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Journal of Traditional Chinese Medicine >

2026 , Vol. 46 >Issue 2: 447 - 457

DOI: https://doi.org/10.19852/j.cnki.jtcm.2026.02.017

Original Articles

Clinical efficacy of abdominal moxibustion at the Zhongji (CV3) in combination with Yiqi Tonglin Yangyin decoction (益气通淋养阴汤) and antibiotics for treating elderly female patients with complicated urinary tract infection

  • HU Yunhao ,
  • ZHANG Yi ,
  • ZHAO Min ,
  • ZHU Danyang ,
  • JIA Xing ,
  • WANG Cunzhou
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  • 1 Department of Traditional Chinese Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China
    2 Department of Traditional Chinese Medicine, Shanghai Changning District Huayang Street Community Health Service Center, Shanghai 200042, China
    3 Department of Urology Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China
Dr. ZHANG Yi, Department of Traditional Chinese Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China. zyyy522@163.com; Tel: +86-13816630909

Received date: 2024-12-12

  Accepted date: 2025-06-19

  Online published: 2026-04-04

Supported by

Cultivation of Young Traditional Chinese Medicine Practitioners in Changning District(2021CNQNZY005);Observation on the Therapeutic Effect of "Lung-Kidney Co-treatment and Moxibustion-drug Combination" in Preventing the Recurrence of Urinary Tract Infection in Elderly Women(CNKW2022014)

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Abstract

OBJECTIVE: To investigate the clinical effect of abdominal moxibustion at the Zhongji (CV3) combined with Yiqi Tonglin Yangyin decoction (益气通淋养阴汤) and antibiotics on elderly women with complicated urinary tract infections.

METHODS: One hundred and forty-four elderly female patients diagnosed with complicated urinary tract infections and admitted to our hospital were selected for this study. They were randomly assigned to two groups: the dual treatment group, consisting of 72 patients, treated with antibiotics combined with Yiqi Tonglin Yangyin decoction, and the triple treatment group, comprising 72 patients, who received abdominal moxibustion at the Zhongji (CV3) in addition to the dual treatment. The clinical efficacy, Traditional Chinese Medicine (TCM) syndrome score, immune function indicators, oxidative stress status indicators, symptom recovery, and recurrence were evaluated and compared.

RESULTS: Before treatment, there was no statistically significant differences observed in the TCM syndrome score, levels of immunoglobulin A (IgA), immunoglobulin M (IgM), xanthine oxidoreductase (XOD), malondialdehyde (MDA) and superoxide dismutase (SOD) between the two groups (P >0.05). After treatment, the triple group exhibited a significantly higher overall response rate (95.9% > 84.7%) compared to the dual group. Moreover, the triple group demonstrated elevated levels of IgA, IgM, and SOD, a lower TCM syndrome score, and reduced levels of XOD and MDA, along with a diminished recurrence rate. Additionally, patients in the triple group experienced a shorter time to return to normal symptoms, bacteriuria, and a routine urine output.

CONCLUSION: Abdominal moxibustion at the Zhongji (CV3), combined with Yiqi Tonglin Yangyin decoction and antibiotics for treating complicated urinary tract infections in elderly women, can effectively improve the clinical symptoms, TCM syndromes, and immune function of patients. Additionally, it can reduce oxidative stress, promote patient recovery, and lower the recurrence rate with pronounced comprehensive efficacy.

Key words： aged; women; urinary tract infections; antibiotics; Zhongji (CV3); Yiqi Tonglin Yangyin decoction

Cite this article

HU Yunhao , ZHANG Yi , ZHAO Min , ZHU Danyang , JIA Xing , WANG Cunzhou . Clinical efficacy of abdominal moxibustion at the Zhongji (CV3) in combination with Yiqi Tonglin Yangyin decoction (益气通淋养阴汤) and antibiotics for treating elderly female patients with complicated urinary tract infection[J]. Journal of Traditional Chinese Medicine, 2026 , 46(2) : 447 -457 . DOI: 10.19852/j.cnki.jtcm.2026.02.017

