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Journal of Traditional Chinese Medicine ›› 2017, Vol. 37 ›› Issue (05): 650-658.

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Effect of acupuncture plus conventional treatment on brain activity in ischemic stroke patients: a regional homogeneity analysis

Wu Ping, Zeng Fang, Li Yongxin, Li Ji, Qiu Lihua, Qin Wei, Luo Lu, Yin Canxin, Xiong Yan, Bai Yu, Wang Dan, Zhou Yumei, Liang Fanrong   

  1. Department of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine;Institute of Clinical Anatomy, School of Basic Medical Sciences, Southern Medical University;Department of Acupuncture and Rehabilitation, The First Teaching Hospital, Chengdu University of Traditional Chinese Medicine;Radiology Department, West China Hospital of Sichuan University;Life Sciences Research Center, School of Life Sciences and Technology, Xidian University;China Academy of Chinese Medical Sciences;World Federation of Acupuncture-Moxibustion Societies;
  • Accepted:2017-10-15 Online:2017-10-15 Published:2022-04-04
  • Supported by:
    Supported by the National Natural Science Foundation of China(NSFC):Acupoint Sensitization Research(No.81590950), the State Key Program for Basic Research of China:Clinical Evaluation of the Basic Rules of Acupoint Specification and Basic Biological Study on CNS Targeting Integration(No.2012CB518501), NSFC:Study on the CNS Integration Mechanism of Spine-dredging Technique in Treating Ischemia Stroke(No.81072864)

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Abstract: OBJECTIVE: To determine differences in cerebral activity evoked by acupuncture and conventional stroke treatment, and identify the treatment targets.METHODS: In total, 21 patients were randomly divided into two groups. Group A(11 patients) received both acupuncture and conventional treatment, while group B(10 patients) received conventional treatment only. Resting-state functional magnetic resonance imaging(f MRI) was performed on each participant before and after treatment. Regional homogeneity analysis was performed to investigate the potential mechanism of acupuncture treatment by comparing differences in cerebral activity between treatments.RESULTS: Group A showed higher Re Ho in the frontal lobe(BA6, BA46), supra-marginal gyrus(BA40),middle temporal gyrus(BA21), cerebellum, and insula. Group B showed higher Re Ho in the frontal lobe(BA6) and parietal lobe(BA3, BA7).CONCLUSION: Acupuncture and conventional treatment triggered relatively different clinical efficacy and brain responses. Acupuncture treatment more significantly improved the symptoms of stroke patients. More marked changes in sensory,emotional, and motor areas(including the frontal lobe, middle temporal gyrus, cerebellum, and insula) might reflect the specific acupuncture mechanism.

Key words: Acupuncture, Magnetic resonance imaging, Stroke, Cerebral activity, Regional homogeneity analysis

Cite this article

Wu Ping, Zeng Fang, Li Yongxin, Li Ji, Qiu Lihua, Qin Wei, Luo Lu, Yin Canxin, Xiong Yan, Bai Yu, Wang Dan, Zhou Yumei, Liang Fanrong. Effect of acupuncture plus conventional treatment on brain activity in ischemic stroke patients: a regional homogeneity analysis[J]. Journal of Traditional Chinese Medicine, 2017, 37(05): 650-658.