Y 2019 | 31/31 | 37.3±11.8 | ACE | EA | 1/2 w | 3/1 w | 8 w | 8 w | NO | ||||||
Qiao L 2016 | 30/30 | 18-60 | ACE | MA | 1/1 w | 7/1 w | 8 w | 8 w | NO | ||||||
Ren CC, Ge BH 2016 | 36/36 | 32±9 | ACE | EA | 1/1 w | 4/1 w | 8 w | 8 w | NO | ||||||
Sun FJ 2020 | 25/25 | 26.2±5.9 | ACE | MA | 1/21 d | 4/1 w | 8 w | 8 w | NO | ||||||
Wang Z, Pang XH, Ma M 2020 | 56/56 | 43.5±2.7 | ACE | MA | 1/4 w | 2/1 w | 4 w | 4 w | NO | ||||||
Wu XM, Zheng YS, Zhou HN 2015 | 32/30 | 33.0±11.0 | ACE | EA | 1/10 d | 1/1 w | 6 w | 6 w | NO | ||||||
Wu XN 2015 | 80/80 | 41.1±12.0 | ACE | EA | 1/1 w | 1/1 w | 12 w | 12 w | YES | ||||||
Wu XN et al 2017 | 76/73 | 43.2±11.0 | ACE | EA | 1/1 w | 4/1 w | 12 w | 12 w | NO | ||||||
Xu DJ 2019 | 30/30 | 29.6±4.4 | ACE | MA | 1/15 d | 7/1 w | 12 w | 12 w | NO | ||||||
Xu WZ 2017 | 30/30 | 30.4±6.6 | ACE | MA | 1/1 w | 3/1 w | 8 w | 8 w | YES | ||||||
Yan XR 2015 | 27/27 | 32.4±11.9 | ACE | EA | 1/10 d | 4/1 w | 4 w | 6 w | YES | ||||||
Yang Q 2015 | 39/33 | 41.4 | ACE | MA | 1/1 w | 4/1 w | 10 w | 10 w | NO | ||||||
Yang YF 2015 | 65/65 | 35.5±6.3 | ACE | MA | 1/1 w | 5/1 w | 8 w | 8 w | NO | ||||||
Zhang H, Ding TH 2017 | 40/40 | 18-55 | ACE | MA | 1/1 w | 4/1 w | 12 w | 12 w | NO | ||||||
Zhang HT 2015 | 30/30 | 18-60 | ACE | MA | 1/2 w | 4/1 w | 6 w | 6 w | NO | ||||||
Zhang Y 2017 | 33/33 | 42.8±12.2 | ACE | MA | 1/15 d | 7/1 w | 12 w | 12 w | NO | ||||||
Zhao HY, Ai BW 2015 | 50/50 | 42.21 | ACE | EA | 1/10 d | 5/1 w | 6 w | 6 w | YES | ||||||
Zheng X, Ji HC 2015 | 40/40 | 15-56 | ACE | MA | 1/2 w | 4/1 w | 12 w | 12 w | NO | ||||||
Zheng X et al 2018 | 43/43 | 41.0±5.0 | ACE | EA | 1/1 w | 4/1 w | 8 w | 8 w | NO | ||||||
Zhou L et al 2017 | 33/33 | 18-60 | ACE | MA | 1/4 w | 2/1 w | 4 w | 4 w | NO | ||||||
Zhou W et al 2019 | 45/45 | 21-45 | ACE | MA | 1/10 d | 4/1 w | 8 w | 8 w | YES | ||||||
Zhu Q 2017 | 33/33 | 18-60 | ACE | MA | 1/2 w | 4/1 w | 8 w | 8 w | NO |
Table 1 Characteristics of included studies
ID | Sample size(T/C) | Age (years) | Interventions | Treatment frequency | Treatment duration | Diet and Exercise | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
T | C | T | C | T | C | ||||||||||
Chen RZ 2016 | 47/47 | 42.8±2.9 | ACE | MA | 1/1 w | 6/1 w | 8 w | 8 w | NO | ||||||
Chen YY et al 2015 | 40/40 | 29 | ACE | MA | 1/3 w | 4/1 w | 12 w | 10 w | NO | ||||||
Di YL 2016 | 41/41 | 31.5±6.8 | ACE | MA | 1/1 w | 4/1 w | 8 w | 8 w | NO | ||||||
Duan YQ et al 2018 | 25/25 | 18-45 | ACE | MA | 1/15 d | 7/1 w | 8 w | 8 w | YES | ||||||
He LY et al 2017 | 30/28 | 38.2±2.8 | ACE | EA | 1/2 w | 5/1 w | 12 w | 12 w | NO | ||||||
