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Journal of Traditional Chinese Medicine >

2024 , Vol. 44 >Issue 2: 408 - 416

DOI: https://doi.org/10.19852/j.cnki.jtcm.20240203.002

Reviews

Complementary and alternative medicine on cognitive defects and neuroinflammation after sepsis

  • Zhenxuan LI ,
  • Xuerui WANG ,
  • Ulloa Luis ,
  • Youssef Ayman ,
  • Yunjing BAI ,
  • Xiaolong XU ,
  • Qingquan LIU
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  • 1 Department of Infectious Diseases, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China
    2 Beijing Key Laboratory of Basic Research with Traditional Chinese Medicine on Infectious Diseases, Beijing 100010, China
    3 Infection immunity laboratory, Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China
    4 Clinical College of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China
    5 Center for Perioperative Organ Protection, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA

Received date: 2023-01-22

  Accepted date: 2023-04-27

  Online published: 2024-02-03

Supported by

Youth Project of National Natural Science Foundation of China: the Mechanism Study of Shenfuhuang Formula on Cognitive Impairment and Synaptic Plasticity in Sepsis via IL-33/ST2 Pathway-mediated Microglial Polarization(82004292);Special Project of National Natural Science Foundation of China: Study on the Mechanism and Material Basis of Jinhua Qinggan Granules in Regulating the Cytokine Storm of Viral Pneumonia(82141202);The National Interdisciplinary Innovation Team of TCM under the State Administration of TCM(ZYYCXTD-D-202201);The Financial project of Beijing Municipal Health Commission: Study on Pharmacodynamic Mechanism of Traditional Chinese Medicine in Treating Viral Pneumonia

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Abstract

Sepsis-associated encephalopathy (SAE) is a common manifestation of sepsis, ranging from mild confusion and delirium to severe cognitive impairment and deep coma. SAE is associated with higher mortality and long-term outcomes, particularly substantial declines in cognitive function. The mechanisms of SAE probably include neuroinflammation that is mediated by systemic inflammation and ischemic lesions in the brain, a disrupted blood-brain barrier, oxidative stress, neurotransmitter dysfunction, and severe microglial activation. Increasing evidence suggests that complementary and alternative medicine, especially Traditional Chinese Medicine (TCM), is favorable in alleviating cognitive decline after sepsis. Here, we summarized the studies of traditional herbal remedies, TCM formulas and acupuncture therapy in animal models of neurological dysfunctions after sepsis in recent decades and reviewed their potential mechanisms.

Key words： sepsis-associated encephalopathy; cognitive dysfunction; complementary therapies; neuroinflammatory diseases; medicine, Chinese traditional; review

Cite this article

Zhenxuan LI , Xuerui WANG , Ulloa Luis , Youssef Ayman , Yunjing BAI , Xiaolong XU , Qingquan LIU . Complementary and alternative medicine on cognitive defects and neuroinflammation after sepsis[J]. Journal of Traditional Chinese Medicine, 2024 , 44(2) : 408 -416 . DOI: 10.19852/j.cnki.jtcm.20240203.002

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