Journal of Traditional Chinese Medicine ›› 2024, Vol. 44 ›› Issue (4): 694-702.DOI: 10.19852/j.cnki.jtcm.20240627.001
• Original articles • Previous Articles Next Articles
ZHENG Jingrui1, CHEN Weijian1, YE Binbin1, MO Ziyao1, DU Qunqun2, QIN Renan2, NIE Ke1()
Received:
2023-03-21
Accepted:
2023-09-05
Online:
2024-08-15
Published:
2024-06-27
Contact:
Prof. NIE Ke, School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, China. ZHENG Jingrui, CHEN Weijian, YE Binbin, MO Ziyao, DU Qunqun, QIN Renan, NIE Ke. Zhuangyao Jianshen pill (壮腰健肾丸) ameliorates testosterone-induced benign postatic hyperplasia in rats[J]. Journal of Traditional Chinese Medicine, 2024, 44(4): 694-702.
Group | n | Body weight (g) | Prostate wet weight (g) | Prostate index (mg/g) |
---|---|---|---|---|
Con | 8 | 535.600±8.920 | 1.576±0.102 | 2.940±0.169 |
BPH | 8 | 451.900±9.540a | 2.413±0.043a | 5.354±0.134a |
Fin | 8 | 478.700±9.690 | 1.970±0.029b | 4.124±0.079d |
ZYJSP 0.6 g/kg | 8 | 464.400±13.820 | 2.043±0.133c | 4.448±0.253b |
ZYJSP 1.2 g/kg | 8 | 459.000±12.450 | 1.954±0.042b | 4.271±0.112d |
ZYJSP 2.4 g/kg | 8 | 458.800±11.790 | 2.049±0.085c | 4.469±0.153b |
Table 1 Body weight, prostate wet weight and prostate index
Group | n | Body weight (g) | Prostate wet weight (g) | Prostate index (mg/g) |
---|---|---|---|---|
Con | 8 | 535.600±8.920 | 1.576±0.102 | 2.940±0.169 |
BPH | 8 | 451.900±9.540a | 2.413±0.043a | 5.354±0.134a |
Fin | 8 | 478.700±9.690 | 1.970±0.029b | 4.124±0.079d |
ZYJSP 0.6 g/kg | 8 | 464.400±13.820 | 2.043±0.133c | 4.448±0.253b |
ZYJSP 1.2 g/kg | 8 | 459.000±12.450 | 1.954±0.042b | 4.271±0.112d |
ZYJSP 2.4 g/kg | 8 | 458.800±11.790 | 2.049±0.085c | 4.469±0.153b |
Figure 1 HE staining of prostate of rats in each group (× 100) A1: control group, × 100 original image; B1: BPH model group, × 100 original image; C1: finasteride-treated group, × 100 original image; D1: ZYJSP low dose group, × 100 original image; E1: ZYJSP medium dose group, × 100 original image; F1: ZYJSP high dose group, × 100 original image; A2: control group, partially enlarged pictures × 200; B2: BPH model group, partially enlarged pictures × 200; C2: finasteride-treated group, partially enlarged pictures × 200; D2: ZYJSP low dose group, partially enlarged pictures × 200; E2: ZYJSP medium dose group, partially enlarged pictures × 200; F2: ZYJSP high dose group, partially enlarged pictures × 200. Control group: intraperitoneal injection with normal saline, twice a week for 4 weeks; gavaged with ultrapure water daily, 28 d. BPH model group: Intraperitoneal injection of testosterone propionate for 28 d; gavaged with ultrapure water daily, 28 d. Finasteride-treated group: Intraperitoneal injection of testosterone propionate for 28 d; gavaged with finasteride (1.05 mg/kg) daily, 28 d. ZYJSP low dose group: Intraperitoneal injection of testosterone propionate for 28 d; gavaged with ZYJSP (0.6 g/kg) daily, 28 d. ZYJSP medium dose group: Intraperitoneal injection of testosterone propionate for 28 d; gavaged with ZYJSP (1.2 g/kg) daily, 28 d. ZYJSP high dose group: Intraperitoneal injection of testosterone propionate for 28 d; gavaged with ZYJSP (2.4 g/kg) daily, 28 d. BPH: benign prostatic hyperplasia; ZYJSP: Zhuangyao Jianshen pill; HE: hematoxylin and eosin.
