Advanced Search

Journal of Traditional Chinese Medicine >

2024 , Vol. 44 >Issue 2: 388 - 395

DOI: https://doi.org/10.19852/j.cnki.jtcm.20240203.004

Effectivenss of electroacupuncture for skeletal muscle pain in Parkinson's disease: a Clinical randomized controlled trial

  • Shaosong WANG ,
  • Jingqing SUN ,
  • Qingyin FENG ,
  • Bin LI ,
  • Xin WANG ,
  • Fan YUAN ,
  • Yingxue CUI
Expand
  • Department of acupuncture, Beijing Hospital of Traditional Chinese Medicine, Beijing 100010, China

Received date: 2023-08-05

  Accepted date: 2023-12-12

  Online published: 2024-02-03

Supported by

The Droject of National Famous Old Chinese Medicine Experts Inheritance Studio Construction: the National Project of Taking Inheriting Experience of Prestigious Chinese Physicians Wang Linpeng(ZY202275)

Fold

Abstract

OBJECTIVE: To explore the effect of electroacupuncture on skeletal muscle pain in Parkinson's disease (PD).

METHODS: A single-center randomized controlled trial was conducted with sixty patients with Parkinson's disease with skeletal muscle pain were randomly divided into electroacupuncture group and sham acupuncture control group with 30 patients each. The electric acupuncture group was treated with electric acupuncture, while the control group was treated with Park needle pseudoacupuncture. Both groups were treated 5 times a week for a total of 4 weeks, and both groups completed 20 treatments. King's Parkinson's Pain Scale (KPPS) and visual analog scale (VAS) were used before and after treatment to evaluate the pain degree of patients. Real-time shear wave elastography (SWE) and modified Ashworth score (MAS) were used to evaluate the changes of muscle tone. Parkinson's comprehensive Score Scale (MDS-UPDRS, including UPDRSⅡ and UPDRS Ⅲ) was used to evaluate exercise ability. Hamilton Depression Scale (HAMD) score was used to evaluate the emotional changes of patients. Spearman correlation analysis was used to explore the correlation between pain degree and muscle tone, exercise ability and emotion.

RESULTS: During the study, one case fell off in the control group, and 30 cases were eventually included in the analysis and treatment group and 29 cases in the control group. After treatment, Young's modulus of biceps and quadriceps and shear wave velocity of biceps were decreased in electroacupuncture group compared with before treatment, while KPPS score, VAS score, UPDRSⅡ, UPDRS Ⅲ and modified Ashworth score were decreased, with statistical significance (P < 0.05). There was no statistical significance in control group (P > 0.05). After treatment, KPPS score, VAS score, UPDRSⅡ and UPDRS Ⅲ, MAS, HAMD score, Young's modulus of biceps and shear wave velocity in electroacupuncture group were significantly lower than those in control group (P < 0.05). Spearman correlation analysis showed that KPPS score was positively correlated with UPDRS Ⅲ (r = 0.414, P < 0.05). KPPS score was positively correlated with HAMD score (r = 0.576, P < 0.01).

CONCLUSION: Electroacupuncture therapy can effectively improve skeletal muscle pain in patients with Parkinson's disease, reduce the muscle hardness of patients, improve patients' daily life ability, and improve patients' emotional disorders. The degree of skeletal muscle pain in PD patients is correlated with motor ability and emotional disorders, but there is no significant correlation between the degree of skeletal muscle pain and the muscle tone of PD patients.

Key words： Parkinson disease; muscle, skeletal, pain; electroacupuncture; muscle tention; mood disorders; randomized controlled trial

Cite this article

Shaosong WANG , Jingqing SUN , Qingyin FENG , Bin LI , Xin WANG , Fan YUAN , Yingxue CUI . Effectivenss of electroacupuncture for skeletal muscle pain in Parkinson's disease: a Clinical randomized controlled trial[J]. Journal of Traditional Chinese Medicine, 2024 , 44(2) : 388 -395 . DOI: 10.19852/j.cnki.jtcm.20240203.004

