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Journal of Traditional Chinese Medicine ›› 2016, Vol. 36 ›› Issue (02): 238-242.

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Correlation between the transdermal characteristics of pseudoephedrine and amygdalin in majiepingchuan in vitro

Kong Hui, Qu Huihua, Qu Baoping, Zeng Wenhao, Zhao Yan, Wang Xueqian, Wang Qingguo   

  1. School of Preclinical Medicine,Beijing University of Chinese Medicine;Center of Scientific Experiment, Beijing University of Chinese Medicine;School of Chinese Materia Medica, Beijing University of Chinese Medicine;School of Preclinical Medicine, Beijing University of Chinese Medicine;
  • Accepted:2016-04-15 Online:2016-04-15 Published:2022-04-05

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Abstract: OBJECTIVE: To analyze the transdermal profile of pseudoephedrine and amygdalin in the Traditional Chinese Medicine majiepingchuan in rat skin and to reveal their interaction.METHODS: A Franz diffusion cell was used in vitro to evaluate the transdermal parameters of cumulative transdermal flux(Q_(tot)), cumulative transmission(T_(tot)), and mean penetration rate(Kp) of pseudoephedrine and amygdalin in majiepingchuan. Linear regression analyses of Q_(tot)over time of pseudoephedrine vs amygdalin and their ratios was adopted for correlation evaluation.RESULTS: At 1, 2, 4, 6, and 8 h, the Q_(tot),T_(tot)and Kp of pseudoephedrine showed a good correlation with that of amygdalin.CONCLUSION: There was a small difference in theratios of Q_(tot), T_(tot)and Kp between pseudoephedrine and amygdalin, and a correlation between them.

Key words: Pseudoephedrine, Amygdalin, Ma jiepingchuan, Transdermal flux, Correlation

Cite this article

Kong Hui, Qu Huihua, Qu Baoping, Zeng Wenhao, Zhao Yan, Wang Xueqian, Wang Qingguo. Correlation between the transdermal characteristics of pseudoephedrine and amygdalin in majiepingchuan in vitro[J]. Journal of Traditional Chinese Medicine, 2016, 36(02): 238-242.