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Journal of Traditional Chinese Medicine ›› 2026, Vol. 46 ›› Issue (5): 1240-1247.DOI: 10.19852/j.cnki.jtcm.2026.05.016

• Original Articles • Previous Articles     Next Articles

Role of Longgu (Os Draconis) in the compatibility of Chaihu Longgu Muli decoction (chaihulonggudulitang)

BAI Donghan1, XING Zi2, CHEN Shumin3, HUANG Nanxi4, WANG Qiaochu5, ZHANG Zihao5, XIN Xueying6, LUO Lu7,8()   

  1. 1 Department of Pharmacy, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
    2 Shandong Center for Food and Drug Evaluation & Inspection 16122 Jingshi Road, No., Jinan 250014, China
    3 Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China
    4 Department of Oncology, Georgetown University, Washington, DC 20057, United States
    5 Department of Biochemistry and Molecular and Cellular Biology, Georgetown University, Washington, DC 20057, United States
    6 Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    7 Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77030, United States
    8 Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
  • Received:2024-12-24 Accepted:2025-07-11 Online:2026-10-15 Published:2026-10-09
  • Contact: Dr. LUO Lu, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. lluo@icmm.ac.cn, Telephone: +86-17319300018
  • Supported by:
    National Natural Science Foundation of China: Study on the Antipyretic Material Basis and Mechanism of Raw Gypsum and Baihu Decoction Based on Metallomics and Gut Microbiota(82204610);Qihang Talent Program: Study on the in vitro and in vivo Metabolic Patterns of Arsenic from Realgar and Compound Huangdai Tablets and Its Effects on the Gut Microbiota in Rats(L2022046);Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences: Origin Identification and Quality Evaluation of Artificial Products and Artificially Optimized Products of Mineral Medicines(CI2021A04013);Fundamental Research Funds for the Central Public Welfare Research Institutes: Construction of a Natural Product Database against Pathogenic Microorganisms(ZZ15-YQ-041);Fundamental Research Funds for the Central Public Welfare Research Institutes: Construction of a Natural Product Database against Pathogenic Microorganisms(L2021029)

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Abstract:

OBJECTIVE: To investigate the role of Longgu (Os Draconis) in the physicochemical compatibility of Chaihu Longgu Muli decoction (chaihulonggudulitang).

METHODS: Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), high-performance liquid chromatography (HPLC), and ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) were used to determine particle size, polydispersity index, zeta potential, pH, viscosity, surface tension, and chemical components of the Chaihu Longgu Muli decoction and comparator decoctions.

RESULTS: It was discovered that Chaihu Longgu Muli decoction forms a smaller, more uniform, and stable particle structure. By comparing measurements of pH values, liquid viscosity coefficients, surface tension, and the yield of freeze-dried powder, it was concluded that this structure promotes the dissolution of components, indicating a more complex interaction than a simple physical mixture Using techniques such as FTIR, ultraviolet spectroscopy, HPLC, and UPLC-Q-TOF-MS, it was demonstrated that Longgu (Os Draconis) can synergistically interact with components such as triterpenoid saponins, phenolic acids, and flavonoids in herbal medicines through hydroxyl and carboxyl groups. These interactions do not affect the types of components in the system but contribute to the stability and dissolution of the components of Chaihu Longgu Muli decoction.

CONCLUSION: This research preliminarily reveals the role of Longgu (Os Draconis) in compound compatibility, offering insights for the modernization of Traditional Chinese Medicine and contributing to the theoretical framework of compound compatibility.

Key words: Longgu (Os Draconis), Chaihu (Radix Bupleuri Chinensis), Muli (Concha Ostreae), mineral medicine, Chinese medicine compatibility

Cite this article

BAI Donghan, XING Zi, CHEN Shumin, HUANG Nanxi, WANG Qiaochu, ZHANG Zihao, XIN Xueying, LUO Lu. Role of Longgu (Os Draconis) in the compatibility of Chaihu Longgu Muli decoction (chaihulonggudulitang)[J]. Journal of Traditional Chinese Medicine, 2026, 46(5): 1240-1247.