Journal of Traditional Chinese Medicine ›› 2023, Vol. 43 ›› Issue (5): 944-954.DOI: 10.19852/j.cnki.jtcm.20230727.001
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Electroacupuncture ameliorates cardiac dysfunction in myocardial ischemia model rats: a potential role of the hypothalamic-pituitary-adrenal axis
WANG Kun1, ZHOU Jie2, CUI Shuai3, WU Xin3, ZHU Guoqi1, WU Shengbing1(
), ZHOU Meiqi4()
- 1 Key Laboratory of Xin’an Medicine, Ministry of Education, Anhui University of Chinese Medicine, Hefei 230038, China
2 Department of Acupuncture and Moxibustion, the Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310053, China
3 Colleges of Acupuncture and Massage, Anhui University of Chinese Medicine, Hefei 230038, China
4 Bozhou Institute of Chinese Medicine, Anhui Academy of Traditional Chinese Medicine, Bozhou 236800, China
-
Received:2022-06-26Accepted:2022-09-14Online:2023-10-15Published:2023-06-27 -
Contact:Prof. ZHOU Meiqi, Bozhou Institute of Chinese Medicine, Anhui Academy of Traditional Chinese Medicine,meiqizhou@163.com ; Prof. WU Shengbing, Key Laboratory of Xin’an Medicine, Ministry of Education, Anhui University of Chinese Medicine,wsb922@126.com . Telephone: +86-551-65169752 -
Supported by:Natural Science Foundation-funded Project: Exploring the Mechanism of Anti-Ischemic Effect of Acupuncture Based on the Regulation of Hippocampal-HPA Axis by Glutamatergic Neurons(82004462);Opening Project of Zhejiang Provincial Preponderant and Characteristic Subject of Key University (Chinese Traditional Medicine): Study of the Mechanism of Action of Acupuncture in the Treatment of Myocardial Ischemia in Rats Based on the Amygdala Glutamatergic System-Mediated Affective Changes(ZYXYB2019002);National Key Research and Development Program of China: Influence of Heart and Lung Meridians on Heart and Lung Function(SQ2018YFC170298);National Natural Science Foundation of Anhui: Mechanism of Action of Intestinal Flora Involved in the Intervention of Myocardial Ischemia by Acupuncture of the Heart Meridian(1908085MH289)
Cite this article
WANG Kun, ZHOU Jie, CUI Shuai, WU Xin, ZHU Guoqi, WU Shengbing, ZHOU Meiqi. Electroacupuncture ameliorates cardiac dysfunction in myocardial ischemia model rats: a potential role of the hypothalamic-pituitary-adrenal axis[J]. Journal of Traditional Chinese Medicine, 2023, 43(5): 944-954.
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Table 1 Comparison of hemorheology in each group
| Group | n | Low shear rates (1/s)(/mPa.s) | Low shear rates (5/s)(/mPa.s) | Middle shear rates (30/s)(/mPa.s) | High shear rates (200/s)(/mPa.s) | Plasma viscosity (/mPa.s) | RBC aggregation index |
|---|---|---|---|---|---|---|---|
| Sham | 6 | 32.86±1.99 | 13.14±0.61 | 6.84±0.23 | 4.79±0.11 | 1.42±0.06 | 6.24±0.33 |
| Model | 6 | 47.41±2.83a | 17.86±1.01c | 8.95±0.50c | 6.03±0.35a | 1.64±0.02c | 7.44±0.15c |
| EA | 6 | 33.14±3.20b | 13.22±1.28d | 7.08±0.57d | 4.89±0.11d | 1.36±0.06b | 6.32±0.35d |
| Control | 6 | 44.41±1.98 | 17.88±0.78 | 9.13±0.28 | 6.32±0.14 | 1.55±0.04 | 7.56±0.05 |
Table 1 Comparison of hemorheology in each group
| Group | n | Low shear rates (1/s)(/mPa.s) | Low shear rates (5/s)(/mPa.s) | Middle shear rates (30/s)(/mPa.s) | High shear rates (200/s)(/mPa.s) | Plasma viscosity (/mPa.s) | RBC aggregation index |
|---|---|---|---|---|---|---|---|
| Sham | 6 | 32.86±1.99 | 13.14±0.61 | 6.84±0.23 | 4.79±0.11 | 1.42±0.06 | 6.24±0.33 |
| Model | 6 | 47.41±2.83a | 17.86±1.01c | 8.95±0.50c | 6.03±0.35a | 1.64±0.02c | 7.44±0.15c |
| EA | 6 | 33.14±3.20b | 13.22±1.28d | 7.08±0.57d | 4.89±0.11d | 1.36±0.06b | 6.32±0.35d |
| Control | 6 | 44.41±1.98 | 17.88±0.78 | 9.13±0.28 | 6.32±0.14 | 1.55±0.04 | 7.56±0.05 |
Figure 1 HR and ECG-ST levels in the study rats A-D: ECGs of each group rats. A: Sham group; B: Model group; C: EA group; D: Control group; E: HR in the Sham, Model, EA and Control groups; F: ECG-ST level in the Sham, Model, EA and Control groups. Sham: performed with sham surgery without ligation; Model: received surgery to ligate the LAD; EA: model rats with EA at Shenmen (HT7)-Tongli (HT5) segment; Control: model rats with EA at points lying 5 and 10 mm from the base of the tail. ECG: electrocardiogram; EA: electroacupunture; HR: heart rate; ST: ST-segment; LAD: left anterior descending artery. aP < 0.01, compared with the Sham group; bP < 0.01, compared with the Model group; Data are presented as mean ± standard error of mean (n = 6). Analysis of variance was performed to compare the differences among the groups.
