Journal of Traditional Chinese Medicine ›› 2024, Vol. 44 ›› Issue (4): 813-821.DOI: 10.19852/j.cnki.jtcm.20240515.004
• Original articles • Previous Articles Next Articles
WU Yijuan, SUN Xinghong, GUO Haixia, ZHANG Xiangan()
Received:
2023-02-02
Accepted:
2023-07-31
Online:
2024-08-15
Published:
2024-05-15
Contact:
Prof. ZHANG Xiangan, Department of Anorectology, the first Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China. Supported by:
WU Yijuan, SUN Xinghong, GUO Haixia, ZHANG Xiangan. Study on the effect and mechanism of Yanghe decoction Huacai (阳和汤化裁) on tissue repair of Yin syndrome after anal fistula surgery[J]. Journal of Traditional Chinese Medicine, 2024, 44(4): 813-821.
Group | n | 10th day after surgery | 15th day after surgery |
---|---|---|---|
Control | 60 | 2 (1, 2) | 1 (1, 1) |
Treatment | 60 | 3 (3, 3) | 2 (2, 2) |
Z value | -8.86 | -7.1 | |
P value | < 0.01 | < 0.01 |
Table 1 Comparison of secretion scores between the two groups of patients [M (P25, P75)]
Group | n | 10th day after surgery | 15th day after surgery |
---|---|---|---|
Control | 60 | 2 (1, 2) | 1 (1, 1) |
Treatment | 60 | 3 (3, 3) | 2 (2, 2) |
Z value | -8.86 | -7.1 | |
P value | < 0.01 | < 0.01 |
Group | n | 10th day after surgery | 15th day after surgery |
---|---|---|---|
Control | 60 | 2 (2, 2) | 2 (1, 2) |
Treatment | 60 | 2.5 (2, 3) | 2 (2, 3) |
Z value | -6.275 | -6.701 | |
P value | < 0.01 | < 0.01 |
Table 2 Comparison of traumatic granulation tissue scores between the two groups of patients [M (P25, P75)]
Group | n | 10th day after surgery | 15th day after surgery |
---|---|---|---|
Control | 60 | 2 (2, 2) | 2 (1, 2) |
Treatment | 60 | 2.5 (2, 3) | 2 (2, 3) |
Z value | -6.275 | -6.701 | |
P value | < 0.01 | < 0.01 |
Figure 1 Comparison of traumatic bFGF expression after surgery in 10th and 15th after surgery A: treatment group: bFGF at 10th after surgery (× 200); B: treatment group: bFGF at 15th after surgery (× 200); C: control group: bFGF at 10th after surgery (× 200); D: control group: bFGF at 15th after surgery (× 200). Control group: the patients have routine drug changes since the first postoperative day (disinfection with iodophor, sterile gauze coverage, and tape wrapping); treatment group: based on treatment in the control group, patients in this group were given oral Yanghe decoction Huacai on the 5th post-operative day. Dyeing method of all pictures are the immunohistochemistry. bFGF: basic fibroblast growth factor.
Figure 2 Comparison of traumatic TGF-β1expression after surgery in 10th and 15th A: treatment group: TGF-β1 at 10th after surgery (× 200); B: treatment group: TGF-β1 at 15th after surgery (× 200); C: control group: TGF-β1 at 10th after surgery (× 200); D: control group: TGF-β1 at 15th after surgery (× 200). Control group: the patients have routine drug changes since the first postoperative day (disinfection with iodophor, sterile gauze coverage, and tape wrapping); treatment group: based on treatment in the control group, patients in this group were given oral Yanghe decoction Huacai on the 5th post-operative day. Dyeing method of all pictures are the immunohistochemistry. TGF-β1: transforming growth factor β1.
Figure 3 Comparison of traumatic EGF expression after surgery in 10th and 15th after surgery A: treatment group: EGF at 10th after surgery (× 200); B: treatment group: EGF at 15th after surgery (× 200); C: control group: EGF at 10th after surgery (× 200); D: control group: EGF at 15th after surgery (× 200). Control group: the patients have routine drug changes since the first postoperative day (disinfection with iodophor, sterile gauze coverage, and tape wrapping); treatment group: based on treatment in the control group, patients in this group were given oral Yanghe decoction Huacai on the 5th post-operative day. Dyeing method of all pictures are the immunohistochemistry. EGF: epidermal growth factor.
Group | Case | Minimum time | Longest time | $\bar{x}±s$ | t value | P value |
---|---|---|---|---|---|---|
Control | 60 | 21 | 33 | 28±3 | 9.124 | < 0.01 |
Treatment | 60 | 17 | 27 | 22±3 |
Table 3 Comparison of wound healing time between two groups of patients (d)
Group | Case | Minimum time | Longest time | $\bar{x}±s$ | t value | P value |
---|---|---|---|---|---|---|
Control | 60 | 21 | 33 | 28±3 | 9.124 | < 0.01 |
Treatment | 60 | 17 | 27 | 22±3 |
Group | n | Heal | Effect | Improve | No effect | Z value | P value |
---|---|---|---|---|---|---|---|
Control group | 60 | 33 | 24 | 3 | 0 | -4.555 | < 0.01 |
Treatment group | 60 | 55 | 5 | 0 | 0 |
Table 4 Comparison of clinical outcomes between the two groups of patients (n)
Group | n | Heal | Effect | Improve | No effect | Z value | P value |
---|---|---|---|---|---|---|---|
Control group | 60 | 33 | 24 | 3 | 0 | -4.555 | < 0.01 |
Treatment group | 60 | 55 | 5 | 0 | 0 |
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