Original Articles

Clinical observation of white eye distribution in patients with hyperlipidemia: an artificial intelligence digital visual examination technique

  • Tianli SONG ,
  • Haixia LI ,
  • Li'an LIU
Expand
  • 1 Department of Cardiology, the Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing100053, China
    2 National College, Beijing University of Chinese Medicine, Beijing 100029, China

Received date: 2024-07-12

  Accepted date: 2024-12-11

  Online published: 2024-12-31

Supported by

National Natural Science Foundation of China:Study on the Mechanism of Improving Cardiac Remodelling in Post-infarction Ischaemic Cardiomyopathy through lncRNA-Maternally Expressed Gene3/miR-223/ Stromal Interaction Molecule 1 Calcium Signalling Axis by Activate Blood and Reassure Formula(81973682);National Social Science Fund: Study on the Verification and Construction of the Theory System of Sanjiao Phase Fire and Yang Support Under the View of Civilisation Traceability(21VJXG037);First Published: a Randomised Controlled Study of Fuyang Qiangxin Tang in the Treatment of Moderate to Severe Heart Failure(2024-1-4151);Project for Enhancing Clinical Research and Achievement Transformation Capabilities of High-Level Traditional Chinese Medicine Hospitals: Evaluation of the Efficacy and Preclinical Study of Fuyang Qiangxin Granules, a Traditional Chinese Medicine for Heart Failure(HLCMHPP2023045)

Abstract

OBJECTIVE: To explore the clinical observation of white eye distribution characteristics of hyperlipidemic patients based on artificial intelligence digital eye diagnosis technology.

METHODS: One hundred and fifty subjects were examined in the outpatient and inpatient departments of Guang'anmen Hospital of the China Academy of Traditional Chinese Medicine from 01 February 2022 to 01 February 2023, including 80 cases in the hyperlipidemic patient (HLP) group and 70 cases in the normal lipid level patient (NC) group. The two groups were collected and extracted by the artificial intelligence visual diagnostic instrument and analyzed by the MyEyeD-10 white eye shadowless imaging health intelligence analysis system. Finally, SPSS 26.0 (Version X; IBM Corp., Armonk, NY, USA) was used for statistical processing.

RESULTS: Significant differences were noted in the scores of "spot" and "foggy" features between the two groups. Between groups, the "spot" feature score of the white eye morphology in the HLP group (11.07 ± 3.22) was higher than that in the NC group (7.50 ± 4.11) (P <0.01). Moreover, the "foggy" feature score of the eye morphology in the HLP group (8.37 ± 2.25) was higher than that in the NC group (P <0.01), higher than that of the NC group (5.72 ± 1.21) (P <0.05). There were significant differences in the "A" (stomach), "B", "O" (spleen), and "M" (liver) eye-contact region scores between the two groups, and the "B", "O" (spleen) and "M" (liver) eye-contact region scores were significantly different. The scores of the white eye channel region in the HLP group were significantly higher than those in the control group, with the "A", "B", and "O" regions (P <0.01), "M" region (P <0.01), "A", "B", "O", and "M" region (P <0.01). "M" zone (P <0.05). The scores of "dull red" and "yellow" features were significantly different, and the scores of "dull red" and "yellow" colors of the white eye choroid in the HLP group were significantly higher than those in the HLP group. The scores of "dull red" and "yellow" were significantly higher in the HLP group than in the NC group (P <0.01).

CONCLUSION: The morphological features of the white eye ocular image, the white eye chakra's color, and the bulbar conjunctiva's vascular zoning are closely related to hyperlipidemia. Importantly, these provide a reference for the objectivity and precision of the identification of Chinese medicine by looking at the eyes.

Cite this article

Tianli SONG , Haixia LI , Li'an LIU . Clinical observation of white eye distribution in patients with hyperlipidemia: an artificial intelligence digital visual examination technique[J]. Journal of Traditional Chinese Medicine, 2025 , 45(5) : 1135 -1143 . DOI: 10.19852/j.cnki.jtcm.20241231.001

