Journal of Traditional Chinese Medicine ›› 2024, Vol. 44 ›› Issue (6): 1067-1081.DOI: 10.19852/j.cnki.jtcm.20240927.002

• Meta-Analyses •     Next Articles

Network Meta-analysis of the clinical efficacy and safety of kidney-tonifying and bone-strengthening therapies for the treatment of rheumatoid arthritis with kidney deficiency type

GAN Chang1,2,3, TAO Qingwen2,3, YI Haoying1,2,3, BIAN Yuting1,2,3, WANG Jianming2,3()   

  1. 1 School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
    2 Department of Traditional Chinese Medicine Rheumatology, China-Japan Friendship Hospital, Beijing 100029, China
    3 Beijing Key Lab for Immune-Mediated Inflammatory Diseases, China-Japan Friendship Hospital, Beijing 100029, China
  • Received:2023-09-10 Accepted:2023-12-22 Online:2024-12-15 Published:2024-09-27
  • Contact: Prof. WANG Jianming, Department of Traditional Chinese Medicine Rheumatology, China-Japan Friendship Hospital, Beijing 100029, China. wangjianming@zryhyy.com.cn Telephone: +86-13910890713
  • Supported by:
    National Natural Science Foundation of China: Therapy which Invigorating Kidney and Strengthening Bone Regulates the Balance between Osteoblast and Osteoclast in Treating Rheumatoid Arthritis Bone Destruction: a Mechanism Study(82074223);National Natural Science Foundation of China: Therapy which Invigorating Kidney and Strengthening Bone Regulates the Balance between Osteoblast and Osteoclast in Treating Rheumatoid Arthritis Bone Destruction: a Mechanism Study(82274435);Fifth Batch of National Training Program for Clinical Excellence in Chinese Medicine(2022178)

Abstract:

OBJECTIVE: To compare the efficacy and safety of different Traditional Chinese Medicine (TCM)-based kidney-tonifying and bone-strengthening therapies for rheumatoid arthritis (RA).

METHODS: The current Bayesian network Meta-analysis compared different TCM-based kidney-tonifying and bone-strengthening therapies for RA. Eight electronic databases and two trial registration platforms were searched. RevMan 5.4 and Stata 16 software were employed.

RESULTS: A total of 42 studies involving 3779 cases were included. The results showed that the most effective intervention for improving efficacy was Wanbi decoction (顽痹汤); Bushen Quhan Zhiwang decoction (补肾祛寒治尪汤) was superior in reducing the incidence of adverse reactions; and Qiwei Tongbi oral liquid (七味通痹口服液) effectively reduced C-reactive protein and erythrocyte sedimentation rate levels.

CONCLUSION: Combining TCMs with conventional Western Medicine can improve the clinical efficacy of RA treatments, reduce inflammatory indexes, and result in a higher safety profile. However, this conclusion needs to be verified by more high-quality randomized controlled trials.

Key words: arthritis, rheumatoid, Medicine, Chinese Traditional, tonifying kidney and strengthening bones, network Meta-analysis

Cite this article

GAN Chang, TAO Qingwen, YI Haoying, BIAN Yuting, WANG Jianming. Network Meta-analysis of the clinical efficacy and safety of kidney-tonifying and bone-strengthening therapies for the treatment of rheumatoid arthritis with kidney deficiency type[J]. Journal of Traditional Chinese Medicine, 2024, 44(6): 1067-1081.