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Journal of Traditional Chinese Medicine ›› 2017, Vol. 37 ›› Issue (05): 616-620.

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Effectiveness of Xielikang capsules in treating HIV-related diarrhea by increasing the plasma concentration of interleukin-17

Zhang Xiaowei, Guo Huijun, Li Zhen, Xu Liran, Zhang Aiping, Ji Aiying   

  1. Department of Clinical Research Center of Acquired Immune Deficiency Syndrome Acquired Immune Deficiency Syndrome,The First Affiliated Hospital of Henan University of Traditional Chinese Medicine;Department of Obstetrics and Gynecology,Zhengzhou Hospital of Traditional Chinese Medicine;Department of Digestion, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine;
  • Accepted:2017-10-15 Online:2017-10-15 Published:2022-04-04
  • Supported by:
    Supported by Special Scientific Research Grant from The National Clinical Research Base of the National Administration of Traditional Chinese Medicine:Study on the Mechanism of Xielikang Capsules Based on the Intestinal Mucosal Immunity and Inflammation Injury(No.JDZX2012021), the National Special Science and Technology Program on Major Infectious Diseases:the Clinical Research Base of Acquired Immune Deficiency Syndrome Acquired Immune Deficiency Syndrome Prevention and Treatment With Traditional Chinese Medicine TCM(No.2012ZX10005010-001-002), Natural Science Foundation of Henan Province(No.162300410186), Henan Key Science and Technology Project(No.142102310511), Henan Traditional Chinese Medicine Research(No.2015ZY02096)

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Abstract: OBJECTIVE: To evaluate the efficacy of Xielikang capsules(XLKC) in the treatment of HIV-related diarrhea(HRD) and its effect on the plasma concentration of interleukin-17(IL-17).METHODS: This was a randomized, open-label, pos-itively-controlled clinical trial. Sixty-seven HRD patients were randomly assigned to two groups: one group was treated with XLKC(n = 35), the other with diosmectite(Smecta~?, n = 32). All patients were treated for 4 weeks. The HRD symptom scores were evaluated in each patient based on the frequency of diarrhea, and the quality and shape of the stool according to the Chinese Medicine Clinical Treatment of AIDS Program. The plasma concentration of IL-17 before and after treatment was measured with ELISA.RESULTS: Compared with the Smecta~? group, the XLKC group had a significantly reduced frequency of diarrhea and HRD symptom score regarding the quality and shape of stools(P < 0.05). The IL-17 concentration in the peripheral blood of the XLKC group was significantly increased after treatment,while the IL-17 concentration in the Smecta~? group significantly decreased after treatment.CONCLUSION: XLKC improves the symptoms of patients with HRD, and increases the plasma concentration of IL-17.

Key words: HIV, Acquired immunodeficiency syndrome, Diarrhea, Interleukin-17, Xielikang capsules

Cite this article

Zhang Xiaowei, Guo Huijun, Li Zhen, Xu Liran, Zhang Aiping, Ji Aiying. Effectiveness of Xielikang capsules in treating HIV-related diarrhea by increasing the plasma concentration of interleukin-17[J]. Journal of Traditional Chinese Medicine, 2017, 37(05): 616-620.