Journal of Traditional Chinese Medicine ›› 2023, Vol. 43 ›› Issue (3): 574-581.DOI: 10.19852/j.cnki.jtcm.20220214.001
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TANG Yanping(), LI Peicai, LIU Xi, LIU Lei, GONG Yanxia, WEI Xiaodong, LIU Lina, YANG Li
Received:
2021-12-12
Accepted:
2022-02-11
Online:
2023-06-15
Published:
2022-02-14
Contact:
Professor TANG Yanping, Department of Gastroenterology, Tianjin Nankai Hospital, Tianjin 300100, China. cb1699@sina.com. Telephone: +86-22-27435105
Supported by:
TANG Yanping, LI Peicai, LIU Xi, LIU Lei, GONG Yanxia, WEI Xiaodong, LIU Lina, YANG Li. A single-center retrospective study on epidemiological and Traditional Chinese Medicine syndrome characteristics of 21010 patients with reflux/heartburn symptoms[J]. Journal of Traditional Chinese Medicine, 2023, 43(3): 574-581.
Item | Diseases | χ2/ F value | P value | ||||
---|---|---|---|---|---|---|---|
RE | NERD | RH | FH | ||||
Gender [n (%)] | Male | 2639 (42) | 4693 (45) | 972 (40) | 561 (30) | 152.76 | <0.0001a |
Female | 3645 (58) | 5734 (55) | 1458 (60) | 1309 (70) | |||
Age (years) | 45.3±12.1 | 48.1±13.6 | 42.1±12.6 | 42.9±11.5 | 208.7 | <0.0001a | |
Duration (years) | 0.5±0.3 | 2.5±0.2 | 2.2±0.5 | 3.4±0.5 | 69610.0 | <0.0001a | |
Total number | 6284 | 10426 | 2430 | 1870 | - | - | |
Percent (%) | 29.9 | 49.6 | 11.6 | 8.9 | - | - |
Table 1 General statistics of RE, NERD, RH and FH ($\bar{x}±s$)
Item | Diseases | χ2/ F value | P value | ||||
---|---|---|---|---|---|---|---|
RE | NERD | RH | FH | ||||
Gender [n (%)] | Male | 2639 (42) | 4693 (45) | 972 (40) | 561 (30) | 152.76 | <0.0001a |
Female | 3645 (58) | 5734 (55) | 1458 (60) | 1309 (70) | |||
Age (years) | 45.3±12.1 | 48.1±13.6 | 42.1±12.6 | 42.9±11.5 | 208.7 | <0.0001a | |
Duration (years) | 0.5±0.3 | 2.5±0.2 | 2.2±0.5 | 3.4±0.5 | 69610.0 | <0.0001a | |
Total number | 6284 | 10426 | 2430 | 1870 | - | - | |
Percent (%) | 29.9 | 49.6 | 11.6 | 8.9 | - | - |
Figure 1 Number and sex distribution of patients in four groups The order of the number of cases in each group was as follows: NERD>RE>RH>FH; meanwhile, the proportion of women in each group is higher than that of men. RE: reflux esophagitis; NERD: non-erosive reflux esophagitis; RH: reflux hypersensitivity; FH: functional heartburn.
