Journal of Traditional Chinese Medicine >
Traditional Chinese Medicine for the prevention and treatment of adolescent idiopathic scoliosis: scientific understanding and a multimodal therapeutic approach
Received date: 2025-03-25
Accepted date: 2025-09-24
Online published: 2026-06-08
Supported by
2020 Zhejiang Provincial Traditional Chinese Medicine Xinmiao Program(Project Number: Zhejiang Traditional Chinese Medicine Administration [2021] No. 1);2021 Zhejiang Provincial High-Level Health Talents Training Program – Medical Rising Star Program(Project Number: Zhejiang Provincial Health Commission Office [2021] No. 40);Project was Funded by the China Scholarship Council; and the 2021 Backbone Talent Training Program for the Internationalization of Traditional Chinese Medicine of the National Administration of Traditional Chinese Medicine(Project Number: National Traditional Chinese Medicine Certification [2021] No. 48)
Adolescent Idiopathic Scoliosis (AIS) is a common spinal disorder characterized by deviations in the coronal, sagittal, and axial planes. As AIS progresses with age, it compromises biomechanical function and increasingly impacts pulmonary function and psychological well-being. Bracing and Physiotherapeutic Scoliosis-Specific Exercises (PSSE) are commonly used conservative treatments for AIS. However, Traditional Chinese Medicine (TCM) has been gaining increasing attention in conservative AIS management. This study examines the effectiveness of TCM and its integrative therapies in AIS treatment, with particular emphasis on the foundational TCM concept of “preventive treatment of disease”. A three-level prevention strategy is proposed, highlighting the importance of early detection, timely treatment, and proactive intervention. This framework aims to promote a scientific understanding of TCM approaches and their synergistic use with other therapies in AIS management, offering new perspectives and potential directions for future.
LIN Kaifeng , ZENG Zhongliao , SUN Yan , SUN Fangzhou , ZHANG Han , SUN Jing , JIANG Ling , Jeffrey D. Deng , LI Min , LIANG Bocheng . Traditional Chinese Medicine for the prevention and treatment of adolescent idiopathic scoliosis: scientific understanding and a multimodal therapeutic approach[J]. Journal of Traditional Chinese Medicine, 2026 , 46(3) : 745 -756 . DOI: 10.19852/j.cnki.jtcm.2026.03.015
| 1. | Illes TS, Lavaste F, Dubousset JF. The third dimension of scoliosis: the forgotten axial plane. Orthop Traumatol Surg Res 2019; 105: 351-9. |
| 2. | Negrini S, Donzelli S, Aulisa AG, et al. 2016 SOSORT guidelines: orthopaedic and rehabilitation treatment of idiopathic scoliosis during growth. Scoliosis Spinal Disord 2018; 13: 3. |
| 3. | Theroux J, Brown BT, Marchese R, et al. The impact of pregnancy on women with adolescent idiopathic scoliosis: a scoping review. Eur J Phys Rehabil Med 2023; 59: 505-21. |
| 4. | Peng Y, Wang S, Qiu G, Zhang J, Zhuang Q. Research progress on the etiology and pathogenesis of adolescent idiopathic scoliosis. Chin Med J (Engl) 2020; 133: 483-93. |
| 5. | Di Felice F, Zaina F, Donzelli S, Negrini S. The natural history of idiopathic scoliosis during growth: a Meta-analysis. Am J Phys Med Rehabil 2018; 97: 346-56. |
| 6. | Qi X, Peng C, Fu P, Zhu A, Jiao W. Correlation between physical activity and adolescent idiopathic scoliosis: a systematic review. BMC Musculoskelet Disord 2023; 24: 978. |
| 7. | Yu H, Khanshour AM, Ushiki A, et al. Association of genetic variation in COL11A 1 with adolescent idiopathic scoliosis. Elife 2024; 12: RP89762. |
