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Journal of Traditional Chinese Medicine >

2023 , Vol. 43 >Issue 3: 582 - 587

DOI: https://doi.org/10.19852/j.cnki.jtcm.20230208.001

Effectiveness of Traditional Chinese Medicine on coronavirus disease 2019 in 92 patients: a retrospective study

  • Guihua XU ,
  • Feifei CHEN ,
  • Wei ZHANG ,
  • Yingen WU ,
  • Xiaorong CHEN ,
  • Kehua SHI ,
  • Zhenwei WANG ,
  • Miaoyan SHI ,
  • Xing ZHANG ,
  • Yunfei LU ,
  • Weian YUAN ,
  • Hua LYU ,
  • Xuan CHEN
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  • 1 Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    2 Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
    3 Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China
    4 Shanghai Hospital of Traditional Chinese Medicine, Shanghai 200071, China
    5 Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai 200437, China

Received date: 2022-01-21

  Accepted date: 2022-04-10

  Online published: 2023-02-08

Supported by

Shanghai Science and Technology Committee, Clinical Study on the Treatment of COVID-19 with Traditional Chinese Medicine(2041195020002);Shanghai Infectious Disease Prevention and Treatment Ability Cultivation Project of Traditional Chinese Medicine(ZYYB-NLPY-09);Shanghai Infectious Disease Prevention and Treatment Ability Cultivation Project of Traditional Chinese Medicine(ZYYB-NLPY-15);Shanghai Key Clinical Specialty(shslczdzk05101);Shanghai Key Clinical Laboratory of Traditional Chinese Medicine(20dz2272200);Shanghai Health Commission, Shanghai Chinese Medicine Administration Emergency Scientific Research Project, Clinical Study on Prevention and Treatment of New Coronavirus Pneumonia with Integrated Chinese And Western Medicine(2020YJ01)

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Abstract

OBJECTIVE: To investigate the antipyretic effect of early treatment with Traditional Chinese Medicine (TCM) on coronavirus disease 2019 (COVID-19) patients.

METHODS: We retrospectively analyzed 369 patients from January 26th, 2020 to April 15th, 2020, who had been diagnosed with COVID-19. Among 92 eligible cases, 45 cases were identified as treatment group Ⅰ (n = 45) and 47 cases were identified as treatment group Ⅱ. Patients in the treatment group Ⅰ were treated with TCM herbal decoction within 5 d after admission. Patients in the treatment group Ⅱ were treated with TCM herbal decoction after the 6th admission day. The onset time of antipyretic effect, the antipyretic time, the time of negative oropharyngeal swab nucleic acid conversion, and the changes of cell count in blood routine test were compared.

RESULTS: The treatment group I showed shorter average antipyretic duration (4 vs 7 d; P<0.05), and shorter average time for polymerase chain reaction (PCR) nucleic acid test results to turn negative (7 vs 11 d; P<0.05) than the treatment group II. For patients (n = 54) with body temperature>38 ℃, patients in the treatment group I had shorter median onset time of antipyretic effect than those in the treatment group II (3 vs 4 d; P<0.05). The absolute lymphocyte (LYMPH) count and absolute eosinophil (EOS) count on the 3rd day after admission and the neutrophil/lymphocyte ratio on the 6th day after admission of patients in the treatment group I were notably different from those in the treatment group II at the same time point (P <0.05). Based on Spearman's rank correlation analysis, the change of body temperature on the 3rd day after admission was positively correlated with the increase of EOS count and the increase of EOS count and LYMPH counts on the 6th day after admission (P <0.01).

CONCLUSIONS: Early TCM intervention within 5 d after hospital admission shortened the onset time of antipyretic effect and fever duration of COVID-19 patients, reduced the time required for PCR test results to turn negative. Moreover, early TCM intervention also improved the results of inflammatory markers for COVID-19 patients. LYMPH and EOS counts can be used as indicators of TCM antipyretic effect.

Key words： COVID-19; medicine, Chinese traditional; antipyretics; immune-inflammatory parameters; retrospective studies

Cite this article

Guihua XU , Feifei CHEN , Wei ZHANG , Yingen WU , Xiaorong CHEN , Kehua SHI , Zhenwei WANG , Miaoyan SHI , Xing ZHANG , Yunfei LU , Weian YUAN , Hua LYU , Xuan CHEN . Effectiveness of Traditional Chinese Medicine on coronavirus disease 2019 in 92 patients: a retrospective study[J]. Journal of Traditional Chinese Medicine, 2023 , 43(3) : 582 -587 . DOI: 10.19852/j.cnki.jtcm.20230208.001

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