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Journal of Traditional Chinese Medicine >

2026 , Vol. 46 >Issue 2: 261 - 273

DOI: https://doi.org/10.19852/j.cnki.jtcm.2026.02.001

Systematic Review

A Meta-analysis of Traditional Chinese Medicine constitution distribution in people with functional constipation

  • WANG Xuehui ,
  • SUN Yuxin ,
  • Birling Yoann ,
  • LI Xun ,
  • ZHAO Ruotong ,
  • ZHENG Youyou ,
  • SONG Zhenmei ,
  • ZHANG Yanli ,
  • DU Hongbo ,
  • WANG Jianyun ,
  • LI Yinqing ,
  • LIU Zhaolan ,
  • LIU Jianping
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  • 1 Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
    2 NICM Health Research Institute, Western Sydney University, Westmead 2145, New South Wales, Australia
    3 Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China
    4 Department of Gastroenterology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
    5 Department of Spleen and Stomach Diseases, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China
    6 Hebei Yuzhilin Pharmaceutical Co., Ltd., and Hebei Technology Innovation Center of Precise nutrition and health, Shijiazhuang 050000, China

WANG Xuehui and SUN Yuxin are co-first authors and contributed equally to this work

LIU Zhaolan, Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China. lzl1019@163.com

Received date: 2024-12-20

  Accepted date: 2025-06-11

  Online published: 2026-04-04

Supported by

Mixed Research Was Conducted to Formulate Countermeasures for the Output Bottleneck of Clinical Research Results in International First-Class Chinese Patent Medicine(90020172120032);Design, Data Management, and Statistical Analysis of a Post-Marketing Cross-Sectional Survey of Biantong Brand Tiantian Capsules(90020171720006)

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Abstract

OBJECTIVE: To investigate the distribution of Traditional Chinese Medicine (TCM) constitution among individuals with functional constipation, which would provide insights for developing constitution-targeted prevention and treatment strategies.

METHODS: A systematic search was conducted across eight databases (China National Knowledge Infrastructure Database, Wanfang Database, China Science and Technology Journal for Chinese Technical Periodicals, SinoMed, PubMed, Web of Science, Embase, and the Cochrane Library) to identify relevant observational studies assessing Traditional Chinese Medicine (TCM) constitution types among people with functional constipation. The protocol for this review has been registered on International Prospective Register of Systematic Reviews (registration number: CRD42022345996).

RESULTS: A total of sixteen cross-sectional studies involving 2976 participants were included in this review. Among functional constipation patients, the proportions of Yin-deficiency, Yang-deficiency, and Qi-deficiency constitution were 27.0% [95% confidence interval (CI) 19.9% to 36.7%], 25.2% (95% CI 17.5% to 35.0%) and 23.7% (95% CI 15.8% to 34.0%), respectively. Besides, females accounted for a higher percentage of the population with functional constipation in the included studies, and most patients were aged 45 years or older. These findings may reflect the demographic characteristics of the general functional constipation population, where older adults and women are more commonly affected. The impact of gender and age on TCM constitution distribution merits further exploration.

CONCLUSION: Our finding revealed that Yin-deficiency, Yang-deficiency, and Qi-deficiency are the predominant TCM constitution types in people with functional constipation. This study suggests that clinicians should focus on patients with these TCM constitution types in the prevention and management of functional constipation. Larger sample sizes and more rigorous methodological designs are needed in future studies. Furthermore, future researches should also focus on developing individualized prevention and treatment strategies based on different TCM constitution types.

Key words： physical constitution theory; cross-sectional studies; correlation; systematic review; Meta-analysis

Cite this article

WANG Xuehui , SUN Yuxin , Birling Yoann , LI Xun , ZHAO Ruotong , ZHENG Youyou , SONG Zhenmei , ZHANG Yanli , DU Hongbo , WANG Jianyun , LI Yinqing , LIU Zhaolan , LIU Jianping . A Meta-analysis of Traditional Chinese Medicine constitution distribution in people with functional constipation[J]. Journal of Traditional Chinese Medicine, 2026 , 46(2) : 261 -273 . DOI: 10.19852/j.cnki.jtcm.2026.02.001

