Advanced Search

Journal of Traditional Chinese Medicine >

2024 , Vol. 44 >Issue 4: 813 - 821

DOI: https://doi.org/10.19852/j.cnki.jtcm.20240515.004

Original articles

Study on the effect and mechanism of Yanghe decoction Huacai (阳和汤化裁) on tissue repair of Yin syndrome after anal fistula surgery

  • Yijuan WU ,
  • Xinghong SUN ,
  • Haixia GUO ,
  • Xiangan ZHANG
Expand
  • Department of Anorectology, the first Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China

Received date: 2023-02-02

  Accepted date: 2023-07-31

  Online published: 2024-05-15

Supported by

Special Research Project on Chinese Medicine in Henan Province(Clinical Observation of Yanghe Decoction on Tissue Repair after Anal Fistula Operation, 2017ZY2058);Henan Provincial Science and Technology Tackling Project(Effect and Mechanism of Yanghe Decoction on Tissue Repair after Anal Fistula Operation, 182102310289)

Fold

Abstract

OBJECTIVE: To observe the clinical efficacy and safety of Yanghe decoction Huacai (阳和汤化裁) for the repair of Yin syndrome wounds with slow-healing after anal fistula surgery.

METHODS: A total of 120 patients with slow-healing negative wounds with after low-grade anal fistula surgery who met the inclusion criteria were divided into a treatment group and a control group based on a random number table method, with 60 patients in the treatment group and 60 patients in the control group. The treatment group was given Yanghe decoction Huacai in combination with routine treatment; the control group was only given routine treatment, in which the wound surface was disinfected with iodine, and then covered with sterile gauze. The course of treatment in both groups was 10 d. After treatment, the wound secretion score, wound granulation tissue score, the expression levels of basic fibroblast growth factor (bFGF), transforming growth factor β1 (TGF-β1), and epidermal growth factor (EGF) in the wound, wound healing time and clinical efficacy were compared.

RESULTS: There was no significant difference in age or gender between the two groups (P > 0.05). On the 10th and 15th days after the surgery, the wound secretion scores were higher in the treatment group than in the control group (P < 0.01). Comparing the two groups at the 10th and 15th day after surgery, the granulation tissue growth scores in the treatment group were better than the in control group (P < 0.01). On the 10th and 15th day after operation, the expression levels of bFGF, TGF-β1 and EGF factors in the treatment group were stronger than those in the control group. The healing time of the wounds in the treatment group was significantly shorter than in the control group (P < 0.01). The clinical efficacy of the two groups after treatment was compared, and the overall efficacy of the treatment group was significantly higher than that of the control group (P < 0.01).

CONCLUSIONS: Yanghe decoction Huacai have significant efficacy in the treatment of slow-healing wounds with Yin syndrome after anal fistula surgery. It improves wound secretions, promotes the growth of wound granulation tissue, and shortens wound healing time. Its mechanism of action may be related to the control of wound inflammation. It is related to increasing the expression of bFGF, TGF-β1 and EGF in wound tissue, and promoting wound angiogenesis and fibroblast proliferation.

Key words： Yanghe decoction huacai; rectal fistula; general surgery; intercellular signaling peptides and proteins; negative wound; mechanism

Cite this article

Yijuan WU , Xinghong SUN , Haixia GUO , Xiangan ZHANG . Study on the effect and mechanism of Yanghe decoction Huacai (阳和汤化裁) on tissue repair of Yin syndrome after anal fistula surgery[J]. Journal of Traditional Chinese Medicine, 2024 , 44(4) : 813 -821 . DOI: 10.19852/j.cnki.jtcm.20240515.004

