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Journal of Traditional Chinese Medicine >

2023 , Vol. 43 >Issue 4: 686 - 694

DOI: https://doi.org/10.19852/j.cnki.jtcm.2023.04.005

Analgesic efficacy of median nerve stimulation in mice with chemotherapy-induced peripheral neuropathy via modulation of brain-derived neurotrophic factor expression

  • Kang Dong-Wook ,
  • Choi Jae-Gyun ,
  • Ju Song Hee ,
  • Kim Jaehyuk ,
  • Lee Miae ,
  • Kim Taehee ,
  • Kang Suk-Yun ,
  • Ryu Yeonhee ,
  • Seung Yoo Hwa ,
  • Sun Lee Jin ,
  • Bong Park Jin ,
  • Do Lee Sang ,
  • Kim Hyun-Woo
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  • 1 Department of Physiology and Medical Science, College of Medicine and Brain Research Institute, Chungnam National University, Daejeon 35015, Republic of Korea
    2 KM Fundamental Research Division Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea
    3 East-West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University, Daejeon 35234, Republic of Korea
    4 Department of Surgery, Chungnam National University Hospital, Daejeon 35015, Republic of Korea
    5 Laboratory of Veterinary Pharmacology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea

Received date: 2021-12-16

  Accepted date: 2022-08-03

  Online published: 2023-07-03

Supported by

“Korea Health Technology R & D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health and Welfare, Republic of Korea(HI15C0007);“Chungnam National University, and Basic Science Research Program through the National Research Foundation of Korea(2021R1F1A1062509);Study on the Angiotensin Converting Enzyme Inhibitor (ACEi)-related Pain Mechanism by Mediating Substance P, Bradykinin and Angiotensin II Activities(2021R1A6A3A01086598);Study on the Role and Interaction Mechanisms of BDNF and APE1/Ref-1 in Animal Models of Chronic Pain Accompanied with Depression

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Abstract

OBJECTIVE: Chemotherapeutic agents such as docetaxel (DTX) can trigger chemotherapy-induced peripheral neuropathy (CIPN), which is characterized by unbearable pain. This study was designed to investigate the analgesic effect and related neuronal mechanism of low-frequency median nerve stimulation (LFMNS) on DTX-induced tactile hypersensitivity in mice.

METHODS: To produce CIPN, DTX was administered intraperitoneally 4 times, once every 2 d, to male ICR mice. LFMNS was performed on the wrist area, and the pain response was measured using von Frey filaments on both hind paws. Western blot and immunofluorescence staining were performed using dorsal root ganglion and spinal cord samples to measure the expression of brain-derived neurotrophic factor (BDNF).

RESULTS: Repeated LFMNS significantly attenuated the DTX-induced abnormal sensory response and suppressed the enhanced expression of BDNF in the DRG neurons and spinal dorsal area.

CONCLUSIONS: LFMNS might be an effective non-pharmaceutical option for treating patients suffering from CIPN via regulating the expression of peripheral and central BDNF.

Key words： analgesia; brain-derived neurotrophic factor; chemotherapy-induced peripheral neuropathy; docetaxel; nerve stimulation

Cite this article

Kang Dong-Wook , Choi Jae-Gyun , Ju Song Hee , Kim Jaehyuk , Lee Miae , Kim Taehee , Kang Suk-Yun , Ryu Yeonhee , Seung Yoo Hwa , Sun Lee Jin , Bong Park Jin , Do Lee Sang , Kim Hyun-Woo . Analgesic efficacy of median nerve stimulation in mice with chemotherapy-induced peripheral neuropathy via modulation of brain-derived neurotrophic factor expression[J]. Journal of Traditional Chinese Medicine, 2023 , 43(4) : 686 -694 . DOI: 10.19852/j.cnki.jtcm.2023.04.005

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