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Journal of Traditional Chinese Medicine ›› 2020, Vol. 40 ›› Issue (5): 738-748.DOI: 10.19852/j.cnki.jtcm.2020.05.003

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Effectiveness and safety of traditional Chinese medical therapy for cancer-related fatigue: a systematic review and Meta-analysis of randomized controlled trials

Zhao Yueyang, Wang Sumei, Li Jinhua, Zhou Yushu, Wu Wanyin, Swei Sunny Hann   

  1. Department of Hematology,Department of Medical Oncology, Laboratory of Tumor Biology, Guangdong Provincial Hospital of Chinese Medicine,The Second Clinical Medical College, Guangzhou University of Chinese Medicine;
  • Online:2020-10-15 Published:2020-10-15
  • Supported by:
    Supported by Grants from the Natural Science Foundation of China (No. 81903991,No. 81974543), the Natural Science Foundation of Guangdong Province (No. 2017A030310326,No. 2019A1515011362), the Guangzhou science and technology plan project (No. 201804010149,No.202002030155), the Chinese medicine science and technology research project of Guangdong Provincial Hospital of Chinese Medicine (No. YN2019MJ09), the Major Research Projects in First-class Disciplines of Guangzhou University of Chinese Medicine (No. A1260619111001), the Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome (No. ZH2020KF03)

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Abstract: OBJECTIVE: To assess the effectiveness and safety of traditional Chinese medical therapy for cancer-related fatigue.METHODS: We systematically searched eight electronic databases up to June 2017 for randomized clinical trials of traditional Chinese medical therapy for cancer-related fatigue. Two authors independently extracted data and assessed the risk bias of the included trials using the Cochrane Handbook.Data were analyzed by Rev Man 5.2 software.RESULTS: A total of 23 trials involving 1832 participants identified with cancer-related fatigue were included. Twenty trials reported a beneficial effect of traditional Chinese medical therapy on cancer-related fatigue. On pooling the data from Chinese herbal medicine therapy and acupuncture or moxibustion therapy, respectively, significant differences were found between experimental groups and control groups. Fatigue improvement rates showed significant differences between traditional Chinese medical therapy and control groups [odds ratio(OR), 7.62; 95% confidence interval(CI), 3.75-15.49;P < 0.000 01; and OR, 3.78; 95% CI, 2.29-6.23; P

Key words: Neoplasms, Fatigue, Medicine,Chinese Traditional, Quality of life, Systematic review, Randomized clinical trial

Cite this article

Zhao Yueyang, Wang Sumei, Li Jinhua, Zhou Yushu, Wu Wanyin, Swei Sunny Hann. Effectiveness and safety of traditional Chinese medical therapy for cancer-related fatigue: a systematic review and Meta-analysis of randomized controlled trials[J]. Journal of Traditional Chinese Medicine, 2020, 40(5): 738-748.