Figure 1 HR and ECG-ST levels in the study rats A-D: ECGs of each group rats. A: Sham group; B: Model group; C: EA group; D: Control group; E: HR in the Sham, Model, EA and Control groups; F: ECG-ST level in the Sham, Model, EA and Control groups. Sham: performed with sham surgery without ligation; Model: received surgery to ligate the LAD; EA: model rats with EA at Shenmen (HT7)-Tongli (HT5) segment; Control: model rats with EA at points lying 5 and 10 mm from the base of the tail. ECG: electrocardiogram; EA: electroacupunture; HR: heart rate; ST: ST-segment; LAD: left anterior descending artery. aP < 0.01, compared with the Sham group; bP < 0.01, compared with the Model group; Data are presented as mean ± standard error of mean (n = 6). Analysis of variance was performed to compare the differences among the groups.
Figure 2 Histopathological comparison of myocardial tissue in each group (HE staining method, × 200) A-D: representative images of HE staining of myocardial tissue to identify pathological damage. A: Sham group; B: Model group; C: EA group; D: Control group; E: GPBB levels in the Sham, Model, EA and Control groups; F: H-FABP levels in the Sham, Model, EA and Control groups. Sham: performed with sham surgery without ligation; Model: received surgery to ligate the LAD; EA: model rats with EA at Shenmen (HT7)-Tongli (HT5) segment; Control: model rats with EA at points lying 5 and 10 mm from the base of the tail. HE: hematoxylin-eosin; EA: electroacupunture; GPBB: recombinant human glycogen phosphorylase; H-FABP: heart-type fatty acid binding protein; LAD: left anterior descending artery. Data are presented as mean± standard error of mean (n = 6). Analysis of variance was performed to compare the differences among the groups. aP < 0.01, compared with the Sham group; bP < 0.05, compared with the Model group; cP < 0.01, compared with the Model group.
Figure 2 Histopathological comparison of myocardial tissue in each group (HE staining method, × 200) A-D: representative images of HE staining of myocardial tissue to identify pathological damage. A: Sham group; B: Model group; C: EA group; D: Control group; E: GPBB levels in the Sham, Model, EA and Control groups; F: H-FABP levels in the Sham, Model, EA and Control groups. Sham: performed with sham surgery without ligation; Model: received surgery to ligate the LAD; EA: model rats with EA at Shenmen (HT7)-Tongli (HT5) segment; Control: model rats with EA at points lying 5 and 10 mm from the base of the tail. HE: hematoxylin-eosin; EA: electroacupunture; GPBB: recombinant human glycogen phosphorylase; H-FABP: heart-type fatty acid binding protein; LAD: left anterior descending artery. Data are presented as mean± standard error of mean (n = 6). Analysis of variance was performed to compare the differences among the groups. aP < 0.01, compared with the Sham group; bP < 0.05, compared with the Model group; cP < 0.01, compared with the Model group.
