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Journal of Traditional Chinese Medicine ›› 2012, Vol. 32 ›› Issue (02): 243-248.DOI: 10.1016/s0254-6272(13)60019-9

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Effects of hydroxy safflower Yellow-A on tumor capillary angiogenesis in transplanted human gastric adenocarcinoma BGC-823 tumors in nude mice

Xi Sheng Yan , Zhang Qian , Liu Chao Yang , Jie Hua , Yue Li Feng , Gao Xue Min   

  1. Department of Traditional Chinese Medicine of Medical College of Xiamen University;School of Basic Medical Sciences of Beijing University of Chinese Medicine;Tumor research center,Cancer Hospital of Chinese Academy of Medical Sciences;
  • Accepted:2012-06-15 Online:2012-06-15 Published:2012-06-15

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Abstract: OBJECTIVE:To study the effects of hydroxy safflower yellow A(HSYA) on tumor capillary angiogenesis in transplanted human gastric adenocarcinoma BGC-823 tumors in nude mice.METHODS:BGC-823 cells were injected subcutaneously into the right anterior armpit of nude mice to establish an animal model of transplanted tumors.After 24 h,18 nude mice injected with tumor cells were randomized into model,control,and HSYA 0.028 g/L groups,with six mice in each group.Transplanted tumors were excised on day 20.Tumor inhibition ratios were calculated for the transplanted tumors.Pathological changes and capillary angiogenesis in the tumors were observed by light microscopy.RESULTS:Tumors in the model group grew more quickly than those in the control and HSYA groups,with inhibition ratios of 48% and 30%,respectively.The microvessel count in the HSYA group was lower than in the model group(P

Key words: Hydroxy safflower yellow-A(HSYA), Transplantation tumor, BGC-823, CD34, MVD, Tumor capillary angiogenesis

Cite this article

Xi Sheng Yan , Zhang Qian , Liu Chao Yang , Jie Hua , Yue Li Feng , Gao Xue Min. Effects of hydroxy safflower Yellow-A on tumor capillary angiogenesis in transplanted human gastric adenocarcinoma BGC-823 tumors in nude mice[J]. Journal of Traditional Chinese Medicine, 2012, 32(02): 243-248.