| 8. | Zakine S, Marty H, Courtin T, et al. How is familial idiopathic scoliosis transmitted? analysis of 26 pedigrees. Orthop Traumatol Surg Res 2025: 104229. |
| 9. | Zhao YX. Research progress of single nucleotide polymorphism and adolescent idiopathic scoliosis. Kunming Yi Ke Da Xue Xue Bao 2022; 43: 156-64. |
| 10. | Hernandez-Miranda LR, Ibrahim DM, Ruffault P, et al. Mutation in LBX1/Lbx1 precludes transcription factor cooperativity and causes congenital hypoventilation in humans and mice. Proc Natl Acad Sci U S A 2018; 115: 13021-26. |
| 11. | Sun P, He L, Jia K, et al. Regulation of body length and bone mass by Gpr126/Adgrg6. Sci Adv 2020; 6: eaaz0368. |
| 12. | Song H, Park K. Regulation and function of SOX9 during cartilage development and regeneration. Semin Cancer Biol 2020; 67: 12-23. |
| 13. | Bian F, Hansen V, Feng HC, et al. The G protein-coupled receptor ADGRG6 maintains mouse growth plate homeostasis through IHH signaling. J Bone Miner Res 2024; 39: 1644-58. |
| 14. | Tang NLS, Yeung H, Hung VWY, et al. Genetic epidemiology and heritability of AIS: a study of 415 Chinese female patients. J Orthop Res 2012; 30: 1464-69. |
| 15. | Li J, Liu C, Xu Y, et al. Gut microbiota alterations in adolescent idiopathic scoliosis are associated with aberrant bone homeostasis. Orthop Surg 2024; 16: 965-75. |
| 16. | Zhao ZR. Mechanism of osteonectin promoting osteogenic differentiation of bone marrow-derived mesenchymal stem cells and its correlation with adolescent idiopathic scoliosis. Zhuan Hua Yi Xue Za Zhi 2024; 13: 177-82. |
| 17. | Zhao X, Pan A, Hai Y. Greater pelvic obliquity in adolescent idiopathic scoliosis combined with hip dysplasia. Eur Spine J 2024; 33: 680-6. |
| 18. | Almahmoud OH, Baniodeh B, Musleh R, Asmar S, Zyada M, Qattousah H. Overview of adolescent idiopathic scoliosis and associated factors: a scoping review. Int J Adolesc Med Health 2023; 35: 437-41. |
| 19. | Liang Z, Li J, Tang H, et al. Critical role of NLRP3 in causing paravertebral muscle injury in adolescent idiopathic scoliosis. Clin Transl Med 2024; 14: e1528. |
| 20. | Wang Y, Xia N, Gu M, et al. Neuromuscular disturbances in adolescent idiopathic scoliosis observed from the anticipatory muscle activations in scapula stabilizers: a cross-sectional study. BMC Musculoskelet Disord 2024; 25: 1019. |
| 21. | Li T. Diagnostic significance and considerations of growth hormone stimulation testing and insulin-like growth factor 1 in growth hormone deficiency. Zhong Guo Dang Dai Er Ke Za Zhi 2023; 25: 1193-97. |
| 22. | Yang Y, Yang M, Shi D, et al. Single-cell RNA seq reveals cellular landscape-specific characteristics and potential etiologies for adolescent idiopathic scoliosis. JOR Spine 2021; 4: e1184. |
| 23. | Wang YY. Reflections on treatment of adolescent idiopathic scoliosis with Traditional Chinese Medicine manipulation. Shanghai Zhong Yi Yao Za Zhi 2023; 57: 56-8. |
| 24. | Tian G. A review on treating adolescent idiopathic scoliosis in TCM. Zhong Yi Lin Chuang Yan Jiu 2022; 14: 126-9. |
| 25. | Nanjing College of Traditional Chinese Medicine, Department of Medical Classics. Translated and annotated Su Wen of the Huang Di Nei Jing. Shanghai: Shanghai Scientific and Technical Publishers, 1959: 187, 325. |
| 26. | Tang ZH (Qing dynasty). Zhong Xi Hui Tong Yi Jing Jing Yi. Zhang LG, annot. Beijing: Xueyuan Press, 2012: 23. |
| 27. | Li DY (Jin dynasty). Pi Wei Lun. In: Wang GC, Fu F, Zhang NS, et al., eds. Complete medical works of Li Dongyuan. Beijing: China Press of Traditional Chinese Medicine, 2006: 336. |
| 28. | Hebei Medical College. Collated and annotated edition of the Lingshu Jing. Beijing: People's Medical Publishing House, 1982: 187-92. |
