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Journal of Traditional Chinese Medicine ›› 2017, Vol. 37 ›› Issue (05): 567-587.

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Effect of Aidi injection plus transarterial chemoembolization on primary hepatic carcinoma: a systematic review and Meta-analysis

Shen Zhengjie, Gu Wenzhe, Cheng Haibo, Shen Weixing, Sun Dongdong, Zeng Yun, Tao Lihuiping, Wu Mianhua   

  1. First Clinical Medical College, Nanjing University of Chinese Medicine;Department of Medical Oncology, Zhangjiagang First People's Hospital;Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor,Nanjing University of Chinese Medicine;Translational Medicine Research Center, Nanjing University of Chinese Medicine;Department of Otolaryngology, Zhangjiagang Hospital of Traditional Chinese Medicine;Translational Medicine Research Center,Nanjing University of Chinese Medicine;Nanjing University of Chinese Medicine;Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine;Department of Medical Oncology, Jiangsu Cancer Hospital;
  • Accepted:2017-10-15 Online:2017-10-15 Published:2022-04-04
  • Supported by:
    Supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)SJZZ15_0119

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Abstract: OBJECTIVE: To assess the efficacy and safety of Aidi injection plus transarterial chemoembolization(TACE) in patients with primary hepatic carcinoma.METHODS: A comprehensive research of seven electronic databases was performed for comparative studies evaluating Aidi injection combined with TACE for primary hepatic carcinoma until September 2016. Two authors independently extracted data and assessed the methodological quality of the included trials using the Cochrane risk of bias tool from the Cochrane Handbook version 5.1.0. Data was synthesized by using Rev Man 5.3 software.RESULTS: Forty-nine studies involving 3435 patients met the inclusion criteria, most of which were low methodological quality. Compared with TACE alone, Aidi injection plus TACE can significantly improve the efficiency rate [RR = 1.33, 95% CI(1.24, 1.43), P < 0.000 01], clinical beneficial rate[RR = 1.25, 95% CI(1.17, 1.33), P < 0.000 01], survival rate [6 months, RR = 1.19, 95% CI(1.09, 1.29), P < 0.000 01], 18 months, [RR = 2.00, 95% CI(1.26,3.20), P < 0.004], 24 months, [RR = 1.44, 95% CI(1.22, 1.70), P < 0.0001], 36 months, [RR = 1.50, 95%CI(1.07, 2.11), P = 0.02 < 0.05], quality of life [RR =1.84, 95% CI(1.64, 2.05), P < 0.000 01] and immune function [CD3+, MD = 11.12, 95% CI(7.93, 14.30),P < 0.000 01], CD4 +, [MD = 10.37, 95% CI(7.29,13.45), P < 0.000 01], CD4+/CD8+, [MD = 0.30, 95%CI(0.07, 0.53), P = 0.01 < 0.05], NK, [MD = 7.49, 95%CI(6.64, 8.34), P < 0.000 01]. A significant improvement was also found in improvement of symptoms[RR = 1.64, 95%CI(1.38, 1.94), P < 0.000 01], leukopenia [RR = 0.60, 95% CI(0.54, 0.66), P < 0.000 01],thrombocytopenia [RR = 0.46, 95% CI(0.34, 0.61),P < 0.000 01], nausea and vomiting incidence [RR =0.66, 95% CI(0.54, 0.81), P < 0.0001), liver damage rate [RR = 0.57, 95% CI(0.42, 0.77), P = 0.0003 < 0.05].CONCLUSION: The results suggested that Aidi injection plus TACE significantly improve the clinical effect of TACE, and reduce the incidence of adverse events. However, rigorous multicenter trials with larger size are warranted to further confirm the findings.

Key words: Carcinoma,hepatocellular, Chemoembolization,therapeutic, Aidi injection, Review, Meta-analysis

Cite this article

Shen Zhengjie, Gu Wenzhe, Cheng Haibo, Shen Weixing, Sun Dongdong, Zeng Yun, Tao Lihuiping, Wu Mianhua. Effect of Aidi injection plus transarterial chemoembolization on primary hepatic carcinoma: a systematic review and Meta-analysis[J]. Journal of Traditional Chinese Medicine, 2017, 37(05): 567-587.