Abstract: OBJECTIVE:To assess the total and soluble oxalate contents of commonly used Chinese medicinal herbs.METHODS:Twenty-two Chinese medicinal herbs were extracted in both acid and water prior to determination of total and soluble oxalate,respectively.Oxalate was assayed in herbal extracts using a well-established enzymatic procedure.RESULTS:Among the 22 medicinal herbs,there was significant variation in oxalate content;Houttuynia cordata contained the highest amount of soluble oxalate(2146 mg/100 g) and Selaginella doederleinii contained the lowest amount(71 mg/100g).CONCLUSION:The results indicated that different Chinese medicinal herbs,even from the same family,contain significantly different amounts of oxalate.In susceptible individuals,the use of medicinal herbs with the highest oxalate contents could increase risk of kidney stone formation.

Key words: Drugs, Chinese herbal, Oxalates, Kidney calculi