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Journal of Traditional Chinese Medicine >

2022 , Vol. 42 >Issue 3: 426 - 431

DOI: https://doi.org/10.19852/j.cnki.jtcm.2022.03.009

Research Article

Phytochemical analysis and inhibitory effects of Calligonum polygonoides on pancreatic α-amylase and β-glucosidase enzymes

  • Ahmed Mushtaq ,
  • Sher Naila ,
  • Mushtaq Nadia ,
  • Ali Khan Rahmat
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  • 1 Department of Biotechnology, Faculty of Biological Sciences, University of Science & Technology, Bannu 28100, KPK-Pakistan
    2 Department of Botany, Faculty of Biological Sciences, University of Science & Technology, Bannu 28100, KPK-Pakistan
Prof. Mushtaq Ahmed, Chairman Department of Biotechnology, University of Science and Technology, Bannu, 28100 Khyberpakhtunkhwa.mushtaq213@yahoo.com,Telephone: +9292-8633425

Received date: 2021-01-11

  Accepted date: 2021-03-28

  Online published: 2022-05-20

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Abstract

OBJECTIVES: To estimate the existence of phyto-chemicals and then to determine the antidiabetic activity against α-amylase and β-glucosidase inhibition in vitro.

METHODS: The study was carried out by following standard procedures.

RESULTS: Phytochemicals analysis indicated the presence of different phytochemicals. The total phenolic content was 6.055 mg GAE/g and the total flavonoid content was 5.706 mg RU/g in the plant extract. The total saponins, alkaloids, and tannins contents were (0.044%), (2.88%) and (2.862 nm) respectively. α-amylase inhibition activity of Calligonum polygonoides (CP) extract was 70% with IC50 of 610 μg/mL and that of β-gluco-sidase inhibition activity was 65% with IC50 of 640 µg/mL.

CONCLUSION: The findings reported for the first time the antidiabetes-promoting effects of an extract of CP in vitro, thus validating their promising anti-diabetes potential.

Key words： Calligonum polygonoides; phytochemicals; alpha-amylases; beta-glucosidase

Cite this article

Ahmed Mushtaq , Sher Naila , Mushtaq Nadia , Ali Khan Rahmat . Phytochemical analysis and inhibitory effects of Calligonum polygonoides on pancreatic α-amylase and β-glucosidase enzymes[J]. Journal of Traditional Chinese Medicine, 2022 , 42(3) : 426 -431 . DOI: 10.19852/j.cnki.jtcm.2022.03.009

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