References

1. Antonini A, Tinazzi M. Targeting pain in Parkinson’s disease. Lancet Neurol 2015; 14: 1144-5.
2. Silverdale MA, Kobylecki C, Kass-Iliyya L, et al. A detailed clinical study of pain in 1957 participants with early/moderate Parkinson’s disease. Parkinsonism Relat Disord 2018; 56: 27-32.
3. Ernst M, Folkerts AK, Gollan R, et al. Physical exercise for people with Parkinson's disease: a systematic review and network Meta-analysis. Cochrane Database Syst Rev 2023; 1: CD013856.
4. Kim YE, Kim HJ, Yun JY, et al. Musculoskeletal problems affect the quality of life of patients with Parkinson’s disease. J Movem Disord 2018; 11: 133-8.
5. Tueth LE, Duncan RP. Musculoskeletal pain in Parkinson’s disease: a narrative review. Neurodegener Dis Manag 2021; 11: 373-85.
6. Kim YE, Lee WW, Yun JY, Yang HJ, Kim HJ, Jeon BS. Musculoskeletal problems in Parkinson’s disease: neglected issues. Parkinsonism Relat Disord 2013; 19: 666-9.
7. Chaudhuri KR, Rizos A, Trenkwalder C, et al. King’s Parkinson’s disease pain scale, the first scale for pain in PD: an international validation. Mov Disord 2015; 30: 1623-31.
8. Butera KA, Roff SR, Buford TW, Cruz-Almeida Y. The impact of multisite pain on functional outcomes in older adults: biopsychosocial considerations. Pain Res 2019; 12: 1115-25.
9. Wasner G, Deuschl G. Pains in Parkinson disease-many syndromes under one umbrella. Nat Rev Neurol 2012; 8: 284-94.
10. Deuel LM, Seeberger LC. Complementary therapies in Parkinson disease: a review of acupuncture, Taichi, Qigong, Yoga, and Cannabis. Neurotherapeutics 2020, 17: 1434-55.
11. Jang JH, Yeom MJ, Ahn S. Acupuncture inhibits neuroinflammation and gut microbial dysbiosis in a mouse model of Parkinson's disease. Brain Behav Immun 2020; 89: 641-55.
12. Fan JQ, Lu WJ, Tan WQ. Acupuncture for Parkinson's disease: from theory to practice. Biomed Pharmacother 2022; 149: 112907.
13. Wang S, Guo J, Feng Q, et al. Effectivenss of “Rou Jin Zhi Tong” needling on the treatment of patients with Parkinson's disease accompanied by different types of pain. Zhong Yi Za Zhi 2021; 62: 609-14.
14. Parkinson's disease and movement disorders group, Chinese society of neurology; Chinese medical doctor association, branch of neurology, Parkinson's disease and movement disorders. Diagnostic criteria of Parkinson's disease in China (2016 edition). Zhong Hua Shen Jing Ke Za Zhi 2016; 49: 268-71.
15. Lyu Y, Cheng J, Fan B, et al. ICD-11 classification of chronic pain Chinese compiled version. Zhong Guo Teng Tong Yi Xue Za Zhi 2018; 24: 801-5.
16. Li J, Zhu B, Gu Z, et al. Musculoskeletal pain in Parkinson’s disease. Front Neurol 2022; 12: 756538.
17. He P. Clinical application of acupuncture and moxibustion “He Shi San Tong” Method (TCM master He Puren's acupuncture and moxibustion heart method series). Beijing: People's Medical Publishing House, 2014: 77-8.
18. Institute of acupuncture and moxibustion, China academy of Chinese medical sciences. Name and location of meridian points. Beijing: State Administration for Market Regulation, Standardization Administration, 2021: 8, 10, 19, 14, 15, 37, 38.
19. Feng S, Li B, Zhang H, et al. Placebo control and methodological problems in acupuncture clinical trials. Zhong Guo Zhen Jiu 2021, 42: 437-41.
20. Martinez-Martin P, Rizos AM, Wetmore J, et al. First comprehensive tool for screening pain in Parkinson’s disease: the King's Parkinson's disease pain questionnaire. Eur J Neurol 2018; 25: 1255-61.
21. Li Q. Technical progress of ultrasonic shear wave elastography. Zhong Guo Yi Liao She Bei 2017; 32: 101-5.
22. Feng Y. Clinical anesthesia series:pain volume. Beijing: Peking University Medical Press, 2010: 24-5.
23. Goetz CG, Stebbins GT, Chmura TA, Fahn S, Poewe W, Tanner CM. Teaching program for the movement disorder society‐sponsored revision of the unified Parkinson's disease rating scale: (MDS‐UPDRS). Movem Disord 2010; 25: 1190-4.
24. Rw B, Smith M. Interrater reliability of a modified ashworth scale of muscle spasticity. Phys Ther 1987; 67: 206-7.
25. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gener Psychiat 1961; 4: 561-71.
26. Antonini A, Barone P, Marconi R, et al. The progression of non-motor symptoms in Parkinson’s disease and their contribution to motor disability and quality of life. J Neurol 2012; 259: 2621-31.
27. Aarsland D, Br?nnick K, Alves G, et al. The spectrum of neuropsychiatric symptoms in patients with early untreated Parkinson's disease. J Neurol Neurosurg Psychiatry 2009; 80: 928-30.
28. Cai L. Clinical assessment of pain symptoms and associated factor analysis. In: Neurology Professional Committee of Jiangxi Society of Integrated Traditional Chinese and Western Medicine, editors. Compilation of papers of the eighth Academic Exchange meeting of Neurology Professional Committee of Jiangxi Society of Integrated Traditional Chinese and Western Medicine; 2019 May 31; Jiangxi, China. Nanchang: Neurology Professional Committee of Jiangxi Society of Integrated Traditional Chinese and Western Medicine, 2019: 4-5.
Options
Outlines

/

〈 〉