| 29. | Wu Q (Qing dynasty). Yi Zong Jin Jian. Beijing: People's Medical Publishing House, 2006: 336-42. |
| 30. | Lin DR (Tang dynasty). Xian Shou Li Shang Xu Duan Mi Fang. Hu XF, Ding JH, et al., coll. Beijing: People's Medical Publishing House, 2006: 23-8. |
| 31. | Li L, Yu SH, Zhou X, et al. Clinical practice guidelines of Traditional Chinese Medicine rehabilitation for idiopathic scoliosis in children and adolescents. Kang Fu Yi Xue 2023; 33: 295-302. |
| 32. | Xiao Z. Intervention guideline for idiopathic scoliosis in adolescents. Zhong Yi Yao Guan Li Za Zhi 2023; 31: 127. |
| 33. | Li HY. Effect of tendon massage combined with orthopedic therapy in the treatment of the adolescent scoliosis. Shu Li Yi Xue Za Zhi 2019; 32: 212-4. |
| 34. | Luo D, Jiang CL, Shi FY, et al. Observation on the therapeutic effect of Pingmi massage in the treatment of idiopathic early-onset scoliosis. Zhong Guo Zhong Yi Yao Ke Ji 2024; 31: 457-9. |
| 35. | Chen HY, Yin XD, Zhang TQ, et al. Thirty cases of adolescent idiopathic scoliosis were treated with 3D printed braces combined with tendon manipulation and spinal adjustment techniques. Zhong Guo Xiang Cun Yi Yao 2024; 31: 10-2. |
| 36. | Li ZJ, Tan CX, Li SL, et al. Early clinical intervention study of Xiguan bone setting adjustment method on adolescent idiopathic scoliosis. Zhong Yi Yao Lin Chuang Za Zhi 2023; 35: 1798-802. |
| 37. | Zhang P, Shen X, Zhang L, Wang S, Wu Q. Effect of sling exercise combined with Schroth therapy on adolescents with mild idiopathic scoliosis: a twelve-week randomized controlled trial. J Back Musculoskelet Rehabil 2024; 37: 379-88. |
| 38. | Du JM, Wang ZQ, Yang ZJ. The effect of massage combined with traction on idiopathic scoliosis guided by the “holistic view”. Zhong Guo Yi Yao Ke Xue 2022; 12: 91-5. |
| 39. | Grabala P, Galgano MA, Grabala M, Buchowski JM. Radiological and pulmonary results of surgical treatment of severe idiopathic scoliosis using preoperative halo gravity traction compared with less invasive temporary internal distraction in staged surgery in adolescents. J Clin Med 2024; 13: 2875. |
| 40. | Xu BY, Qi LT, Wang Y, et al. Clinical efficacy of short-term halo-pelvic traction combined with surgery in the treatment of severe spinal deformities. Beijing Da Xue Xue Bao (Yi Xue Ban) 2020; 52: 875-80. |
| 41. | Wang J, Hai Y, Han B, Zhou L, Zhang Y. Preoperative halo-gravity traction combined with one-stage posterior spinal fusion surgery following for severe rigid scoliosis with pulmonary dysfunction: a cohort study. BMC Surg 2024; 24: 286. |
| 42. | Gao L, Qu XY, Shen PF, et al. Effect of spinal balance therapy in adolescent idiopathic scoliosis. Anhui Yi Yao 2020; 24: 2390-3. |
| 43. | Zhu AQ. Observation on the therapeutic effect of Wuqinxi combined with rotational breathing training in the treatment of adolescent idiopathic scoliosis. Shanghai: Shanghai TCM University, 2020: 1-70. |
| 44. | Chen YK. Observation on the short-term clinical efficacy of Q-version Baduanjin in the treatment of adolescent idiopathic scoliosis. Fuzhou: Fuzhou TCM University, 2022: 1-52. |
| 45. | Wu D, Yan XP. The empirical study on the effect of Taijiquan's cloud hand technology on spinal curvature. Beijing Ti Yu Da Xue Xue Bao 2017; 40: 129-37. |
| 46. | Chen YH, Tang YH, Wang HY, et al. Effect of aerobic endurance training combined with electroacupuncture stimulation therapy on postoperative rehabilitation of patients with scoliosis. Zhong Hua Quan Ke Yi Xue 2022; 20: 1215-7. |
| 47. | Wang Z, Lu L, Wang L. Observation on the therapeutic effect of laser acupuncture combined with Schroth therapy on adolescent idiopathic scoliosis. Pak J Med Sci 2024; 40: 1174-9. |
