Journal of Traditional Chinese Medicine ›› 2022, Vol. 42 ›› Issue (5): 818-824.DOI: 10.19852/j.cnki.jtcm.2022.05.010
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Preliminary single-arm study of brain effects during transcutaneous auricular vagus nerve stimulation treatment of recurrent depression by resting-state functional magnetic resonance imaging
CHEN Limei, SUN Jifei, GUO Chunlei, LI Xiaojiao, WANG Zhi, Hong Yang(
), FANG Jiliang()
- Radiology Department, Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 10003, China
-
Received:2022-01-12Accepted:2022-06-23Online:2022-10-15Published:2022-09-02 -
Contact:Hong Yang,FANG Jiliang -
About author:Hong Yang, Radiology Department, Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 10003, China. hongyang671129@126.com Telephone: +86-13683338202; +86-13810233838
Prof. FANG Jiliang, Radiology Department, Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 10003, China. fangmgh@163.com;
-
Supported by:National Natural Science Foundation of China: Neuroimaging Study of Transcutaneous Auricular Vagus Nerve Stimulation in Treatment of Refractory Depression Based on Emotion Cognition Circuit(81774433);Prediction of Curative Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Depression based on MRI and Machine Learning Technology(82174282);Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences: Study on the Mechanism and Efficacy Prediction of Transcutaneous Auricular Vagus Nerve Stimulation in the Treatment of Depression based on MRI Brain Imaging and Intestinal Flora(CI2021A03316)
Cite this article
CHEN Limei, SUN Jifei, GUO Chunlei, LI Xiaojiao, WANG Zhi, Hong Yang, FANG Jiliang. Preliminary single-arm study of brain effects during transcutaneous auricular vagus nerve stimulation treatment of recurrent depression by resting-state functional magnetic resonance imaging[J]. Journal of Traditional Chinese Medicine, 2022, 42(5): 818-824.
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Table 1 Clinical scale scores of patients with recurrent depression before treatment (week 0) and after taVNS treatment (week 8) (n = 22)
| Clinical Scale | Scale scores of week 0 ( | Scale scores of week 8 ( | Reduction of 8th week ( | Comparison of scale scores before and after 8 weeks (P) |
|---|---|---|---|---|
| HAMD-17 | 23±4 | 5±3 | 18±4 | 0.00 |
| HAMA | 24±7 | 5±4 | 19±69 | 0.00 |
| SDS | 51±7 | 31±8 | 20±9 | 0.00 |
| SAS | 44±7 | 27±7a | 16±8 | 0.00 |
| RRS | 38±16 | 21±14 | 17±12 | 0.00 |
Table 1 Clinical scale scores of patients with recurrent depression before treatment (week 0) and after taVNS treatment (week 8) (n = 22)
| Clinical Scale | Scale scores of week 0 ( | Scale scores of week 8 ( | Reduction of 8th week ( | Comparison of scale scores before and after 8 weeks (P) |
|---|---|---|---|---|
| HAMD-17 | 23±4 | 5±3 | 18±4 | 0.00 |
| HAMA | 24±7 | 5±4 | 19±69 | 0.00 |
| SDS | 51±7 | 31±8 | 20±9 | 0.00 |
| SAS | 44±7 | 27±7a | 16±8 | 0.00 |
| RRS | 38±16 | 21±14 | 17±12 | 0.00 |
Figure 1 Brain functional connectivity changes before and after taVNS treatments A: seed point: left posterior globus. 1: right postcentral gyrus; 2: right inferior parietal lobule; B: seed point: right posterior globus. 1: right postcentral gyrus; 2: right inferior parietal lobule; 3: left inferior parietal gyrus; 4: right supermarginal gyrus; 5: left superior parietal gyrus; 6: left postcentral gyrus; 7: left precuneus; 8: left supramarginal gyrus; C: seed point: right posterior caudate tail. 9: right cerebellum; 10: right calcarine gyrus; 11: right lingual gyrus.
Figure 1 Brain functional connectivity changes before and after taVNS treatments A: seed point: left posterior globus. 1: right postcentral gyrus; 2: right inferior parietal lobule; B: seed point: right posterior globus. 1: right postcentral gyrus; 2: right inferior parietal lobule; 3: left inferior parietal gyrus; 4: right supermarginal gyrus; 5: left superior parietal gyrus; 6: left postcentral gyrus; 7: left precuneus; 8: left supramarginal gyrus; C: seed point: right posterior caudate tail. 9: right cerebellum; 10: right calcarine gyrus; 11: right lingual gyrus.