Huang Q 2020 | 39/39 | 38.3±2.5 | ACE | MA | 1/1 w | 4/1 w | 12 w | 12 w | NO | ||||||
Huang W et al 2017 | 40/40 | 20-45 | ACE | EA | 1/10 d | 4/1 w | 8 w | 8 w | YES | ||||||
Jin WW, Chen ZL 2016 | 80/80 | 39.2±4.8 | ACE | EA | 1/2 w | 5/1 w | 6 w | 6 w | YES | ||||||
Li MM et al 2017 | 30/30 | 37.43 | ACE | EA | 1/2 w | 2/1 w | 8 w | 8 w | NO | ||||||
Li MM et al 2018 | 33/33 | 31.61 | ACE | EA | 1/2 w | 2/1 w | 8 w | 8 w | NO | ||||||
Li QL 2016 | 40/40 | 33.4±2.4 | ACE | EA | 1/15 d | 2/1 w | 12 w | 12 w | NO | ||||||
Liu Y 2019 | 31/31 | 37.3±11.8 | ACE | EA | 1/2 w | 3/1 w | 8 w | 8 w | NO | ||||||
Qiao L 2016 | 30/30 | 18-60 | ACE | MA | 1/1 w | 7/1 w | 8 w | 8 w | NO | ||||||
Ren CC, Ge BH 2016 | 36/36 | 32±9 | ACE | EA | 1/1 w | 4/1 w | 8 w | 8 w | NO | ||||||
Sun FJ 2020 | 25/25 | 26.2±5.9 | ACE | MA | 1/21 d | 4/1 w | 8 w | 8 w | NO | ||||||
Wang Z, Pang XH, Ma M 2020 | 56/56 | 43.5±2.7 | ACE | MA | 1/4 w | 2/1 w | 4 w | 4 w | NO | ||||||
Wu XM, Zheng YS, Zhou HN 2015 | 32/30 | 33.0±11.0 | ACE | EA | 1/10 d | 1/1 w | 6 w | 6 w | NO | ||||||
Wu XN 2015 | 80/80 | 41.1±12.0 | ACE | EA | 1/1 w | 1/1 w | 12 w | 12 w | YES | ||||||
Wu XN et al 2017 | 76/73 | 43.2±11.0 | ACE | EA | 1/1 w | 4/1 w | 12 w | 12 w | NO | ||||||
Xu DJ 2019 | 30/30 | 29.6±4.4 | ACE | MA | 1/15 d | 7/1 w | 12 w | 12 w | NO | ||||||
Xu WZ 2017 | 30/30 | 30.4±6.6 | ACE | MA | 1/1 w | 3/1 w | 8 w | 8 w | YES | ||||||
Yan XR 2015 | 27/27 | 32.4±11.9 | ACE | EA | 1/10 d | 4/1 w | 4 w | 6 w | YES | ||||||
Yang Q 2015 | 39/33 | 41.4 | ACE | MA | 1/1 w | 4/1 w | 10 w | 10 w | NO | ||||||
Yang YF 2015 | 65/65 | 35.5±6.3 | ACE | MA | 1/1 w | 5/1 w | 8 w | 8 w | NO | ||||||
Zhang H, Ding TH 2017 | 40/40 | 18-55 | ACE | MA | 1/1 w | 4/1 w | 12 w | 12 w | NO | ||||||
Zhang HT 2015 | 30/30 | 18-60 | ACE | MA | 1/2 w | 4/1 w | 6 w | 6 w | NO | ||||||
Zhang Y 2017 | 33/33 | 42.8±12.2 | ACE | MA | 1/15 d | 7/1 w | 12 w | 12 w | NO | ||||||
Zhao HY, Ai BW 2015 | 50/50 | 42.21 | ACE | EA | 1/10 d | 5/1 w | 6 w | 6 w | YES | ||||||
Zheng X, Ji HC 2015 | 40/40 | 15-56 | ACE | MA | 1/2 w | 4/1 w | 12 w | 12 w | NO | ||||||
Zheng X et al 2018 | 43/43 | 41.0±5.0 | ACE | EA | 1/1 w | 4/1 w | 8 w | 8 w | NO | ||||||
Zhou L et al 2017 | 33/33 | 18-60 | ACE | MA | 1/4 w | 2/1 w | 4 w | 4 w | NO | ||||||
Zhou W et al 2019 | 45/45 | 21-45 | ACE | MA | 1/10 d | 4/1 w | 8 w | 8 w | YES | ||||||
Zhu Q 2017 | 33/33 | 18-60 | ACE | MA | 1/2 w | 4/1 w | 8 w | 8 w | NO |
Figure 3 Comparison between ACE and Acupuncture A: forest plot of effectiveness rate; B: forest plot of BMI; C: forest plot of waist circumference; D: forest plot of body mass. ACE: acupoint catgut embedding; BMI: body mass index.
