OBJECTIVE: To prospectively study the accuracy of the palliative prognostic index(PPI) survival prediction model combined with Traditional Chinese Medicine(TCM) syndrome differentiation.METHODS: The PPI survival prediction model was used to predict survival time. Patients' real survival time was recorded. The survival time was calculated using the Kaplan-Meier method, and the logrank method was used to test the difference.RESULTS: The average PPI survival prediction score of 227 patients was 5.83(95% CI: 5.29-6.37). There was a significant difference in the real-life period between the different PPI groups(P < 0.05). PPI group Ⅰ(predicted survival of > 6 weeks) showed the highest predictive sensitivity and PPI group Ⅱ(predicted survival of 3-6 weeks) showed the highest predictive specificity. According to TCM syndrome differentiation, 82 cases(36%) were diagnosed with liver and kidney Yin deficiency(typeⅣ). The actual survival time of type IV patients was significantly shorter than that of other types of patients(mean: 21.85 vs 28.70, P = 0.007). In group median survival time of type Ⅰ,the and 34 d, reⅣsp patients and other types was 25 ectively(P < 3 weeks, Ⅲthe whose predicted surv specificity of PPI survival prediction was higher in type patients.ⅣCONCLUSION: This study shows that the PPI predictive tool for survival rate has important value.TCM syndrome differentiation and typing has certain significance for further classification and survival prediction.