Group | n | DHT (nmol/L) | E2 (ng/L) | T (nmol/L) | E2/T |
---|---|---|---|---|---|
Con | 8 | 3.69±0.05 | 114.20±4.00 | 8.23±0.13 | 13.88±0.48 |
BPH | 8 | 5.16±0.06a | 98.95±1.04a | 11.67±0.73a | 8.48±0.11a |
Fin | 8 | 3.87±0.04b | 120.10±1.26b | 8.87±0.09b | 13.54±0.20b |
ZYJSP 0.6 g/kg | 8 | 4.37±0.04b | 113.80±0.68b | 9.81±0.14b | 11.62±0.21b |
ZYJSP 1.2 g/kg | 8 | 4.13±0.06b | 115.40±1.05b | 9.32±1.00b | 12.40±0.22b |
ZYJSP 2.4 g/kg | 8 | 4.15±0.65b | 116.80±1.43b | 9.20±0.14b | 12.71±0.16b |
Table 2 Effect of ZYJSP on sex hormone levels in BPH rats
Group | n | DHT (nmol/L) | E2 (ng/L) | T (nmol/L) | E2/T |
---|---|---|---|---|---|
Con | 8 | 3.69±0.05 | 114.20±4.00 | 8.23±0.13 | 13.88±0.48 |
BPH | 8 | 5.16±0.06a | 98.95±1.04a | 11.67±0.73a | 8.48±0.11a |
Fin | 8 | 3.87±0.04b | 120.10±1.26b | 8.87±0.09b | 13.54±0.20b |
ZYJSP 0.6 g/kg | 8 | 4.37±0.04b | 113.80±0.68b | 9.81±0.14b | 11.62±0.21b |
ZYJSP 1.2 g/kg | 8 | 4.13±0.06b | 115.40±1.05b | 9.32±1.00b | 12.40±0.22b |
ZYJSP 2.4 g/kg | 8 | 4.15±0.65b | 116.80±1.43b | 9.20±0.14b | 12.71±0.16b |
Group | n | IL-6 (pg/mL) | IL-8 (ng/L) |
---|---|---|---|
Con | 8 | 26.7±1.8 | 45.3±2.9 |
BPH | 8 | 56.2±2.2a | 150.9±6.7a |
Fin | 8 | 30.8±3.1b | 71.9±4.1b |
ZYJSP 0.6 g/kg | 8 | 41.1±2.6c | 91.6±8.1b |
ZYJSP 1.2 g/kg | 8 | 37.1±3.6d | 87.6±4.5b |
ZYJSP 2.4 g/kg | 8 | 40.6±5.1c | 111.2±4.3b |
Table 3 Effect of ZYJSP on IL-6 and IL-8 levels in BPH rats
Group | n | IL-6 (pg/mL) | IL-8 (ng/L) |
---|---|---|---|
Con | 8 | 26.7±1.8 | 45.3±2.9 |
BPH | 8 | 56.2±2.2a | 150.9±6.7a |
Fin | 8 | 30.8±3.1b | 71.9±4.1b |
ZYJSP 0.6 g/kg | 8 | 41.1±2.6c | 91.6±8.1b |
ZYJSP 1.2 g/kg | 8 | 37.1±3.6d | 87.6±4.5b |
ZYJSP 2.4 g/kg | 8 | 40.6±5.1c | 111.2±4.3b |
Group | n | MDA (nmol/mL) | SOD (U/mL) |
---|---|---|---|
Con | 8 | 12.4±0.9 | 100.5±2.9 |
BPH | 8 | 20.4±0.9a | 78.6±4.0e |
Fin | 8 | 12.0±1.3b | 93.9±2.8c |
ZYJSP 0.6 g/kg | 8 | 12.5±1.7c | 92.2±1.6d |
ZYJSP 1.2 g/kg | 8 | 13.4±1.3c | 94.4±3.4c |
ZYJSP 2.4 g/kg | 8 | 14.0±1.7d | 91.8±2.4d |
Table 4 Effect of ZYJSP on MDA and SOD levels in BPH rats
Group | n | MDA (nmol/mL) | SOD (U/mL) |
---|---|---|---|
Con | 8 | 12.4±0.9 | 100.5±2.9 |
BPH | 8 | 20.4±0.9a | 78.6±4.0e |
Fin | 8 | 12.0±1.3b | 93.9±2.8c |
ZYJSP 0.6 g/kg | 8 | 12.5±1.7c | 92.2±1.6d |
ZYJSP 1.2 g/kg | 8 | 13.4±1.3c | 94.4±3.4c |
ZYJSP 2.4 g/kg | 8 | 14.0±1.7d | 91.8±2.4d |
Group | n | BUN (mmol/L) | CRE (μmol/L) |
---|---|---|---|
Con | 8 | 5.38±0.36 | 45.07±3.60 |
BPH | 8 | 6.63±0.25a | 46.14±4.80 |
Fin | 8 | 5.32±0.43b | 41.27±3.37 |
ZYJSP 0.6 g/kg | 8 | 6.03±0.19 | 40.69±3.79 |
ZYJSP 1.2 g/kg | 8 | 5.58±0.23 | 37.36±3.58 |
ZYJSP 2.4 g/kg | 8 | 6.49±0.19 | 39.03±3.29 |