Mood disorder | Disease | χ2 value | P value | |||||
---|---|---|---|---|---|---|---|---|
RE | NERD | RH | FH | |||||
Anxiety | Total number (n) | 1005 | 3336 | 1312 | 1178 | 139.58 | <0.0001a | |
Gender [n (%)] | Male | 452 (45) | 1401 (42) | 367 (28) | 342 (29) | |||
Female | 553 (55) | 1935 (58) | 945 (72) | 836 (71) | ||||
Depression | Total number (n) | 377 | 1460 | 608 | 823 | 35.53 | <0.0001a | |
Gender [n (%)] | Male | 200 (53) | 861 (59) | 383 (63) | 568 (70) | |||
Female | 177 (47) | 599 (41) | 225 (37) | 255 (30) | ||||
Anxiety combined with depression | Total number (n) | 251 | 1147 | 389 | 411 | 2.00 | 0.5689a | |
Gender [n (%)] | Male | 118 (47) | 585 (51) | 187 (48) | 201 (49) | |||
Female | 133 (53) | 562 (49) | 202 (52) | 210 (51) | ||||
Total [n (%)] | 1131 (18) | 3649 (35) | 1531 (63) | 1590 (85) | 3520.24 | <0.000a |
Table 2 Statistics of anxiety and depression disorders in RE, NERD, RH and FH patients
Mood disorder | Disease | χ2 value | P value | |||||
---|---|---|---|---|---|---|---|---|
RE | NERD | RH | FH | |||||
Anxiety | Total number (n) | 1005 | 3336 | 1312 | 1178 | 139.58 | <0.0001a | |
Gender [n (%)] | Male | 452 (45) | 1401 (42) | 367 (28) | 342 (29) | |||
Female | 553 (55) | 1935 (58) | 945 (72) | 836 (71) | ||||
Depression | Total number (n) | 377 | 1460 | 608 | 823 | 35.53 | <0.0001a | |
Gender [n (%)] | Male | 200 (53) | 861 (59) | 383 (63) | 568 (70) | |||
Female | 177 (47) | 599 (41) | 225 (37) | 255 (30) | ||||
Anxiety combined with depression | Total number (n) | 251 | 1147 | 389 | 411 | 2.00 | 0.5689a | |
Gender [n (%)] | Male | 118 (47) | 585 (51) | 187 (48) | 201 (49) | |||
Female | 133 (53) | 562 (49) | 202 (52) | 210 (51) | ||||
Total [n (%)] | 1131 (18) | 3649 (35) | 1531 (63) | 1590 (85) | 3520.24 | <0.000a |
Classification | Number | Heat stagnation in liver and stomach syndrome | Heat gallbladder invading stomach syndrome | Qi depression and phlegm obstruction syndrome | Blood stasis obstructing collaterals syndrome | Deficiency of Qi and inversion syndrome | Spleen deficiency and dampness-heat syndrome |
---|---|---|---|---|---|---|---|
RE | 6284 | 2450 (38.99) | 1307 (20.80) | 969 (15.42) | 818 (13.02) | 401 (6.38) | 339 (5.39) |
NERD | 10426 | 3534 (33.90) | 1428 (13.70) | 2464 (23.63) | 286 (2.74) | 1301 (12.48) | 1413 (13.55) |
Functional esophageal disease | 4300 | 1100 (25.58) | 557 (12.95) | 1555 (36.16) | 173 (4.02) | 262 (6.09) | 653 (15.19) |
Table 3 Distribution statistics of TCM syndromes in 21010 patients with reflux / heartburn symptoms [n (%)]
Classification | Number | Heat stagnation in liver and stomach syndrome | Heat gallbladder invading stomach syndrome | Qi depression and phlegm obstruction syndrome | Blood stasis obstructing collaterals syndrome | Deficiency of Qi and inversion syndrome | Spleen deficiency and dampness-heat syndrome |
---|---|---|---|---|---|---|---|
RE | 6284 | 2450 (38.99) | 1307 (20.80) | 969 (15.42) | 818 (13.02) | 401 (6.38) | 339 (5.39) |
NERD | 10426 | 3534 (33.90) | 1428 (13.70) | 2464 (23.63) | 286 (2.74) | 1301 (12.48) | 1413 (13.55) |
Functional esophageal disease | 4300 | 1100 (25.58) | 557 (12.95) | 1555 (36.16) | 173 (4.02) | 262 (6.09) | 653 (15.19) |
