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Journal of Traditional Chinese Medicine ›› 2015, Vol. 35 ›› Issue (06): 632-636.DOI: 10.1016/S0254-6272(15)30151-5

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Efficacy and safety of Aloe vera syrup for the treatment of gastroesophageal reflux disease: a pilot randomized positive-controlled trial

Yunes Panahi, Hossein Khedmat, Ghasem Valizadegan, Reza Mohtashami, Amirhossein Sahebkar   

  1. Chemical Injuries Research Center,Baqiyatallah University of Medical Sciences;Baqiyatallah Research Center for Gastroenterology and Liver Diseases,Baqiyatallah University of Medical Sciences;Baqiyatallah University of Medical Sciences;Medicine,Quran and Hadith Research Center,Baqiyatallah University of Medical Sciences;Biotechnology Research Center,Mashhad University of Medical Sciences;Metabolic Research Centre,Royal Perth Hospital,School of Medicine and Pharmacology,University of Western Australia;
  • Accepted:2015-12-15 Online:2015-12-15 Published:2022-04-05

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Abstract: OBJECTIVE: To investigate the use of Aloe vera(A.vera) for the treatment of gastroesophageal reflux disease(GERD) symptoms and compare its effects with those of omeprazole and ranitidine.METHODS: In this pilot, randomized controlled trial, 79 subjects were allocated to A. vera syrup(standardized to 5.0 mg polysaccharide per m L of syrup)at a dose of 10 m L/d, omeprazole capsule(20 g/d)or ranitidine tablet(150 mg in a fasted state in the morning and 150 mg 30 min before sleep at night)for a period of 4 weeks. The frequencies of eight main symptoms of GERD(heartburn, food regurgitation, flatulence, belching, dysphagia, nausea,vomiting and acid regurgitation) were assessed at weeks 2 and 4 of the trial.RESULTS: A. vera was safe and well tolerated and reduced the frequencies of all the assessed GERD symptoms, with no adverse events requiring withdrawal.CONCLUSION: A. vera may provide a safe and effective treatment for reducing the symptoms of GERD.

Key words: Aloe vera, Gastroesophageal reflux disease, Complementary therapies, Treatment outcome, Randomized controlled trial

Cite this article

Yunes Panahi, Hossein Khedmat, Ghasem Valizadegan, Reza Mohtashami, Amirhossein Sahebkar. Efficacy and safety of Aloe vera syrup for the treatment of gastroesophageal reflux disease: a pilot randomized positive-controlled trial[J]. Journal of Traditional Chinese Medicine, 2015, 35(06): 632-636.