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Journal of Traditional Chinese Medicine ›› 2019, Vol. 39 ›› Issue (03): 285-296.DOI: 10.19852/j.cnki.jtcm.2019.03.001

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Efficacy and safety of ginkgo injections in the treatment of angina pectoris caused by coronary heart disease in China: a network Meta-analysis and systematic review

Tan Di, Wu Jiarui, Jing Zhiwei, Duan Xiaojiao, Cui Yingying, Liu Shi   

  1. Department of Clinical Pharmacology of Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine;China Academy of Chinese Medical Sciences;
  • Online:2019-06-15 Published:2019-06-15
  • Supported by:
    Supported by National Natural Science Foundation of China(Study on the Key Influencing Factors of Anaphylaxis in Traditional Chinese Medicine Injection No.81473547;and Multidimensional Clinical Evaluation Model of Salvia Injection for the Treatment of Unstable Angina Pectoris,No.81673829)

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Abstract: OBJECTIVE:To assess the clinical efficacy and safety of ginkgo injections(GIs)combined with conventional treatment(CT)against angina pectoris(AP)due to coronary heart disease(CH D).METHODS:Randomized controlled trials(RCTs)that used GIs to treat AP were searched in SinoMed,PubMed,China National Knowledge Infrastructure Database,Chinese Scientific Journals Database,Wanfang Database,Embase and Cochrane Library until March 2017.The Cochrane "risk of bias" method was used to evaluate the methodological quality of RCTs.Data were analyzed using Stata v13.1 and WinBUGS v1.4.3.RESULTS:A total of 73 RCTs involving 7621 patients were included.A Bayesian network Meta-analysis of RCTs was undertaken,and the advantages of four types of Gl-supplemented CT in AP treatment were determined.CONCLUSION:Gl-assisted CT was more effective against AP than CT alone.However,based on the limitations of the study,additional high-quality RCTs are required to confirm our findings.

Key words: Ginkgo injections, Angina pectoris, Network Meta-analysis, Systematic review

Cite this article

Tan Di, Wu Jiarui, Jing Zhiwei, Duan Xiaojiao, Cui Yingying, Liu Shi. Efficacy and safety of ginkgo injections in the treatment of angina pectoris caused by coronary heart disease in China: a network Meta-analysis and systematic review[J]. Journal of Traditional Chinese Medicine, 2019, 39(03): 285-296.