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Journal of Traditional Chinese Medicine ›› 2018, Vol. 38 ›› Issue (05): 787-796.

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Effects of Ziyin Jianghuo Ningxin decoction plus dehydroepiandrosterone and femoston in treatment of patients with menopausal symptoms

Lin Jing, Zhu Jun, Tian Fubo, Chen Lanting, Zhang Yang, Wang Yan, Wang Mingyan, Hans-Jürgen Gober, Li Dajin, Wang Ling   

  1. Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, IBS, Shanghai Medical College, Fudan University;Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases;The Academy of Integrative Medicine of Fudan University;Department of Obstetrics and Gynecology, Wenling People's Hospital, Wenzhou Medical University;Heilongjiang University of Chinese Medicine;Department of Pharmacy, Kepler University Clinic,Neuromed Campus;
  • Online:2018-10-15 Published:2018-10-15
  • Supported by:
    Supported by the National Natural Science Foundation of China(No.31571196), the Science and Technology Commission of Shanghai Municipality 2015 YIXUEYINGDAO project(No.15401932200), the FY2008 JSPS Postdoctoral Fellowship for Foreign Researchers P08471, the National Natural Science Foundation of China(No.30801502), the Shanghai Pujiang Program(No.11PJ1401900), Development Project of Shanghai Peak Disciplines-Integrative Medicine(No.20150407)

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Abstract: OBJECTIVE: To determine the therapeutic effect of Ziyin Jianghuo Ningxin Decoction(ZYJHNXD) plus dehydroepiandrosterone(DHEA) and menopausalhormone therapy(MHT) in patients suffering from menopausal symptoms identified as, in terms of Traditional Chinese Medicine, symptom pattern of Yin deficiency with hyperactive fire.METHODS: Totally 180 postmenopausal women aged 40 to 60 years were assigned into four groups and accepted femoston, femoston with ZYJHNXD,femoston with DHEA, femoston with ZYJHNXD and DHEA therapies, respectively, for three months.Common questionnaire-based measure instruments included modified Kupperman index(MKI),Hamilton Rating Scale for Anxiety(HAMA), and Hamilton Rating Scale for Depression(HAMD). Follicle-stimulating hormone(FSH), luteinizing hormone(LH), estradiol(E2), 5-hydroxyindole-3-acetic acid(5-HIAA), norepinephrine(NE), dopamine(DA),bone mineral density(BMD), and sleep quality were evaluated before and three months after the treatments.RESULTS: In all four groups, the scores of MKI, HAMA, HAMD and the levels of FSH, LH decreased significantly(P < 0.05) after the treatment, while the levels of E2, 5-HIAA, NE, and DA showed obvious elevation(P < 0.05). The group receiving ZYJHNXD and DHEA combined with femoston had superiority in the preservation of bone mineral density and improvement of total sleep time and nighttime sleep time over the other three groups.CONCLUSION: ZYJHNXD and DHEA combined with MHT therapy have a favorable outcome in managing menopausal symptoms, restoring hormone levels, preventing skeletal rarefaction or osteoporosis,and improving sleep quality for postmenopausal women.

Key words: Menopausal symptoms, Menopausal hormone therapy, Femoston,Ziyin Jianghuo Ningxin Decoction, Dehydroepiandrosterone

Cite this article

Lin Jing, Zhu Jun, Tian Fubo, Chen Lanting, Zhang Yang, Wang Yan, Wang Mingyan, Hans-Jürgen Gober, Li Dajin, Wang Ling. Effects of Ziyin Jianghuo Ningxin decoction plus dehydroepiandrosterone and femoston in treatment of patients with menopausal symptoms[J]. Journal of Traditional Chinese Medicine, 2018, 38(05): 787-796.