Abstract: OBJECTIVE:To study the use of a bone-strengthening pill to treat ischemic necrosis of the femoral head.METHODS:A model of castration in rats with osteoporosis and a model of ischemic necrosis in the bilateral femoral heads of young rats were used to detect bone density,bone formation measurements,lipid deposition in the femoral head,the distribution of capillaries in the femoral head and other relevant biochemical indices.RESULTS:In model rats,bone-strengthening pills were able to increase the bone density,the unit volume of bony trabeculae,the width of bony trabeculae,and the unit volume of the bony cortex.They could also enhance the mineral apposition rate in the femoral head and the seam width of osteoid deposition.Furthermore,there was a reduction in lipid deposition in the femoral head,and enriched distribution of arteries in the femoral head.Bone-related biochemical detections showed an increase in alkaline phosphatase staining and a decrease in tartaric acidic phosphatase staining.CONCLUSION:The results show that bone-strengthening pills can obviously promote bony growth,cause an increase in bone density,restore blood circulation,inhibit the occurrence and development of bony necrosis,and accelerate the repair of necrotic bones,with no toxic side-effects.

Key words: Bone-strengthening pill, Necrosis of femoral head, Osteoporosis