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Journal of Traditional Chinese Medicine ›› 2017, Vol. 37 ›› Issue (01): 64-75.

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Effect on platelet aggregation activity: extracts from 31 Traditional Chinese Medicines with the property of activating blood and resolving stasis

Chen Cen, Wang Fengqin, Xiao Wen, Xia Zhining, Hu Guang, Wan Jianbo, Yang Fengqing   

  1. School of Chemistry and Chemical Engineering, Chongqing University;School of Pharmacy and Bioengineering,Chongqing University of Technology;State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences,University of Macau;
  • Accepted:2017-02-15 Online:2017-02-15 Published:2022-04-04
  • Supported by:
    the National Natural Science Foundation of China(Magnetic Nanoparticles-based Cell Affinity Capillary Electrochromatography and Its Applications,No.21275169, Screening of Bioactive Compounds From Typical Huoxue Huayu Medicine by Platelet Based Capillary Electrochromatography,No.81202886), the Fundamental Research Funds for the Central Universities(Study on the Quality Control Method for the Animal Glue Medicine,No.CQDXWL-2012-028), the Chongqing Postdoctoral Funds(No.RC20120027)

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Abstract: OBJECTIVE: To evaluate the anti-platelet aggregation effects of extracts from 31 Traditional Chinese Medicines(TCM) with the property of activating blood and resolving stasis in terms of TCM theory.METHODS: The 31 TCMs extracts were prepared using water, 90% ethanol and ethyl acetate., and the effects on anti-platelet aggregation were tested on a platelet aggregation analyzer in vitro with adenosine 5'-diphosphate, bovine thrombin and arachi-donic acid(AA) as aggregation inducers, respectively. Aspirin was the positive control.RESULTS: Lots of the tested TCMs had inhibitory effects with concentration-dependent manner on platelet aggregations induced by various agonists.Especially, some of the TCMs such as Chuanxiong(Rhizoma Chuanxiong), Yanhusuo(Rhizoma Corydalis Yanhusuo) and Danshen(Radix Salviae Miltiorrhizae) showed good anti-platelet aggregation effect similar or higher than that in positive control group.CONCLUSION: The study provided scientific references that several TCMs such as Chuanxiong(Rhizoma Chuanxiong), Yanhusuo(Rhizoma Corydalis Yanhusuo) and Danshen(Radix Salviae Miltiorrhizae),possess the property of anti-platelet aggregation.

Key words: Platelet aggregation inhibitors, Adenosine diphosphate, Thrombin, Arachidonic acid, Blood activating stasis removing, Medicine, Chinese traditional

Cite this article

Chen Cen, Wang Fengqin, Xiao Wen, Xia Zhining, Hu Guang, Wan Jianbo, Yang Fengqing. Effect on platelet aggregation activity: extracts from 31 Traditional Chinese Medicines with the property of activating blood and resolving stasis[J]. Journal of Traditional Chinese Medicine, 2017, 37(01): 64-75.