Table 2 Changes of brain regions function connectivity in patients with recurrent depression after 8 weeks of taVNS treatment
| Seed | Brodmann's area | Region with altered FC | Peak MNI coordinate (X,Y,Z) | Voxels | t valuea | |
|---|---|---|---|---|---|---|
| Left globus pallidus | 3 | Right postcentral gyrus | (52, –24,60) | 142 | –4.00 | |
| 1 | Right inferior parietal gyrus | (50,–33,57) | 26 | –4.86 | ||
| Right globus pallidus | 48 | Left superior marginal gyrus | (–60,-21,33) | 67 | –3.43 | |
| 48 | Left postcentral gyrus | (–58,-20,30) | 50 | –3.91 | ||
| 5 | Left superior parietal gyrus | (-19,–51,67) | 28 | –3.28 | ||
| 2 | Left inferior parietal gyrus | (–43,–28,39) | 39 | –2.99 | ||
| 5 | Left precuneus | (–12,–56,67) | 16 | –4.53 | ||
| 3 | Right postcentral gyrus | (45,–26,39) | 78 | –3.56 | ||
| 2 | Right superior marginal gyrus | (44,–31,39) | 38 | –3.51 | ||
| Right caudate | 18 | Right lingual gyrus | (11,–80,–5) | 104 | –2.93 | |
| 17 | Right calcarine gyrus | (6,–71,14) | 75 | –3.01 | ||
| 30 | Right cerebellum | (12,–43,–14) | 26 | –3.29 | ||
Table 2 Changes of brain regions function connectivity in patients with recurrent depression after 8 weeks of taVNS treatment
| Seed | Brodmann's area | Region with altered FC | Peak MNI coordinate (X,Y,Z) | Voxels | t valuea | |
|---|---|---|---|---|---|---|
| Left globus pallidus | 3 | Right postcentral gyrus | (52, –24,60) | 142 | –4.00 | |
| 1 | Right inferior parietal gyrus | (50,–33,57) | 26 | –4.86 | ||
| Right globus pallidus | 48 | Left superior marginal gyrus | (–60,-21,33) | 67 | –3.43 | |
| 48 | Left postcentral gyrus | (–58,-20,30) | 50 | –3.91 | ||
| 5 | Left superior parietal gyrus | (-19,–51,67) | 28 | –3.28 | ||
| 2 | Left inferior parietal gyrus | (–43,–28,39) | 39 | –2.99 | ||
| 5 | Left precuneus | (–12,–56,67) | 16 | –4.53 | ||
| 3 | Right postcentral gyrus | (45,–26,39) | 78 | –3.56 | ||
| 2 | Right superior marginal gyrus | (44,–31,39) | 38 | –3.51 | ||
| Right caudate | 18 | Right lingual gyrus | (11,–80,–5) | 104 | –2.93 | |
| 17 | Right calcarine gyrus | (6,–71,14) | 75 | –3.01 | ||
| 30 | Right cerebellum | (12,–43,–14) | 26 | –3.29 | ||
Figure 2 Correlation between the clinical data and the brain FCs A: the FC subtracted values between right globus and left inferior parietal gyrus were negatively correlated with HAMD -17 score subtracted values. B: the FC subtracted values between right globus and the left globus and right postcentral gyrus were negatively correlated with HAMD-17 score subtracted values; C: the FC subtracted values between the right globus and right postcentral gyrus were negatively correlated with SDS subtracted values; D: the FC subtracted values between the right globus and right postcentral gyrus was negatively correlated with SAS subtracted values. HAMD-17: 17-item Hamilton Depression Rating Scale; SDS: Self-Rating Depression Scale; SAS: Self-Rating Anxiety Scale.
Figure 2 Correlation between the clinical data and the brain FCs A: the FC subtracted values between right globus and left inferior parietal gyrus were negatively correlated with HAMD -17 score subtracted values. B: the FC subtracted values between right globus and the left globus and right postcentral gyrus were negatively correlated with HAMD-17 score subtracted values; C: the FC subtracted values between the right globus and right postcentral gyrus were negatively correlated with SDS subtracted values; D: the FC subtracted values between the right globus and right postcentral gyrus was negatively correlated with SAS subtracted values. HAMD-17: 17-item Hamilton Depression Rating Scale; SDS: Self-Rating Depression Scale; SAS: Self-Rating Anxiety Scale.
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