References

1. Fu SH, Lu G. The relationship between functional constipation and the constitution of Traditional Chinese Medicine: discussion based on previous literature. Zhong Yi Yao Lin Chuang Za Zhi 2021; 33: 410-3.
2. Luo WZ. Preliminary study on the distribution of traditional Chinese medicine constitution in patients with functional constipation. Nanjing: Nanjing University of Chinese Medicine, 2017: 1-37.
3. Barberio B, Judge C, Savarino EV, Ford AC. Global prevalence of functional constipation according to the Rome criteria: a systematic review and Meta-analysis. Lancet Gastroenterol Hepatol 2021; 6: 638-48.
4. Cheng XY, Sun WJ, Jin S, Tan JL, Fang H. Correlation and significance of age, sex, traditional Chinese medicine syndrome types and constitutions in patients with chronic functional constipation. Shi Jie Zhong Yi Yao 2021; 13: 2625-8.
5. Ding XJ, Wang WH, Dong X, et al. Distribution of TCM syndromes, constitution, anxiety, and depression in college students with functional constipation. Shaanxi Zhong Yi Yao Da Xue Xue Bao 2020; 43: 77-81.
6. Liu N, Hung J, He L. Exploration of the correlation between symptoms of functional constipation and Chinese medicine constitution. Shi Jie Zui Xin Yi Xue Xin Xi Wen Zhai 2019; 19: 158-9.
7. Song YN. Study on the correlation between functional constipation, TCM constitution, and dietary habits. Guangzhou: Guangzhou University of Chinese Medicine, 2015: 1-42.
8. Qi ZL, Li J. Professor Gan Aiping’s experience in the treatment of diabetic constipation. Zhong Guo Ji Xu Yi Xue Jiao Yu 2019; 11: 138-9.
9. Bharucha AE, Pemberton JH, Locke GR 3rd. American Gastroenterological Association technical review on constipation. Gastroenterology 2013; 144: 218-38.
10. Li L, Yao H, Wang J, Li Y, Wang Q. The role of Chinese medicine in health maintenance and disease prevention: application of constitution theory. Am J Chin Med 2019; 47: 495-506.
11. Mu TY, Zhu QY, Chen LS, et al. Traditional Chinese Medicine constitution types of high-normal blood pressure: a Meta-analysis. Heliyon 2023; 9: e13438.
12. Wang Q. Body constitution identification is the starting point of curing disease. Huan Qiu Zhong Yi Yao 2019; 3: 5-6.
13. Classification and determination of constitution in TCM (ZYYXH/T157-2009). Shi Jie Zhong Xi Yi Jie He Za Zhi 2009; 4: 303-4.
14. Zhou M, Wang M. Professor Wang Min’s application of TCM constitution-based treatment for chronic constipation. Guo Ji Gan Ran Bing Xue 2020; 9: 152.
15. Liang X, Wang Q, Jiang Z, et al. Clinical research linking Traditional Chinese Medicine constitution types with diseases: a literature review of 1639 observational studies. J Tradit Chin Med 2020; 40: 690-702.
16. Jia YT. Correlation analysis between mental and psychological factors in constipation patients and TCM body constitution. Chengdu: Chengdu University of Traditional Chinese Medicine, 2012: 1-51.
17. Wei J, Zeng SM, Luo PJ, Liang Q, Huang GH. Research progress in the treatment of functional constipation with Traditional Chinese Medicine. Liaoning Zhong Yi Yao Da Xue Xue Bao 2019; 21: 119-23.
18. Liu GZ. Identification of functional constipation and Chinese medicine treatment. Zhong Guo Lin Chuang Yi Xue 2012; 32: 126.
19. Kuang TY. Use of diet to treat functional constipation and diarrhea according to constitution. Yin Shi Ke Xue 2004: 19: 22.
20. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. JAMA 2000; 283: 2008-12.
21. Luo H, Wang Q. Systematic review and Meta-analysis on the correlation between constitutional types of Traditional Chinese Medicine and metabolic syndrome. Beijing Zhong Yi Yao Da Xue Xue Bao 2016; 39: 325-34.
22. Specialized Committee of Digestive System Diseases, Chinese Society of Integrative Medicine. Consensus on the diagnosis and treatment of functional constipation in integrative medicine. Zhong Guo Zhong Xi Yi Jie He Xiao Hua Za Zhi 2018; 26: 18-26.
23. Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC. Functional bowel disorders. Gastroenterology 2006; 130: 1480-91.
24. Mearin F, Lacy BE, Chang L, et al. Bowel disorders. Gastroenterology 2016; 150: 1393-407.
25. Zhu YB, Wang Q, Origasa H. Evaluation on the reliability and validity of the Constitution in Chinese Medicine Questionnaire (CCMQ). Zhong Guo Xing Wei Yi Xue Ke Xue 2007; 16: 651-4.
26. Zeng XT, Liu H, Cheng X, Ling WD. Meta-analysis series No. 4: quality evaluation tools for observational studies. Zhong Guo Xun Zheng Xin Xue Guan Yi Xue Za Zhi 2012; 4: 297-9.
27. Pequeno NPF, Cabral NLA, Marchioni DM, et al. Quality of life assessment instruments for adults: a systematic review of population-based studies. Health Qual Life Outcomes 2020; 18: 208.
