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Journal of Traditional Chinese Medicine ›› 2020, Vol. 40 ›› Issue (2): 167-187.DOI: 10.19852/j.cnki.jtcm.2020.02.001

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Comparative efficacy and safety of Chinese herbal injections combined with transcatheter hepatic arterial chemoembolization in treatment of liver cancer: a bayesian network Meta-analysis

Zhang Dan, Wang Kaihuan, Zheng Jiewen, Wu Jiarui, Duan Xiaojiao, Ni Mengwei, Liu Shuyu, Zhang Bing, Zhao Yi   

  1. Department of Clinical Pharmacology of Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine;
  • Online:2020-04-15 Published:2020-04-15
  • Supported by:
    Supported by the National Natural Science Foundation of China (Study on the Key Influential Factors of Anaphylaxis Induced by Chinese Herbal Injection Based on Three-dimensional Database and Multi-dimensional Data Mining,No.81473547;Establishment of Multi-dimensional Clinical Evaluation Model of Danshen Injection for Treating Unstable Angina Pectoris Based on Bayesian Network Meta Analysis,No.81673829)

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Abstract: OBJECTIVE: To address the optimal Chinese herbal injections(CHIs) against liver cancer, the present network Meta-analysis is designed to investigate the comparative efficacy and safety of different CHIs.METHODS: Several electronic databases were searched up to June 1 st, 2017. The quality assessment was conducted and network Meta-analysis was performed to compare the efficacy and safety of different CHIs plus transcatheter hepatic arterial chemoembolization(TACE). Primary outcomes were 1-year and 2-year survival rate, the secondary outcomes includes the clinical effective rate, performance status and the adverse reactions(ADRs). Data analysis was applied Stata 13.0 and Win BUGS 1.4 software.RESULTS: A total of 105 randomized controlled trials(RCTs) were identified for inclusion in this analysis, with data for 7683 patients and 13 CHIs. The results suggested that Javanica oil emulsion,Huachansu injection plus TACE were more favorable for 1-year and 2-year survival rate than other CHIs. Kanglaite, Astragalus polysaccharide injection plus TACE showed superiority in the clinical effective rate and performance status over other CHIs.And Shenmai injection plus TACE was superior to reducing ADRs than other CHIs for patients with liver cancer.CONCLUSION: Our findings indicated that receiving CHIs combined with TACE may have therapeutic benefits for patients with liver cancer in improving survival rate, clinical effective rate, the performance status and alleviating the ADRs.

Key words: Liver neoplasms, Chemoembolization,therapeutic, Drugs,Chinese herbal, Injections, Network Meta-analysis

Cite this article

Zhang Dan, Wang Kaihuan, Zheng Jiewen, Wu Jiarui, Duan Xiaojiao, Ni Mengwei, Liu Shuyu, Zhang Bing, Zhao Yi. Comparative efficacy and safety of Chinese herbal injections combined with transcatheter hepatic arterial chemoembolization in treatment of liver cancer: a bayesian network Meta-analysis[J]. Journal of Traditional Chinese Medicine, 2020, 40(2): 167-187.