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Journal of Traditional Chinese Medicine >

2024 , Vol. 44 >Issue 5: 871 - 884

DOI: https://doi.org/10.19852/j.cnki.jtcm.20240806.007

Traditional Chinese Medicine in the treatment of recurrent respiratory tract infections in children: an overview of systematic reviews and Meta-analyses

  • Yasheng DENG ,
  • Siyin HAN ,
  • Lanhua XI ,
  • Hui HUANG ,
  • Tianwei LIANG ,
  • Yiqing ZHENG ,
  • Yanping FAN ,
  • Jiang LIN
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  • 1 School of Basic Medical Sciences, Guangxi University of Chinese Medicine, Nanning 530200, China
    2 School of Basic Medical Sciences, Guangxi University of Chinese Medicine, Guangxi Key Laboratory of Marine Drugs, Nanning 530200, China
    3 Department of Pharmacy, Hainan Traditional Chinese Medicine Hospital, Haikou 570203, China

Received date: 2023-06-02

  Accepted date: 2023-11-16

  Online published: 2024-08-06

Supported by

Study on the Mechanisms of Multi-target Immunomodulation by Hydrolyzed Nanzhu Tablets in Children with RRTI Based on scRNA-seq Technology(82060825);Huang Danian-type Teacher Team of National Universities-Teacher Team of Basic Course of Chinese and Western Medicine (Ministry of Education Teacher Letter [2022] No.2);Guangxi Famous Chinese Medicine Doctor Lin Jiang Inheritance Studio (Gui TCM Scienceand Education Development [2021] No. 6);Guangxi First-class Discipline of Chinese Medicine (Gui Textbook Research [2022] No. 1);Guangxi Interdisciplinary Innovation Team of Chinese Medicine(GZKJ2302)

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Abstract

OBJECTIVE: To evaluate and summarise the evidence from published Meta-analyses/systematic reviews (MAs/SRs) of Traditional Chinese Medicine (TCM) in the treatment of recurrent respiratory tract infections (RRTIs) and to provide a scientific basis for the clinical treatment of RRTIs with TCM.

METHODS: Studies were retrieved from Chinese and English databases including the China National Knowledge Infrastructure, Wanfang database, China Science and Technology Journal Database, SinoMed, PubMed, Web of Science, the Cochrane Library and EMbase from their establishment date to March 2023. Involved studies were screened, extracted, and evaluated for quality by two researchers independently. The a measurement tool to assess systematic reviews (AMSTAR) 2 scale was used for methodological quality evaluation, as well as the preferred reporting items for systematic reviews and Meta-analyses (PRISMA) 2020 statement for report quality evaluation, the risk of bias in systematic reviews (ROBIS) tool for risk of bias, and the grading of recommendations, assessment, development and evaluation (GRADE) quality assessment tool for evidence quality.

RESULTS: Twenty MAs/SRs studies were included, including analyses of 274 original studies involving 38 335 patients with RRTIs. The AMSTAR 2 scale evaluation results showed that 19 studies were of very low quality and one of moderate quality. The ROBIS evaluation results showed that 11 MAs/SRs were at high risk and nine at low risk of bias. The PRISMA 2020 report quality showed the included studies had scores between 23.5 and 35.5, among them one with high quality, 17 with moderate quality and two with low quality. The GRADE system results showed that among 126 outcome indicators, only 17 had moderate quality of evidence, 27 had low quality, 82 had very low quality, and none had high quality.

CONCLUSIONS: The MAs/SRs methodological quality of using TCM for treatment RRTIs is generally poor, the quality of reports as well as of evidence is generally low, and the risk of bias is high; therefore we should treat these results with caution.

Key words： respiratory tract infections; child; medicine, Chinese traditional; Meta-analysis; systematic review; randomized controlled trial

Cite this article

Yasheng DENG , Siyin HAN , Lanhua XI , Hui HUANG , Tianwei LIANG , Yiqing ZHENG , Yanping FAN , Jiang LIN . Traditional Chinese Medicine in the treatment of recurrent respiratory tract infections in children: an overview of systematic reviews and Meta-analyses[J]. Journal of Traditional Chinese Medicine, 2024 , 44(5) : 871 -884 . DOI: 10.19852/j.cnki.jtcm.20240806.007

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