28. Hu J, Dong Y, Chen X, et al. Prevalence of suicide attempts among Chinese adolescents: a Meta-analysis of cross-sectional studies. Compr Psychiatry 2015; 61: 78-89.
29. von Elm E, Altman DG, Egger M, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Int J Surg 2014; 12: 1495-9.
30. Liu JP. GRADE methods in traditional medicine. Integr Med Res 2022; 11: 100836.
31. Guyatt GH, Oxman AD, Schünemann HJ, Tugwell P, Knottnerus A. GRADE guidelines: a new series of articles in the Journal of Clinical Epidemiology. J Clin Epidemiol 2011; 64: 380-2.
32. Ye Z, Wang L, Yang T, et al. Gender of infant and risk of postpartum depression: a meta-analysis based on cohort and case-control studies. J Matern Fetal Neonatal Med 2022; 35: 2581-90.
33. Jin ZC, Zhou XH, He J. Statistical methods for dealing with publication bias in Meta-analysis. Stat Med 2015; 34: 343-60.
34. Wang CJ, Zeng L, Zhang H, Zhu SW. Distribution characteristics of traditional Chinese medicine constitution and TCM syndrome types in 210 cases of functional constipation among the Buyi ethnic group in Qiannan Prefecture. Zhong Guo Min Zu Min Jian Yi Yao 2024; 30: 64-7.
35. Zhang JY, Huang XF, Liu H. The relationship between functional constipation and constitution. Henan Zhong Yi 2021; 41: 1718-21.
36. Li M, Zhou HF, Ding SQ. Analysis of the constitutional characteristics of chronic functional constipation in Chinese medicine. Shaanxi Zhong Yi 2017; 38: 149-51.
37. Yang M, Lin XY, Lang SM, Liu ZH, Yang XM. Study on TCM constitutional characteristics of functional constipation in college students. Kang Fu Xue Bao 2014; 24: 13-5.
38. Zhang Q, Yao Q, Zhong C. Distribution features of constipation patients’ constitution types differentiated by TCM. Wei Chang Bing Xue 2017; 37: 40-2.
39. Fu SH. A questionnaire-based study on the relevance of the three-dimensional model of “disease-syndrome-constitution” in functional constipation. Shenyang: Liaoning University of Traditional Chinese Medicine, 2021: 1-27.
40. Guo R. Effect of health education for community elderly constipation patients with yin-deficiency constitution after TCM constitution identification. Harbin: Heilongjiang University of Chinese Medicine, 2015: 1-46.
41. Chen X. Study on the etiology and somatology of functional constipation in middle-aged and elderly people in Fuzhou. Fuzhou: Fujian University of Traditional Chinese Medicine, 2015: 1-22.
42. Shi GD. Relationship between elderly functional constipation and TCM constitution. Xianyang: Shaanxi University of Chinese Medicine, 2014: 1-22.
43. Zhao CY. Study on the disease characteristics of functional constipation with a questionnaire. Guangzhou: Guangzhou University of Chinese Medicine, 2015: 1-37.
44. Chen FM.The study of correlation between Traditional Chinese Medicine constitution and functional constipation.In: China Association of Chinese Medicine, editors. Proceedings of the 2015 Annual Academic Conference of the Anorectal Branch of the China Association of Chinese Medicine and National Conference on the Release of the Epidemiological Survey of Anorectal Diseases; 2015 Oct 16-17; Zhengzhou, China. Beijing: China Association of Chinese Medicine, 2015: 371-3.
45. Zhao HB, Wu XJ, Yang Y, Liang TY, Ge ZM. Logistic regression analysis of relative risk factors for chronic functional constipation and Chinese medicine constitution types. Zhong Yi Za Zhi 2017; 58: 1393-8.
46. Bai F, Luo H, Wang L, et al. A Meta-analysis of the association between diabetes mellitus and Traditional Chinese Medicine constitution. Evid Based Complement Alternat Med 2021; 2021: 6390530.
47. Song Y, Ma J, Hu PJ, Zhang B. Geographic distribution and secular trend of menarche in 9-18-year-old Chinese Han girls. Beijing Da Xue Xue Bao 2011; 43: 360-4.
48. Chan YY. Clinical curative observation of warm moxibustion needle therapy for functional constipation with phlegm constitution. Guangzhou: Guangzhou University of Chinese Medicine, 2017: 1-37.
49. Wang Q, Zhu YB. Epidemiological survey of TCM constitution in the general population in China: based on data from 21 948 cases in 9 provinces and cities in China. Zhong Hua Zhong Yi Yao Za Zhi 2009; 24: 7-12.
50. Cai K, Cui JH, Shen F, et al. An observational study on the TCM constitution of chronic constipation in the elderly. Zhejiang Zhong Yi Za Zhi 2016; 51: 874-5.
51. Wang YF. Distribution of TCM constitution types and analysis of related factors in functional constipation patients in Lingnan. Guangzhou: Guangzhou University of Chinese Medicine, 2021: 1-39.
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