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Journal of Traditional Chinese Medicine >

2026 , Vol. 46 >Issue 1: 14 - 21

DOI: https://doi.org/10.19852/j.cnki.jtcm.2026.01.002

Systematic Reviews

Efficacy of Tongxie Yaofang (痛泻要方) compared with pinaverium bromide on irritable bowel syndrome with liver depression and spleen deficiency: a systematic review and Meta-analysis

  • Mi ZHOU ,
  • Huaien BU ,
  • Dongjun WANG ,
  • Naijin ZHANG ,
  • Xuan SUN ,
  • Zhikui TIAN ,
  • Hongwu WANG
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  • 1 School of Health Science and Engineering, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
    2 College of Traditional Chinese Medicine, North China University of Science and Technology, Tangshan 063000, China

Received date: 2023-08-22

  Accepted date: 2024-03-12

  Online published: 2026-01-28

Supported by

National Key Basic Research and Development Plan(973 Plan);Research on Traditional Chinese Medicine Original Thinking and Health State Identification Method System(2011CB505406)

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Abstract

OBJECTIVE: To compare the efficacy of Tongxie Yaofang (痛泻要方, TXYF) versus pinaverium bromide for the treatment of diarrheal irritable bowel syndrome (IBS-D) with liver depression and spleen deficiency.

METHODS: A search of the China National Knowledge Infrastructure Database, China Science and Technology Journal Database, Wanfang Database, PubMed, EMBASE, Cochrane Library and Web of Science databases was conducted from database creation to the 28th of September 2022. Meta-analysis was performed using Revman 5.4 software.

RESULTS: Twelve randomized controlled trials comprising 1058 patients were included in the analysis. TXYF was more efficacious in improving the clinical symptoms of patients. Comparison of the efficacy rate, Traditional Chinese Medicine Evidence Score (TCM-PES), self-rating anxiety scale anxiety score, self-rating depression scale depression score, adverse reaction rate and calcitonin gene-related peptide (CGRP) levels showed that TXYF was significantly superior to pinaverium bromide treatment (P < 0.05); there was no statistically significant difference in the plasma vasoactive peptide level between the two groups (P > 0.05). Funnel plots of the total efficacy rate and TCM-PES were asymmetrically distributed, suggesting publication bias. The GRADEpro Guideline Development Tool was also used to evaluate the studies, and the evidence rating of the included studies was not high.

CONCLUSIONS: Although the results of this study suggest that TXYF may be superior for the treatment of IBS-D with liver depression and spleen deficiency, as compared to pinaverium bromide, definitive conclusions are unable to be drawn at this time due to flaws in the overall design of the included trials. Therefore, more rigorous trials are needed to determine the benefit and safety of TXYF.

Key words： irritable bowel syndrome; diarrhea pinaverium bromide; liver depression; spleen deficiency; Tongxie Yaofang

Cite this article

Mi ZHOU , Huaien BU , Dongjun WANG , Naijin ZHANG , Xuan SUN , Zhikui TIAN , Hongwu WANG . Efficacy of Tongxie Yaofang (痛泻要方) compared with pinaverium bromide on irritable bowel syndrome with liver depression and spleen deficiency: a systematic review and Meta-analysis[J]. Journal of Traditional Chinese Medicine, 2026 , 46(1) : 14 -21 . DOI: 10.19852/j.cnki.jtcm.2026.01.002

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