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Journal of Traditional Chinese Medicine >

2013 , Vol. 33 >Issue 01: 98 - 102

DOI: https://doi.org/10.1016/s0254-6272(13)60108-9

Mailuoning prevents high-glucose-mediated human umbilical vein endothelial cells apoptosis

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  • Department of Ophthalmonogy, Jiangsu Province Hospital on Integration of Chinese and Western Medicine;Department of Endocrinology, Jiangsu Province Hospital on Integration of Chinese and Western Medicine;Laboratory of Cellular and Molecular Biology, Jiangsu Province Academy of Traditional Chinese Medicine;

Accepted date: 2013-02-15

  Online published: 2013-02-15

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Abstract

OBJECTIVE: To investigated the role of Mailuoning in the prevention of high-glucose-mediated ce apoptosis in human umbilical vein endothelial cell (HUVEC) and the mechanisms involved. METHODS: MTT assay was used to investigate ce viability, western blot was used to investigate pro tein expression, and flow cytometric detection technology was used to detect cell apoptosis. RESULTS: Exposure of HUVEC to high glucose (50 mM) significantly suppressed cell viability and increased cell apoptosis compared with normal glu cose (11 mM) (all P

Key words： Umbilical veins, Endothelial cells, Mailu-oning, Diabetes complications, Hyperglycemia, Apoptosis, p38 mitogen-activated protein kinases

Cite this article

Wei Wang, Chao Liu, Jie Yang, Xueting Cai, Wuguang Lu, Zhenhua Gu, Peng Cao . Mailuoning prevents high-glucose-mediated human umbilical vein endothelial cells apoptosis[J]. Journal of Traditional Chinese Medicine, 2013 , 33(01) : 98 -102 . DOI: 10.1016/s0254-6272(13)60108-9

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