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Journal of Traditional Chinese Medicine >

2026 , Vol. 46 >Issue 2: 509 - 516

DOI: https://doi.org/10.19852/j.cnki.jtcm.2026.02.022

Reviews

Therapeutic potential of garlic-derived exosome like nanovesicles: challenge and opportunity

  • Masoumeh Amiri ,
  • Mozafar Khazaei ,
  • Tayebeh Sadat Tabatabai ,
  • Leila Rezakhani
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  • 1 Clinical Research Development Center, Imam Khomeini and Mohammad Kermanshahi and Farabi Hospitals, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran
    2 Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran
    3 Department of Tissue Engineering, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran
    4 Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud 36147-73943, Iran
Dr. Leila Rezakhani, Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran; Department of Tissue Engineering, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran

Received date: 2025-07-22

  Accepted date: 2025-12-06

  Online published: 2026-04-04

Supported by

Kermanshah University of Medical Sciences, Kermanshah, Iran(IR.KUMS.AEC.1402.036)

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Abstract

Recent advancements in nanotechnology have catalyzed interest in exosome-like nanovesicles derived from garlic, exploring their potential therapeutic applications. This review assesses the therapeutic efficacy of garlic-derived exosome-like nanovesicles (GaELNVs), emphasizing their antimicrobial, anticancer, antioxidant, and anti-inflammatory properties, alongside their utility in drug delivery systems. Synthesizing diverse studies, this review discusses methodologies for GaELNV isolation, characterization (including high-speed centrifugation, sequential centrifugation, and sucrose gradient purification), and application. GaELNVs exhibit notable therapeutic potential, evidenced by their capacity to mitigate brain inflammation, enhance cognitive function, improve glucose metabolism, and show minimal immunogenicity. These effects are attributed to their modulation of inflammatory cytokines and other molecular pathways. Moreover, GaELNVs demonstrate robust biocompatibility, stability in acidic environments, and efficient targeting capabilities. In conclusion, this review underscores the promising therapeutic applications of GaELNVs, particularly as a pioneering drug delivery system. However, further investigations are imperative to optimize clinical deployment and comprehensively elucidate their mechanisms of action.

Key words： garlic; nanovesicles; exosome; therapeutic; review

Cite this article

Masoumeh Amiri , Mozafar Khazaei , Tayebeh Sadat Tabatabai , Leila Rezakhani . Therapeutic potential of garlic-derived exosome like nanovesicles: challenge and opportunity[J]. Journal of Traditional Chinese Medicine, 2026 , 46(2) : 509 -516 . DOI: 10.19852/j.cnki.jtcm.2026.02.022

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