Table 2 Levels of ACTH and CORT in the study rats
| Group | n | ACTH level (pg/mL) | CORT level (ng/mL) |
|---|---|---|---|
| Sham | 6 | 43.56± 1.39 | 10.01± 0.63 |
| Model | 6 | 71.99± 2.96a | 15.9± 0.80a |
| EA | 6 | 49.22± 2.38b | 10.7± 0.22b |
| Control | 6 | 67.73± 0.92 | 15.1± 0.31 |
Table 2 Levels of ACTH and CORT in the study rats
| Group | n | ACTH level (pg/mL) | CORT level (ng/mL) |
|---|---|---|---|
| Sham | 6 | 43.56± 1.39 | 10.01± 0.63 |
| Model | 6 | 71.99± 2.96a | 15.9± 0.80a |
| EA | 6 | 49.22± 2.38b | 10.7± 0.22b |
| Control | 6 | 67.73± 0.92 | 15.1± 0.31 |
Figure 3 Expression of Vim and GFAP in the hippocampus in the study rats (immunofluorescence staining, × 400) A: representative Western blots of Vim and GFAP; B: Vimentin/β-actin quantification; C: GFAP/β-actin quantification of the blots in the Sham, Model, EA and Control groups; D: representative of immunofluorescence images of GFAP in the hippocampus. D1, D2, D3: Sham group; D4, D5, D6: Model group; D7, D8, D9: EA group; D10, D11, D12: Control group; D1, D4, D7, D10: merged images of GFAP and DAPI; D2, D5, D8, D11: expressed GFAP in the hippocampus; D3, D6, D9, D12: expressed DAPI in the hippocampus. Sham: performed with sham surgery without ligation; Model: received surgery to ligate the LAD; EA: model rats with EA at Shenmen (HT7)-Tongli (HT5) segment; Control: model rats with EA at points lying 5 and 10 mm from the base of the tail. EA: electroacupunture; Vim: vimentin; GFAP: glial fibrillary acidic protein; DAPI: 4',6-diamidino-2-phenylindole; LAD: left anterior descending artery. Data are presented as mean ± standard error of mean (n = 3). Analysis of variance was performed to compare the differences among the groups. aP < 0.01, compared with the Sham group; bP < 0.01, compared with the Model group.
Figure 3 Expression of Vim and GFAP in the hippocampus in the study rats (immunofluorescence staining, × 400) A: representative Western blots of Vim and GFAP; B: Vimentin/β-actin quantification; C: GFAP/β-actin quantification of the blots in the Sham, Model, EA and Control groups; D: representative of immunofluorescence images of GFAP in the hippocampus. D1, D2, D3: Sham group; D4, D5, D6: Model group; D7, D8, D9: EA group; D10, D11, D12: Control group; D1, D4, D7, D10: merged images of GFAP and DAPI; D2, D5, D8, D11: expressed GFAP in the hippocampus; D3, D6, D9, D12: expressed DAPI in the hippocampus. Sham: performed with sham surgery without ligation; Model: received surgery to ligate the LAD; EA: model rats with EA at Shenmen (HT7)-Tongli (HT5) segment; Control: model rats with EA at points lying 5 and 10 mm from the base of the tail. EA: electroacupunture; Vim: vimentin; GFAP: glial fibrillary acidic protein; DAPI: 4',6-diamidino-2-phenylindole; LAD: left anterior descending artery. Data are presented as mean ± standard error of mean (n = 3). Analysis of variance was performed to compare the differences among the groups. aP < 0.01, compared with the Sham group; bP < 0.01, compared with the Model group.
Figure 4 Intraperitoneal injection of CORT aggravated the expression of GPBB, H-FABP and GFAP A: the levels of GPBB in Model and Model + CORT rats (n = 6); B: the levels of H-FABP in Model and Model + CORT rats (n = 6); C: Western blotting of GFAP in the Model and Model+CORT groups showing expression of GFAP (n = 3); D: GFAP/β-actin quantification of the blots in the Model and Model + CORT groups (n = 3). Model: received surgery to ligate the LAD; Model + CORT: injected with CORT at a dose of 20 mg/kg in a saline vehicle. GPBB: recombinant human glycogen phosphorylase; H-FABP: heart-type fatty acid binding protein; CORT: corticosterone; GFAP: glial fibrillary acidic protein; LAD: left anterior descending artery. Data are presented as mean ± standard error of mean. Analysis of variance was performed to compare the differences among the groups. aP < 0.01, compared with the Model group; bP < 0.05, compared with the Model group.
Figure 4 Intraperitoneal injection of CORT aggravated the expression of GPBB, H-FABP and GFAP A: the levels of GPBB in Model and Model + CORT rats (n = 6); B: the levels of H-FABP in Model and Model + CORT rats (n = 6); C: Western blotting of GFAP in the Model and Model+CORT groups showing expression of GFAP (n = 3); D: GFAP/β-actin quantification of the blots in the Model and Model + CORT groups (n = 3). Model: received surgery to ligate the LAD; Model + CORT: injected with CORT at a dose of 20 mg/kg in a saline vehicle. GPBB: recombinant human glycogen phosphorylase; H-FABP: heart-type fatty acid binding protein; CORT: corticosterone; GFAP: glial fibrillary acidic protein; LAD: left anterior descending artery. Data are presented as mean ± standard error of mean. Analysis of variance was performed to compare the differences among the groups. aP < 0.01, compared with the Model group; bP < 0.05, compared with the Model group.
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