Table 5 Effect of ZYJSP on BUN and CRE levels in BPH rats
Group | n | BUN (mmol/L) | CRE (μmol/L) |
---|---|---|---|
Con | 8 | 5.38±0.36 | 45.07±3.60 |
BPH | 8 | 6.63±0.25a | 46.14±4.80 |
Fin | 8 | 5.32±0.43b | 41.27±3.37 |
ZYJSP 0.6 g/kg | 8 | 6.03±0.19 | 40.69±3.79 |
ZYJSP 1.2 g/kg | 8 | 5.58±0.23 | 37.36±3.58 |
ZYJSP 2.4 g/kg | 8 | 6.49±0.19 | 39.03±3.29 |
Group | n | EGF (pg/mL) | IGF-1 (ng/mL) |
---|---|---|---|
Con | 8 | 41.2±3.8 | 250.7±11.6 |
BPH | 8 | 66.3±5.2a | 393.4±23.3a |
Fin | 8 | 45.0±4.2b | 274.1±15.6c |
ZYJSP 0.6 g/kg | 8 | 48.0±4.3c | 293.1±28.3c |
ZYJSP 1.2 g/kg | 8 | 46.1±2.7c | 290.7±21.4c |
ZYJSP 2.4 g/kg | 8 | 53.4±4.0 | 321.2±33.8 |
Table 6 Effect of ZYJSP on EGF and IGF-1 levels in BPH rats
Group | n | EGF (pg/mL) | IGF-1 (ng/mL) |
---|---|---|---|
Con | 8 | 41.2±3.8 | 250.7±11.6 |
BPH | 8 | 66.3±5.2a | 393.4±23.3a |
Fin | 8 | 45.0±4.2b | 274.1±15.6c |
ZYJSP 0.6 g/kg | 8 | 48.0±4.3c | 293.1±28.3c |
ZYJSP 1.2 g/kg | 8 | 46.1±2.7c | 290.7±21.4c |
ZYJSP 2.4 g/kg | 8 | 53.4±4.0 | 321.2±33.8 |
Figure 2 Section of prostate tissues reacting with Cyclin D1 primary antibody (× 100) A1: control group, × 100 original image; B1: BPH model group, × 100 original image; C1: finasteride-treated group, × 100 original image; D1: ZYJSP low dose group, × 100 original image; E1: ZYJSP medium dose group, × 100 original image; F1: ZYJSP high dose group, × 100 original image; A2: control group, partially enlarged pictures × 200; B2: BPH model group, partially enlarged pictures × 200; C2: finasteride-treated group, partially enlarged pictures × 200; D2: ZYJSP low dose group, partially enlarged pictures × 200; E2: ZYJSP medium dose group, partially enlarged pictures × 200; F2: ZYJSP high dose group, partially enlarged pictures × 200. Control group: intraperitoneal injection with normal saline, twice a week for 4 weeks; gavaged with ultrapure water daily, 28 d. BPH model group: Intraperitoneal injection of testosterone propionate for 28 d; gavaged with ultrapure water daily, 28 d. Finasteride-treated group: Intraperitoneal injection of testosterone propionate for 28 d; gavaged with finasteride (1.05 mg/kg) daily, 28 d. ZYJSP low dose group: Intraperitoneal injection of testosterone propionate for 28 d; gavaged with ZYJSP (0.6 g/kg) daily, 28 d. ZYJSP medium dose group: Intraperitoneal injection of testosterone propionate for 28 d; gavaged with ZYJSP (1.2 g/kg) daily, 28 d. ZYJSP high dose group: Intraperitoneal injection of testosterone propionate for 28 d; gavaged with ZYJSP (2.4 g/kg) daily, 28 d. BPH: benign prostatic hyperplasia; ZYJSP: Zhuangyao Jianshen pill.
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