| 48. | Lang JW, Jin LQ, Luo JC, et al. Effects of acupuncture combined with bone-setting therapy to treat tourette syndrome: a three-arm randomized controlled trial. J Tradit Chin Med 2025; 45: 176-83. |
| 49. | Qing Q, Xiang Z, Sent LH, Xueli Q. Observation on 33 cases of adolescent idiopathic scoliosis treated by ultra-micro needle knife combined with balance reduction and bone-setting massage method. Zhejiang Zhong Yi Za Zhi 2021; 56: 910-1. |
| 50. | Qiu MH, Fan CL, Lin H. Observations on the efficacy of collateral-unblocking and origin-consolidating acupuncture plus cupping for scoliosis. Shanghai Zhen Jiu Za Zhi 2021; 40: 1424-30. |
| 51. | Wang YY, Dong S, Li B, et al. Update evidence of effectiveness on pain relieving of cupping therapy: a systematic review and Meta-analysis of randomized controlled trials. J Tradit Chin Med 2025; 45: 234-53. |
| 52. | Jiang WH, Huiqi Li, Tang XH. Clinical observation of traction combined with “Long's orthopedic manipulation technique” for early adolescent idiopathic scoliosis. Ya Tai Chuan Tong Yi Yao 2023; 19: 85-9. |
| 53. | Xia Q, Lv ZZ, Pan JY, et al. Clinical observation on the treatment of adolescent idiopathic scoliosis by applying floating acupuncture combined with easy canning based on bowstring theory. Zhong Guo Zhong Yi Yao Ke Ji 2023; 30: 1085-7. |
| 54. | Yuan ZX, Fan DH, Lin Y, et al. The effect of traditional Chinese acupuncture combined with bone-setting massage in the treatment of adolescent idiopathic scoliosis and its influence on the degree of pain and Cobb angle. Neimenggu Zhong Yi Yao 2021; 40: 98-9. |
| 55. | Zhang XY, Zeng H, Li ZP, et al. Research progress on pathogenesis of osteoporosis and intervention of Traditional Chinese Medicine: a review. Zhong Guo Shi Yan Fang Ji Xue Za Zhi 2025; 31: 311-20. |
| 56. | Zhang YL, Huang YL, Xiao F, et al. Effect of Jingui Shenqiwan on diabetic osteoporosis in mice via AGEs/RANKL/NF-κB pathway based on theory of “kidneys governing bones”. Zhong Guo Shi Yan Fang Ji Xue Za Zhi 2023; 29: 11-20. |
| 57. | Lai KD, Hu XX, Lu GS, et al. Mechanism of total flavonoids from Spatholobi caulis in inhibiting osteoclast differentiation based on network pharmacology and experimental validation. Zhong Yao Yao Li Yu Lin Chuang 2023; 39: 62-9. |
| 58. | Wang SM, Guo JH, Li YY. Effect of Traditional Chinese Medicine fumigation combined with rehabilitation training and nursing on recovery of scoliosis and quality of life. Shi Yong Zhong Yi Nei Ke Za Zhi 2023; 37: 98-101. |
| 59. | Xie RT, Wei WM, Huang JJ, et al. Effect of Chinese medicine tincture combined with Schrott therapy on adolescent idiopathic scoliosis. Zhong Wai Yi Xue Yan Jiu 2020; 18: 35-7. |
| 60. | Li M, Nie Q, Liu J, Jiang Z. Prevalence of scoliosis in children and adolescents: a systematic review and Meta-analysis. Front Pediatr 2024; 12: 1399049. |
| 61. | Duke A, Marchese R, Komatsu DE, Barsi J. Radiation in adolescent idiopathic scoliosis management: estimated cumulative pre-operative, intra-operative, and post-operative exposure. Orthop Res Rev 2022; 14: 487-93. |
| 62. | Covell NB, Chari T, Hendren S, Poehlein E, Green CL, Catanzano AAJ. A framework for studying healthcare equity in adolescent idiopathic scoliosis: scoping review and Meta-analysis of existing literature. J Am Acad Orthop Surg 2024; 32: e452-65. |
| 63. | Charalampidis A, Diarbakerli E, Dufvenberg M, et al. Nighttime bracing or exercise in moderate-grade adolescent idiopathic scoliosis: a randomized clinical trial. JAMA Netw Open 2024; 7: e2352492. |
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