Journal of Traditional Chinese Medicine ›› 2023, Vol. 43 ›› Issue (1): 6-13.DOI: 10.19852/j.cnki.jtcm.2023.01.004
• Meta-analysises • Previous Articles Next Articles
LI Wei1, XIA Ping2, SUN Wei1, ZHAO Jing1, LIU Qiong1, GENG Lianyi1, ZHOU Yao3(), GAO Kun1()
Received:
2021-12-12
Accepted:
2022-03-28
Online:
2023-02-15
Published:
2023-01-10
Contact:
ZHOU Yao,GAO Kun
About author:
Dr. GAO Kun, Division of Nephrology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China. kungao@njucm.edu.cn. Telephone:+86-13584020606Supported by:
LI Wei, XIA Ping, SUN Wei, ZHAO Jing, LIU Qiong, GENG Lianyi, ZHOU Yao, GAO Kun. Effects of the Huangkui capsule (黄葵胶囊) on chronic kidney disease: a systematic review and Meta-analysis[J]. Journal of Traditional Chinese Medicine, 2023, 43(1): 6-13.
Study | Intervention | Number of participants (treatment/control) | Duration (days) | Result reported | ||
---|---|---|---|---|---|---|
Treatment | Control | |||||
Wei JM et al 201813 | HKC 15+bailing capsule 12 capsules/d | WST | 45/44 | 56 | Scr, 24-h proteinuria | |
Wang F et al 201214 | HKC 15 | WST | 38/36 | 56 | Scr | |
Wang EM 2012 | HKC 15+reduced glutathione 1.2 g/d | WST | 20/20 | 56 | Scr, BUN, 24-h proteinuria | |
Wang YX 2020 | HKC 15+reduced glutathione 2.4 g/d | WST | 50/50 | 56 | 24-h proteinuria | |
Li F 201916 | HKC 15+Haikun capsule 6 capsules/d | Haikun capsule 6 capsules/d | 57/56 | 84 | Scr, BUN, 24-h proteinuria, GFR | |
Dai YW et al 201117 | HKC 15+Honghua injection 20 mg/d | WST | 30/25 | 84 | Scr, BUN, 24-h proteinuria, GFR | |
Cao S et al 20165 | HKC 15+TW 60 mg/d | TW 60 mg/d | 40/40 | 84 | Scr, BUN | |
Jiang CL 201223 | HKC 15 | WST | 16/16 | 56 | BUN | |
Mao WJ et al 201218 | HKC 15+telmisartan 80 mg/d | WST | 35/35 | 84 | Scr, 24-h proteinuria, ALB | |
Dai JH 201319 | HKC 15+Ginkgo-damole injection 20 mg/d | WST | 16/16 | 56 | Scr, BUN, 24-h proteinuria | |
Heng CZ et al 201320 | HKC 15+losartan potassium 50 mg/d | Losartan pota-ssium 50 mg/d | 30/30 | 84 | Scr, 24-h proteinuria, ALB | |
Zhang B 201321 | HKC 15+alprostadil injection 20 μg/d | WST | 14/14 | 84 | Scr | |
Zhang ZX 201622 | HKC 9+valsartan 80 mg/d | WST | 45/45 | 56 | Scr, BUN |
Table 1 Characteristics of included article
Study | Intervention | Number of participants (treatment/control) | Duration (days) | Result reported | ||
---|---|---|---|---|---|---|
Treatment | Control | |||||
Wei JM et al 201813 | HKC 15+bailing capsule 12 capsules/d | WST | 45/44 | 56 | Scr, 24-h proteinuria | |
Wang F et al 201214 | HKC 15 | WST | 38/36 | 56 | Scr | |
Wang EM 2012 | HKC 15+reduced glutathione 1.2 g/d | WST | 20/20 | 56 | Scr, BUN, 24-h proteinuria | |
Wang YX 2020 | HKC 15+reduced glutathione 2.4 g/d | WST | 50/50 | 56 | 24-h proteinuria | |
Li F 201916 | HKC 15+Haikun capsule 6 capsules/d | Haikun capsule 6 capsules/d | 57/56 | 84 | Scr, BUN, 24-h proteinuria, GFR | |
Dai YW et al 201117 | HKC 15+Honghua injection 20 mg/d | WST | 30/25 | 84 | Scr, BUN, 24-h proteinuria, GFR | |
Cao S et al 20165 | HKC 15+TW 60 mg/d | TW 60 mg/d | 40/40 | 84 | Scr, BUN | |
Jiang CL 201223 | HKC 15 | WST | 16/16 | 56 | BUN | |
Mao WJ et al 201218 | HKC 15+telmisartan 80 mg/d | WST | 35/35 | 84 | Scr, 24-h proteinuria, ALB | |
Dai JH 201319 | HKC 15+Ginkgo-damole injection 20 mg/d | WST | 16/16 | 56 | Scr, BUN, 24-h proteinuria | |
Heng CZ et al 201320 | HKC 15+losartan potassium 50 mg/d | Losartan pota-ssium 50 mg/d | 30/30 | 84 | Scr, 24-h proteinuria, ALB | |
Zhang B 201321 | HKC 15+alprostadil injection 20 μg/d | WST | 14/14 | 84 | Scr | |
Zhang ZX 201622 | HKC 9+valsartan 80 mg/d | WST | 45/45 | 56 | Scr, BUN |
Figure 3 Results of the Meta-analysis of the efficacy of Huangkui capsule versus control group A: forest plot of comparison of Scr; B: forest plot of comparison of BUN; C: forest plot of comparison of 24-h Urine protein; D: forest plot of comparison of Serum Albumin; E: forest plot of comparison of GFR. Scr: serum creatinine; BUN: blood urea nitrogen; GFR: glomerular filtration rate.
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