References

1. Jain SK, Kaza RC, Pahwa M, et al. Role of cyanoacrylate in the management of low fistula in ano: a prospective study. Int J Colorectal Dis 2008; 23: 355-8.
2. Farag AFA, Elbarmelgi MY, Mostafa M, et al. One stage fistulectomy for high anal fistula with reconstruction of anal sphincter without fecal diversion. Asian J Surg 2019; 42: 792-6.
3. García-Olmo D, Van Assche G, Tagarro I, et al. Prevalence of anal fistulas in Europe: systematic literature reviews and population-based database analysis. Adv Ther 2019; 36: 3503-18.
4. Schlichtemeier S, Tou S. Treatment for complex anal fistula, are we any wiser? Colorectal Dis 2018; 20: 1067-68.
5. Li X, Zhi C, Shi Y, et al. Research on high anal fistula: a bibliometric analysis. Ann Palliat Med 2021; 10: 11492-503.
6. Andreou C, Zeindler J, Oertli D, et al. Longterm outcome of anal fistula-a retrospective study. Sci Rep 2020; 10: 6483.
7. Zheng CJ, Wang YH. Advances in Chinese medicine research on postoperative trauma healing of anal fistula. Shi Jie Zhong Xi Yi Jie He Za Zhi 2014; 9: 207-9.
8. Guo S, Dipietro LA. Factors affecting wound healing. J Dent Res 2010; 89: 219-29.
9. Qiu JM, Yang GG, Wang HT, et al. Feasibility of ambulatory surgery for anal- fistula with LIFT procedure. BMC Gastroenterol 2019; 19: 81.
10. Li Q, Song JZ, Li H, et al. Effect of Ma Yinglong musk hemorrhoid cream on postoperative wound healing in patients with perianal abscess. Zhong Cheng Yao 2019; 41: 2547-49.
11. LU JH. Study on the effect of self-proposed muscle regeneration formula on wound healing of postoperative patients with anal fistula. Sichuan Zhong Yi 2015; 33: 128-30.
12. Li N, Hu YN, Wang XX, et al. Research progress on chemical composition, pharmacological effects and quality control of deer horn gum. Zhong Yao Cai 2021; 44: 1774-80.
13. Tang Y, Xiao D, Liu ZY, et al. Current status and perspectives of the research on turtle gum. Zhong Hua Zhong Yi Yao Za Zhi 2019; 34: 2593-98.
14. Hu HL, Xiao D, Wang L, et al. Study on the ameliorative effect of turtle shell gum on cyclophosphamide-induced anemia in rats. Zhong Yi Yao Xin Xi 2021; 38: 49-52.
15. Tang Y, Xiao D, He QH, et al. Effect of turtle shell gum on immune function in cyclophosphamide-induced immuno-compromised rats. Zhong Hua Zhong Yi Yao Za Zhi 2021; 36: 4681-86.
16. YAN FX, XIE YY, CHEN C, et al. Research progress on the changes of chemical composition and pharmacological effects of Radix Rehmanniae during concoction. Shi Zhen Guo Yi GuoYao 2021; 32: 2493-95.
17. Fei YY, Zhang Z, Chen XQ, Li W. Study on the inhibitory activity of cinnamon essential oil against enterohemorrhagic Escherichia coli O157:H7. Shi Pin Yu Fa Jiao Gong Ye 2022; 48: 63-7.
18. Cai HY, Li H, Li WH, et al. Effects of cinnamon on blood glucose and blood lipids in rats with kidney Yang deficiency. Zhong Hua Zhong Yi Yao Xue Kan 2021; 39: 105-8.
19. Zhao Y, Wang QB, Hao XC, et al. Research progress on the wound healing-promoting effect of Baihe. Zhong Yao Cai 2020; 43: 1027-31.
20. Duan YD, Yang L, Chai CZ, et al. Study on the effects of the main active components in Ephedra on primary dysmenorrhea model mice. Shi Jie Zhong Xi Yi Jie He Za Zhi 2018; 13: 344-7+ 52.
21. Baron JM, Baron JM, Glatz M, et al. Optimal support of wound healing: new insights. Dermatology 2020; 236: 593-600.
22. Mokoena D, Dhilip Kumar SS, Houreld NN, et al. Role of photobiomodulation on the activation of the Smad pathway via TGF-β in wound healing. J Photochem Photobiol B 2018; 189: 138-144.
23. Ruiz-Ca?ada C, Bernabé-García á, Liarte S, et al. Chronic wound healing by amniotic membrane: TGF-β and EGF signaling modulation in re-epithelialization. Front Bioeng Biotechnol 2021; 9: 689328.
24. Liu HY, Huang WL, Xiao WM, et al. Effect of negative pressure therapy on the number of microvessels and expression of PDGF and EGF in burn wounds of elderly patients with deep burns. Xi Bei Guo Fang Yi Xue Za Zhi 2017; 38: 608-13.
25. Chen ZC, Li J, Chen T. Clinical study on the treatment of residual wounds of II and III degree burns with hemopectin combined with basic fibroblast growth factor. Zhong Guo Yi Yao Dao Bao 2018; 15: 105-8.
26. Gonzalez AC, Costa TF, Andrade ZA, et al. Wound healing-a literature review. An Bras Dermatol 2016; 91: 614-20.
Options
Outlines

/

〈 〉