Classification | Number | Heat stagnation in liver and stomach syndrome | Heat gallbladder invading stomach syndrome | Qi depression and phlegm obstruction syndrome | Blood Stasis obstructing collaterals syndrome | Deficiency of Qi and inversion syndrome | Spleen deficiency and dampness-heat syndrome | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
RH | 2430 | 635 (26.13) | 323 (13.29) | 832 (34.24) | 101 (4.16) | 158 (6.50) | 381 (15.68) | ||||||||
FH | 1870 | 465 (24.87) | 234 (12.51) | 723 (38.66) | 72 (3.85) | 104 (5.56) | 272 (14.55) |
Table 4 Distribution of TCM syndromes in 4300 patients with functional esophageal disease [n (%)]
Classification | Number | Heat stagnation in liver and stomach syndrome | Heat gallbladder invading stomach syndrome | Qi depression and phlegm obstruction syndrome | Blood Stasis obstructing collaterals syndrome | Deficiency of Qi and inversion syndrome | Spleen deficiency and dampness-heat syndrome | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
RH | 2430 | 635 (26.13) | 323 (13.29) | 832 (34.24) | 101 (4.16) | 158 (6.50) | 381 (15.68) | ||||||||
FH | 1870 | 465 (24.87) | 234 (12.51) | 723 (38.66) | 72 (3.85) | 104 (5.56) | 272 (14.55) |
Item | Classification of RE | χ2/F value | P value | ||||
---|---|---|---|---|---|---|---|
A | B | C | D | ||||
Total [n (%)] | 5272 (83.9) | 855 (13.6) | 138 (2.2) | 19 (0.3) | - | ||
Gender (n) | Male | 2054 | 489 | 84 | 12 | 124.68 | <0.0001 |
female | 3218 | 366 | 54 | 7 | |||
Age (years) | 42.9±11.5 | 43.7±11.9 | 46.8±12.6 | 48.2±13.8 | 7.20 | <0.0001 | |
Duration (years) | 0.3±0.1 | 0.5±0.2 | 0.6±0.2 | 0.6±0.4 | 896.00 | <0.0001 | |
Mood disorder [n (%)] | Anxiety | 848 (16) | 138 (16) | 18 (13) | 1 (5) | 1.65 | 0.6480 |
Depression | 306 (6) | 59 (7) | 10 (7) | 2 (11) | |||
Anxiety combined with depression | 205(4) | 39 (5) | 6 (4) | 1 (5) | |||
Teatment of PPI for 8 weeks [n (%)] | Recovery | 2272 (43) | 320 (38) | 43 (31) | 4 (21) | - | - |
Improved | 2521 (48) | 372 (43) | 52 (38) | 8 (42) | |||
Ineffective | 479 (9) | 163 (19) | 43 (31) | 7 (37) | |||
Effective rate (%) | 91 | 81 | 69 | 63 | 146.63 | <0.0001 |
Table 5 General situation of RE patients, combined with emotional disorders, 8-week PPI efficacy statistics
Item | Classification of RE | χ2/F value | P value | ||||
---|---|---|---|---|---|---|---|
A | B | C | D | ||||
Total [n (%)] | 5272 (83.9) | 855 (13.6) | 138 (2.2) | 19 (0.3) | - | ||
Gender (n) | Male | 2054 | 489 | 84 | 12 | 124.68 | <0.0001 |
female | 3218 | 366 | 54 | 7 | |||
Age (years) | 42.9±11.5 | 43.7±11.9 | 46.8±12.6 | 48.2±13.8 | 7.20 | <0.0001 | |
Duration (years) | 0.3±0.1 | 0.5±0.2 | 0.6±0.2 | 0.6±0.4 | 896.00 | <0.0001 | |
Mood disorder [n (%)] | Anxiety | 848 (16) | 138 (16) | 18 (13) | 1 (5) | 1.65 | 0.6480 |
Depression | 306 (6) | 59 (7) | 10 (7) | 2 (11) | |||
Anxiety combined with depression | 205(4) | 39 (5) | 6 (4) | 1 (5) | |||
Teatment of PPI for 8 weeks [n (%)] | Recovery | 2272 (43) | 320 (38) | 43 (31) | 4 (21) | - | - |
Improved | 2521 (48) | 372 (43) | 52 (38) | 8 (42) | |||
Ineffective | 479 (9) | 163 (19) | 43 (31) | 7 (37) | |||
Effective rate (%) | 91 | 81 | 69 | 63 | 146.63 | <0.0001 |
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