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Journal of Traditional Chinese Medicine ›› 2012, Vol. 32 ›› Issue (04): 584-589.DOI: 10.1016/s0254-6272(13)60075-8

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Therapeutic potential of intravenous Xuebijing on transforming growth factor β_1 and procollagen type III peptide in patients with acute paraquat poisoning

Xuebing Zheng, Xiaoli Sun, Piyong Ma, Zhongming Liu, Nan Jiang   

  1. Department of Geriatric Medicine,China-Japan Union Hospital,Jilin University;Department of Emergency Medicine,China-Japan Union Hospital,Jilin University;College of Foreign Language,Changchun University of Science and Technology;
  • Accepted:2012-12-15 Online:2012-12-15 Published:2012-12-15

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Abstract: OBJECTIVE:Paraquat(PQ) poisoning-induced pulmonary fibrosis causes asphyxiation and death.The therapeutic potential of intravenous Xuebijing therapy in PQ poisoning patients and its underlying immunomodulatory effects on transforming growth factor(TGF)-β1 and procollagen type III peptide(PIIIP) were investigated.METHODS:Thirty-six acute PQ poisoning patients were randomly assigned to conventional therapy(Group A) and intravenous Xuebijing administration plus conventional therapy(Group B).Twenty volunteers served as controls(Group C).Blood samples were collected upon admission(day 0) and at post-treatment days 5,10,and 14.TGF-β1 and PIIIP concentrations were determined by ELISA and analyzed for intra-and inter-group differences over time.One-month follow-up was conducted for determining the mortality rate.RESULTS:TGF-β1 and PIIIP levels were significantly higher in PQ poisoning patients and increased over time(Groups A and B vs C,P

Key words: Paraquat, Poisoning, Receptors,transforming growth factor beta, Peptides, Xuebijing,intravenous

Cite this article

Xuebing Zheng, Xiaoli Sun, Piyong Ma, Zhongming Liu, Nan Jiang. Therapeutic potential of intravenous Xuebijing on transforming growth factor β_1 and procollagen type III peptide in patients with acute paraquat poisoning[J]. Journal of Traditional Chinese Medicine, 2012, 32(04): 584-589.