References

1. Karr S. Epidemiology and management of hyperlipidemia. Am J Manag Care 2017; 23: S139-48.
2. Xu CX, Pan RL, Dong MC, et al. Based on intestinal flora, to investigate the mechanism of lipid-lowering effect of total glucosides of robust ligustrum on golden hamsters with hyperlipidemia. Chin Pharmacol Bull 2024; 40: 476-83.
3. Lee S, Kim H, Kim C, et al. Effect of methanol extract of Schisandrae Fructus on high fat diet induced hyperlipidemic mice. J Tradit Chin Med 2019; 39: 818-25.
4. Yao YS, Li TD, Zeng ZH. Mechanisms underlying direct actions of hyperlipidemia on myocardium: an updated review. Lipids Health Dis 2020; 19: 23.
5. Tummala R, Gupta M, Devanabanda RA, et al. Bempedoic acid and its role in contemporary management of hyperlipidemia in atherosclerosis. Ann Med 2022; 54: 1287-96.
6. Zhang NQ, Feng YM. Huang Di Nei Jing. Wuhan: Hubei Science and Technology Press, 2022: 89-90.
7. Xing RW. Huang Di Nei Jing Lingshu. Wuhan: Huazhong University of Science and Technology Press, 2017: 52-5.
8. Wei GN, Zhang K. Tu Jie Huang Di Nei Jing Lingshu. Beijing: Ancient Books of Traditional Chinese Medicine Publishing House, 2018: 33-6.
9. Yang SY. Ren Zhai Zhi Zhi. Beijing: Ancient Books of Traditional Chinese Medicine Publishing House, 2016: 77-8.
10. Wang ZW, Liu J, Li JJ, et al. Guidelines for lipid management in China (2023). Zhong Guo Xun Huan Za Zhi 2023; 38: 237-71.
11. National Health Commission of the People's Republic of China. Dietary guidelines for adults with hyperlipidemia (2023 Edition). Quan Ke Yi Xue Lin Chuang Yu Jiao Yu 2023; 21: 581-3.
12. Liang Y. Diagnostic value of intelligent analysis system of White Eye imaging for diabetic microvascular disease. Jinan: Shandong University of Traditional Chinese Medicine, 2023: 65-8.
13. Wei XQ. A study on the distribution of TCM syndromes of diabetic retinopathy based on "eye Diagnostic Instrument" and analysis of related factors. Chengdu: Chengdu University of Traditional Chinese Medicine, 2023: 26-7.
14. Liu X, Zhang QY, Quan HH, et al. Analyzed the visual features of hypertension and its correlation with the syndrome elements based on digital visual diagnosis technology. Zhong Guo Zhong Yi Ji Chu Yi Xue Za Zhi 2024; 30: 413-7.
15. Song TL, Ma J, Li HX, Sun YZ. A correlation study on the characteristics and pathogenesis of the ocular network in hypertensive patients based on the theory of eye diagnosis in Traditional Chinese Medicine and the analysis of white eye imaging AI and optical technology. Zhong Hua Zhong Yi Yao Xue Kan 2024; 42: 15-9+285-7.
16. National Health Commission Disease Control and Prevention Bureau. Report on nutrition and chronic diseases in China 2020. Beijing: People's Medical Publishing House, 2021: 21-5.
17. Yang SY. Ren Zhai Zhi Zhi Fang ed. Shanghai: Ancient Books of Traditional Chinese Medicine Publishing House, 1991: 52-3.
18. Gong Z. Literature study of the Huang Di Nei Jing Su Wen Jie Zhu. Jinan: Shandong University of Traditional Chinese Medicine, 2009: 52.
19. Asiedu K, Krishnan AV, Kwai N, Poynten A, Markoulli M. Conjunctival microcirculation in ocular and systemic microvascular disease. Clin Exp Optom 2023; 106: 694-702.
20. Baykal C, Polat AE, Yazganoglu KD, Buyukbabani N. The clinical spectrum of xanthomatous lesions of the eyelids. Int J Dermatol 2017; 56: 981-92.
21. Fliesler SJ. Introduction to the thematic review series: seeing 2020: lipids and lipid-soluble molecules in the eye. J Lipid Res 2010; 51: 13.
22. El-Sayyad HI, Elmansi AA, Bakr EH. Hypercholesterolemia-induced ocular disorder: ameliorating role of phytotherapy. Nutrition 2015; 31: 1307-16.
23. Frank RN. Diabetic retinopathy and systemic factors. Middle East Afr J Ophthalmol 2015; 22: 151-6.
24. Chou YY, Ma J, Su X, Zhong Y. Emerging insights into the relationship between hyperlipidemia and the risk of diabetic retinopathy. Lipids Health Dis 2020; 19: 241.
25. Huo J, Duan JG, Liu LS, et al. Evaluation of individualized treatment of nonproliferative diabetic retinopathy: a multicenter, randomized, parallel-controlled study. J Tradit Chin Med 2022; 42: 90-5.
26. Zhang MZ, Hao XH, Tanh YT, et al. Efficacy and safety of Buyang Huanwu decoction for diabetic peripheral neuropathy: a systematic review and Meta-analysis. J Tradit Chin Med 2023; 43: 841-50.
27. Heng XP, Wang ZT, Yang LQ, et al. Dangua Fang regulating tricarboxylic acid cycle and respiratory chain and its mechanism in diabetic rats. J Tradit Chin Med 2023; 43: 1150-9.
28. Zhang JM, Liang SL, Nie P, et al. Efficacy of Kushen decoction on high-fat-diet-induced hyperlipidemia in rats. J Tradit Chin Med 2022; 42: 364-71.
29. Chen BJ, Huang XD, Peng HT, et al. Effectiveness and safety of red yeast rice predominated by monacolin K β-hydroxy acid form for hyperlipidemia treatment and management. J Tradit Chin Med 2022; 42: 264-71.
Outlines

/