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Journal of Traditional Chinese Medicine ›› 2013, Vol. 33 ›› Issue (01): 98-102.DOI: 10.1016/s0254-6272(13)60108-9

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Mailuoning prevents high-glucose-mediated human umbilical vein endothelial cells apoptosis

Wei Wang, Chao Liu, Jie Yang, Xueting Cai, Wuguang Lu, Zhenhua Gu, Peng Cao   

  1. Department of Ophthalmonogy, Jiangsu Province Hospital on Integration of Chinese and Western Medicine;Department of Endocrinology, Jiangsu Province Hospital on Integration of Chinese and Western Medicine;Laboratory of Cellular and Molecular Biology, Jiangsu Province Academy of Traditional Chinese Medicine;
  • Accepted:2013-02-15 Online:2013-02-15 Published:2013-02-15

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Abstract: OBJECTIVE: To investigated the role of Mailuoning in the prevention of high-glucose-mediated ce apoptosis in human umbilical vein endothelial cell (HUVEC) and the mechanisms involved. METHODS: MTT assay was used to investigate ce viability, western blot was used to investigate pro tein expression, and flow cytometric detection technology was used to detect cell apoptosis. RESULTS: Exposure of HUVEC to high glucose (50 mM) significantly suppressed cell viability and increased cell apoptosis compared with normal glu cose (11 mM) (all P

Key words: Umbilical veins, Endothelial cells, Mailu-oning, Diabetes complications, Hyperglycemia, Apoptosis, p38 mitogen-activated protein kinases

Cite this article

Wei Wang, Chao Liu, Jie Yang, Xueting Cai, Wuguang Lu, Zhenhua Gu, Peng Cao. Mailuoning prevents high-glucose-mediated human umbilical vein endothelial cells apoptosis[J]. Journal of Traditional Chinese Medicine, 2013, 33(01): 98-102.