Figure 4 Comparison between ACE and acupuncture (plus diet and exercise) A: forest plot of effectiveness rate; B: forest plot of BMI; C: forest plot of waist circumference; D: forest plot of body mass. ACE: acupoint catgut embedding; BMI: body mass index.
Outcome | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | No of participants (studies) | Certainty of the evidence (GRADE) | |
---|---|---|---|---|---|
Risk with acupuncture | Risk with ACE | ||||
Effectiveness rate | 802 per 1000 | 96 per 1000 (64 to 128) | RR 1.12 (1.08 to 1.16) | 1837 (24 RCTs) | ???? MODERATEa |
Effectiveness rate (plus diet and exercise) | 802 per 1000 | 96 per 1000 (152 to 281) | RR 1.12 (1.35 to 1.19) | 707 (8 RCTs) | ???? LOWa,b |
BMI | The mean BMI was 0 | MD 1.12 lower (–2.09 to–0.14) | - | 1305 (17 RCTs) | ???? VERY LOWa,b,c |
BMI (plus diet and exercise) | The mean BMI (plus diet and exercise) was 0 | MD 0.88 lower (–1.35 to –0.4) | - | 624 (6 RCTs) | ???? LOWa,b |
WC | The mean WC was 0 | MD 2.14 lower (–4.22 to –0.06) | - | 935 (12 RCTs) | ???? VERY LOWa,b,c |
WC (plus diet and exercise) | The mean WC (plus diet and exercise) was 0 | MD 1.1 lower (–4.27 to 2.07) | - | 464 (5 RCTs) | ???? VERY LOWa,b,c |
Table 2 Analysis of GRADE Evidence
Outcome | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | No of participants (studies) | Certainty of the evidence (GRADE) | |
---|---|---|---|---|---|
Risk with acupuncture | Risk with ACE | ||||
Effectiveness rate | 802 per 1000 | 96 per 1000 (64 to 128) | RR 1.12 (1.08 to 1.16) | 1837 (24 RCTs) | ???? MODERATEa |
Effectiveness rate (plus diet and exercise) | 802 per 1000 | 96 per 1000 (152 to 281) | RR 1.12 (1.35 to 1.19) | 707 (8 RCTs) | ???? LOWa,b |
BMI | The mean BMI was 0 | MD 1.12 lower (–2.09 to–0.14) | - | 1305 (17 RCTs) | ???? VERY LOWa,b,c |
BMI (plus diet and exercise) | The mean BMI (plus diet and exercise) was 0 | MD 0.88 lower (–1.35 to –0.4) | - | 624 (6 RCTs) | ???? LOWa,b |
WC | The mean WC was 0 | MD 2.14 lower (–4.22 to –0.06) | - | 935 (12 RCTs) | ???? VERY LOWa,b,c |
WC (plus diet and exercise) | The mean WC (plus diet and exercise) was 0 | MD 1.1 lower (–4.27 to 2.07) | - | 464 (5 RCTs) | ???? VERY LOWa,b,c |
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