References

1. Zhang Y, Liu W, Wei G, et al. Bioinspired nanozymes as nanodecoys for urinary tract infection treatment. ACS nano 2024; 18: 9019-30.
2. Liu L, Xie K, Yin M, et al. Lower serum levels of vitamin D in adults with urinary tract infection. Infection 2022; 50: 1-8.
3. Carcamo P, Walter E, Frei CR, et al. A comparison of empiric therapy with cefazolin versus ceftriaxone for patients with complicated urinary tract infections in a tertiary care veterans affairs medical center. BMC Infect Dis 2025; 25: 302.
4. Wagenlehner F, Caballero VR, Maheshwari V, et al. Efficacy of treatment options for complicated urinary tract infections including acute pyelonephritis: a systematic literature review and network Meta-analysis. J Comp Eff Res 2025; 14: e240214.
5. Polo JM, Sánchez JLA, Suárez JA, et al. The importance of antimicrobial strategies associated with clinical cure and increased microbiological eradication in patients with complicated urinary tract infections and high risk of relapse. Eur Urol Open Sci 2025; 71: 165-71.
6. Spangler FL, Williams C, Aberger ME, et al. Clinical utility of PCR compared to conventional culture and sensitivity testing for management of complicated urinary tract infections in adults: Part II. Evaluation of diagnostic concordance, discordant results, and antimicrobial selection efficacy. Diagn Microbiol Infect Dis 2025; 111: 116646.
7. Guerriero S, Matteini E, Gross MM, et al. Complicated urinary tract infections: an update of new and developing antibiotics. Expert Opin Pharmacother 2025; 26: 167-77.
8. Coyle ME, Zhang AL, Xue CC. Authors’ reply re: acupuncture for recurrent urinary tract infection in women: a systematic review and Meta-analysis. BJOG 2020; 127: 1441.
9. Qin X, Coyle ME, Zhang AL, et al. Authors’ reply re: acupuncture for recurrent urinary tract infection in women: a systematic review and Meta-analysis. BJOG 2022; 129: 1169-70.
10. Nehru VJ, Vandakunnel MJ, Brammacharry U, et al. Risk assessment and transmission of fluoroquinolone resistance in drug-resistant pulmonary tuberculosis: a retrospective genomic epidemiology study. Sci Rep 2024; 14: 19719.
11. Qin X, Coyle ME, Yang L, et al. Acupuncture for recurrent urinary tract infection in women: a systematic review and Meta-analysis. BJOG 2020; 127: 1459-68.
12. Guo S, Li X, Li Y, et al. Sitafloxacin pharmacokinetics/ pharmacodynamics against multidrug-resistant bacteria in a dynamic urinary tract infection in vitro model. J Antimicrob Chemother 2022; 78: 141-9.
13. Yang W, Liu P, Zheng Y, et al. Transcriptomic analyses and experimental verification reveal potential biomarkers and biological pathways of urinary tract infection. Bioengineered 2021; 12: 8529-39.
14. Li Y, Yin Y, Peng X, et al. A randomized, active-controlled, multicentre clinical trial to evaluate the efficacy and safety of oral sitafloxacin versus levofloxacin in Chinese adults with acute uncomplicated or complicated urinary tract infection. Ann Med 2021; 53: 217-26.
15. Gu W, Huang W, Zhang J, et al. Evaluation of urinary inflammatory index in rapid screening of urinary tract infection. Sci Rep 2020; 10: 19306.
16. Yang J, Qiu X, Zhou M, et al. Crocetin attenuating urinary tract infection and adherence of uropathogenic E. coli in NRK-52E cells via an inflammatory pathway. J Food Biochem 2021; 45: e13998.
17. Li Y, Jiang L, Luo S, et al. Analysis of characteristics, pathogens and drug resistance of urinary tract infection associated with long-term indwelling double-J stent. Infect Drug Resist 2023; 16: 2089-96.
18. Chen K, Zhu Y, Su H, et al. Modified Zhibai Dihuang pill alleviated urinary tract infection induced by extended-spectrum β-lactamase Escherichia coli in rats by regulating biofilm formation. Pharm Biol 2023; 61: 674-82.
19. Liu H, Qiu S, Chen M, et al. A clinical prediction tool for extended-spectrum β-lactamase-producing enterobacteriaceae urinary tract infection. BMC Infect Dis 2022; 22: 50.
20. Anonymous (Han dynasty). Huang Di Nei Jing. Beijing: People’s Medical Publishing House, 2012: 123.
21. Wu R, Teng X, Song Q, et al. Single-cell RNA sequencing reveals sexual diversity in the human bladder and its prospective impacts on bladder cancer and urinary tract infection. BMC Med Genomics 2023; 16: 122.
22. Mo L, Wang J, Qian J, et al. Antibiotic sensitivity of proteus mirabilis urinary tract infection in patients with urinary calculi. Int J Clin Pract 2022; 2022: 7273627.
23. Li T, Xu Y, Gong X. Clinical efficacy of Tailin formulation combined with continuous low-dose antimicrobial therapy for recurrent urinary tract infection: study protocol for a multicenter, double-blind, randomized, controlled clinical trial. Trials 2021; 22: 901.
24. Hsu YC, Huang HC, Tang KS, et al. Elevated urinary hepcidin level and hypoferremia in infants with febrile urinary tract infection: a prospective cohort study. Children (Basel) 2023; 10: 870.
25. Chen H, Wang Y, Wang ZM, et al. Effect of moxibustion on ureteral stent-related symptoms after ureteroscopic lithotripsy. Zhong Guo Zhen Jiu 2023; 43: 1251-6.
26. Lee HY, Bae GE, Lee SD, et al. Moxibustion as an adjunct for lower urinary tract symptoms associated with benign prostate enlargement: a randomized controlled pilot trial. Medicine (Baltimore) 2020; 99: e18918.
27. Zhang CF, Shen YF, Zhang HY. Efficacy of the herbal cake-separated moxibustion with new-type moxibustion device on urinary retention after spinal cord injury. Zhong Guo Zhen Jiu 2019; 39: 953-6.
28. Wang C, Huang W, Gu Y, et al. Effect of urinary tract infection on the risk of prosthetic joint infection: a systematic review and Meta-analysis. Surgeon 2021; 19: 175-82.
29. Yuan S, Shi Y, Li M, et al. Trends in incidence of urinary tract infection in mainland China from 1990 to 2019. Int J Gen Med 2021; 14: 1413-20.
30. Wang J, Cao Y, Zhang L, et al. Pathogen distribution and risk factors for urinary tract infection in infants and young children with retained double-J catheters. J Int Med Res 2021; 49: 3000605211012379.
31. Ren C, Li Z, Meng F, et al. Endogenous endophthalmitis caused by urinary tract infection: a case report. Medicine (Baltimore) 2023; 102: e36139.
32. Cavalcante RN, Santos ACS, Rodrigues RAS, et al. Wheelchair basketball improves the treatment of urinary tract infection in people with motor disabilities: a clinical trial. Rev Assoc Med Bras (1992) 2022; 68: 559-67.
33. Ding YE. Ding Ganren and the Shanghai Professional College of Chinese Medicine. Zhong hua Yi Shi Za Zhi 2016; 46: 369-72.
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