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Journal of Traditional Chinese Medicine >

2023 , Vol. 43 >Issue 5: 1026 - 1033

DOI: https://doi.org/10.19852/j.cnki.jtcm.2023.05.006

Xiaoyi Yusi decoction (消异育嗣汤) improves in vitro fertilization and embryo transfer outcomes in patients with endometriosis

  • Wenjing JIANG ,
  • Huaying JIANG ,
  • Lihua YUAN ,
  • Yuanhong SA ,
  • Jimei XIAO ,
  • Hongqi SUN ,
  • Jingyan SONG ,
  • Zhengao SUN
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  • 1 First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan 250014, China
    2 Emergency Department, Laizhou Maternal and Child Health Hospital of Shandong, Laizhou 261400, China
    3 College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250014, China
    4 Reproductive and Genetic Center of Integrated Traditional and Western Medicine, the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, China
    5 Department of Traditional Chinese Medicine, Qingyun County Maternity and Child Health Care Hospital of Dezhou, Qingyun 253799, China
    6 Reproductive Center of Heze Hospital of Traditional Chinese Medicine, Heze 274000, China
    7 Zhengzhou Key Laboratory of Children's Infection and Immunity, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou 450000, China
    8 Reproductive and Genetic Center of Integrated Traditional and Western Medicine, the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250011, China
    9 College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250014, China

Received date: 2022-05-23

  Accepted date: 2022-08-12

  Online published: 2023-08-29

Supported by

National Natural Science Fund Project: A Theoretical Study of Renal Reproduction Based on in vitro Fertilization Follicular Fluid Differential Protein-metabolite Global Regulatory Network(81874484)

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Abstract

OBJECTIVE: To investigate the effect of — Xiaoyi Yusi decoction (XYYSD, 消异育嗣汤), a Traditional Chinese Medicine (TCM), on in vitro fertilization and embryo transfer (IVF-ET) in patients with endometriosis, and to study the mechanism underpinning the action.
METHODS: Women who underwent IVF-ET were divided into three groups by simple randomization: the treatment (n = 32; with TCM treatment), patient (n = 28; with endometriosis alone), and control (n = 33; with male factor alone) groups. The luteal phase short-acting gonadotropin-releasing hormone agonist prolonged protocol was used in all three groups. To compare the changes in TCM scores and reproductive outcomes before and after TCM intervention in patients with endometriosis, partial least-squares discriminant analysis was used to analyze the follicular fluid samples of each group and screen and compare metabolites using the MetaboAnalyst software.
RESULTS: The clinical data indicated that following TCM intervention, kidney deficiency and blood stasis symptom patterns improved dramatically in patients with endometriosis and that their clinical pregnancy rate increased significantly (71.9% vs 57.1%, P < 0.05). Metabolomics showed that the two groups of samples were separated before and after TCM intervention. After TCM intervention, the intervention group was close to the control group, indicating that the TCM had a certain effect. Pathway analysis revealed that after TCM intervention, the metabolism of glycerin phospholipid, pyruvate, and citric acid was regulated.
CONCLUSIONS: Through the pyruvate and glycerophospholipid metabolism pathways and tricarboxylic acid cycle, the TCM XYYSD successfully improved kidney deficiency and blood stasis symptom pattern, as well as the clinical reproductive outcomes of patients with endometriosis-related infertility.

Key words： endometriosis; infertility; metabolomics; kidney deficiency; blood stasis; fertilization in vitro; embryo transfer; Xiaoyi Yusi decoction

Cite this article

Wenjing JIANG , Huaying JIANG , Lihua YUAN , Yuanhong SA , Jimei XIAO , Hongqi SUN , Jingyan SONG , Zhengao SUN . Xiaoyi Yusi decoction (消异育嗣汤) improves in vitro fertilization and embryo transfer outcomes in patients with endometriosis[J]. Journal of Traditional Chinese Medicine, 2023 , 43(5) : 1026 -1033 . DOI: 10.19852/j.cnki.jtcm.2023.05.006

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